RU2007147429A - Органические соединения - Google Patents
Органические соединения Download PDFInfo
- Publication number
- RU2007147429A RU2007147429A RU2007147429/04A RU2007147429A RU2007147429A RU 2007147429 A RU2007147429 A RU 2007147429A RU 2007147429/04 A RU2007147429/04 A RU 2007147429/04A RU 2007147429 A RU2007147429 A RU 2007147429A RU 2007147429 A RU2007147429 A RU 2007147429A
- Authority
- RU
- Russia
- Prior art keywords
- group
- alkyl
- chloro
- hydrogen
- acetic acid
- Prior art date
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- 150000002894 organic compounds Chemical class 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims abstract 51
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 24
- 239000001257 hydrogen Substances 0.000 claims abstract 24
- 125000002837 carbocyclic group Chemical group 0.000 claims abstract 23
- 125000003118 aryl group Chemical group 0.000 claims abstract 20
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 229910052736 halogen Inorganic materials 0.000 claims abstract 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 15
- 150000002367 halogens Chemical class 0.000 claims abstract 13
- 125000006647 (C3-C15) cycloalkyl group Chemical group 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 6
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims abstract 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 6
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims abstract 5
- 229910052799 carbon Inorganic materials 0.000 claims abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 5
- 125000003277 amino group Chemical group 0.000 claims abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims abstract 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract 3
- 125000004429 atom Chemical group 0.000 claims abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 125000005842 heteroatom Chemical group 0.000 claims abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 3
- 239000001301 oxygen Substances 0.000 claims abstract 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 3
- 229910052717 sulfur Chemical group 0.000 claims abstract 3
- 239000011593 sulfur Chemical group 0.000 claims abstract 3
- 150000002431 hydrogen Chemical group 0.000 claims 6
- -1 4-methyl-2,1-phenylene Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- SJTYWYNVLFFTSD-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O SJTYWYNVLFFTSD-UHFFFAOYSA-N 0.000 claims 2
- BOIZYIQPIXHURV-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-fluorophenyl]methyl]-4-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(F)C=C1CC1=CC(F)=CC=C1OCC(O)=O BOIZYIQPIXHURV-UHFFFAOYSA-N 0.000 claims 2
- LQHAONOJEMFNCP-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-methylphenyl]methyl]-4-methylphenoxy]acetic acid Chemical compound CC1=CC=C(OCC(O)=O)C(CC=2C(=CC=C(C)C=2)OCC(O)=O)=C1 LQHAONOJEMFNCP-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 125000004185 ester group Chemical group 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 claims 1
- BOCZNUWTUHOLLZ-UHFFFAOYSA-N 2-[2-[1-carboxyethoxy-(3-chloro-5-methylphenyl)methyl]-4-chloro-6-methylphenoxy]propanoic acid Chemical compound C=1C(Cl)=CC(C)=C(OC(C)C(O)=O)C=1C(OC(C)C(O)=O)C1=CC(C)=CC(Cl)=C1 BOCZNUWTUHOLLZ-UHFFFAOYSA-N 0.000 claims 1
- OGIQZJALYXINPX-UHFFFAOYSA-N 2-[2-[2-(carboxymethoxy)-5-chlorobenzoyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1C(=O)C1=CC(Cl)=CC=C1OCC(O)=O OGIQZJALYXINPX-UHFFFAOYSA-N 0.000 claims 1
- HPFHAUZDNSPEKD-UHFFFAOYSA-N 2-[2-[2-(carboxymethoxy)-5-chlorophenyl]sulfanyl-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1SC1=CC(Cl)=CC=C1OCC(O)=O HPFHAUZDNSPEKD-UHFFFAOYSA-N 0.000 claims 1
