RU2009110153A - Лиганды 4-1 вв при воспалительных заболеваниях - Google Patents

Лиганды 4-1 вв при воспалительных заболеваниях Download PDF

Info

Publication number
RU2009110153A
RU2009110153A RU2009110153/10A RU2009110153A RU2009110153A RU 2009110153 A RU2009110153 A RU 2009110153A RU 2009110153/10 A RU2009110153/10 A RU 2009110153/10A RU 2009110153 A RU2009110153 A RU 2009110153A RU 2009110153 A RU2009110153 A RU 2009110153A
Authority
RU
Russia
Prior art keywords
1bbl
amino acids
polypeptide
seq
sequence
Prior art date
Application number
RU2009110153/10A
Other languages
English (en)
Russian (ru)
Inventor
Янг Джун КАНГ (US)
Янг Джун КАНГ
Джиахуай ХАН (US)
Джиахуай ХАН
Original Assignee
Зе Скрипс Ресеч Инститьют (Us)
Зе Скрипс Ресеч Инститьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зе Скрипс Ресеч Инститьют (Us), Зе Скрипс Ресеч Инститьют filed Critical Зе Скрипс Ресеч Инститьют (Us)
Publication of RU2009110153A publication Critical patent/RU2009110153A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
RU2009110153/10A 2006-10-16 2007-10-16 Лиганды 4-1 вв при воспалительных заболеваниях RU2009110153A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85202206P 2006-10-16 2006-10-16
US60/852,022 2006-10-16
US91756107P 2007-05-11 2007-05-11
US60/917,561 2007-05-11

Publications (1)

Publication Number Publication Date
RU2009110153A true RU2009110153A (ru) 2010-11-27

Family

ID=39364965

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009110153/10A RU2009110153A (ru) 2006-10-16 2007-10-16 Лиганды 4-1 вв при воспалительных заболеваниях

Country Status (11)

Country Link
US (1) US20100098689A1 (enExample)
EP (1) EP2097454A2 (enExample)
JP (1) JP2010506921A (enExample)
KR (1) KR20090068376A (enExample)
AU (1) AU2007318219A1 (enExample)
BR (1) BRPI0717744A2 (enExample)
CA (1) CA2666306A1 (enExample)
IL (1) IL197637A0 (enExample)
MX (1) MX2009004021A (enExample)
RU (1) RU2009110153A (enExample)
WO (1) WO2008057171A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100183633A1 (en) * 2008-12-04 2010-07-22 University Of Massachusetts Interleukin 6 and tumor necrosis factor alpha as biomarkers of jnk inhibition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040248157A1 (en) * 2001-09-14 2004-12-09 Michal Ayalon-Soffer Novel polynucleotides encoding soluble polypeptides and methods using same

Also Published As

Publication number Publication date
JP2010506921A (ja) 2010-03-04
BRPI0717744A2 (pt) 2013-11-12
IL197637A0 (en) 2011-08-01
WO2008057171A2 (en) 2008-05-15
KR20090068376A (ko) 2009-06-26
EP2097454A2 (en) 2009-09-09
CA2666306A1 (en) 2008-05-15
MX2009004021A (es) 2009-08-12
US20100098689A1 (en) 2010-04-22
WO2008057171A3 (en) 2008-11-20
AU2007318219A1 (en) 2008-05-15

Similar Documents

Publication Publication Date Title
Lacy et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β
JP6180408B2 (ja) 抗ｐｓｇｌ−１抗体およびその使用
Akram et al. Challenges for biosimilars: focus on rheumatoid arthritis
ES2769123T3 (es) Anticuerpos de quimiocinas PAN ELR+ CXC
EA023406B1 (ru) Антитела к гепцидину и варианты их применения
SG187867A1 (en) Antibodies that bind myostatin, compositions and methods
US20150291689A1 (en) Compositions and Methods for Treating Rheumatoid Arthritis
CN102574923A (zh) 针对人蛋白酶激活受体-2的高亲和力人抗体
TW201726731A (zh) 對TNF-α、IL-17A及IL-17F具特異性之多重特異性抗體分子
TW201439118A (zh) Ｂｍｐ－６抗體
CN107207623A (zh) Fc融合高亲和力IgE受体α链
US12440561B2 (en) Method of diagnosis and treatment of rheumatoid arthritis
CN110461875B (zh) 结合light的抗原结合分子
US20050053600A1 (en) Methods for treating rheumatoid arthritis
Galozzi et al. Development and role in therapy of canakinumab in adult-onset Still’s disease
US9388240B2 (en) Compositions for selective reduction of circulating bioactive soluble TNF and methods for treating TNF-mediated disease
WO2010105446A1 (zh) 抗人肿瘤坏死因子受体α单抗及其应用
WO2013103783A1 (en) Murine il-13 antibodies
JP2025516723A (ja) インターロイキン－１７（ｉｌ－１７）アンタゴニストを使用して腱障害を選択的に治療する方法
US20160244520A1 (en) Compositions and methods for treating psoriatic arthritis
JP2010506921A5 (enExample)
WO2025221933A9 (en) Antibodies and polypeptides comprising variant fc regions
CA2856141C (en) Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy
HK1244016B (zh) FC融合高亲和力IGE受体α链
BR112015020174B1 (pt) Anticorpo que liga gro-alfa, gro-beta, gro-gama, ena-78, gcp-2, nap-2 e il-8 humanos, seu uso e seu processo de produção, e molécula de dna

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20111005