RU2009132516A - Новая кристаллическая форма пиперациллиннатрия - Google Patents

Новая кристаллическая форма пиперациллиннатрия Download PDF

Info

Publication number
RU2009132516A
RU2009132516A RU2009132516/04A RU2009132516A RU2009132516A RU 2009132516 A RU2009132516 A RU 2009132516A RU 2009132516/04 A RU2009132516/04 A RU 2009132516/04A RU 2009132516 A RU2009132516 A RU 2009132516A RU 2009132516 A RU2009132516 A RU 2009132516A
Authority
RU
Russia
Prior art keywords
sinium
piperacillin
crystalline form
new crystalline
dioxopiperazine
Prior art date
Application number
RU2009132516/04A
Other languages
English (en)
Inventor
Масару МОУРИ (JP)
Масару МОУРИ
Даи НИСИКАВА (JP)
Даи НИСИКАВА
Original Assignee
Тояма Кемикал Ко., Лтд. (Jp)
Тояма Кемикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тояма Кемикал Ко., Лтд. (Jp), Тояма Кемикал Ко., Лтд. filed Critical Тояма Кемикал Ко., Лтд. (Jp)
Publication of RU2009132516A publication Critical patent/RU2009132516A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Кристалл моногидрата (2S,5R,6R)-6-((2R)-2-((4-этил-2,3-диоксопиперазин-1-карбонил)амино)-2-фенилацетиламино)-3,3-диметил-7-оксо-4-тиа-1-азабицикло[3.2.0]гептан-2-карбоксилата натрия, имеющий углы дифракции 3,7, 5,5, 7,3, 11,6, 14,5 и 18,0°, выражаемые через 2θ в порошковом рентгеновском дифракционном анализе. ! 2. Кристалл моногидрата (2S,5R,6R)-6-((2R)-2-((4-этил-2,3-диоксопиперазин-1-карбонил)амино)-2-фенилацетиламино)-3,3-диметил-7-оксо-4-тиа-1-азабицикло[3.2.0]гептан-2-карбоксилата натрия, имеющий углы дифракции 5,6, 7,8, 12,3, 15,5, 17,5, 23,3, 24,8 и 28,5°, выражаемые через 2θ в порошковом рентгеновском дифракционном анализе.

Claims (2)

1. Кристалл моногидрата (2S,5R,6R)-6-((2R)-2-((4-этил-2,3-диоксопиперазин-1-карбонил)амино)-2-фенилацетиламино)-3,3-диметил-7-оксо-4-тиа-1-азабицикло[3.2.0]гептан-2-карбоксилата натрия, имеющий углы дифракции 3,7, 5,5, 7,3, 11,6, 14,5 и 18,0°, выражаемые через 2θ в порошковом рентгеновском дифракционном анализе.
2. Кристалл моногидрата (2S,5R,6R)-6-((2R)-2-((4-этил-2,3-диоксопиперазин-1-карбонил)амино)-2-фенилацетиламино)-3,3-диметил-7-оксо-4-тиа-1-азабицикло[3.2.0]гептан-2-карбоксилата натрия, имеющий углы дифракции 5,6, 7,8, 12,3, 15,5, 17,5, 23,3, 24,8 и 28,5°, выражаемые через 2θ в порошковом рентгеновском дифракционном анализе.
RU2009132516/04A 2007-01-31 2008-01-29 Новая кристаллическая форма пиперациллиннатрия RU2009132516A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-020758 2007-01-31
JP2007020758 2007-01-31

Publications (1)

Publication Number Publication Date
RU2009132516A true RU2009132516A (ru) 2011-03-10

Family

ID=39673961

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009132516/04A RU2009132516A (ru) 2007-01-31 2008-01-29 Новая кристаллическая форма пиперациллиннатрия

Country Status (12)

