RU2010148785A - Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани - Google Patents
Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани Download PDFInfo
- Publication number
- RU2010148785A RU2010148785A RU2010148785/10A RU2010148785A RU2010148785A RU 2010148785 A RU2010148785 A RU 2010148785A RU 2010148785/10 A RU2010148785/10 A RU 2010148785/10A RU 2010148785 A RU2010148785 A RU 2010148785A RU 2010148785 A RU2010148785 A RU 2010148785A
- Authority
- RU
- Russia
- Prior art keywords
- protein
- cell
- secrets
- vector
- dna encoding
- Prior art date
Links
- 230000008929 regeneration Effects 0.000 title claims abstract 4
- 238000011069 regeneration method Methods 0.000 title claims abstract 4
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 102000018803 Calgranulin A Human genes 0.000 claims abstract 37
- 108010052500 Calgranulin A Proteins 0.000 claims abstract 37
- 102000018755 Calgranulin B Human genes 0.000 claims abstract 36
- 108010052495 Calgranulin B Proteins 0.000 claims abstract 36
- 210000004027 cell Anatomy 0.000 claims abstract 25
- 210000001519 tissue Anatomy 0.000 claims abstract 10
- 239000000463 material Substances 0.000 claims abstract 9
- 210000002798 bone marrow cell Anatomy 0.000 claims abstract 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract 7
- 238000000034 method Methods 0.000 claims abstract 6
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 230000004936 stimulating effect Effects 0.000 claims abstract 3
- 230000017423 tissue regeneration Effects 0.000 claims abstract 3
- 230000001939 inductive effect Effects 0.000 claims abstract 2
- 230000001737 promoting effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-119324 | 2008-04-30 | ||
| JP2008119324 | 2008-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010148785A true RU2010148785A (ru) | 2012-06-10 |
Family
ID=41255155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010148785/10A RU2010148785A (ru) | 2008-04-30 | 2009-04-30 | Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110097309A1 (OSRAM) |
| EP (1) | EP2301560A4 (OSRAM) |
| JP (3) | JP5814549B2 (OSRAM) |
| KR (1) | KR20110027665A (OSRAM) |
| CN (1) | CN102076351A (OSRAM) |
| AU (1) | AU2009240885A1 (OSRAM) |
| BR (1) | BRPI0911436A2 (OSRAM) |
| CA (1) | CA2722906A1 (OSRAM) |
| RU (1) | RU2010148785A (OSRAM) |
| WO (1) | WO2009133940A1 (OSRAM) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2649069C2 (ru) * | 2012-10-25 | 2018-04-02 | Дженомикс Ко., Лтд. | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 |
| US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| US12421498B2 (en) | 2017-12-01 | 2025-09-23 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| US12428458B2 (en) | 2018-02-08 | 2025-09-30 | StemRIM Inc. | Therapeutic agent for psoriasis |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2722906A1 (en) * | 2008-04-30 | 2009-11-05 | Genomix Co., Ltd. | Pharmaceutical agent for promoting the functional regeneration of damaged tissue |
| EP2301559A4 (en) * | 2008-04-30 | 2012-05-02 | Genomix Co Ltd | MEDIUM FOR THE RECRUITMENT OF PLURIPOTENTIAL STEM CELLS FROM BONE MARROW IN THE PERIPHERAL CYCLE |
| AU2009240888B2 (en) | 2008-04-30 | 2014-10-09 | Genomix Co., Ltd. | Method for collecting functional cells in vivo with high efficiency |
| RU2016135937A (ru) * | 2009-10-28 | 2018-12-11 | Дженомикс Ко., Лтд. | Средства для стимуляции регенерации тканей путем привлечения мезинхимных стволовых клеток и/или плюрипотентных стволовых клеток костного мозга в кровь |
| JP5852773B2 (ja) * | 2010-06-01 | 2016-02-03 | ピアス株式会社 | 骨髄間葉系幹細胞の誘引剤の製造方法、骨髄間葉系幹細胞の誘引方法、及び、骨髄間葉系幹細胞の誘引剤を製造するための使用 |
