RU2012140691A - Вакцины на основе неинтегрирующегося ретровирусного вектора - Google Patents
Вакцины на основе неинтегрирующегося ретровирусного вектора Download PDFInfo
- Publication number
- RU2012140691A RU2012140691A RU2012140691/10A RU2012140691A RU2012140691A RU 2012140691 A RU2012140691 A RU 2012140691A RU 2012140691/10 A RU2012140691/10 A RU 2012140691/10A RU 2012140691 A RU2012140691 A RU 2012140691A RU 2012140691 A RU2012140691 A RU 2012140691A
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- Prior art keywords
- virus
- vlp
- protein
- vector according
- structural proteins
- Prior art date
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- 229960005486 vaccine Drugs 0.000 title claims 3
- 230000001177 retroviral effect Effects 0.000 title 1
- 241000700605 Viruses Species 0.000 claims abstract 25
- 101710172711 Structural protein Proteins 0.000 claims abstract 16
- 108700004025 env Genes Proteins 0.000 claims abstract 14
- 101150030339 env gene Proteins 0.000 claims abstract 14
- 108090000565 Capsid Proteins Proteins 0.000 claims abstract 11
- 102100023321 Ceruloplasmin Human genes 0.000 claims abstract 9
- 102000040430 polynucleotide Human genes 0.000 claims abstract 8
- 108091033319 polynucleotide Proteins 0.000 claims abstract 8
- 239000002157 polynucleotide Substances 0.000 claims abstract 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 108060003393 Granulin Proteins 0.000 claims abstract 4
- 239000000427 antigen Substances 0.000 claims abstract 4
- 102000036639 antigens Human genes 0.000 claims abstract 4
- 108091007433 antigens Proteins 0.000 claims abstract 4
- 208000006454 hepatitis Diseases 0.000 claims abstract 4
- 231100000283 hepatitis Toxicity 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 241001115402 Ebolavirus Species 0.000 claims abstract 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract 3
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims abstract 3
- 230000001580 bacterial effect Effects 0.000 claims abstract 3
- 230000003612 virological effect Effects 0.000 claims abstract 3
- 241000710929 Alphavirus Species 0.000 claims abstract 2
- 241000711950 Filoviridae Species 0.000 claims abstract 2
- 241000710831 Flavivirus Species 0.000 claims abstract 2
- 101710177291 Gag polyprotein Proteins 0.000 claims abstract 2
- 241000711549 Hepacivirus C Species 0.000 claims abstract 2
- 241000712431 Influenza A virus Species 0.000 claims abstract 2
- 241000713196 Influenza B virus Species 0.000 claims abstract 2
- 241000713666 Lentivirus Species 0.000 claims abstract 2
- 101710125418 Major capsid protein Proteins 0.000 claims abstract 2
- 208000000932 Marburg Virus Disease Diseases 0.000 claims abstract 2
- 208000030156 Marburg disease Diseases 0.000 claims abstract 2
- 201000011013 Marburg hemorrhagic fever Diseases 0.000 claims abstract 2
- 108010015780 Viral Core Proteins Proteins 0.000 claims abstract 2
- 230000003308 immunostimulating effect Effects 0.000 claims abstract 2
- 206010022000 influenza Diseases 0.000 claims abstract 2
- 238000004806 packaging method and process Methods 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims abstract 2
- 230000003362 replicative effect Effects 0.000 claims abstract 2
- 241000712461 unidentified influenza virus Species 0.000 claims abstract 2
- 101710091045 Envelope protein Proteins 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 7
- 101710188315 Protein X Proteins 0.000 claims 7
- 102100021696 Syncytin-1 Human genes 0.000 claims 7
- 108010052285 Membrane Proteins Proteins 0.000 claims 3
- 210000000234 capsid Anatomy 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000004777 protein coat Anatomy 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 abstract 1
Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
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- A—HUMAN NECESSITIES
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- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
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- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
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- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2790/00—Viroids or subviral agents
- C12N2790/00011—Details
- C12N2790/00023—Virus like particles [VLP]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2790/00—Viroids or subviral agents
- C12N2790/00011—Details
- C12N2790/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16028509P | 2009-03-13 | 2009-03-13 | |
| US61/160,285 | 2009-03-13 | ||
| US16676909P | 2009-04-05 | 2009-04-05 | |
| US61/166,769 | 2009-04-05 | ||
| US16708809P | 2009-04-06 | 2009-04-06 | |
| US61/167,088 | 2009-04-06 | ||
| PCT/US2010/027262 WO2010105251A2 (en) | 2009-03-13 | 2010-03-13 | Non-integrating retroviral vector vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012140691A true RU2012140691A (ru) | 2014-03-27 |
Family
ID=42729161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012140691/10A RU2012140691A (ru) | 2009-03-13 | 2010-03-13 | Вакцины на основе неинтегрирующегося ретровирусного вектора |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120135034A1 (enExample) |
| EP (1) | EP2405945A4 (enExample) |
| JP (1) | JP2012520084A (enExample) |
| CN (1) | CN102438658A (enExample) |
| CA (1) | CA2754603A1 (enExample) |
| RU (1) | RU2012140691A (enExample) |
