RU2005122934A - Соединения для нормализации цикла сна/бодрствования - Google Patents
Соединения для нормализации цикла сна/бодрствования Download PDFInfo
- Publication number
- RU2005122934A RU2005122934A RU2005122934/14A RU2005122934A RU2005122934A RU 2005122934 A RU2005122934 A RU 2005122934A RU 2005122934/14 A RU2005122934/14 A RU 2005122934/14A RU 2005122934 A RU2005122934 A RU 2005122934A RU 2005122934 A RU2005122934 A RU 2005122934A
- Authority
- RU
- Russia
- Prior art keywords
- containing compound
- specified
- cytidine
- mammal
- sleep
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 28
- 238000010606 normalization Methods 0.000 title 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 10
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 10
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 10
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 8
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 6
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 6
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 6
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 5
- 229960005305 adenosine Drugs 0.000 claims 5
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 claims 4
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 3
- 229960003624 creatine Drugs 0.000 claims 3
- 239000006046 creatine Substances 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- 208000019116 sleep disease Diseases 0.000 claims 3
- 208000020685 sleep-wake disease Diseases 0.000 claims 3
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 3
- 229940045145 uridine Drugs 0.000 claims 3
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 208000010340 Sleep Deprivation Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (18)
1. Способ нормализации цикла сна/бодрствования млекопитающего, включающий введение млекопитающему терапевтически эффективного количества соединения, выбранного из группы, состоящей из цитидин-содержащего соединения, цитозин-содержащего соединения, уридин-содержащего соединения, креатин-содержащего соединения, аденозин-содержащего соединения и соединения, повышающего уровень аденозина, таким образом нормализуя цикл сна/бодрствования указанного млекопитающего.
2. Способ по п.1, где указанное введение уменьшает усталость или слабость, повышает бодрствование или улучшает качество сна указанного млекопитающего в течение дня.
3. Способ по п.1, где указанным цитидин-содержащим соединением является цитидин.
4. Способ по п.1, где указанное цитидин-содержащее соединение, дополнительно содержит холин.
5. Способ по п.1, где указанным цитидин-содержащим соединением является ЦДФ-холин.
6. Способ по п.5, где указанный ЦДФ-холин вводят перорально.
7. Способ по п.1, где указанным цитидин-содержащим соединением является ЦДФ.
8. Способ по п.1, где указанное введение является хроническим.
9. Способ по п.1, где указанным млекопитающим является человек.
10. Способ по п.9, где указанным человеком является ребенок или подросток.
11. Способ по п.9, где указанным человеком является пожилой взрослый.
12. Способ лечения расстройства сна, включающий введение млекопитающему терапевтически эффективного количества соединения, выбранного из группы, состоящей из цитидин-содержащего соединения, цитозин-содержащего соединения, уридин-содержащего соединения, креатин-содержащего соединения, аденозин-содержащего соединения и соединения, повышающего уровень аденозина.
13. Способ по п.12, где указанное расстройство сна вызвано расстройством, связанным со злоупотреблением веществами, вызывающими зависимость.
14. Способ по п.13, где указанное расстройство связанное со злоупотреблением веществами, вызывающими зависимость, представляет собой употребление или зависимость от алкоголя, кофеина или кокаина.
15. Способ по п.12, где указанным расстройством сна является бессонница, констриктивное или обструктивное апноэ во сне, синдром беспокойных ног, периодические движения конечностей, проблема сонливости или нарколепсия.
16. Способ по п.12, где указанным цитидин-содержащим соединением является ЦДФ-холин.
17. Способ повышения когнитивной функции, включающий введение терапевтически эффективного количества соединения, выбранного из группы, состоящей из цитидин-содержащего соединения, цитозин-содержащего соединения, уридин-содержащего соединения, креатин-содержащего соединения, аденозин-содержащего соединения и соединения, повышающего уровень аденозина, млекопитающему, страдающему от депривации сна, повышая, таким образом когнитивную функцию указанного млекопитающего.
