JP2011510667A5 - - Google Patents

Info

Publication number

JP2011510667A5

JP2011510667A5 JP2010545343A JP2010545343A JP2011510667A5 JP 2011510667 A5 JP2011510667 A5 JP 2011510667A5 JP 2010545343 A JP2010545343 A JP 2010545343A JP 2010545343 A JP2010545343 A JP 2010545343A JP 2011510667 A5 JP2011510667 A5 JP 2011510667A5

Authority

JP

Japan

Prior art keywords

composition according

polypeptide

composition

cartilage degeneration

progression

Prior art date

2009-02-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000203 mixture Substances 0.000 claims description 36
• 229920001184 polypeptide Polymers 0.000 claims description 34
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 34
• 239000000427 antigen Substances 0.000 claims description 24
• 102000036639 antigens Human genes 0.000 claims description 24
• 108091007433 antigens Proteins 0.000 claims description 24
• 210000000845 cartilage Anatomy 0.000 claims description 19
• 230000007850 degeneration Effects 0.000 claims description 15
• 230000002265 prevention Effects 0.000 claims description 11
• 201000008482 osteoarthritis Diseases 0.000 claims description 10
• 238000009472 formulation Methods 0.000 claims description 6
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
• 229940039227 diagnostic agent Drugs 0.000 claims description 4
• 239000000032 diagnostic agent Substances 0.000 claims description 4
• 239000013604 expression vector Substances 0.000 claims description 4
• 238000000338 in vitro Methods 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 3
• 238000001514 detection method Methods 0.000 claims description 3
• 239000003814 drug Substances 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 108090000695 Cytokines Proteins 0.000 claims description 2
• 102000004127 Cytokines Human genes 0.000 claims description 2
• 102000004190 Enzymes Human genes 0.000 claims description 2
• 108090000790 Enzymes Proteins 0.000 claims description 2
• 108010002352 Interleukin-1 Proteins 0.000 claims description 2
• 239000008366 buffered solution Substances 0.000 claims description 2
• 239000013599 cloning vector Substances 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 102000003675 cytokine receptors Human genes 0.000 claims description 2
• 108010057085 cytokine receptors Proteins 0.000 claims description 2
• 230000000593 degrading effect Effects 0.000 claims description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
• 238000013268 sustained release Methods 0.000 claims description 2
• 239000012730 sustained-release form Substances 0.000 claims description 2
• 206010003246 arthritis Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 230000008355 cartilage degradation Effects 0.000 description 1
• 230000000149 penetrating effect Effects 0.000 description 1
• 239000008177 pharmaceutical agent Substances 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1