RU2012134366A - Терапевтические конструкции апиразы, средства на основе апиразы и способы получения - Google Patents
Терапевтические конструкции апиразы, средства на основе апиразы и способы получения Download PDFInfo
- Publication number
- RU2012134366A RU2012134366A RU2012134366/10A RU2012134366A RU2012134366A RU 2012134366 A RU2012134366 A RU 2012134366A RU 2012134366/10 A RU2012134366/10 A RU 2012134366/10A RU 2012134366 A RU2012134366 A RU 2012134366A RU 2012134366 A RU2012134366 A RU 2012134366A
- Authority
- RU
- Russia
- Prior art keywords
- apyrase
- sequence
- soluble
- cells
- evlp
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 15
- 230000001225 therapeutic effect Effects 0.000 title 1
- 102000007347 Apyrase Human genes 0.000 claims abstract 13
- 108010007730 Apyrase Proteins 0.000 claims abstract 13
- 210000004027 cell Anatomy 0.000 claims abstract 6
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims abstract 6
- 102100029725 Ectonucleoside triphosphate diphosphohydrolase 3 Human genes 0.000 claims abstract 4
- 101001012432 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 3 Proteins 0.000 claims abstract 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000001963 growth medium Substances 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000002609 medium Substances 0.000 claims abstract 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims abstract 2
- 241000282887 Suidae Species 0.000 claims abstract 2
- 238000004458 analytical method Methods 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- 102000039446 nucleic acids Human genes 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000005571 anion exchange chromatography Methods 0.000 claims 2
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29469510P | 2010-01-13 | 2010-01-13 | |
| US61/294,695 | 2010-01-13 | ||
| PCT/US2011/021187 WO2011088244A1 (en) | 2010-01-13 | 2011-01-13 | Therapeutic apyrase constructs, apyrase agents, and production methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012134366A true RU2012134366A (ru) | 2014-02-20 |
Family
ID=44304650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012134366/10A RU2012134366A (ru) | 2010-01-13 | 2011-01-13 | Терапевтические конструкции апиразы, средства на основе апиразы и способы получения |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8771683B2 (enExample) |
| EP (1) | EP2523971B1 (enExample) |
| JP (1) | JP5913130B2 (enExample) |
| KR (1) | KR20130009744A (enExample) |
| AU (1) | AU2011205248A1 (enExample) |
| BR (1) | BR112012017243A2 (enExample) |
| CA (1) | CA2787016C (enExample) |
| IL (1) | IL220882A0 (enExample) |
| RU (1) | RU2012134366A (enExample) |
| WO (1) | WO2011088244A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104039337B (zh) * | 2014-03-12 | 2020-06-02 | 株式会社资生堂 | 对皮肤应答于外部刺激的镇静剂和用于镇静该应答的方法 |
| CN105018442A (zh) * | 2014-04-23 | 2015-11-04 | Apt治疗公司 | 改进的en-腺苷三磷酸双磷酸酶 |
| UY38299A (es) * | 2018-07-18 | 2020-02-28 | Novartis Ag | Apirasas solubilizadas, métodos y usos |
| TW202146042A (zh) * | 2020-03-06 | 2021-12-16 | 瑞典商阿斯特捷利康公司 | 用於治療動脈和靜脈血栓形成的協同且靶向的組成物 |
| JP7657041B2 (ja) | 2020-08-19 | 2025-04-04 | アストラゼネカ・アクチエボラーグ | 併用療法 |
| JP7547996B2 (ja) * | 2020-12-22 | 2024-09-10 | トヨタ自動車株式会社 | コイルの製造方法 |
| CN120129530A (zh) | 2022-10-28 | 2025-06-10 | 阿斯利康(瑞典)有限公司 | 以40mg至240mg的剂量用于在治疗缺血事件中使用的重组腺苷三磷酸双磷酸酶蛋白 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322678A (en) | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
| EP1297168A2 (en) | 2000-07-03 | 2003-04-02 | Gala Design, Inc. | Expression vectors |
