RU2012106072A - Способ получения арилзамещенных пиразолов - Google Patents
Способ получения арилзамещенных пиразолов Download PDFInfo
- Publication number
- RU2012106072A RU2012106072A RU2012106072/04A RU2012106072A RU2012106072A RU 2012106072 A RU2012106072 A RU 2012106072A RU 2012106072/04 A RU2012106072/04 A RU 2012106072/04A RU 2012106072 A RU2012106072 A RU 2012106072A RU 2012106072 A RU2012106072 A RU 2012106072A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- carbon atoms
- alkoxy
- formula
- halogen
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 27
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 14
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 229910052736 halogen Inorganic materials 0.000 claims abstract 11
- 150000002367 halogens Chemical group 0.000 claims abstract 11
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 8
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 7
- 239000000460 chlorine Chemical group 0.000 claims abstract 7
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract 7
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000004438 haloalkoxy group Chemical group 0.000 claims abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910052794 bromium Inorganic materials 0.000 claims abstract 3
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 3
- 239000011737 fluorine Substances 0.000 claims abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract 3
- 125000004001 thioalkyl group Chemical group 0.000 claims abstract 3
- KOPFEFZSAMLEHK-UHFFFAOYSA-N 1h-pyrazole-5-carboxylic acid Chemical class OC(=O)C=1C=CNN=1 KOPFEFZSAMLEHK-UHFFFAOYSA-N 0.000 claims abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims abstract 2
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 230000008030 elimination Effects 0.000 claims abstract 2
- 238000003379 elimination reaction Methods 0.000 claims abstract 2
- 125000005842 heteroatom Chemical group 0.000 claims abstract 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000002955 isolation Methods 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 239000001301 oxygen Substances 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- 239000011593 sulfur Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 19
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- -1 aryl substituted pyrazole derivatives Chemical class 0.000 claims 2
- UIEABCXJWANXFS-UHFFFAOYSA-N 1h-pyrazol-5-ylmethanol Chemical class OCC=1C=CNN=1 UIEABCXJWANXFS-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 1
- 0 *CC(C=C1N)=**1c1ncccc1 Chemical compound *CC(C=C1N)=**1c1ncccc1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166238 | 2009-07-23 | ||
| EP09166238.7 | 2009-07-23 | ||
| PCT/EP2010/004285 WO2011009551A1 (de) | 2009-07-23 | 2010-07-14 | Verfahren zum herstellen von aryl-substituierten pyrazolen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012106072A true RU2012106072A (ru) | 2013-08-27 |
Family
ID=41509007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012106072/04A RU2012106072A (ru) | 2009-07-23 | 2010-07-14 | Способ получения арилзамещенных пиразолов |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8299260B2 (enEXAMPLES) |
| EP (1) | EP2456760B1 (enEXAMPLES) |
| JP (1) | JP5872467B2 (enEXAMPLES) |
| KR (1) | KR101701335B1 (enEXAMPLES) |
| CN (1) | CN102482223B (enEXAMPLES) |
| BR (1) | BR112012001477A8 (enEXAMPLES) |
| DK (1) | DK2456760T3 (enEXAMPLES) |
| ES (1) | ES2474015T3 (enEXAMPLES) |
| IL (1) | IL217270A0 (enEXAMPLES) |
| IN (1) | IN2012DN00635A (enEXAMPLES) |
| MX (1) | MX2012000876A (enEXAMPLES) |
| RU (1) | RU2012106072A (enEXAMPLES) |
| TW (1) | TWI482764B (enEXAMPLES) |
| WO (1) | WO2011009551A1 (enEXAMPLES) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2243777A1 (de) | 2009-04-03 | 2010-10-27 | Bayer CropScience AG | Verfahren zum Herstellen von Pyridyl-substituierten Pyrazolen |