- CBYKCRPSWLZBMW-UHFFFAOYSA-N 2-[2-[[2-(2-carboxypropan-2-yloxy)-5-chlorophenyl]methyl]-4-chlorophenoxy]-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OC(C)(C)C(O)=O CBYKCRPSWLZBMW-UHFFFAOYSA-N 0.000 claims 1
- PWVRTSVTEBDMJG-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-3,5,6-trichlorophenyl]methyl]-3,4,6-trichlorophenoxy]acetic acid Chemical compound OC(=O)COC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(Cl)C(Cl)=CC(Cl)=C1OCC(O)=O PWVRTSVTEBDMJG-UHFFFAOYSA-N 0.000 claims 1
- OZWFWSMTJXJBKD-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]-4-chlorophenoxy]-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O OZWFWSMTJXJBKD-UHFFFAOYSA-N 0.000 claims 1
- FJMQTBUJTXVGPH-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]-4-methylsulfonylphenoxy]acetic acid Chemical compound CS(=O)(=O)C1=CC=C(OCC(O)=O)C(CC=2C(=CC=C(Cl)C=2)OCC(O)=O)=C1 FJMQTBUJTXVGPH-UHFFFAOYSA-N 0.000 claims 1
- UYGNLQGEKJMMPW-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]-4-nitrophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1CC1=CC([N+]([O-])=O)=CC=C1OCC(O)=O UYGNLQGEKJMMPW-UHFFFAOYSA-N 0.000 claims 1
- LFNZZMDJWLNDON-UHFFFAOYSA-N 2-[2-[[2-(carboxymethoxy)phenyl]methyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=CC=C1CC1=CC(Cl)=CC=C1OCC(O)=O LFNZZMDJWLNDON-UHFFFAOYSA-N 0.000 claims 1
- BKEAWZNCCQSEAT-UHFFFAOYSA-N 2-[4-bromo-2-[[5-bromo-2-(carboxymethoxy)phenyl]methyl]phenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Br)C=C1CC1=CC(Br)=CC=C1OCC(O)=O BKEAWZNCCQSEAT-UHFFFAOYSA-N 0.000 claims 1
- WNHRQTWQPKYCQK-UHFFFAOYSA-N 2-[4-chloro-2-[(4-chloro-2-hydroxyphenyl)methyl]phenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1CC1=CC=C(Cl)C=C1O WNHRQTWQPKYCQK-UHFFFAOYSA-N 0.000 claims 1
- KORWLPVXXKRQFU-UHFFFAOYSA-N 2-[4-chloro-2-[[5-chloro-2-(2-ethoxy-2-oxoethoxy)phenyl]methyl]phenoxy]acetic acid Chemical compound CCOC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O KORWLPVXXKRQFU-UHFFFAOYSA-N 0.000 claims 1
- GYQTXISSJAMIFO-UHFFFAOYSA-N 2-[4-chloro-2-[[5-chloro-2-(2-methoxy-2-oxoethoxy)phenyl]methyl]phenoxy]acetic acid Chemical compound COC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O GYQTXISSJAMIFO-UHFFFAOYSA-N 0.000 claims 1
- JXDMMCNWSZMSAQ-UHFFFAOYSA-N 2-[4-chloro-2-[[5-chloro-2-(2-oxo-2-propan-2-yloxyethoxy)phenyl]methyl]phenoxy]acetic acid Chemical compound CC(C)OC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O JXDMMCNWSZMSAQ-UHFFFAOYSA-N 0.000 claims 1
- URICLRSVMYKICO-UHFFFAOYSA-N 2-[4-chloro-2-[[5-chloro-2-[2-(2-methylpropoxy)-2-oxoethoxy]phenyl]methyl]phenoxy]acetic acid Chemical compound CC(C)COC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O URICLRSVMYKICO-UHFFFAOYSA-N 0.000 claims 1
- ZXYOIXJYHSSPNZ-UHFFFAOYSA-N 2-[4-chloro-2-[[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]methyl]phenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(=O)NC1CC1 ZXYOIXJYHSSPNZ-UHFFFAOYSA-N 0.000 claims 1
- GXVYQCSRLFWPPJ-UHFFFAOYSA-N 2-[4-tert-butyl-2-[[5-tert-butyl-2-(carboxymethoxy)phenyl]methyl]phenoxy]acetic acid Chemical compound CC(C)(C)C1=CC=C(OCC(O)=O)C(CC=2C(=CC=C(C=2)C(C)(C)C)OCC(O)=O)=C1 GXVYQCSRLFWPPJ-UHFFFAOYSA-N 0.000 claims 1
- DEXJMKACDOXYPA-UHFFFAOYSA-N 3-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]phenyl]propanoic acid Chemical compound OC(=O)CCC1=CC=CC=C1CC1=CC(Cl)=CC=C1OCC(O)=O DEXJMKACDOXYPA-UHFFFAOYSA-N 0.000 claims 1
- DLLGIZACHUEAHT-UHFFFAOYSA-N 4-[2-[[2-(carboxymethoxy)-5-chlorophenyl]methyl]-4-chlorophenoxy]butanoic acid Chemical compound OC(=O)CCCOC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1OCC(O)=O DLLGIZACHUEAHT-UHFFFAOYSA-N 0.000 claims 1
- SMDNCSKZPGUUDI-UHFFFAOYSA-N 4-[4-chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenoxy]butanoic acid Chemical compound OC(=O)CCCOC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O SMDNCSKZPGUUDI-UHFFFAOYSA-N 0.000 claims 1
