CA2754603A1 - Non-integrating retroviral vector vaccines - Google Patents
Non-integrating retroviral vector vaccines Download PDFInfo
- Publication number
- CA2754603A1 CA2754603A1 CA2754603A CA2754603A CA2754603A1 CA 2754603 A1 CA2754603 A1 CA 2754603A1 CA 2754603 A CA2754603 A CA 2754603A CA 2754603 A CA2754603 A CA 2754603A CA 2754603 A1 CA2754603 A1 CA 2754603A1
- Authority
- CA
- Canada
- Prior art keywords
- vector
- virus
- hiv
- protein
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940027606 retroviral vector vaccine Drugs 0.000 title description 2
- 239000013598 vector Substances 0.000 claims abstract description 300
- 241000700605 Viruses Species 0.000 claims abstract description 132
- 238000000034 method Methods 0.000 claims abstract description 68
- 230000028993 immune response Effects 0.000 claims abstract description 60
- 238000004806 packaging method and process Methods 0.000 claims abstract description 58
- 230000001177 retroviral effect Effects 0.000 claims abstract description 49
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 43
- 239000002157 polynucleotide Substances 0.000 claims abstract description 43
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 43
- 101710172711 Structural protein Proteins 0.000 claims abstract description 38
- 239000002245 particle Substances 0.000 claims abstract description 27
- 241001465754 Metazoa Species 0.000 claims abstract description 22
- 230000003362 replicative effect Effects 0.000 claims abstract description 16
- 210000004027 cell Anatomy 0.000 claims description 155
- 102100034349 Integrase Human genes 0.000 claims description 145
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 131
- 108090000623 proteins and genes Proteins 0.000 claims description 121
- 102000004169 proteins and genes Human genes 0.000 claims description 106
- 101710091045 Envelope protein Proteins 0.000 claims description 90
- 101710188315 Protein X Proteins 0.000 claims description 90
- 108010061833 Integrases Proteins 0.000 claims description 79
- 241000124008 Mammalia Species 0.000 claims description 61
- 108091007433 antigens Proteins 0.000 claims description 56
- 102000036639 antigens Human genes 0.000 claims description 56
- 239000000427 antigen Substances 0.000 claims description 52
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 43
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 102000004127 Cytokines Human genes 0.000 claims description 29
- 108090000695 Cytokines Proteins 0.000 claims description 29
- 101710149951 Protein Tat Proteins 0.000 claims description 29
- 210000004962 mammalian cell Anatomy 0.000 claims description 28
- 208000001490 Dengue Diseases 0.000 claims description 27
- 206010012310 Dengue fever Diseases 0.000 claims description 27
- 208000025729 dengue disease Diseases 0.000 claims description 27
- 101710132601 Capsid protein Proteins 0.000 claims description 25
- 239000013612 plasmid Substances 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 22
- 230000002519 immonomodulatory effect Effects 0.000 claims description 21
- 108090000565 Capsid Proteins Proteins 0.000 claims description 20
- 230000030833 cell death Effects 0.000 claims description 20
- 102100023321 Ceruloplasmin Human genes 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 17
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims description 16
- 102100037357 Thymidylate kinase Human genes 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 241000713666 Lentivirus Species 0.000 claims description 14
- 241000712461 unidentified influenza virus Species 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 108020004705 Codon Proteins 0.000 claims description 12
- 210000000234 capsid Anatomy 0.000 claims description 12
- 108700004025 env Genes Proteins 0.000 claims description 12
- 210000005260 human cell Anatomy 0.000 claims description 12
- 230000003612 virological effect Effects 0.000 claims description 12
- 108010065805 Interleukin-12 Proteins 0.000 claims description 11
- 101150030339 env gene Proteins 0.000 claims description 11
- 241000711549 Hepacivirus C Species 0.000 claims description 10
- 102000013462 Interleukin-12 Human genes 0.000 claims description 10
- 108091030071 RNAI Proteins 0.000 claims description 10
- 238000010171 animal model Methods 0.000 claims description 10
- 230000000692 anti-sense effect Effects 0.000 claims description 10
- 230000009368 gene silencing by RNA Effects 0.000 claims description 10
- 230000001717 pathogenic effect Effects 0.000 claims description 10