Country Link
US (1) US20100063273A1 (ru)
EP (1) EP2128162A4 (ru)
JP (1) JP5173842B2 (ru)
KR (1) KR20090104855A (ru)
CN (1) CN101611040A (ru)
AU (1) AU2008210929A1 (ru)
BR (1) BRPI0808375A2 (ru)
CA (1) CA2676803A1 (ru)
IL (1) IL200087A0 (ru)
MX (1) MX2009008124A (ru)
RU (1) RU2009132516A (ru)
WO (1) WO2008093650A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011040386A1 (ja) * 2009-09-30 2011-04-07 富山化学工業株式会社 ピペラシリンナトリウム・１水和物の新規な結晶
AU2012389714B2 (en) * 2012-09-14 2017-05-04 Xiangbei Welman Pharmaceutical Co., Ltd. Cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing same and uses thereof
CN102977119A (zh) * 2012-12-14 2013-03-20 江西富祥药业股份有限公司 一种用溶媒法制备哌拉西林钠的工艺
CN109134497A (zh) * 2017-07-24 2019-01-04 陈立平 一种1/2水哌拉西林钠化合物
CN109160918A (zh) * 2017-07-27 2019-01-08 海南美兰史克制药有限公司 一种1/4水哌拉西林钠化合物及其药物组合物制剂
CN113209030B (zh) * 2021-04-27 2023-04-25 海南通用康力制药有限公司 哌拉西林钠他唑巴坦钠无菌粉针剂的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL47168A (en) * 1974-05-09 1979-07-25 Toyama Chemical Co Ltd Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same
US4379152A (en) * 1974-05-09 1983-04-05 Toyama Chemical Co., Ltd. Cephalosporins
JPS5123284A (en) 1974-08-13 1976-02-24 Toyama Chemical Co Ltd Shinkina penishirinruino seizoho
DE2732104A1 (de) * 1977-07-15 1979-01-25 Bayer Ag Penicilline, verfahren zu ihrer herstellung und ihre verwendung
JPS5446836A (en) * 1977-09-22 1979-04-13 Sangyo Kagaku Kenkyu Kyokai Antibacterial composition
US4610822A (en) * 1981-03-30 1986-09-09 American Cyanamid Company Process for preparing 6-[D(-)-α-(4-C1 -C4)-alkyl-2,3-dioxo-1-piperazinocarbonylamino)phenylacetamido]penicillanic acids
KR830001969B1 (ko) * 1981-10-06 1983-09-29 김영설 6―｛D―(―) α-(4―에틸-2. 3-디옥소-1 피페라지노카보닐아미노) 페닐(또는 하이드록시페닐)아세트아미도 페니실란산 및 그 염의 제조방법
JPS57118571A (en) * 1981-11-26 1982-07-23 Toyama Chem Co Ltd 1-ethyl-2,3-dioxopiperazine
YU43570B (en) * 1984-05-30 1989-08-31 Krka Process for preparation of derivatives of d()alpha-amino-benzile-penicilyns
PL145700B3 (en) * 1984-08-29 1988-10-31 Tarchominskie Zaklad Farma Method of obtaining 6-/d/-/alpha-/4-ethyl-2,3-dioxy-1-piperazinylocarbonyloamino/-phenylacetamido/-penicillate sodium salt
BG46664A1 (en) * 1985-08-16 1990-02-15 Druzhestven N Izsledovatelski Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid
SI8711089A8 (en) * 1987-06-11 1996-08-31 Krka Tovarna Zdravil Process for preparation of 6-/d(-)-alpha-(4-ethyl-2,3-dioxo-1- piperazine-carboxyamido)-phenylacetamido/-penicillanic acid
GB8816620D0 (en) * 1988-07-13 1988-08-17 Lepetit Spa Rifapentine hydrohalides
DD295852A5 (de) * 1988-07-18 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur herstellung von acylureido-benzylpenicillinen und deren salzen
JPH0232082A (ja) 1988-07-21 1990-02-01 Maruko Seiyaku Kk ペニシリン誘導体の製造方法
WO1990003782A2 (en) * 1988-10-05 1990-04-19 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
JP4749533B2 (ja) * 1999-09-30 2011-08-17 大塚化学株式会社 セファロスポリン結晶
JP4953501B2 (ja) * 1999-09-30 2012-06-13 大塚化学株式会社 ３−セフェム誘導体結晶の製造方法
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
ITMI20011718A1 (it) 2001-08-03 2003-02-03 Istituto Biochimico Italiano Processo per la preparazione del sale sodico dell'acido-6(d-(-)-alpha-(4-etil-2,3-diosso-1-piperazinocarbonilammino)fenilacetammido)penicill
JP2007099763A (ja) * 2005-09-08 2007-04-19 Toyama Chem Co Ltd ピペラシリンナトリウム・１水和物の新規な結晶及びその製造方法
JP2007246514A (ja) * 2006-02-14 2007-09-27 Toyama Chem Co Ltd ピペラシリンナトリウムの新規な結晶

Also Published As

Publication number Publication date
CN101611040A (zh) 2009-12-23
EP2128162A1 (en) 2009-12-02
AU2008210929A1 (en) 2008-08-07
CA2676803A1 (en) 2008-08-07
IL200087A0 (en) 2010-04-15
US20100063273A1 (en) 2010-03-11
JPWO2008093650A1 (ja) 2010-05-20
JP5173842B2 (ja) 2013-04-03
MX2009008124A (es) 2009-10-08
KR20090104855A (ko) 2009-10-06
WO2008093650A1 (ja) 2008-08-07
BRPI0808375A2 (pt) 2014-07-01
EP2128162A4 (en) 2011-05-25

Similar Documents

Publication Publication Date Title
RU2009132516A (ru) Новая кристаллическая форма пиперациллиннатрия
BRPI0506858A (pt) composto, métodos de preparação de monoidrato de gaboxadol cristalino e de anidrato de gaboxadol cristalino, composição farmacêutica, e, uso de um composto
MX2010004576A (es) Derivados de pirimidina novedosos.
MY153985A (en) Aminotriazole derivatives as alx agonists
PL1791571T3 (pl) Radiofluorowane peptydy
TW200732340A (en) Novel forms of tiotropium bromide and processes for preparation thereof
HK1086832A1 (en) Substituted benzosulphonamides as potentiators of glutamate receptors
ZA200807274B (en) Novel pyridine derivatives
UA87153C2 (ru) Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
EA200702109A1 (ru) Алкинилпирролопиримидины и их применение в качестве ингибиторов hsp90
TW200700406A (en) Novel thiophene derivatives
TW200716591A (en) Novel thiophene derivatives
TW200708511A (en) Novel thiophene derivatives
TW200738670A (en) Novel thiophene derivatives
TW200740814A (en) Compounds
HK1120442A1 (en) Novel opioid antagonists
MX2009011578A (es) 6-fenilpirimidinonas como moduladores de pim.
PL1888514T3 (pl) Sole podstawionych estrów kwasu alofanowego i ich zastosowanie w środkach leczniczych
TW200619206A (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
TW200716568A (en) 1H-quinazoline-2,4-diones
EA200801414A1 (ru) Кальцилитические соединения
IL186050A0 (en) Novel isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses thereof in particular as inhibitors of chaperone protein hsp90 activities
IL205696A0 (en) Heterocyclic derivatives, compositions comprising the same and uses thereof
BRPI0606974A2 (pt) uso de compostos de complexo de ferro(iii)
TW200800986A (en) Tetrahydroquinolines, synthesis thereof, and intermediates thereto

Legal Events

Date Code Title Description
FA94 Acknowledgement of application withdrawn (non-payment of fees)

Effective date: 20120709