18.Способ по п.17, где указанным цитидин-содержащим соединением является ЦДФ-холин.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43545702P | 2002-12-20 | 2002-12-20 | |
| US60/435,457 | 2002-12-20 | ||
| US60/435457 | 2002-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005122934A true RU2005122934A (ru) | 2006-01-20 |
| RU2366428C2 RU2366428C2 (ru) | 2009-09-10 |
Family
ID=32682243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005122934/14A RU2366428C2 (ru) | 2002-12-20 | 2003-12-17 | Соединения для нормализации цикла сна/бодрствования |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040176316A1 (ru) |
| EP (1) | EP1589979A4 (ru) |
| JP (2) | JP4717444B2 (ru) |
| CN (1) | CN100563660C (ru) |
| AU (1) | AU2003299715A1 (ru) |
| BR (1) | BR0317586A (ru) |
| CA (1) | CA2508995A1 (ru) |
| MX (1) | MXPA05006781A (ru) |
| NO (1) | NO20052987L (ru) |
| RU (1) | RU2366428C2 (ru) |
| UA (1) | UA88869C2 (ru) |
| WO (1) | WO2004058160A2 (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2425114T3 (es) * | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
| EP1565055B1 (en) * | 2002-11-08 | 2013-06-12 | THE McLEAN HOSPITAL CORPORATION | Compounds for the treatment of tobacco dependence and withdrawal |
| US20050113449A1 (en) * | 2003-10-08 | 2005-05-26 | Renshaw Perry F. | Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications |
| CA2542023A1 (en) * | 2003-10-08 | 2005-09-22 | The Mclean Hospital Corporation | Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids |
| EP1765364A4 (en) * | 2004-06-10 | 2010-09-22 | Mclean Hospital Corp | PYRIMIDINES, SUCH AS Z: B: CYTIDINE, IN THE TREATMENT OF PATIENTS WITH BIPOLAR DISORDER |
| WO2005122767A1 (en) * | 2004-06-10 | 2005-12-29 | Mclean Hospital Corporation | Pyrimidines, such as uridine, in treatments for patients with bipolar disorder |
| EP1784199A4 (en) * | 2004-08-11 | 2010-06-23 | Mclean Hospital Corp | COMPOUNDS FOR TREATING MARIHUANA DEPENDENCE, DEDUCTION AND CONSUMPTION |
| PL1888081T3 (pl) * | 2005-05-23 | 2017-07-31 | Massachusetts Institute Of Technology | Kompozycje zawierające PUFA i sposoby ich zastosowania |
| TW200827367A (en) * | 2006-10-26 | 2008-07-01 | Kyowa Hakko Kogyo Kk | A therapeutic agent for irritable bowel syndrome |
| AU2008322414C1 (en) * | 2007-11-16 | 2014-05-01 | International Ip Holdings Llc | Edible energy composition with low caffeine |
| US20100041621A1 (en) * | 2008-08-15 | 2010-02-18 | Perry Renshaw | Methods and compositions for improving cognitive performance |
| JP5426918B2 (ja) * | 2009-04-20 | 2014-02-26 | 株式会社 伊藤園 | ウリジンを含有する抗疲労剤又は体力向上剤 |
| JP2011032232A (ja) * | 2009-08-04 | 2011-02-17 | Ito En Ltd | 興奮抑制用又は鎮静用組成物及びこれを含む飲食品 |
| JP5989319B2 (ja) | 2011-10-06 | 2016-09-07 | ライオン株式会社 | 睡眠の質改善剤 |
| JP6165852B2 (ja) * | 2012-06-04 | 2017-07-19 | ファイザー・インク | 睡眠障害を治療するためのグレリン受容体逆アゴニストまたはアンタゴニストの使用 |
| KR102245628B1 (ko) * | 2013-04-05 | 2021-04-28 | 라이온 가부시키가이샤 | 내복 조성물 |
| EP3056096B1 (de) * | 2015-02-05 | 2019-07-24 | Smart Sleep GmbH | Verwendung eines Nahrungsergänzungsmittels enthaltend Kreatin zur Reduktion des natürlichen Schlafbedarfs oder zur schnelleren Anpassung der zirkadianen Rhythmik an neue Zeitzonen |
| EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4048316A (en) * | 1974-03-04 | 1977-09-13 | Penn Nathar W | Composition for antagonizing the narcotic effects of barbiturate addiction and withdrawal effects, and for treatment of barbiturate poisoning |