- 108010052285 Membrane Proteins Proteins 0.000 claims description 9
- 102000018697 Membrane Proteins Human genes 0.000 claims description 9
- 244000052769 pathogen Species 0.000 claims description 9
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 8
- 108010002350 Interleukin-2 Proteins 0.000 claims description 8
- 102000000588 Interleukin-2 Human genes 0.000 claims description 8
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 8
- 108700004029 pol Genes Proteins 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 7
- 241000711950 Filoviridae Species 0.000 claims description 7
- 241000710831 Flavivirus Species 0.000 claims description 7
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 7
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 7
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 7
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 7
- 108010050904 Interferons Proteins 0.000 claims description 7
- 102000014150 Interferons Human genes 0.000 claims description 7
- 102000015696 Interleukins Human genes 0.000 claims description 7
- 108010063738 Interleukins Proteins 0.000 claims description 7
- 108010087302 Viral Structural Proteins Proteins 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 7
- 208000006454 hepatitis Diseases 0.000 claims description 7
- 231100000283 hepatitis Toxicity 0.000 claims description 7
- 230000035772 mutation Effects 0.000 claims description 7
- 244000045947 parasite Species 0.000 claims description 7
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 7
- 241001115402 Ebolavirus Species 0.000 claims description 6
- 241000712431 Influenza A virus Species 0.000 claims description 6
- 241000713196 Influenza B virus Species 0.000 claims description 6
- 241001115401 Marburgvirus Species 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 108700004026 gag Genes Proteins 0.000 claims description 6
- 101150098622 gag gene Proteins 0.000 claims description 6
- 101150088264 pol gene Proteins 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 206010022000 influenza Diseases 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- 108700010070 Codon Usage Proteins 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 241000713869 Moloney murine leukemia virus Species 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- 229940037003 alum Drugs 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000710929 Alphavirus Species 0.000 claims description 3
- 108060003393 Granulin Proteins 0.000 claims description 3
- 101710125418 Major capsid protein Proteins 0.000 claims description 3
- 241000714177 Murine leukemia virus Species 0.000 claims description 3
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims description 3
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 241000714165 Feline leukemia virus Species 0.000 claims description 2
- 101710177291 Gag polyprotein Proteins 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 101710102179 Thymidylate kinase Proteins 0.000 claims 8
- 229940047124 interferons Drugs 0.000 claims 5
- 229940047122 interleukins Drugs 0.000 claims 5
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 1
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 description 57
- 108010064607 phosphoglucokinase Proteins 0.000 description 50
- 241000713311 Simian immunodeficiency virus Species 0.000 description 41
- 241000701022 Cytomegalovirus Species 0.000 description 26
- 241000723806 Sugarcane mosaic virus Species 0.000 description 24
- 108700029229 Transcriptional Regulatory Elements Proteins 0.000 description 24
- 230000001124 posttranscriptional effect Effects 0.000 description 24
- 241001430294 unidentified retrovirus Species 0.000 description 16
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 15
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 description 13
- 230000026683 transduction Effects 0.000 description 13
- 238000010361 transduction Methods 0.000 description 13
- 208000005176 Hepatitis C Diseases 0.000 description 10
- 230000005847 immunogenicity Effects 0.000 description 9
- 230000010354 integration Effects 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 7
- 210000000612 antigen-presenting cell Anatomy 0.000 description 7
- 208000030507 AIDS Diseases 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 201000004792 malaria Diseases 0.000 description 6
- 230000010076 replication Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108010033174 Deoxycytidine kinase Proteins 0.000 description 5
- 102100029588 Deoxycytidine kinase Human genes 0.000 description 5
