RU2009114762A - Комплексы пиридина с бораном - Google Patents
Комплексы пиридина с бораном Download PDFInfo
- Publication number
- RU2009114762A RU2009114762A RU2009114762/04A RU2009114762A RU2009114762A RU 2009114762 A RU2009114762 A RU 2009114762A RU 2009114762/04 A RU2009114762/04 A RU 2009114762/04A RU 2009114762 A RU2009114762 A RU 2009114762A RU 2009114762 A RU2009114762 A RU 2009114762A
- Authority
- RU
- Russia
- Prior art keywords
- methylpyridine
- borane
- ethyl
- borane complex
- complex according
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B6/00—Hydrides of metals including fully or partially hydrided metals, alloys or intermetallic compounds ; Compounds containing at least one metal-hydrogen bond, e.g. (GeH3)2S, SiH GeH; Monoborane or diborane; Addition complexes thereof
- C01B6/06—Hydrides of aluminium, gallium, indium, thallium, germanium, tin, lead, arsenic, antimony, bismuth or polonium; Monoborane; Diborane; Addition complexes thereof
- C01B6/10—Monoborane; Diborane; Addition complexes thereof
- C01B6/13—Addition complexes of monoborane or diborane, e.g. with phosphine, arsine or hydrazine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Комплекс борана формулы (1) ! ! в которой R1 и R2 независимо друг от друга означают C1-C8-алкил, C1-C8-алкоксигруппу, С1-С8-алкокси-С1-С8-алкил или галоген при условии, что R1 и R2 одновременно не обозначают метил, когда R2 находится в положении 4 или 6 пиридинового кольца. ! 2. Комплекс борана по п.1, в котором R2 присоединен в положении 5 пиридинового кольца. ! 3. Комплекс борана по п.2, в котором R1 означает метил и R2 означает этил. ! 4. Комплекс борана по п.1, в котором замещенным пиридином является 2,3-лутидин, 2,5-лутидин, 5-этил-2-метилпиридин, 4-этил-2-метилпиридин, 3-этил-2-метилпиридин, 2,5-диэтилпиридин, 5-пропил-2-метилпиридин, 4-пропил-2-метилпиридин, 5-изопропил-2-метилпиридин, 5-трет-бутил-2-метилпиридин, 5-н-гексил-2-метилпиридин, 4-изобутил-2-метилпиридин, 2,4-дипропилпиридин, 5-метоксиметил-2-метилпиридин или 5-этоксиметил-2-метилпиридин. !5. Комплекс борана по п.1, в котором замещенным пиридином является 5-этил-2-метилпиридин. ! 6. Раствор, содержащий по меньшей мере один из комплексов борана по п.1 и по меньшей мере один растворитель. ! 7. Раствор по п.6, в котором растворитель, содержащий замещенный пиридин, применяется для образования комплекса борана формулы (1). ! 8. Раствор по п.6, в котором концентрация комплексов борана равна от 0,05 до 6,5 моль/л. ! 9. Раствор по п.8, в котором растворителем является тетрагидрофуран, 2-метилтетрагидрофуран, диметилсульфид, 1,6-тиоксан, толуол, гексан или циклогексан. ! 10. Способ синтеза комплексов борана по п.1, включающий стадию реакции источника борана с соответствующим замещенным пиридином. ! 11. Применение комплекса борана по п.1 в органических реакциях. ! 12. Применение по п.11, в котором органической реакцией является восс�
Claims (13)
1. Комплекс борана формулы (1)
в которой R1 и R2 независимо друг от друга означают C1-C8-алкил, C1-C8-алкоксигруппу, С1-С8-алкокси-С1-С8-алкил или галоген при условии, что R1 и R2 одновременно не обозначают метил, когда R2 находится в положении 4 или 6 пиридинового кольца.
2. Комплекс борана по п.1, в котором R2 присоединен в положении 5 пиридинового кольца.
3. Комплекс борана по п.2, в котором R1 означает метил и R2 означает этил.
4. Комплекс борана по п.1, в котором замещенным пиридином является 2,3-лутидин, 2,5-лутидин, 5-этил-2-метилпиридин, 4-этил-2-метилпиридин, 3-этил-2-метилпиридин, 2,5-диэтилпиридин, 5-пропил-2-метилпиридин, 4-пропил-2-метилпиридин, 5-изопропил-2-метилпиридин, 5-трет-бутил-2-метилпиридин, 5-н-гексил-2-метилпиридин, 4-изобутил-2-метилпиридин, 2,4-дипропилпиридин, 5-метоксиметил-2-метилпиридин или 5-этоксиметил-2-метилпиридин.
5. Комплекс борана по п.1, в котором замещенным пиридином является 5-этил-2-метилпиридин.
6. Раствор, содержащий по меньшей мере один из комплексов борана по п.1 и по меньшей мере один растворитель.
7. Раствор по п.6, в котором растворитель, содержащий замещенный пиридин, применяется для образования комплекса борана формулы (1).
8. Раствор по п.6, в котором концентрация комплексов борана равна от 0,05 до 6,5 моль/л.
9. Раствор по п.8, в котором растворителем является тетрагидрофуран, 2-метилтетрагидрофуран, диметилсульфид, 1,6-тиоксан, толуол, гексан или циклогексан.
10. Способ синтеза комплексов борана по п.1, включающий стадию реакции источника борана с соответствующим замещенным пиридином.
11. Применение комплекса борана по п.1 в органических реакциях.
12. Применение по п.11, в котором органической реакцией является восстановление функциональной группы или реакция гидроборирования с алкенами и алкинами.
