RU2012113138A - Автоматизированный радиохимический синтез - Google Patents
Автоматизированный радиохимический синтез Download PDFInfo
- Publication number
- RU2012113138A RU2012113138A RU2012113138/04A RU2012113138A RU2012113138A RU 2012113138 A RU2012113138 A RU 2012113138A RU 2012113138/04 A RU2012113138/04 A RU 2012113138/04A RU 2012113138 A RU2012113138 A RU 2012113138A RU 2012113138 A RU2012113138 A RU 2012113138A
- Authority
- RU
- Russia
- Prior art keywords
- fluoride
- nitro
- formula
- suitable source
- hydrogen
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 23
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 9
- 239000001257 hydrogen Substances 0.000 claims abstract 9
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims abstract 8
- 239000002243 precursor Substances 0.000 claims abstract 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 7
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 claims abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 4
- 150000002431 hydrogen Chemical group 0.000 claims abstract 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 4
- 235000003270 potassium fluoride Nutrition 0.000 claims abstract 4
- 239000011698 potassium fluoride Substances 0.000 claims abstract 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical group 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- 239000003960 organic solvent Substances 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims abstract 2
- KRHYYFGTRYWZRS-BJUDXGSMSA-M fluorine-18(1-) Chemical compound [18F-] KRHYYFGTRYWZRS-BJUDXGSMSA-M 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000006654 (C3-C12) heteroaryl group Chemical group 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- IEUFLMRWISENBI-UHFFFAOYSA-N C[N+](C)(C)[N+]([O-])=O Chemical compound C[N+](C)(C)[N+]([O-])=O IEUFLMRWISENBI-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005210 alkyl ammonium group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0917611.6 | 2009-10-08 | ||
| GBGB0917611.6A GB0917611D0 (en) | 2009-10-08 | 2009-10-08 | Automated radiosynthesis |
| US25089209P | 2009-10-13 | 2009-10-13 | |
| US61/250,892 | 2009-10-13 | ||
| PCT/EP2010/065077 WO2011042529A1 (en) | 2009-10-08 | 2010-10-08 | Automated radiosynthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012113138A true RU2012113138A (ru) | 2013-11-20 |
Family
ID=41402710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012113138/04A RU2012113138A (ru) | 2009-10-08 | 2010-10-08 | Автоматизированный радиохимический синтез |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8946410B2 (https=) |
| EP (1) | EP2486040B1 (https=) |
| JP (1) | JP5870031B2 (https=) |
| KR (1) | KR20120095359A (https=) |
| CN (1) | CN102548996B (https=) |
| AU (1) | AU2010305355B2 (https=) |
| BR (1) | BR112012007701A2 (https=) |
| CA (1) | CA2774031A1 (https=) |
| GB (1) | GB0917611D0 (https=) |
| IL (1) | IL218454A0 (https=) |
| IN (1) | IN2012DN02214A (https=) |
| MX (1) | MX2012003994A (https=) |
| NZ (1) | NZ598659A (https=) |
| RU (1) | RU2012113138A (https=) |
| WO (1) | WO2011042529A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201105445D0 (en) * | 2011-03-31 | 2011-05-18 | Ge Healthcare Ltd | Radiolabelled flumazenil derivatives |
| KR101441406B1 (ko) * | 2011-05-25 | 2014-11-04 | 주식회사 바이오이미징코리아 | 디아릴이오도늄 염 전구체를 이용한 플로오린-18이 표지된 플루마제닐의 제조 방법 |
| GB201209082D0 (en) * | 2012-05-24 | 2012-07-04 | Ge Healthcare Ltd | Purification method |
| CN112979658B (zh) * | 2021-02-22 | 2022-05-31 | 南湖实验室 | 一种氟马西尼的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA806016B (en) * | 1979-10-04 | 1981-09-30 | Hoffmann La Roche | Imidazodiazepine derivatives |
| CA1184175A (en) * | 1981-02-27 | 1985-03-19 | Walter Hunkeler | Imidazodiazepines |
| GB8927928D0 (en) | 1989-12-11 | 1990-02-14 | Roussel Lab Ltd | Chemical compounds |
| JP3537914B2 (ja) * | 1995-05-18 | 2004-06-14 | 株式会社生体機能研究所 | ［１８ｆ］フルオロ芳香族化合物の製造法 |
| FI101305B1 (fi) * | 1996-03-18 | 1998-05-29 | Map Medical Technologies Oy | Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatsepiini-johdannaiset ja niiden käyttö diagnostiikassa |
| GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
| WO2007141529A1 (en) * | 2006-06-09 | 2007-12-13 | Ge Healthcare Limited | Fluoridation method |
| GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
-
2009
- 2009-10-08 GB GBGB0917611.6A patent/GB0917611D0/en not_active Ceased
-
2010
- 2010-10-08 JP JP2012532611A patent/JP5870031B2/ja not_active Expired - Fee Related
- 2010-10-08 BR BR112012007701A patent/BR112012007701A2/pt not_active IP Right Cessation
- 2010-10-08 MX MX2012003994A patent/MX2012003994A/es not_active Application Discontinuation
- 2010-10-08 EP EP10762695.4A patent/EP2486040B1/en not_active Not-in-force
- 2010-10-08 IN IN2214DEN2012 patent/IN2012DN02214A/en unknown
- 2010-10-08 KR KR1020127009090A patent/KR20120095359A/ko not_active Withdrawn
- 2010-10-08 RU RU2012113138/04A patent/RU2012113138A/ru not_active Application Discontinuation
- 2010-10-08 US US13/394,655 patent/US8946410B2/en not_active Expired - Fee Related
- 2010-10-08 CN CN201080045665.4A patent/CN102548996B/zh not_active Expired - Fee Related
- 2010-10-08 NZ NZ598659A patent/NZ598659A/en not_active IP Right Cessation
- 2010-10-08 AU AU2010305355A patent/AU2010305355B2/en not_active Ceased
- 2010-10-08 WO PCT/EP2010/065077 patent/WO2011042529A1/en not_active Ceased
- 2010-10-08 CA CA2774031A patent/CA2774031A1/en not_active Abandoned
-
2012
- 2012-03-04 IL IL218454A patent/IL218454A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012007701A2 (pt) | 2015-09-08 |
| AU2010305355B2 (en) | 2015-09-24 |
| CN102548996B (zh) | 2016-06-01 |
| EP2486040A1 (en) | 2012-08-15 |
| MX2012003994A (es) | 2012-04-30 |
| NZ598659A (en) | 2014-02-28 |
| IN2012DN02214A (https=) | 2015-08-21 |
| JP2013507343A (ja) | 2013-03-04 |
| GB0917611D0 (en) | 2009-11-25 |
| US8946410B2 (en) | 2015-02-03 |
| EP2486040B1 (en) | 2017-06-21 |
| CA2774031A1 (en) | 2011-04-14 |
| US20120190843A1 (en) | 2012-07-26 |
| CN102548996A (zh) | 2012-07-04 |
| AU2010305355A1 (en) | 2012-04-05 |
| IL218454A0 (en) | 2012-04-30 |
| JP5870031B2 (ja) | 2016-02-24 |
| KR20120095359A (ko) | 2012-08-28 |
| WO2011042529A1 (en) | 2011-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150422 |