| WO (1) | WO2010105251A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2680537C1 (ru) * | 2018-02-13 | 2019-02-22 | Общество с ограниченной ответственностью "Нанолек" | Лентивирусная плазмида (варианты), способ ее получения (варианты), набор праймеров для получения лентивирусного плазмидного вектора (варианты) |
| RU2680703C1 (ru) * | 2018-02-13 | 2019-02-25 | Общество с ограниченной ответственностью "Нанолек" | Кассета, предназначенная для получения плазмидных векторов, используемых для создания клеток-продуцентов вирусоподобных частиц (ВПЧ) вируса гриппа |
| RU2681439C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | Вирусоподобная частица вируса гриппа и способ ее получения |
| RU2681482C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | MDCK клетка-продуцент белков вируса гриппа (варианты) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2825032A1 (en) * | 2011-01-27 | 2012-08-02 | Lentigen Corporation | Advanced prime and boost vaccine |
| JP6143231B2 (ja) | 2011-06-10 | 2017-06-07 | ブルーバード バイオ， インコーポレイテッド | 副腎脳白質ジストロフィおよび副腎脊髄神経障害のための遺伝子療法ベクター |
| US9713635B2 (en) * | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| EP2831095B1 (en) * | 2012-03-30 | 2018-11-28 | Immune Design Corp. | Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign |
| US20160175388A1 (en) * | 2013-06-15 | 2016-06-23 | Tocagen Inc. | Immunosuppressive components associated with retroviral replicating vectors |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| EP3137100B1 (en) | 2014-04-15 | 2023-12-20 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
| MA41382A (fr) * | 2015-03-20 | 2017-11-28 | Univ Temple | Édition génique basée sur le système crispr/endonucléase à induction par tat |
| CN107614008A (zh) * | 2015-03-20 | 2018-01-19 | 蓝鸟生物公司 | 载体制剂 |
| US11078495B2 (en) | 2015-10-15 | 2021-08-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for integration defective lentiviral vectors |
| GB201715052D0 (en) * | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| CN111447947B (zh) | 2017-12-07 | 2024-01-12 | 默沙东有限责任公司 | 登革病毒疫苗组合物的制剂 |
| WO2020018715A1 (en) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| JP2022513113A (ja) | 2018-11-26 | 2022-02-07 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫寛容のための組成物および方法 |
| CN114258398A (zh) | 2019-06-13 | 2022-03-29 | 总医院公司 | 工程化的人内源性病毒样颗粒及使用其递送至细胞的方法 |
| BR112023001272A2 (pt) | 2020-07-24 | 2023-04-04 | Massachusetts Gen Hospital | Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células |
| AU2022377374A1 (en) * | 2021-10-25 | 2024-05-02 | Genvivo, Inc. | Compositions and methods for therapeutic or vaccine delivery |
Family Cites Families (11)
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| CA2286819A1 (en) * | 1997-04-17 | 1998-10-22 | Flossie Wong-Staal | Use of lentiviral vectors for antigen presentation in dendritic cells |
| US5994136A (en) * | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| EP2371955A1 (en) * | 2002-09-26 | 2011-10-05 | K.U. Leuven Research & Development | Integrase cofactor |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| WO2005023313A1 (en) * | 2003-09-09 | 2005-03-17 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to hiv humans |
| EP1675613B1 (en) * | 2003-09-15 | 2012-05-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Hiv vaccines based on env of multiple clades of hiv |
| FR2872170B1 (fr) * | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
| AU2005309485A1 (en) * | 2004-11-24 | 2006-06-01 | Nanovector Limited | Viral vectors |
| EP1858332A4 (en) * | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| GB0526211D0 (en) * | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| PT2020444T (pt) * | 2007-08-03 | 2017-08-29 | Pasteur Institut | Vetores de transferência lentivirais deficientes não integrativos para vacinas |
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- 2010-03-13 JP JP2011554266A patent/JP2012520084A/ja not_active Withdrawn
- 2010-03-13 RU RU2012140691/10A patent/RU2012140691A/ru not_active Application Discontinuation
- 2010-03-13 WO PCT/US2010/027262 patent/WO2010105251A2/en not_active Ceased
- 2010-03-13 US US13/256,216 patent/US20120135034A1/en not_active Abandoned
- 2010-03-13 CA CA2754603A patent/CA2754603A1/en not_active Abandoned
- 2010-03-13 CN CN2010800204988A patent/CN102438658A/zh active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2680537C1 (ru) * | 2018-02-13 | 2019-02-22 | Общество с ограниченной ответственностью "Нанолек" | Лентивирусная плазмида (варианты), способ ее получения (варианты), набор праймеров для получения лентивирусного плазмидного вектора (варианты) |
| RU2680703C1 (ru) * | 2018-02-13 | 2019-02-25 | Общество с ограниченной ответственностью "Нанолек" | Кассета, предназначенная для получения плазмидных векторов, используемых для создания клеток-продуцентов вирусоподобных частиц (ВПЧ) вируса гриппа |
| RU2681439C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | Вирусоподобная частица вируса гриппа и способ ее получения |
| RU2681482C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | MDCK клетка-продуцент белков вируса гриппа (варианты) |
Also Published As
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|---|---|
| CA2754603A1 (en) | 2010-09-16 |
| WO2010105251A2 (en) | 2010-09-16 |
| EP2405945A4 (en) | 2012-09-12 |
| US20120135034A1 (en) | 2012-05-31 |
| JP2012520084A (ja) | 2012-09-06 |
| CN102438658A (zh) | 2012-05-02 |
| EP2405945A2 (en) | 2012-01-18 |
| WO2010105251A3 (en) | 2011-01-27 |
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