| US7247300B1 (en) | 2002-11-07 | 2007-07-24 | Apt Therapeutics, Inc. | Therapeutic use of soluble CD39L3 |
| EP1733045A4 (en) | 2004-02-27 | 2008-08-13 | Apt Therapeutics Inc | DESIGN AND THERAPEUTIC USE OF ADPASE-ENHANCED APYRASES |
| US7294484B2 (en) * | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
-
2011
- 2011-01-13 US US13/522,311 patent/US8771683B2/en active Active
- 2011-01-13 WO PCT/US2011/021187 patent/WO2011088244A1/en not_active Ceased
- 2011-01-13 KR KR1020127021160A patent/KR20130009744A/ko not_active Withdrawn
- 2011-01-13 AU AU2011205248A patent/AU2011205248A1/en not_active Abandoned
- 2011-01-13 RU RU2012134366/10A patent/RU2012134366A/ru not_active Application Discontinuation
- 2011-01-13 CA CA2787016A patent/CA2787016C/en active Active
- 2011-01-13 JP JP2012549089A patent/JP5913130B2/ja active Active
- 2011-01-13 BR BR112012017243A patent/BR112012017243A2/pt not_active Application Discontinuation
- 2011-01-13 EP EP11733394.8A patent/EP2523971B1/en active Active
-
2012
- 2012-07-11 IL IL220882A patent/IL220882A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2787016C (en) | 2018-01-23 |
| EP2523971A1 (en) | 2012-11-21 |
| CA2787016A1 (en) | 2011-07-21 |
| JP2013516991A (ja) | 2013-05-16 |
| US8771683B2 (en) | 2014-07-08 |
| AU2011205248A1 (en) | 2012-08-02 |
| JP5913130B2 (ja) | 2016-04-27 |
| KR20130009744A (ko) | 2013-01-23 |
| EP2523971B1 (en) | 2015-02-25 |
| IL220882A0 (en) | 2012-09-24 |
| EP2523971A4 (en) | 2013-06-05 |
| US20130142775A1 (en) | 2013-06-06 |
| BR112012017243A2 (pt) | 2017-09-19 |
| WO2011088244A1 (en) | 2011-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012134366A (ru) | Терапевтические конструкции апиразы, средства на основе апиразы и способы получения | |
| RU2011145567A (ru) | Улучшенные аминокислотные последовательности против il-6r и содержащие их полипептиды для лечения связанных с il-6r заболеваний и нарушений | |
| RU2014138499A (ru) | АНТИГЕНСВЯЗЫВАЮЩАЯ МОЛЕКУЛА ДЛЯ УСКОРЕНИЯ ИСЧЕЗНОВЕНИЯ АНТИГЕНА ЧЕРЕЗ FycRIIB | |
| EA201300054A1 (ru) | Полипептид, обладающий активностью бета-глюкозидазы, и его применение | |
| BR112012020705A2 (pt) | axmi221z, axmi222z, axmi224z, e axmi225z genes de delta-endotoxina e métodos para sua utilização. | |
| CN113121705B (zh) | 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用 | |
| JP2013516991A5 (enExample) | ||
| CN109593805B (zh) | 一种利用l-氨基酸连接酶一步法合成l-肌肽的方法 | |
| RU2017113926A (ru) | Композиция для получения тагатозы и способ получения тагатозы из фруктозы | |
| ES2643485T3 (es) | Hialuronidasa bacteriana y proceso para su producción | |
| JP2009519013A5 (enExample) | ||
| EA201490379A1 (ru) | Варианты белков axmi205 и способы их применения | |
| EA201691192A1 (ru) | Гены токсинов axmi477, axmi482, axmi486 и axmi525 и способы их применения | |
| UA122856C2 (uk) | Варіантний інсектицидний ген ахмі115 та способи його застосування | |
| RU2669996C2 (ru) | Новый мутантный белок орнитиндекарбоксилаза и его применение | |
| CN105683216B (zh) | 人源egf结构域蛋白及其应用 | |
| CN103756983A (zh) | 一种天然哺乳动物尿酸酶制备方法 | |
| KR20170074120A (ko) | 과당으로부터 알로오스를 생산하는 균주 및 이를 이용한 알로오스 생산방법 | |
| CN115820578B (zh) | 突变体组合物、融合酶及胶原三肽的制备方法 | |
| CN109251881A (zh) | 一株异源表达腈水合酶的大肠杆菌重组菌及其应用 | |
| CN109196099A (zh) | 用于生产活性肝细胞生长因子（hgf）的方法 | |
| CN101942422A (zh) | 粘质沙雷氏菌d-乳酸脱氢酶基因,克隆、表达重组菌株及重组酶的研究 | |
| CN105112391B (zh) | 一种人源精氨酸酶突变体及其制备方法和用途 | |
| KR20100028042A (ko) | 폰 빌리브란트 인자 프로펩티드로부터 성숙한 폰 빌리브란트 인자를 제조하는 방법 | |
| JP2010527588A5 (enExample) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150624 |