RU2011122615A - Живой аттенуированный респираторно-синцитиальный вирус - Google Patents
Живой аттенуированный респираторно-синцитиальный вирус Download PDFInfo
- Publication number
- RU2011122615A RU2011122615A RU2011122615/10A RU2011122615A RU2011122615A RU 2011122615 A RU2011122615 A RU 2011122615A RU 2011122615/10 A RU2011122615/10 A RU 2011122615/10A RU 2011122615 A RU2011122615 A RU 2011122615A RU 2011122615 A RU2011122615 A RU 2011122615A
- Authority
- RU
- Russia
- Prior art keywords
- gene
- protein encoded
- nucleotide
- amino acid
- mutation
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title claims abstract 39
- 241000700605 Viruses Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims abstract 146
- 235000018102 proteins Nutrition 0.000 claims abstract 91
- 102000004169 proteins and genes Human genes 0.000 claims abstract 91
- 101150082239 G gene Proteins 0.000 claims abstract 60
- 241000725643 Respiratory syncytial virus Species 0.000 claims abstract 42
- 150000001413 amino acids Chemical class 0.000 claims abstract 36
- 235000001014 amino acid Nutrition 0.000 claims abstract 30
- 230000003612 virological effect Effects 0.000 claims abstract 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract 17
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract 16
- 235000013922 glutamic acid Nutrition 0.000 claims abstract 16
- 239000004220 glutamic acid Substances 0.000 claims abstract 16
- 239000004471 Glycine Substances 0.000 claims abstract 14
- 101150034814 F gene Proteins 0.000 claims abstract 12
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims abstract 12
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims abstract 11
- 235000004279 alanine Nutrition 0.000 claims abstract 10
- 101150062031 L gene Proteins 0.000 claims abstract 8
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims abstract 8
- 239000004472 Lysine Substances 0.000 claims abstract 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract 6
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract 6
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 5
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims abstract 5
- 239000002773 nucleotide Substances 0.000 claims 55
- 125000003729 nucleotide group Chemical group 0.000 claims 55
- 230000035772 mutation Effects 0.000 claims 53
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 16
- 230000002163 immunogen Effects 0.000 claims 6
- 101150033828 NS1 gene Proteins 0.000 claims 5
- 102220227441 rs899935666 Human genes 0.000 claims 5
- 229930024421 Adenine Natural products 0.000 claims 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 4
- 229960000643 adenine Drugs 0.000 claims 4
- 102200108568 rs1046611742 Human genes 0.000 claims 4
- 102200105394 rs1060501198 Human genes 0.000 claims 4
- 102220317346 rs145871499 Human genes 0.000 claims 4
- 102220268734 rs1555338682 Human genes 0.000 claims 4
- 102220044516 rs202197835 Human genes 0.000 claims 4
- 102220081964 rs765911841 Human genes 0.000 claims 4
- 102220597378 Cellular tumor antigen p53_E294K_mutation Human genes 0.000 claims 3
- 101150095629 NS2 gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 102200024306 rs35193847 Human genes 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 101150028074 2 gene Proteins 0.000 abstract 1
- 101150090724 3 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/135—Respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18564—Methods of inactivation or attenuation by serial passage
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19832708P | 2008-11-05 | 2008-11-05 | |
| US61/198,327 | 2008-11-05 | ||
| PCT/US2009/063024 WO2010053883A1 (en) | 2008-11-05 | 2009-11-03 | Live, attentuated respiratory syncytial virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011122615A true RU2011122615A (ru) | 2012-12-20 |