- 101710204837 Envelope small membrane protein Proteins 0.000 description 5
- 101710145006 Lysis protein Proteins 0.000 description 5
- 102000006601 Thymidine Kinase Human genes 0.000 description 5
- 108020004440 Thymidine kinase Proteins 0.000 description 5
- 230000000890 antigenic effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 230000002458 infectious effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 230000006798 recombination Effects 0.000 description 4
- 238000005215 recombination Methods 0.000 description 4
- 229940124718 AIDS vaccine Drugs 0.000 description 3
- 229940033330 HIV vaccine Drugs 0.000 description 3
- 241000725171 Mokola lyssavirus Species 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 3
- 241001068263 Replication competent viruses Species 0.000 description 3
- 241000712907 Retroviridae Species 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 238000010839 reverse transcription Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 210000002845 virion Anatomy 0.000 description 3
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 3
- 108091062157 Cis-regulatory element Proteins 0.000 description 2
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 2
- 241001663880 Gammaretrovirus Species 0.000 description 2
- 241000713813 Gibbon ape leukemia virus Species 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 208000037357 HIV infectious disease Diseases 0.000 description 2
- 101001027052 Homo sapiens Thymidylate kinase Proteins 0.000 description 2
- 102100034353 Integrase Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 241000282553 Macaca Species 0.000 description 2
- 241000711504 Paramyxoviridae Species 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 241000711931 Rhabdoviridae Species 0.000 description 2
- 241000714474 Rous sarcoma virus Species 0.000 description 2
- 241000710924 Togaviridae Species 0.000 description 2
- 241000711975 Vesicular stomatitis virus Species 0.000 description 2
- 206010058874 Viraemia Diseases 0.000 description 2
- 241000710886 West Nile virus Species 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 108010078428 env Gene Products Proteins 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 208000005252 hepatitis A Diseases 0.000 description 2
- 208000002672 hepatitis B Diseases 0.000 description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 238000007852 inverse PCR Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000005170 neoplastic cell Anatomy 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 241000701242 Adenoviridae Species 0.000 description 1
- 241001664176 Alpharetrovirus Species 0.000 description 1
- 208000009828 Arbovirus Infections Diseases 0.000 description 1
- 241000712892 Arenaviridae Species 0.000 description 1
- 241001533362 Astroviridae Species 0.000 description 1
- 241000701412 Baculoviridae Species 0.000 description 1
- 241001231757 Betaretrovirus Species 0.000 description 1
- 241000713704 Bovine immunodeficiency virus Species 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 241000713756 Caprine arthritis encephalitis virus Species 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 208000001528 Coronaviridae Infections Diseases 0.000 description 1
- 241001663879 Deltaretrovirus Species 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 1
- 238000011510 Elispot assay Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010066919 Epidemic polyarthritis Diseases 0.000 description 1
- 241001663878 Epsilonretrovirus Species 0.000 description 1
- 241000713730 Equine infectious anemia virus Species 0.000 description 1
- 241000713800 Feline immunodeficiency virus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 241000713858 Harvey murine sarcoma virus Species 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000700586 Herpesviridae Species 0.000 description 1
- 101710121996 Hexon protein p72 Proteins 0.000 description 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
- 101000800463 Homo sapiens Transketolase Proteins 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 241000713333 Mouse mammary tumor virus Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 241000701945 Parvoviridae Species 0.000 description 1
- 241000150350 Peribunyaviridae Species 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 108010076039 Polyproteins Proteins 0.000 description 1
- 241000700625 Poxviridae Species 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 108010001267 Protein Subunits Proteins 0.000 description 1
