JP2012520084A - 非組み込み型レトロウイルスベクターワクチン - Google Patents

非組み込み型レトロウイルスベクターワクチン Download PDF

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JP2012520084A
JP2012520084A JP2011554266A JP2011554266A JP2012520084A JP 2012520084 A JP2012520084 A JP 2012520084A JP 2011554266 A JP2011554266 A JP 2011554266A JP 2011554266 A JP2011554266 A JP 2011554266A JP 2012520084 A JP2012520084 A JP 2012520084A
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vector
protein
virus
hiv
cell
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JP2012520084A5 (enExample
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ボロ ドロプリック
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レンチゲン コーポレイション
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
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    • A61K39/002Protozoa antigens
    • A61K39/015Hemosporidia antigens, e.g. Plasmodium antigens
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
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    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
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    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/50Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6072Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
    • C12N2810/6081Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/48Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/50Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Tropical Medicine & Parasitology (AREA)
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  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011554266A 2009-03-13 2010-03-13 非組み込み型レトロウイルスベクターワクチン Withdrawn JP2012520084A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16028509P 2009-03-13 2009-03-13
US61/160,285 2009-03-13
US16676909P 2009-04-05 2009-04-05
US61/166,769 2009-04-05
US16708809P 2009-04-06 2009-04-06
US61/167,088 2009-04-06
PCT/US2010/027262 WO2010105251A2 (en) 2009-03-13 2010-03-13 Non-integrating retroviral vector vaccines

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JP2012520084A true JP2012520084A (ja) 2012-09-06
JP2012520084A5 JP2012520084A5 (enExample) 2013-04-25

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JP2011554266A Withdrawn JP2012520084A (ja) 2009-03-13 2010-03-13 非組み込み型レトロウイルスベクターワクチン

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US (1) US20120135034A1 (enExample)
EP (1) EP2405945A4 (enExample)
JP (1) JP2012520084A (enExample)
CN (1) CN102438658A (enExample)
CA (1) CA2754603A1 (enExample)
RU (1) RU2012140691A (enExample)
WO (1) WO2010105251A2 (enExample)

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RU2013139565A (ru) * 2011-01-27 2015-03-10 Лентиджен Корпорейшн Усовершенствованная праймерная и бустерная вакцина
AU2012267512B2 (en) * 2011-06-10 2014-11-20 Bluebird Bio, Inc. Gene therapy vectors for adrenoleukodystrophy and adrenomyeloneuropathy
US9713635B2 (en) * 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
EP2831095B1 (en) 2012-03-30 2018-11-28 Immune Design Corp. Lentiviral vector particles having improved transduction efficiency for cells expressing dc-sign
ES2745103T3 (es) * 2013-06-15 2020-02-27 Tocagen Inc Partículas inmunosupresivas similares a virus basadas en gammaretrovirus
EP2878674A1 (en) * 2013-11-28 2015-06-03 Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) Stable episomes based on non-integrative lentiviral vectors
AU2015247727A1 (en) 2014-04-15 2016-11-03 University Of Virginia Patent Foundation Isolated T cell receptors and methods of use therefor
MA41382A (fr) * 2015-03-20 2017-11-28 Univ Temple Édition génique basée sur le système crispr/endonucléase à induction par tat
US20180094280A1 (en) * 2015-03-20 2018-04-05 Bluebird Bio, Inc. Vector formulations
US11078495B2 (en) 2015-10-15 2021-08-03 The University Of North Carolina At Chapel Hill Methods and compositions for integration defective lentiviral vectors
GB201715052D0 (en) * 2017-09-19 2017-11-01 Oxford Genetics Ltd Vectors
CA3083772A1 (en) 2017-12-07 2019-06-13 Merck Sharp & Dohme Corp. Formulations of dengue virus vaccine compositions
RU2680703C1 (ru) * 2018-02-13 2019-02-25 Общество с ограниченной ответственностью "Нанолек" Кассета, предназначенная для получения плазмидных векторов, используемых для создания клеток-продуцентов вирусоподобных частиц (ВПЧ) вируса гриппа
RU2681439C1 (ru) * 2018-02-13 2019-03-06 Общество с ограниченной ответственностью "Нанолек" Вирусоподобная частица вируса гриппа и способ ее получения
RU2681482C1 (ru) * 2018-02-13 2019-03-06 Общество с ограниченной ответственностью "Нанолек" MDCK клетка-продуцент белков вируса гриппа (варианты)
RU2680537C1 (ru) * 2018-02-13 2019-02-22 Общество с ограниченной ответственностью "Нанолек" Лентивирусная плазмида (варианты), способ ее получения (варианты), набор праймеров для получения лентивирусного плазмидного вектора (варианты)
WO2020018715A1 (en) 2018-07-17 2020-01-23 Massachusetts Institute Of Technology Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof
WO2020112904A1 (en) 2018-11-26 2020-06-04 Massachusetts Institute Of Technology Compositions and methods for immune tolerance
US20220259617A1 (en) 2019-06-13 2022-08-18 The General Hospital Corporation Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
MX2023001028A (es) 2020-07-24 2023-04-24 Massachusetts Gen Hospital Particulas similares a virus potenciadas y metodos de uso de las mismas para suministro a celulas.
EP4423288A4 (en) * 2021-10-25 2025-09-10 Genvivo Inc COMPOSITIONS AND METHODS OF THERAPEUTIC OR VACCINAL ADMINISTRATION

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WO1998046083A1 (en) * 1997-04-17 1998-10-22 The Regents Of The University Of California Use of lentiviral vectors for antigen presentation in dendritic cells
US5994136A (en) * 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
WO2004029246A2 (en) * 2002-09-26 2004-04-08 K.U.Leuven Research And Development Integrase cofactor
GB0225786D0 (en) * 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
EP1677832A1 (en) * 2003-09-09 2006-07-12 VIRxSYS Corporation Lentivirus vector-based approaches for generating an immune response to hiv humans
WO2005034992A2 (en) * 2003-09-15 2005-04-21 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv vaccines based on env of multiple clades of hif
FR2872170B1 (fr) * 2004-06-25 2006-11-10 Centre Nat Rech Scient Cnrse Lentivirus non interactif et non replicatif, preparation et utilisations
JP2008521405A (ja) * 2004-11-24 2008-06-26 ナノヴェクター・リミテッド ウイルスベクター
WO2006089001A2 (en) * 2005-02-16 2006-08-24 Lentigen Corporation Lentiviral vectors and their use
GB0526211D0 (en) * 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
DK2020444T3 (en) * 2007-08-03 2017-09-11 Pasteur Institut DEFECTIVE NON-INTEGRATIVE LENTIVIRAL TRANSMISSION VECTORS FOR VACCINES

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WO2010105251A3 (en) 2011-01-27
EP2405945A2 (en) 2012-01-18
WO2010105251A2 (en) 2010-09-16
CN102438658A (zh) 2012-05-02
US20120135034A1 (en) 2012-05-31
CA2754603A1 (en) 2010-09-16
RU2012140691A (ru) 2014-03-27
EP2405945A4 (en) 2012-09-12

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