RU2012146630A - Имплантаты в виде резервуаров с замедленным высвобождением для внутрикамерной доставки лекарственных средств - Google Patents
Имплантаты в виде резервуаров с замедленным высвобождением для внутрикамерной доставки лекарственных средств Download PDFInfo
- Publication number
- RU2012146630A RU2012146630A RU2012146630/15A RU2012146630A RU2012146630A RU 2012146630 A RU2012146630 A RU 2012146630A RU 2012146630/15 A RU2012146630/15 A RU 2012146630/15A RU 2012146630 A RU2012146630 A RU 2012146630A RU 2012146630 A RU2012146630 A RU 2012146630A
- Authority
- RU
- Russia
- Prior art keywords
- implant
- aforementioned
- antihypertensive
- polymer
- reservoir
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims abstract 56
- 239000003814 drug Substances 0.000 title claims 7
- 239000002220 antihypertensive agent Substances 0.000 claims abstract 18
- 150000002632 lipids Chemical class 0.000 claims abstract 18
- 230000004410 intraocular pressure Effects 0.000 claims abstract 14
- 229920000642 polymer Polymers 0.000 claims abstract 14
- 230000003276 anti-hypertensive effect Effects 0.000 claims abstract 10
- -1 narrowing pupils Substances 0.000 claims abstract 5
- 229940030600 antihypertensive agent Drugs 0.000 claims abstract 4
- 229920002988 biodegradable polymer Polymers 0.000 claims abstract 4
- 239000004621 biodegradable polymer Substances 0.000 claims abstract 4
- 229920003232 aliphatic polyester Polymers 0.000 claims abstract 3
- 229930003827 cannabinoid Natural products 0.000 claims abstract 3
- 239000003557 cannabinoid Substances 0.000 claims abstract 3
- 229940065144 cannabinoids Drugs 0.000 claims abstract 3
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims abstract 3
- 239000003590 rho kinase inhibitor Substances 0.000 claims abstract 3
- 229920001054 Poly(ethylene‐co‐vinyl acetate) Polymers 0.000 claims abstract 2
- 239000000150 Sympathomimetic Substances 0.000 claims abstract 2
- 102000004136 Vasopressin Receptors Human genes 0.000 claims abstract 2
- 108090000643 Vasopressin Receptors Proteins 0.000 claims abstract 2
- 239000000695 adrenergic alpha-agonist Substances 0.000 claims abstract 2
- 239000000674 adrenergic antagonist Substances 0.000 claims abstract 2
- 239000005557 antagonist Substances 0.000 claims abstract 2
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims abstract 2
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims abstract 2
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims abstract 2
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims abstract 2
- 229920002635 polyurethane Polymers 0.000 claims abstract 2
- 239000004814 polyurethane Substances 0.000 claims abstract 2
- 229920002379 silicone rubber Polymers 0.000 claims abstract 2
- 230000001975 sympathomimetic effect Effects 0.000 claims abstract 2
- 229940064707 sympathomimetics Drugs 0.000 claims abstract 2
- 208000001953 Hypotension Diseases 0.000 claims 8
- 208000021822 hypotensive Diseases 0.000 claims 8
- 230000001077 hypotensive effect Effects 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 229920001610 polycaprolactone Polymers 0.000 claims 4
- 229920001296 polysiloxane Polymers 0.000 claims 4
- 230000001575 pathological effect Effects 0.000 claims 3
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 3
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 claims 2
- 229960002470 bimatoprost Drugs 0.000 claims 2
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229960004605 timolol Drugs 0.000 claims 2
- 229960002368 travoprost Drugs 0.000 claims 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims 1
- KSBKLOORIKSXDP-BWJWWNBBSA-N (2s)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;(4r,6r)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide Chemical compound CCN[C@@H]1C[C@@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 KSBKLOORIKSXDP-BWJWWNBBSA-N 0.000 claims 1
- NWIUTZDMDHAVTP-KRWDZBQOSA-N (S)-betaxolol Chemical compound C1=CC(OC[C@@H](O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-KRWDZBQOSA-N 0.000 claims 1
- WROUWQQRXUBECT-UHFFFAOYSA-N 2-ethylacrylic acid Chemical compound CCC(=C)C(O)=O WROUWQQRXUBECT-UHFFFAOYSA-N 0.000 claims 1
- ZUIFJYRNWWNOPB-PPHPATTJSA-N 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;(2s)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 ZUIFJYRNWWNOPB-PPHPATTJSA-N 0.000 claims 1
- YUWPMEXLKGOSBF-GACAOOTBSA-N Anecortave acetate Chemical compound O=C1CC[C@]2(C)C3=CC[C@]4(C)[C@](C(=O)COC(=O)C)(O)CC[C@H]4[C@@H]3CCC2=C1 YUWPMEXLKGOSBF-GACAOOTBSA-N 0.000 claims 1
- ISZJXIYRLAGBMH-IQMDKZJJSA-N CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.CCNC(=O)CCC\C=C/CC1C(O)CC(O)[C@@H]1\C=C\C(O)CCc1ccccc1 Chemical compound CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.CCNC(=O)CCC\C=C/CC1C(O)CC(O)[C@@H]1\C=C\C(O)CCc1ccccc1 ISZJXIYRLAGBMH-IQMDKZJJSA-N 0.000 claims 1
- 108090000312 Calcium Channels Proteins 0.000 claims 1
- 102000003922 Calcium Channels Human genes 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 102100024450 Prostaglandin E2 receptor EP4 subtype Human genes 0.000 claims 1