| US4115576A (en) * | 1974-04-02 | 1978-09-19 | Penn Nathar W | Compositions and method of employing the same for inhibiting alcohol intoxication |
| US4027017A (en) * | 1974-07-16 | 1977-05-31 | Chugai Seiyaku Kabushiki Kaisha | Method of treating alcoholism |
| IT1200589B (it) * | 1985-02-14 | 1989-01-27 | Gibipharma Spa | Derivati naturali attivita farmagologica |
| JPS63208524A (ja) * | 1987-02-25 | 1988-08-30 | Nippon Oil & Fats Co Ltd | 睡眠リズム改善剤 |
| US5691320A (en) * | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
| JPH0418034A (ja) * | 1990-05-11 | 1992-01-22 | Kanegafuchi Chem Ind Co Ltd | 点眼組成物 |
| US5635486A (en) * | 1990-05-11 | 1997-06-03 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Ophthalmic composition comprising a sleep adjusting substance |
| PT100525B (pt) * | 1991-05-29 | 1999-10-29 | Abbott Lab | Azaspiranos substituidos imunomodulares, seu uso e composicoes farmaceuticas que os contem |
| US5704361A (en) * | 1991-11-08 | 1998-01-06 | Mayo Foundation For Medical Education And Research | Volumetric image ultrasound transducer underfluid catheter system |
| US5278176A (en) * | 1992-08-21 | 1994-01-11 | Abbott Laboratories | Nicotine derivatives that enhance cognitive function |
| US5472958A (en) * | 1994-08-29 | 1995-12-05 | Abbott Laboratories | 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function |
| AU4070597A (en) * | 1996-08-16 | 1998-03-06 | The Texas A & M University System | Modifying insect cell gylcosylation pathways with baculovirus expression vectors |
| GB9623859D0 (en) * | 1996-11-15 | 1997-01-08 | Chiroscience Ltd | Novel compounds |
| US5958896A (en) * | 1997-08-08 | 1999-09-28 | The Mclean Hospital | Cytidine-containing and cytosine-containing compounds as treatments for stimulant exposure |
| US5977174A (en) * | 1997-11-26 | 1999-11-02 | Neuromedica, Inc. | Cholinergic compositions and uses thereof |
| US6153653A (en) * | 1997-11-26 | 2000-11-28 | Protarga, Inc. | Choline compositions and uses thereof |
| WO2000006174A1 (en) * | 1998-07-31 | 2000-02-10 | Massachusetts Institute Of Technology | Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases |
| DE19929995B4 (de) * | 1999-06-30 | 2004-06-03 | Skw Trostberg Ag | Verwendung von Kreatin und/oder Kreatin-Derivaten zur Behandlung von Befindlichkeitsstörungen bei Frauen |
| ES2425114T3 (es) * | 2000-03-16 | 2013-10-11 | The Mclean Hospital Corporation | CDP-colina y uridina para el tratamiento del abuso del acohol |
| ES2170649B1 (es) * | 2000-03-29 | 2003-06-16 | Ferrer Int | Uso de la cdp-colina en el tratamiento de la abstinencia alcoholica. |
| US6277855B1 (en) * | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| US20030114415A1 (en) * | 2001-12-14 | 2003-06-19 | Wurtman Richard J. | Compositions and methods for treating and preventing memory impairment using citicoline |
-
2003
- 2003-12-17 BR BR0317586-3A patent/BR0317586A/pt not_active IP Right Cessation
- 2003-12-17 WO PCT/US2003/040450 patent/WO2004058160A2/en active Application Filing
- 2003-12-17 US US10/740,075 patent/US20040176316A1/en not_active Abandoned
- 2003-12-17 JP JP2004563786A patent/JP4717444B2/ja not_active Expired - Fee Related
- 2003-12-17 EP EP03799995A patent/EP1589979A4/en not_active Withdrawn
- 2003-12-17 AU AU2003299715A patent/AU2003299715A1/en not_active Abandoned
- 2003-12-17 RU RU2005122934/14A patent/RU2366428C2/ru not_active IP Right Cessation
