RU2007139143A - Способ получения метилкобаламина - Google Patents
Способ получения метилкобаламина Download PDFInfo
- Publication number
- RU2007139143A RU2007139143A RU2007139143/04A RU2007139143A RU2007139143A RU 2007139143 A RU2007139143 A RU 2007139143A RU 2007139143/04 A RU2007139143/04 A RU 2007139143/04A RU 2007139143 A RU2007139143 A RU 2007139143A RU 2007139143 A RU2007139143 A RU 2007139143A
- Authority
- RU
- Russia
- Prior art keywords
- methylation
- reducing agent
- carried out
- sodium borohydride
- dimethyl carbonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Способ получения метилкобаламина, который включает метилирование цианокобаламина или гидроксокобаламина диметилкарбонатом в присутствии восстановителя. ! 2. Способ по п.1, в котором метилирование проводят в присутствии реагента, связывающего цианид-ион в водной или водно-органической среде. ! 3. Способ по п.1 или 2, в котором в качестве восстановителя используют боргидрид натрия. ! 4. Способ по п.1 или 2, в котором в качестве связывающего реагента используют сульфат железа (II) или хлорид кобальта (II). ! 5. Способ по п.1, в котором реакцию проводят последовательным или совместным добавлением боргидрида натрия и диметилкарбоната.
Claims (5)
1. Способ получения метилкобаламина, который включает метилирование цианокобаламина или гидроксокобаламина диметилкарбонатом в присутствии восстановителя.
2. Способ по п.1, в котором метилирование проводят в присутствии реагента, связывающего цианид-ион в водной или водно-органической среде.
3. Способ по п.1 или 2, в котором в качестве восстановителя используют боргидрид натрия.
4. Способ по п.1 или 2, в котором в качестве связывающего реагента используют сульфат железа (II) или хлорид кобальта (II).
5. Способ по п.1, в котором реакцию проводят последовательным или совместным добавлением боргидрида натрия и диметилкарбоната.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200500703A ES2264374B1 (es) | 2005-03-23 | 2005-03-23 | Procedimiento de fabricacion de la metilcobalamina. |
| ES200500703 | 2005-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007139143A true RU2007139143A (ru) | 2009-04-27 |
Family
ID=36304703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007139143/04A RU2007139143A (ru) | 2005-03-23 | 2006-03-22 | Способ получения метилкобаламина |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1861415A1 (ru) |
| JP (1) | JP2008534458A (ru) |
| KR (1) | KR20070106791A (ru) |
| CN (1) | CN101175764A (ru) |
| AR (1) | AR053558A1 (ru) |
| AU (1) | AU2006226577A1 (ru) |
| BR (1) | BRPI0609125A2 (ru) |
| CA (1) | CA2600987A1 (ru) |
| ES (1) | ES2264374B1 (ru) |
| IL (1) | IL185722A0 (ru) |
| MX (1) | MX2007011649A (ru) |
| NO (1) | NO20075211L (ru) |
| RU (1) | RU2007139143A (ru) |
| TW (1) | TW200700430A (ru) |
| UY (1) | UY29432A1 (ru) |
| WO (1) | WO2006100059A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5779710B2 (ja) * | 2011-05-30 | 2015-09-16 | インターキム ソシエダッド アノニマ デ キャピタル バリアブレＩｎｔｅｒｑｕｉｍ， Ｓ．Ａ． Ｄｅ Ｃ．Ｖ． | メチルコバラミンの合成プロセス |
| CN102391340A (zh) * | 2011-10-31 | 2012-03-28 | 河北玉星生物工程有限公司 | 一种甲钴胺的制备方法 |
| CN103113443B (zh) * | 2013-02-01 | 2015-02-11 | 山东省医药工业研究所 | 一种制备甲钴胺的化学合成方法 |
| CN105218608A (zh) * | 2015-10-29 | 2016-01-06 | 无锡福祈制药有限公司 | 一种甲钴胺的制备方法 |
| CN108948116A (zh) * | 2018-08-30 | 2018-12-07 | 上海应用技术大学 | 一种甲钴胺的绿色合成工艺 |
| CN114874276A (zh) * | 2022-04-21 | 2022-08-09 | 南京工业大学 | 一种改进的合成甲钴胺的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759614A (fr) * | 1969-12-01 | 1971-06-01 | Glaxo Lab Ltd | Elimination d'ions cyanure de solutions de corrinoides |
| US3928320A (en) * | 1971-11-10 | 1975-12-23 | Jean Boige | Process for the preparation of methylcobalamine |
| CN1170841C (zh) * | 1999-12-09 | 2004-10-13 | 卫材株式会社 | 甲基钴胺素的生产方法 |
| ES2558679T3 (es) * | 2001-06-05 | 2016-02-08 | Eisai R&D Management Co., Ltd. | Procedimiento para producir metilcobalamina |
-
2005
- 2005-03-23 ES ES200500703A patent/ES2264374B1/es not_active Expired - Fee Related
-
2006
- 2006-03-16 TW TW095108911A patent/TW200700430A/zh unknown
- 2006-03-17 AR ARP060101046A patent/AR053558A1/es unknown
- 2006-03-21 UY UY29432A patent/UY29432A1/es unknown
- 2006-03-22 CN CNA2006800092280A patent/CN101175764A/zh active Pending
- 2006-03-22 AU AU2006226577A patent/AU2006226577A1/en not_active Abandoned
- 2006-03-22 EP EP06723627A patent/EP1861415A1/en not_active Withdrawn
- 2006-03-22 WO PCT/EP2006/002635 patent/WO2006100059A1/en active Application Filing
- 2006-03-22 KR KR1020077021782A patent/KR20070106791A/ko not_active Application Discontinuation
- 2006-03-22 BR BRPI0609125-3A patent/BRPI0609125A2/pt not_active Application Discontinuation
- 2006-03-22 JP JP2008502319A patent/JP2008534458A/ja not_active Ceased
- 2006-03-22 MX MX2007011649A patent/MX2007011649A/es not_active Application Discontinuation
- 2006-03-22 RU RU2007139143/04A patent/RU2007139143A/ru not_active Application Discontinuation
- 2006-03-22 CA CA002600987A patent/CA2600987A1/en not_active Abandoned
-
2007
- 2007-09-04 IL IL185722A patent/IL185722A0/en unknown
- 2007-10-11 NO NO20075211A patent/NO20075211L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008534458A (ja) | 2008-08-28 |
| CN101175764A (zh) | 2008-05-07 |
| BRPI0609125A2 (pt) | 2010-02-23 |
| AU2006226577A1 (en) | 2006-09-28 |
| IL185722A0 (en) | 2008-01-06 |
| MX2007011649A (es) | 2007-11-14 |
| ES2264374B1 (es) | 2007-11-01 |
| ES2264374A1 (es) | 2006-12-16 |
| UY29432A1 (es) | 2006-06-30 |
| CA2600987A1 (en) | 2006-09-28 |
| WO2006100059A1 (en) | 2006-09-28 |
| AR053558A1 (es) | 2007-05-09 |
| EP1861415A1 (en) | 2007-12-05 |
| NO20075211L (no) | 2007-10-11 |
| TW200700430A (en) | 2007-01-01 |
| KR20070106791A (ko) | 2007-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20091124 |