| CA2834255C (en) | 2011-04-26 | 2021-11-02 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
| KR102146815B1 (ko) | 2012-10-25 | 2020-08-21 | 가부시키가이샤 스템림 | Hmgb1 단편을 이용한 신규 심근경색의 치료법 |
| WO2017045070A1 (en) * | 2015-09-14 | 2017-03-23 | Universite Laval | Anti-s100a8 for treating leukemia |
| MX2019008949A (es) | 2017-01-27 | 2019-10-07 | Stemrim Inc | Agente terapeutico para cardiomiopatia, infarto al miocardio antiguo e insuficiencia cardiaca cronica. |
| MX2019012738A (es) | 2017-04-25 | 2020-02-07 | Shionogi & Co | Peptido para inducir la regeneracion de tejido, y uso del mismo. |
| WO2019017355A1 (ja) * | 2017-07-18 | 2019-01-24 | 株式会社資生堂 | 間葉系幹細胞誘引剤 |
| EP3756679A1 (en) * | 2019-06-28 | 2020-12-30 | Université de Genève | Compositions for use in the treatment of insulin deficiency conditions |
| CN111494423B (zh) * | 2020-04-22 | 2022-01-25 | 上海市东方医院（同济大学附属东方医院） | 一种干细胞组合物及其应用和干细胞滴液 |
| CN115058388A (zh) * | 2022-03-14 | 2022-09-16 | 福建医科大学附属协和医院 | 间充质干细胞创面修复优势功能亚群及其鉴定和应用 |
| CN120837666A (zh) * | 2025-09-22 | 2025-10-28 | 中国人民解放军军事科学院军事医学研究院 | 靶向巨噬细胞s100a9蛋白在肝纤维化治疗中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658894A (en) * | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
| JP3018313B2 (ja) * | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
| EP1114862A3 (de) * | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen |
| HK1047770A1 (zh) * | 2000-02-24 | 2003-03-07 | Xcyte Therapies, Inc. | 细胞的同时刺激与浓缩 |
| DE10121254A1 (de) * | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | MRP8/MRP14 Heterodimers oder seiner Einzelkomponenten alleine oder in Kombination zur Behandlung und/oder Prävention von Hauterkrankungen, Wunden und/oder Wundheilungsstörungen, die durch eine verringerte Menge an MRP8/MRP14 Heterodimeren gekennzeichnet sind |
| WO2002088181A2 (en) * | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | Mrp8/mrp14 heterodimer, or its individual components in combination, for treating and/or preventing skin diseases, wounds and/or wound-healing disturbances |
| BR0209510A (pt) * | 2001-05-09 | 2006-02-07 | Univ Cleveland Hospitals | Conjunto de genes marcadores, método para avaliar os efeitos protetores reparadores e/ou terapêuticos à radiação ultravioleta de um composto ou material, composto ou material tendo efeitos protetores, reparadores ou terapêuticos da radiação ultravioleta, métodos para melhorar e/ou tratar, para reverter e/ou reparar pele fotoavariada ou fotoenvelhecida, e para avaliar se uma substância pode reparar ou reverter os efeitos de fotoavaria ou fotoenvelhecimento relacionados com à exposição à radiação uv, substância ou material tendo efeitos reparadores ou de reversão da fotoavaria ou fotoenvelhecimento, composição ou formulação, formulação anti-fotoavaria ou anti-fotoenvelhecimento fotoprotetora ou terapêutica, métodos para avaliar a avaria na pele ou um substituto de pele induzida por radiação ultravioleta, em seguida à exposição à radiação uv, para prevenir pele fotoenvelhecida ou fotoavariada, para identificar ou selecionar indivìduos que são susceptìveis ou altamente sensìveis à fotoavaria ou fotoenvelhecimento da pele, em seguida à exposição à radiação uv, e, kit para avaliar as propiedades de fotoavaria ou fotoenvelhecimento de uma substância |
| US7220723B2 (en) * | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| ITMI20011986A1 (it) * | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
| WO2003043651A1 (fr) * | 2001-11-19 | 2003-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Medicament mobilisant les cellules souches totipotentes d'un tissu dans le sang peripherique |