Family
ID=41527812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011122615/10A RU2011122615A (ru) | 2008-11-05 | 2009-11-03 | Живой аттенуированный респираторно-синцитиальный вирус |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9011876B2 (OSRAM) |
| EP (1) | EP2346990B1 (OSRAM) |
| JP (2) | JP5016731B2 (OSRAM) |
| KR (1) | KR20110063863A (OSRAM) |
| CN (1) | CN102272295A (OSRAM) |
| AU (1) | AU2009311287C1 (OSRAM) |
| BR (1) | BRPI0921424A2 (OSRAM) |
| CA (1) | CA2742086A1 (OSRAM) |
| CL (1) | CL2011000999A1 (OSRAM) |
| CO (1) | CO6362047A2 (OSRAM) |
| EC (1) | ECSP11011033A (OSRAM) |
| IL (1) | IL212437A0 (OSRAM) |
| MA (1) | MA32878B1 (OSRAM) |
| MX (1) | MX2011004719A (OSRAM) |
| PE (1) | PE20110394A1 (OSRAM) |
| RU (1) | RU2011122615A (OSRAM) |
| TN (1) | TN2011000182A1 (OSRAM) |
| WO (1) | WO2010053883A1 (OSRAM) |
| ZA (1) | ZA201103259B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2346990B1 (en) * | 2008-11-05 | 2016-01-06 | Merck Sharp & Dohme Corp. | Live, attentuated respiratory syncytial virus |
| WO2013026054A2 (en) * | 2011-08-18 | 2013-02-21 | Axella Solutions, Llc | Production of infectious rna viruses in yeast |
| EP2752199A4 (en) | 2011-08-29 | 2015-04-29 | Univ Tokushima | RSV MUCOSA VACCINE |
| AU2014214763B2 (en) * | 2013-02-08 | 2020-02-27 | The Research Foundation For The State University Of New York | Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization |
| EP3798310A1 (en) * | 2013-03-14 | 2021-03-31 | Emory University | Recombinant rsv with silent mutations, vaccines, and methods related thereto |
| US10429129B2 (en) | 2013-10-16 | 2019-10-01 | Merck Sharp & Dohme Corp. | Method of microwave vacuum drying spherical-shaped pellets of biological materials |
| CA2926696A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp | Thermostable respiratory synctial virus (rsv) vaccine compositions |
| WO2017030997A1 (en) * | 2015-08-14 | 2017-02-23 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered ns1 protein function and related materials and methods |
| US11235050B2 (en) | 2015-10-29 | 2022-02-01 | Emory University | Chimeric RSV, immunogenic compositions, and methods of use |
| WO2018057950A1 (en) | 2016-09-23 | 2018-03-29 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| AU2018331467A1 (en) * | 2017-09-15 | 2020-04-30 | Ohio State Innovation Foundation | Vaccines and methods of making and using vaccines for prevention of respiratory syncytial virus (RSV) infections |
| WO2025106787A1 (en) * | 2023-11-17 | 2025-05-22 | Sanofi Pasteur Inc. | Trehalose vaccine formulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2250883A1 (en) * | 1996-04-04 | 1997-10-16 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
| EP1064358A2 (en) | 1998-03-26 | 2001-01-03 | American Cyanamid Company | Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b |
| EP1287152B1 (en) | 1999-07-09 | 2008-12-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Human-bovine chimeric respiratory syncytial virus vaccines |
| US20050176130A1 (en) | 2002-09-27 | 2005-08-11 | Medimmune Vaccines, Inc. | Functional mutations in respiratory syncytial virus |
| JP4783726B2 (ja) * | 2003-03-28 | 2011-09-28 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスサブグループｂ株９３２０に関連する組成物および方法 |
| CN101646768A (zh) * | 2007-02-07 | 2010-02-10 | 生物载体株式会社 | 减毒负链rna病毒 |
| EP2346990B1 (en) * | 2008-11-05 | 2016-01-06 | Merck Sharp & Dohme Corp. | Live, attentuated respiratory syncytial virus |
-
2009
- 2009-11-03 EP EP09748199.8A patent/EP2346990B1/en active Active
- 2009-11-03 BR BRPI0921424A patent/BRPI0921424A2/pt not_active IP Right Cessation
- 2009-11-03 CA CA2742086A patent/CA2742086A1/en not_active Abandoned
- 2009-11-03 KR KR1020117010304A patent/KR20110063863A/ko not_active Ceased