13. Применение комплекса борана по п.1 для восстановительного аминирования альдегидов или кетонов первичными или вторичными аминами.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84614406P | 2006-09-21 | 2006-09-21 | |
| US60/846144 | 2006-09-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009114762A true RU2009114762A (ru) | 2010-10-27 |
| RU2454421C2 RU2454421C2 (ru) | 2012-06-27 |
Family
ID=38896907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009114762/04A RU2454421C2 (ru) | 2006-09-21 | 2007-09-20 | Комплексы пиридина с бораном |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8106200B2 (ru) |
| EP (1) | EP2066631B1 (ru) |
| JP (1) | JP5284262B2 (ru) |
| KR (1) | KR101417160B1 (ru) |
| CN (1) | CN101516846B (ru) |
| AT (1) | ATE504571T1 (ru) |
| AU (1) | AU2007298924B2 (ru) |
| CA (1) | CA2663677C (ru) |
| DE (1) | DE602007013781D1 (ru) |
| DK (1) | DK2066631T3 (ru) |
| ES (1) | ES2362311T3 (ru) |
| IL (1) | IL197375A (ru) |
| NZ (1) | NZ575485A (ru) |
| PL (1) | PL2066631T3 (ru) |
| PT (1) | PT2066631E (ru) |
| RU (1) | RU2454421C2 (ru) |
| TW (1) | TWI423957B (ru) |
| WO (1) | WO2008034886A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2873042C (en) | 2012-05-09 | 2018-09-18 | Cardioinsight Technologies, Inc. | Channel integrity detection |
| US11634748B2 (en) * | 2018-02-14 | 2023-04-25 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
| US10874318B2 (en) | 2018-03-06 | 2020-12-29 | Cardioinsight Technologies, Inc. | Channel integrity detection and reconstruction of electrophysiological signals |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BE634229A (ru) * | 1962-07-11 | |||
| JPS583535B2 (ja) * | 1976-11-25 | 1983-01-21 | コニカ株式会社 | 直接ポジ画像の形成方法 |
| JPS63220135A (ja) * | 1987-03-09 | 1988-09-13 | Mitsubishi Paper Mills Ltd | 直接ポジ用ハロゲン化銀写真乳剤 |
| US6048985A (en) | 1998-12-22 | 2000-04-11 | Mine Safety Appliances Company | Borane-tetrahydrofuran complex method of storing and reacting borane-tetrahydrofuran complex |
| JP3737688B2 (ja) * | 2000-09-14 | 2006-01-18 | 株式会社東芝 | 電子放出素子及びその製造方法 |
| WO2006020639A2 (en) | 2004-08-12 | 2006-02-23 | Sigma-Aldrich Co. | Stabilized borane-tetrahydrofuran complex |
-
2007
- 2007-09-20 ES ES07820436T patent/ES2362311T3/es active Active
- 2007-09-20 KR KR1020097006124A patent/KR101417160B1/ko active IP Right Grant
- 2007-09-20 PL PL07820436T patent/PL2066631T3/pl unknown
- 2007-09-20 WO PCT/EP2007/060003 patent/WO2008034886A1/en active Application Filing
- 2007-09-20 TW TW096135158A patent/TWI423957B/zh active
- 2007-09-20 US US12/441,928 patent/US8106200B2/en active Active
- 2007-09-20 AU AU2007298924A patent/AU2007298924B2/en not_active Ceased
- 2007-09-20 DE DE602007013781T patent/DE602007013781D1/de active Active
- 2007-09-20 NZ NZ575485A patent/NZ575485A/en not_active IP Right Cessation
- 2007-09-20 AT AT07820436T patent/ATE504571T1/de active
- 2007-09-20 JP JP2009528730A patent/JP5284262B2/ja active Active
- 2007-09-20 EP EP07820436A patent/EP2066631B1/en active Active
- 2007-09-20 CN CN2007800350357A patent/CN101516846B/zh not_active Expired - Fee Related
- 2007-09-20 PT PT07820436T patent/PT2066631E/pt unknown
- 2007-09-20 DK DK07820436.9T patent/DK2066631T3/da active
- 2007-09-20 RU RU2009114762/04A patent/RU2454421C2/ru not_active IP Right Cessation
- 2007-09-20 CA CA2663677A patent/CA2663677C/en active Active
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- 2009-03-03 IL IL197375A patent/IL197375A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT2066631E (pt) | 2011-05-03 |
| ATE504571T1 (de) | 2011-04-15 |
| CA2663677A1 (en) | 2008-03-27 |
| DK2066631T3 (da) | 2011-07-25 |
| CN101516846B (zh) | 2012-09-05 |
| WO2008034886A1 (en) | 2008-03-27 |
| US20110207934A1 (en) | 2011-08-25 |
| TW200833664A (en) | 2008-08-16 |
| JP2010504304A (ja) | 2010-02-12 |
| KR101417160B1 (ko) | 2014-07-08 |
| ES2362311T3 (es) | 2011-07-01 |
| US8106200B2 (en) | 2012-01-31 |
| CN101516846A (zh) | 2009-08-26 |
| KR20090055600A (ko) | 2009-06-02 |
| RU2454421C2 (ru) | 2012-06-27 |
| NZ575485A (en) | 2010-11-26 |
| IL197375A0 (en) | 2009-12-24 |
| CA2663677C (en) | 2014-01-14 |
| EP2066631A1 (en) | 2009-06-10 |
| PL2066631T3 (pl) | 2011-09-30 |
| AU2007298924A1 (en) | 2008-03-27 |
| AU2007298924B2 (en) | 2012-08-16 |
| DE602007013781D1 (de) | 2011-05-19 |
| JP5284262B2 (ja) | 2013-09-11 |
| EP2066631B1 (en) | 2011-04-06 |
| TWI423957B (zh) | 2014-01-21 |
| IL197375A (en) | 2013-08-29 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20170921 |