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims 1
- 229940059260 amidate Drugs 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- NPUKDXXFDDZOKR-LLVKDONJSA-N etomidate Chemical compound CCOC(=O)C1=CN=CN1[C@H](C)C1=CC=CC=C1 NPUKDXXFDDZOKR-LLVKDONJSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0510585.3A GB0510585D0 (en) | 2005-05-24 | 2005-05-24 | Organic compounds |
| GB0510585.3 | 2005-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007147429A true RU2007147429A (ru) | 2009-06-27 |
Family
ID=34834562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007147429/04A RU2007147429A (ru) | 2005-05-24 | 2006-05-22 | Органические соединения |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080312322A1 (enExample) |
| EP (1) | EP1888505A1 (enExample) |
| JP (1) | JP2008545672A (enExample) |
| KR (1) | KR20080009214A (enExample) |
| CN (1) | CN101180260A (enExample) |
| AU (1) | AU2006251393A1 (enExample) |
| BR (1) | BRPI0610303A2 (enExample) |
| CA (1) | CA2608678A1 (enExample) |
| GB (1) | GB0510585D0 (enExample) |
| MX (1) | MX2007014785A (enExample) |
| RU (1) | RU2007147429A (enExample) |
| WO (1) | WO2006125593A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2327693T3 (da) | 2007-12-14 | 2012-08-13 | Pulmagen Therapeutics Asthma Ltd | Indoler og terapeutisk anvendelse deraf |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| CN104114169A (zh) | 2011-12-16 | 2014-10-22 | 阿托佩斯治疗有限公司 | 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物 |
| US9255090B2 (en) | 2011-12-21 | 2016-02-09 | Actelion Pharmaceuticals Ltd. | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2565171A (en) * | 1950-06-26 | 1951-08-21 | Allied Lab Inc | 2,2'-methylenebis (4-chlorophenoxyacetic acid) and a method for its production |
| ZA765075B (en) * | 1975-09-25 | 1977-08-31 | American Cyanamid Co | Hypolipemic compounds and method of treatment |
| FR2428629A1 (fr) * | 1978-06-14 | 1980-01-11 | Hexachimie | Nouveaux composes bis(aryloxycarboxyliques), leur preparation et leur utilisation en therapeutique |
| US5387600A (en) * | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
| US7355074B2 (en) * | 2003-02-05 | 2008-04-08 | The University Of Maryland | Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
-
2005
- 2005-05-24 GB GBGB0510585.3A patent/GB0510585D0/en not_active Ceased
-
2006
- 2006-05-22 AU AU2006251393A patent/AU2006251393A1/en not_active Abandoned
- 2006-05-22 MX MX2007014785A patent/MX2007014785A/es not_active Application Discontinuation
- 2006-05-22 JP JP2008512750A patent/JP2008545672A/ja active Pending
- 2006-05-22 RU RU2007147429/04A patent/RU2007147429A/ru not_active Application Discontinuation
- 2006-05-22 BR BRPI0610303-0A patent/BRPI0610303A2/pt not_active IP Right Cessation
- 2006-05-22 CA CA002608678A patent/CA2608678A1/en not_active Abandoned
- 2006-05-22 CN CNA2006800179674A patent/CN101180260A/zh active Pending
- 2006-05-22 KR KR1020077027360A patent/KR20080009214A/ko not_active Withdrawn
- 2006-05-22 EP EP06753777A patent/EP1888505A1/en not_active Withdrawn
- 2006-05-22 WO PCT/EP2006/004844 patent/WO2006125593A1/en not_active Ceased
- 2006-05-22 US US11/915,091 patent/US20080312322A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1888505A1 (en) | 2008-02-20 |
| BRPI0610303A2 (pt) | 2010-06-08 |
| US20080312322A1 (en) | 2008-12-18 |
| MX2007014785A (es) | 2008-02-15 |
| CN101180260A (zh) | 2008-05-14 |
| WO2006125593A1 (en) | 2006-11-30 |
| JP2008545672A (ja) | 2008-12-18 |
| KR20080009214A (ko) | 2008-01-25 |
| CA2608678A1 (en) | 2006-11-30 |
| AU2006251393A1 (en) | 2006-11-30 |
| GB0510585D0 (en) | 2005-06-29 |
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