- 102000002067 Protein Subunits Human genes 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 241000725694 Puma lentivirus Species 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000702247 Reoviridae Species 0.000 description 1
- -1 Rev Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000710942 Ross River virus Species 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 241000710961 Semliki Forest virus Species 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 1
- 241000713880 Spleen focus-forming virus Species 0.000 description 1
- 241000713675 Spumavirus Species 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 241000713325 Visna/maedi virus Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 108700010877 adenoviridae proteins Proteins 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004970 cd4 cell Anatomy 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 108010000742 dTMP kinase Proteins 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000037799 influenza C Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229940027569 lentiviral vector vaccine Drugs 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000007479 persistent immune response Effects 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229940031626 subunit vaccine Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000010648 susceptibility to HIV infection Diseases 0.000 description 1
- 230000005100 tissue tropism Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2790/00—Viroids or subviral agents
- C12N2790/00011—Details
- C12N2790/00023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2790/00—Viroids or subviral agents
- C12N2790/00011—Details
- C12N2790/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16028509P | 2009-03-13 | 2009-03-13 | |
| US61/160,285 | 2009-03-13 | ||
| US16676909P | 2009-04-05 | 2009-04-05 | |
| US61/166,769 | 2009-04-05 | ||
| US16708809P | 2009-04-06 | 2009-04-06 | |
| US61/167,088 | 2009-04-06 | ||
| PCT/US2010/027262 WO2010105251A2 (en) | 2009-03-13 | 2010-03-13 | Non-integrating retroviral vector vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2754603A1 true CA2754603A1 (en) | 2010-09-16 |
Family
ID=42729161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2754603A Abandoned CA2754603A1 (en) | 2009-03-13 | 2010-03-13 | Non-integrating retroviral vector vaccines |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120135034A1 (enExample) |
| EP (1) | EP2405945A4 (enExample) |
| JP (1) | JP2012520084A (enExample) |
| CN (1) | CN102438658A (enExample) |
| CA (1) | CA2754603A1 (enExample) |
| RU (1) | RU2012140691A (enExample) |
| WO (1) | WO2010105251A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2825032A1 (en) * | 2011-01-27 | 2012-08-02 | Lentigen Corporation | Advanced prime and boost vaccine |
| JP6143231B2 (ja) | 2011-06-10 | 2017-06-07 | ブルーバード バイオ， インコーポレイテッド | 副腎脳白質ジストロフィおよび副腎脊髄神経障害のための遺伝子療法ベクター |
| US9713635B2 (en) * | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
| EP2831095B1 (en) * | 2012-03-30 | 2018-11-28 | Immune Design Corp. | Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign |
| US20160175388A1 (en) * | 2013-06-15 | 2016-06-23 | Tocagen Inc. | Immunosuppressive components associated with retroviral replicating vectors |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| EP3137100B1 (en) | 2014-04-15 | 2023-12-20 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
| MA41382A (fr) * | 2015-03-20 | 2017-11-28 | Univ Temple | Édition génique basée sur le système crispr/endonucléase à induction par tat |
| CN107614008A (zh) * | 2015-03-20 | 2018-01-19 | 蓝鸟生物公司 | 载体制剂 |
| US11078495B2 (en) | 2015-10-15 | 2021-08-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for integration defective lentiviral vectors |
| GB201715052D0 (en) * | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| CN111447947B (zh) | 2017-12-07 | 2024-01-12 | 默沙东有限责任公司 | 登革病毒疫苗组合物的制剂 |
| RU2680703C1 (ru) * | 2018-02-13 | 2019-02-25 | Общество с ограниченной ответственностью "Нанолек" | Кассета, предназначенная для получения плазмидных векторов, используемых для создания клеток-продуцентов вирусоподобных частиц (ВПЧ) вируса гриппа |
| RU2681439C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | Вирусоподобная частица вируса гриппа и способ ее получения |
| RU2680537C1 (ru) * | 2018-02-13 | 2019-02-22 | Общество с ограниченной ответственностью "Нанолек" | Лентивирусная плазмида (варианты), способ ее получения (варианты), набор праймеров для получения лентивирусного плазмидного вектора (варианты) |