- 2003-12-17 CA CA002508995A patent/CA2508995A1/en not_active Abandoned
- 2003-12-17 UA UAA200506506A patent/UA88869C2/ru unknown
- 2003-12-17 CN CNB2003801098191A patent/CN100563660C/zh not_active Expired - Fee Related
- 2003-12-17 MX MXPA05006781A patent/MXPA05006781A/es unknown
-
2005
- 2005-06-17 NO NO20052987A patent/NO20052987L/no not_active Application Discontinuation
-
2011
- 2011-01-17 JP JP2011006614A patent/JP2011102319A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4717444B2 (ja) | 2011-07-06 |
| MXPA05006781A (es) | 2005-09-30 |
| US20040176316A1 (en) | 2004-09-09 |
| EP1589979A2 (en) | 2005-11-02 |
| JP2011102319A (ja) | 2011-05-26 |
| BR0317586A (pt) | 2005-11-22 |
| CN100563660C (zh) | 2009-12-02 |
| EP1589979A4 (en) | 2009-04-01 |
| CN1750833A (zh) | 2006-03-22 |
| CA2508995A1 (en) | 2004-07-15 |
| RU2366428C2 (ru) | 2009-09-10 |
| AU2003299715A8 (en) | 2004-07-22 |
| JP2006513214A (ja) | 2006-04-20 |
| WO2004058160A3 (en) | 2005-03-31 |
| NO20052987L (no) | 2005-08-29 |
| NO20052987D0 (no) | 2005-06-17 |
| UA88869C2 (ru) | 2009-12-10 |
| WO2004058160A2 (en) | 2004-07-15 |
| AU2003299715A1 (en) | 2004-07-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2005122934A (ru) | Соединения для нормализации цикла сна/бодрствования | |
| Engstrøm et al. | Sleep-related and non-sleep-related migraine: interictal sleep quality, arousals and pain thresholds | |
| Abad et al. | Diagnosis and treatment of sleep disorders: a brief review for clinicians | |
| Jain et al. | Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence‐based review of objective sleep metrics | |
| Moldofsky | The significance of the sleeping–waking brain for the understanding of widespread musculoskeletal pain and fatigue in fibromyalgia syndrome and allied syndromes | |
| Monk et al. | The Pittsburgh sleep diary | |
| Karacan et al. | Dose‐related sleep disturbances induced by coffee and caffeine | |
| Mahowald et al. | Parasomnias | |
| Naqvi et al. | Sleep architecture in children and adolescents with cystic fibrosis and the association with severity of lung disease | |
| JP2007508358A5 (ru) | ||
| Ciftci et al. | Consequences of hypoxia-reoxygenation phenomena in patients with obstructive sleep apnea syndrome | |
| Manconi et al. | Pramipexole versus ropinirole: polysomnographic acute effects in restless legs syndrome | |
| Sergi et al. | Periodic breathing during sleep in patients affected by fibromyalgia syndrome | |
| Miller et al. | Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes | |
| Cukic et al. | Sleep disorders in patients with bronchial asthma | |
| Mendelson | Sleepiness and hypertension in obstructive sleep apnea | |
| Stradling et al. | Sleep apnoea and hypertension: proof at last? | |
| Mazza et al. | Sleep disorders in the elderly | |
| Reid et al. | Circadian rhythm disorders | |
| Larsen et al. | The sound of silence is music to the heart | |
| Gaultier | Apnea and sleep state in newborns and infants | |
| Kim et al. | Transdermal scopolamine alters phasic REM activity in normal young adults | |
| Parrino et al. | Cyclic alternating patterns and arousals: what is relevant in obstructive sleep apnea? In Memoriam Mario Giovanni Terzano | |
| Lo Coco et al. | Sleep–wake problems in patients with amyotrophic lateral sclerosis: implications for patient management | |
| Giglio et al. | The primary parasomnias: A review for neurologists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20111218 |