| BR112012001477A8 (pt) | 2009-07-23 | 2016-07-12 | Bayer Cropscience Ag | Processo para produzir pirazois substituídos com arila |
| BR112012001558A2 (pt) * | 2009-07-23 | 2016-03-08 | Bayer Cropscience Ag | alcoxienonas e enaminocetonas e um processo para a sua preparação |
| US8242313B2 (en) | 2009-07-23 | 2012-08-14 | Bayer Cropscience Ag | Alkoxy enones and enamino ketones and a process for preparation thereof |
| WO2019224678A1 (en) | 2018-05-21 | 2019-11-28 | Pi Industries Ltd. | A novel process for the preparation of anthranilic diamides |
| PT3823953T (pt) * | 2018-07-20 | 2024-12-16 | Pi Industries Ltd | Um novo processo para a preparação de diamidas antranílicas |
| WO2023021020A1 (en) | 2021-08-19 | 2023-02-23 | Syngenta Crop Protection Ag | Method for controlling diamide resistant pests & compounds therefor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4343832A1 (de) * | 1993-12-22 | 1995-06-29 | Bayer Ag | Substituierte 1-Arylpyrazole |
| US6506747B1 (en) * | 1998-06-05 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents |
| TWI327566B (en) * | 2001-08-13 | 2010-07-21 | Du Pont | Novel substituted ihydro 3-halo-1h-pyrazole-5-carboxylates,their preparation and use |
| CA2454298A1 (en) * | 2001-08-13 | 2003-02-27 | Gary David Annis | Substituted 1h-dihydropyrazoles, their preparation and use |
| DE102006042437A1 (de) | 2006-03-30 | 2007-10-04 | Bayer Cropscience Ag | Wirkstoffkombinationen mit insektiziden Eigenschaften |
| DE102006032168A1 (de) * | 2006-06-13 | 2007-12-20 | Bayer Cropscience Ag | Anthranilsäurediamid-Derivate mit heteroaromatischen Substituenten |
| BR112012001477A8 (pt) | 2009-07-23 | 2016-07-12 | Bayer Cropscience Ag | Processo para produzir pirazois substituídos com arila |
-
2010
- 2010-07-14 BR BR112012001477A patent/BR112012001477A8/pt not_active Application Discontinuation
- 2010-07-14 CN CN201080033361.6A patent/CN102482223B/zh active Active
- 2010-07-14 IN IN635DEN2012 patent/IN2012DN00635A/en unknown
- 2010-07-14 KR KR1020127004601A patent/KR101701335B1/ko active Active
- 2010-07-14 DK DK10734918.5T patent/DK2456760T3/da active
- 2010-07-14 RU RU2012106072/04A patent/RU2012106072A/ru not_active Application Discontinuation
- 2010-07-14 MX MX2012000876A patent/MX2012000876A/es active IP Right Grant
- 2010-07-14 ES ES10734918.5T patent/ES2474015T3/es active Active
- 2010-07-14 WO PCT/EP2010/004285 patent/WO2011009551A1/de active Application Filing
- 2010-07-14 JP JP2012520930A patent/JP5872467B2/ja not_active Expired - Fee Related
- 2010-07-14 EP EP10734918.5A patent/EP2456760B1/de active Active
- 2010-07-22 TW TW099124077A patent/TWI482764B/zh not_active IP Right Cessation
- 2010-07-23 US US12/842,243 patent/US8299260B2/en not_active Expired - Fee Related
-
2011
- 2011-12-29 IL IL217270A patent/IL217270A0/en not_active IP Right Cessation
-
2012
- 2012-09-14 US US13/618,053 patent/US8399679B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012001477A8 (pt) | 2016-07-12 |
| EP2456760A1 (de) | 2012-05-30 |
| DK2456760T3 (da) | 2014-07-14 |
| EP2456760B1 (de) | 2014-05-07 |
| IN2012DN00635A (enEXAMPLES) | 2015-08-21 |
| JP2012533580A (ja) | 2012-12-27 |
| MX2012000876A (es) | 2012-02-01 |
| ES2474015T3 (es) | 2014-07-08 |
| US20130018192A1 (en) | 2013-01-17 |
| KR101701335B1 (ko) | 2017-02-01 |
| US20110028729A1 (en) | 2011-02-03 |
| CN102482223A (zh) | 2012-05-30 |
| US8299260B2 (en) | 2012-10-30 |
| WO2011009551A1 (de) | 2011-01-27 |
| BR112012001477A2 (pt) | 2015-09-01 |
| TW201116519A (en) | 2011-05-16 |
| US8399679B2 (en) | 2013-03-19 |
| TWI482764B (zh) | 2015-05-01 |
| CN102482223B (zh) | 2015-03-04 |
| KR20120039034A (ko) | 2012-04-24 |
| IL217270A0 (en) | 2016-02-29 |
| JP5872467B2 (ja) | 2016-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20141027 |