RU2010136988A - Антигенсвязывающие полипептиды против дегенерации хряща - Google Patents

Антигенсвязывающие полипептиды против дегенерации хряща Download PDF

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Publication number
RU2010136988A
RU2010136988A RU2010136988/10A RU2010136988A RU2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988/10 A RU2010136988/10 A RU 2010136988/10A RU 2010136988 A RU2010136988 A RU 2010136988A RU 2010136988 A RU2010136988 A RU 2010136988A
Authority
RU
Russia
Prior art keywords
binding polypeptide
antigen binding
polypeptide according
antigen
polypeptide
Prior art date
Application number
RU2010136988/10A
Other languages
English (en)
Russian (ru)
Inventor
Дэвид УРЕХ (CH)
Дэвид УРЕХ
Петер ЛИХТЛЕН (CH)
Петер ЛИХТЛЕН
Original Assignee
Деленекс Терапьютикс Аг (Ch)
Деленекс Терапьютикс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Деленекс Терапьютикс Аг (Ch), Деленекс Терапьютикс Аг filed Critical Деленекс Терапьютикс Аг (Ch)
Publication of RU2010136988A publication Critical patent/RU2010136988A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2010136988/10A 2008-02-05 2009-02-05 Антигенсвязывающие полипептиды против дегенерации хряща RU2010136988A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2631708P 2008-02-05 2008-02-05
US61/026,317 2008-02-05
US8887608P 2008-08-14 2008-08-14
US61/088,876 2008-08-14

Publications (1)

Publication Number Publication Date
RU2010136988A true RU2010136988A (ru) 2012-03-20

Family

ID=40568129

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2010136988/10A RU2010136988A (ru) 2008-02-05 2009-02-05 Антигенсвязывающие полипептиды против дегенерации хряща

Country Status (10)

Country Link
US (1) US20110002927A1 (https=)
EP (1) EP2240515A1 (https=)
JP (1) JP2011510667A (https=)
CN (1) CN101939335B (https=)
AU (1) AU2009212079B2 (https=)
BR (1) BRPI0907485A2 (https=)
CA (1) CA2712965A1 (https=)
IL (1) IL206720A0 (https=)
RU (1) RU2010136988A (https=)
WO (1) WO2009097704A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013008697A2 (pt) 2010-09-24 2016-06-21 Massachusetts Inst Technology géis nanoestruturados capazes de liberação controlada de agentes encapsulados
CN104231086B (zh) * 2013-08-27 2019-12-13 北京韩美药品有限公司 双功能融合蛋白及其制备方法和用途
KR101860117B1 (ko) 2013-12-13 2018-05-21 유겐가이샤 머큐리 에셋 매니지먼트 관절 연골 이미징 조성물
EP3452094B1 (en) * 2016-05-06 2021-11-17 The Brigham and Women's Hospital, Inc. Binary self assembled gels for controlled delivery of encapsulated agents to cartilage
CA3113948A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
CN120865334A (zh) * 2025-03-26 2025-10-31 中山大学附属第五医院 一种靶向软骨的阳离子肽类化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013810D0 (en) * 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
KR101457223B1 (ko) * 2005-06-07 2014-11-04 에스바테크 - 어 노바티스 컴파니 엘엘씨 ＴＮＦα를 억제하는 안정적이고 가용성인 항체
ES2820837T3 (es) * 2006-07-10 2021-04-22 Esbatech Alcon Biomed Res Unit Anticuerpos scFv que pasan las capas epitelial y/o endotelial

Also Published As

Publication number Publication date
CA2712965A1 (en) 2009-08-13
JP2011510667A (ja) 2011-04-07
EP2240515A1 (en) 2010-10-20
WO2009097704A1 (en) 2009-08-13
CN101939335A (zh) 2011-01-05
BRPI0907485A2 (pt) 2015-08-04
US20110002927A1 (en) 2011-01-06
AU2009212079A1 (en) 2009-08-13
CN101939335B (zh) 2015-02-11
IL206720A0 (en) 2010-12-30
AU2009212079B2 (en) 2012-08-30

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