| DE60326453D1 (de) * | 2002-07-03 | 2009-04-16 | Ct Cardiologico Monzino S P A | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
| DE60327075D1 (de) * | 2002-07-05 | 2009-05-20 | Univ Laval | Der entzündungsreaktionen |
| GB0226251D0 (en) * | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
| EP1579221A2 (de) * | 2003-01-03 | 2005-09-28 | Alcedo Biotech GmbH | Verwendungen von hmgb, hmgn, hmga proteinen |
| WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
| WO2004084928A1 (en) * | 2003-03-28 | 2004-10-07 | UNIVERSITé LAVAL | S100 protein as neutrophil activator for alleviating neutropenia in cancer treatment |
| EP1768693A1 (en) * | 2004-07-20 | 2007-04-04 | Provincia Italiana Della Congregazione Dei Figli Dell'Immacolata Concezione - Istituto Dermopatico Dell'Immacolata | Use of hmgb1 for wound healing |
| KR100593397B1 (ko) * | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 ｐ 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
| WO2006047820A1 (en) * | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Use of calgranulin a and b in the promotion and inhibition of mineralized tissue formation |
| CA2636788A1 (en) * | 2006-10-30 | 2008-05-08 | Genomix Co., Ltd. | Hmgb protein for use in promoting tissue regeneration |
| EP2301559A4 (en) * | 2008-04-30 | 2012-05-02 | Genomix Co Ltd | MEDIUM FOR THE RECRUITMENT OF PLURIPOTENTIAL STEM CELLS FROM BONE MARROW IN THE PERIPHERAL CYCLE |
| CA2722906A1 (en) * | 2008-04-30 | 2009-11-05 | Genomix Co., Ltd. | Pharmaceutical agent for promoting the functional regeneration of damaged tissue |
| AU2009240888B2 (en) * | 2008-04-30 | 2014-10-09 | Genomix Co., Ltd. | Method for collecting functional cells in vivo with high efficiency |
-
2009
- 2009-04-30 CA CA2722906A patent/CA2722906A1/en not_active Abandoned
- 2009-04-30 WO PCT/JP2009/058519 patent/WO2009133940A1/ja not_active Ceased
- 2009-04-30 KR KR1020107026780A patent/KR20110027665A/ko not_active Withdrawn
- 2009-04-30 BR BRPI0911436A patent/BRPI0911436A2/pt not_active Application Discontinuation
- 2009-04-30 JP JP2010510169A patent/JP5814549B2/ja not_active Expired - Fee Related
- 2009-04-30 CN CN2009801252435A patent/CN102076351A/zh active Pending
- 2009-04-30 AU AU2009240885A patent/AU2009240885A1/en not_active Abandoned
- 2009-04-30 US US12/990,060 patent/US20110097309A1/en not_active Abandoned
- 2009-04-30 RU RU2010148785/10A patent/RU2010148785A/ru not_active Application Discontinuation
- 2009-04-30 EP EP09738877A patent/EP2301560A4/en not_active Withdrawn
-
2014
- 2014-02-05 JP JP2014019961A patent/JP5960735B2/ja active Active
-
2016
- 2016-01-18 JP JP2016006778A patent/JP2016104790A/ja not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2649069C2 (ru) * | 2012-10-25 | 2018-04-02 | Дженомикс Ко., Лтд. | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 |
| US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
| US12421498B2 (en) | 2017-12-01 | 2025-09-23 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| US12428458B2 (en) | 2018-02-08 | 2025-09-30 | StemRIM Inc. | Therapeutic agent for psoriasis |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5814549B2 (ja) | 2015-11-17 |
| JPWO2009133940A1 (ja) | 2011-09-01 |
| JP5960735B2 (ja) | 2016-08-02 |
| BRPI0911436A2 (pt) | 2016-07-12 |
| CN102076351A (zh) | 2011-05-25 |
| JP2014139177A (ja) | 2014-07-31 |
| US20110097309A1 (en) | 2011-04-28 |
| EP2301560A1 (en) | 2011-03-30 |
| EP2301560A4 (en) | 2012-05-09 |
| CA2722906A1 (en) | 2009-11-05 |
| WO2009133940A1 (ja) | 2009-11-05 |
| AU2009240885A1 (en) | 2009-11-05 |
| JP2016104790A (ja) | 2016-06-09 |
| KR20110027665A (ko) | 2011-03-16 |
| AU2009240885A2 (en) | 2011-01-27 |
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