- 2009-11-03 JP JP2011534864A patent/JP5016731B2/ja not_active Expired - Fee Related
- 2009-11-03 RU RU2011122615/10A patent/RU2011122615A/ru not_active Application Discontinuation
- 2009-11-03 CN CN2009801537266A patent/CN102272295A/zh active Pending
- 2009-11-03 WO PCT/US2009/063024 patent/WO2010053883A1/en not_active Ceased
- 2009-11-03 AU AU2009311287A patent/AU2009311287C1/en not_active Ceased
- 2009-11-03 US US13/127,647 patent/US9011876B2/en active Active
- 2009-11-03 PE PE2011000971A patent/PE20110394A1/es not_active Application Discontinuation
- 2009-11-03 MX MX2011004719A patent/MX2011004719A/es unknown
-
2011
- 2011-04-17 IL IL212437A patent/IL212437A0/en unknown
- 2011-04-19 TN TN2011000182A patent/TN2011000182A1/fr unknown
- 2011-05-04 CL CL2011000999A patent/CL2011000999A1/es unknown
- 2011-05-05 EC EC2011011033A patent/ECSP11011033A/es unknown
- 2011-05-05 ZA ZA2011/03259A patent/ZA201103259B/en unknown
- 2011-05-12 CO CO11058596A patent/CO6362047A2/es not_active Application Discontinuation
- 2011-06-03 MA MA33913A patent/MA32878B1/fr unknown
- 2011-08-05 JP JP2011171459A patent/JP5743794B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MA32878B1 (fr) | 2011-12-01 |
| MX2011004719A (es) | 2011-05-31 |
| JP5743794B2 (ja) | 2015-07-01 |
| CO6362047A2 (es) | 2012-01-20 |
| JP2011250798A (ja) | 2011-12-15 |
| BRPI0921424A2 (pt) | 2016-01-05 |
| CN102272295A (zh) | 2011-12-07 |
| JP5016731B2 (ja) | 2012-09-05 |
| ZA201103259B (en) | 2012-01-25 |
| CL2011000999A1 (es) | 2012-07-20 |
| US20110212130A1 (en) | 2011-09-01 |
| CA2742086A1 (en) | 2010-05-14 |
| IL212437A0 (en) | 2011-06-30 |
| TN2011000182A1 (en) | 2012-12-17 |
| EP2346990A1 (en) | 2011-07-27 |
| JP2012507302A (ja) | 2012-03-29 |
| AU2009311287C1 (en) | 2015-02-19 |
| EP2346990B1 (en) | 2016-01-06 |
| AU2009311287A1 (en) | 2010-05-14 |
| KR20110063863A (ko) | 2011-06-14 |
| PE20110394A1 (es) | 2011-06-22 |
| WO2010053883A1 (en) | 2010-05-14 |
| AU2009311287B2 (en) | 2013-02-07 |
| ECSP11011033A (es) | 2011-12-30 |
| US9011876B2 (en) | 2015-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2011122615A (ru) | Живой аттенуированный респираторно-синцитиальный вирус | |
| ES2741729T3 (es) | Vectores y construcciones de liberación de antígenos de virus de la gripe | |
| Lipskaya et al. | Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine‐associated polio cases | |
| ES2839880T3 (es) | Vacuna contra el VRS | |
| RU2011104999A (ru) | Варианты гемагглютинина и нейрамидазы вируса гриппа | |
| RU2016109940A (ru) | Вакцина против бешенства | |
| JP2007502101A5 (OSRAM) | ||
| ES2854673T3 (es) | VSR recombinante con mutaciones silenciosas, vacunas y métodos relacionados con ello | |
| JP2014507146A5 (OSRAM) | ||
| JPWO2021211760A5 (OSRAM) | ||
| JP2011250798A5 (OSRAM) | ||
| JP2012507302A5 (OSRAM) | ||
| ES2533345T3 (es) | Diferentes serotipos del virus de la estomatitis vesicular como vectores de expresión para regímenes de inmunización | |
| RU2018130683A (ru) | Аттенуированный вирус инфекционного бронхита | |
| CN118206622A (zh) | RSV融合前F蛋白的突变体、核酸及mRNA疫苗 | |
| ES2647073T3 (es) | Vacuna contra la IPN | |
| RU2014140731A (ru) | Варианты гемагглютинина и нейраминидазы гриппа | |
| JP2012517239A5 (OSRAM) | ||
| US20250026793A1 (en) | Chimeric betacoronavirus spike polypeptides | |
| JP2011521648A5 (OSRAM) | ||
| CN107635579A (zh) | 非天然发生的猪生殖和呼吸综合征病毒(prrsv)和使用方法 | |
| CN103298936A (zh) | 具有新型流感病毒来源的血凝素蛋白基因的重组痘苗病毒 | |
| Storey et al. | Nucleotide Sequence of the Coding and Flanking Regions of the Human Parainfluenza Virus 3 Hemagglutinin–Neuraminidase Gene: Comparison with Other Paramyxoviruses | |
| CN102603898B (zh) | 与i群禽腺病毒免疫相关融合蛋白及其编码基因与应用 | |
| RU2019113940A (ru) | Мозаичные вакцины от вируса ящура серотипа а |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20130111 |