| RU2681482C1 (ru) * | 2018-02-13 | 2019-03-06 | Общество с ограниченной ответственностью "Нанолек" | MDCK клетка-продуцент белков вируса гриппа (варианты) |
| WO2020018715A1 (en) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| JP2022513113A (ja) | 2018-11-26 | 2022-02-07 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫寛容のための組成物および方法 |
| CN114258398A (zh) | 2019-06-13 | 2022-03-29 | 总医院公司 | 工程化的人内源性病毒样颗粒及使用其递送至细胞的方法 |
| BR112023001272A2 (pt) | 2020-07-24 | 2023-04-04 | Massachusetts Gen Hospital | Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células |
| AU2022377374A1 (en) * | 2021-10-25 | 2024-05-02 | Genvivo, Inc. | Compositions and methods for therapeutic or vaccine delivery |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2286819A1 (en) * | 1997-04-17 | 1998-10-22 | Flossie Wong-Staal | Use of lentiviral vectors for antigen presentation in dendritic cells |
| US5994136A (en) * | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| EP2371955A1 (en) * | 2002-09-26 | 2011-10-05 | K.U. Leuven Research & Development | Integrase cofactor |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| WO2005023313A1 (en) * | 2003-09-09 | 2005-03-17 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to hiv humans |
| EP1675613B1 (en) * | 2003-09-15 | 2012-05-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Hiv vaccines based on env of multiple clades of hiv |
| FR2872170B1 (fr) * | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
| AU2005309485A1 (en) * | 2004-11-24 | 2006-06-01 | Nanovector Limited | Viral vectors |
| EP1858332A4 (en) * | 2005-02-16 | 2011-06-22 | Lentigen Corp | LENTIVIRUS VECTORS AND ITS USE |
| GB0526211D0 (en) * | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| PT2020444T (pt) * | 2007-08-03 | 2017-08-29 | Pasteur Institut | Vetores de transferência lentivirais deficientes não integrativos para vacinas |
-
2010
- 2010-03-13 EP EP10751533A patent/EP2405945A4/en not_active Withdrawn
- 2010-03-13 JP JP2011554266A patent/JP2012520084A/ja not_active Withdrawn
- 2010-03-13 RU RU2012140691/10A patent/RU2012140691A/ru not_active Application Discontinuation
- 2010-03-13 WO PCT/US2010/027262 patent/WO2010105251A2/en not_active Ceased
- 2010-03-13 US US13/256,216 patent/US20120135034A1/en not_active Abandoned
- 2010-03-13 CA CA2754603A patent/CA2754603A1/en not_active Abandoned
- 2010-03-13 CN CN2010800204988A patent/CN102438658A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010105251A2 (en) | 2010-09-16 |
| RU2012140691A (ru) | 2014-03-27 |
| EP2405945A4 (en) | 2012-09-12 |
| US20120135034A1 (en) | 2012-05-31 |
| JP2012520084A (ja) | 2012-09-06 |
| CN102438658A (zh) | 2012-05-02 |
| EP2405945A2 (en) | 2012-01-18 |
| WO2010105251A3 (en) | 2011-01-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20120135034A1 (en) | Non-Integrating Retroviral Vector Vaccines | |
| CN110958887B (zh) | 编码hiv抗原的痘病毒载体及其使用方法 | |
| HK1252608A1 (zh) | 慢病毒基因转移载体及其医学应用 | |
| JP2012520084A5 (enExample) | ||
| JP2010535495A5 (enExample) | ||
| CN102046785A (zh) | 基于慢病毒的免疫原性载体 | |
| Ritter Jr et al. | Human immunodeficiency virus type 2 glycoprotein enhancement of particle budding: role of the cytoplasmic domain | |
| Rabinovich et al. | A novel, live-attenuated vesicular stomatitis virus vector displaying conformationally intact, functional HIV-1 envelope trimers that elicits potent cellular and humoral responses in mice | |
| US20150182617A1 (en) | Glycoproteins for pseudotyping lentivectors | |
| Uhlig et al. | Lentiviral protein transfer vectors are an efficient vaccine platform and induce a strong antigen-specific cytotoxic T cell response | |
| US20170362607A1 (en) | Use of non-subtype b gag proteins for lentiviral packaging | |
| EP2020444B1 (en) | Defective non-integrative lentiviral transfer vectors for vaccines | |
| EP1599592A1 (en) | Infectious flavivirus pseudo-particles containing functional prm and/or e proteins | |
| Anraku et al. | Kunjin replicon-based simian immunodeficiency virus gag vaccines | |
| WO2012118092A1 (ja) | 融合タンパク質 | |
| JP2007505130A5 (enExample) | ||
| JP2004516846A (ja) | Ｈｉｖ様粒子及びその用途 | |
| US20130302368A1 (en) | Advanced Prime and Boost Vaccine | |
| US7981656B2 (en) | Pseudotyped retrovirus with modified ebola glycoprotein | |
| JP2024509976A (ja) | 抗原をｍｈｃ－ｉｉ経路にターゲティングし、宿主におけるｃｄ８＋及びｃｄ４＋ｔ細胞による防御免疫を誘導するレンチウイルスベクター | |
| Maamary | Live attenuated viral vaccine vectors | |
| Schlehuber | Human immunodeficiency virus epitope display on vesicular stomatitis virus | |
| HK1056576A1 (zh) | 含有血凝素活性膜蛋白质的假型逆转录病毒载体 | |
| HK1056576B (en) | Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20150313 |