- 101150109738 Ptger4 gene Proteins 0.000 claims 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims 1
- UCGXLCPNFJKWEF-ZSXJVMONSA-N [3-hydroxy-2,2-bis(hydroxymethyl)propyl] 7-[(1r,2r,3r,5s)-2-[(3r)-3-(1-benzothiophen-2-yl)-3-hydroxypropyl]-3,5-dihydroxycyclopentyl]heptanoate Chemical compound OCC(CO)(CO)COC(=O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)C1=CC2=CC=CC=C2S1 UCGXLCPNFJKWEF-ZSXJVMONSA-N 0.000 claims 1
- 229960000571 acetazolamide Drugs 0.000 claims 1
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 claims 1
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 claims 1
- 229960004324 betaxolol Drugs 0.000 claims 1
- 229940046336 brimonidine / timolol Drugs 0.000 claims 1
- 229960000722 brinzolamide Drugs 0.000 claims 1
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 claims 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 1
- 239000000480 calcium channel blocker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001886 ciliary effect Effects 0.000 claims 1
- 229960003933 dorzolamide Drugs 0.000 claims 1
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims 1
- 229940075885 dorzolamide / timolol Drugs 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
- 229960001160 latanoprost Drugs 0.000 claims 1
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 1
- 229940065183 latanoprost / timolol Drugs 0.000 claims 1
- NSHPHXHGRHSMIK-JRIKCGFMSA-N latrunculin B Chemical class C([C@H]1[C@@]2(O)C[C@H]3C[C@H](O2)CC[C@@H](\C=C/CC\C(C)=C/C(=O)O3)C)SC(=O)N1 NSHPHXHGRHSMIK-JRIKCGFMSA-N 0.000 claims 1
- 229960004771 levobetaxolol Drugs 0.000 claims 1
- 229960000831 levobunolol Drugs 0.000 claims 1
- IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960005489 paracetamol Drugs 0.000 claims 1
- 229960001416 pilocarpine Drugs 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 1
- 229960004317 unoprostone Drugs 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 210000001747 pupil Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32142210P | 2010-04-06 | 2010-04-06 | |
| US61/321,422 | 2010-04-06 | ||
| PCT/US2011/031265 WO2011127064A2 (en) | 2010-04-06 | 2011-04-05 | Sustained-release reservoir implants for intracameral drug delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012146630A true RU2012146630A (ru) | 2014-05-20 |
Family
ID=44065364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012146630/15A RU2012146630A (ru) | 2010-04-06 | 2011-04-05 | Имплантаты в виде резервуаров с замедленным высвобождением для внутрикамерной доставки лекарственных средств |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20130017243A1 (enExample) |
| EP (1) | EP2555749B1 (enExample) |
| JP (2) | JP2013523821A (enExample) |
| KR (1) | KR20130086131A (enExample) |
| CN (1) | CN102905688B (enExample) |
| AU (1) | AU2011237788A1 (enExample) |
| BR (1) | BR112012025581A2 (enExample) |
| CA (1) | CA2795706A1 (enExample) |
| RU (1) | RU2012146630A (enExample) |
| WO (1) | WO2011127064A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US9636255B2 (en) | 2009-02-13 | 2017-05-02 | Dose Medical Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 薬剤溶出眼内インプラント |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (en) * | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| JP5695035B2 (ja) | 2009-06-03 | 2015-04-01 | フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． | 前眼部薬物供給 |
| MX391660B (es) | 2010-03-24 | 2025-03-21 | Jazz Pharmaceuticals Inc | Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas |
| JP2013526572A (ja) | 2010-05-17 | 2013-06-24 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | 眼治療薬の送達のための薬物送達装置 |
| WO2012149278A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Sustained release latanoprost implant |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| US9283231B2 (en) * | 2013-01-31 | 2016-03-15 | Icon Bioscience, Inc. | Sustained release formulations for the treatment of intraocular pressure of glaucoma |
| AU2014216112B2 (en) * | 2013-02-15 | 2019-02-21 | Allergan, Inc. | Sustained drug delivery implant |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
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- 2011-04-05 AU AU2011237788A patent/AU2011237788A1/en not_active Abandoned
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- 2011-04-05 BR BR112012025581A patent/BR112012025581A2/pt not_active IP Right Cessation
- 2011-04-05 EP EP11714895.7A patent/EP2555749B1/en not_active Not-in-force
- 2011-04-05 CA CA2795706A patent/CA2795706A1/en not_active Abandoned
- 2011-04-05 WO PCT/US2011/031265 patent/WO2011127064A2/en not_active Ceased
- 2011-04-05 KR KR1020127029009A patent/KR20130086131A/ko not_active Withdrawn
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| US20150104491A1 (en) | 2015-04-16 |
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| BR112012025581A2 (pt) | 2019-09-24 |
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| JP2013523821A (ja) | 2013-06-17 |
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Legal Events
| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160301 |