RU2005122444A - Композиции в виде содержащих тиотропий растворов с гидрофторуглеродом - Google Patents

Композиции в виде содержащих тиотропий растворов с гидрофторуглеродом Download PDF

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Publication number
RU2005122444A
RU2005122444A RU2005122444/15A RU2005122444A RU2005122444A RU 2005122444 A RU2005122444 A RU 2005122444A RU 2005122444/15 A RU2005122444/15 A RU 2005122444/15A RU 2005122444 A RU2005122444 A RU 2005122444A RU 2005122444 A RU2005122444 A RU 2005122444A
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RU
Russia
Prior art keywords
acid
composition according
hfc
tiotropium
solvent
Prior art date
Application number
RU2005122444/15A
Other languages
English (en)
Russian (ru)
Inventor
Забине ЗИКС (DE)
Забине ЗИКС
Кристель ШМЕЛЬЦЕР (DE)
Кристель Шмельцер
Фридрих ШМИДТ (DE)
Фридрих Шмидт
Original Assignee
Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De)
Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De), Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг filed Critical Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De)
Publication of RU2005122444A publication Critical patent/RU2005122444A/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2005122444/15A 2002-12-16 2003-12-04 Композиции в виде содержащих тиотропий растворов с гидрофторуглеродом RU2005122444A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02028238 2002-12-16
EP02028238.0 2002-12-16

Publications (1)

Publication Number Publication Date
RU2005122444A true RU2005122444A (ru) 2007-01-27

Family

ID=32524008

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005122444/15A RU2005122444A (ru) 2002-12-16 2003-12-04 Композиции в виде содержащих тиотропий растворов с гидрофторуглеродом

Country Status (13)

Country Link
EP (1) EP1575588A1 (fr)
JP (1) JP2006510680A (fr)
KR (1) KR20050085650A (fr)
CN (1) CN1726038A (fr)
AU (1) AU2003303029A1 (fr)
BR (1) BR0317340A (fr)
CA (1) CA2510043A1 (fr)
IL (1) IL169178A0 (fr)
MX (1) MXPA05006383A (fr)
PL (1) PL375868A1 (fr)
RU (1) RU2005122444A (fr)
WO (1) WO2004054580A1 (fr)
ZA (1) ZA200503546B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273603B2 (en) * 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
CN101203513A (zh) * 2005-05-02 2008-06-18 贝林格尔·英格海姆国际有限公司 噻托溴铵的晶型
ES2393794T3 (es) * 2005-05-02 2012-12-28 Boehringer Ingelheim International Gmbh Nuevas formas cristalinas de bromuro de tiotropio
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
US8163913B2 (en) * 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
EP2201934A1 (fr) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Produits de formule d'aérosol de tiotropium avec stabilité chimique améliorée
SG181870A1 (en) 2009-12-23 2012-07-30 Chiesi Farma Spa Aerosol formulation for copd
EP2515855B3 (fr) 2009-12-23 2023-05-03 Chiesi Farmaceutici S.p.A. Polythérapie pour la COPD
GB201200525D0 (en) * 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
GB201200504D0 (en) * 2011-12-19 2012-02-22 Teva Branded Pharmaceutical Prod R & D Inc An inhaler
WO2013127738A1 (fr) 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Nouvelle formulation de tiotropium contenant un gaz propulseur
CA2885767A1 (fr) * 2012-10-23 2014-05-01 Cipla Limited Composition pharmaceutique
US20160250197A1 (en) * 2013-11-22 2016-09-01 Teva Branded Pharmaceutical Products R&D, Inc. An inhalable medicament
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
ES2904823T3 (es) * 2016-09-19 2022-04-06 Mexichem Fluor Sa De Cv Composición farmacéutica que comprende bromuro de tiotropio
ES2841649T5 (es) * 2016-09-19 2024-04-24 Mexichem Fluor Sa De Cv Composición farmacéutica
CA3037080C (fr) 2016-09-19 2021-05-18 Mexichem Fluor S.A. De C.V. Compositions pharmaceutiques stables comprenant de l'indacaterol et du 1,1-difluoroethane (hfa 152a) pour utilisation dans des aerosols-doseurs
BR112019005168A2 (pt) 2016-09-19 2019-06-11 Mexichem Fluor Sa De Cv composição farmacêutica, recipiente vedado, inalador de dose medida, e, métodos para tratar um paciente que sofre ou susceptível de sofrer de um distúrbio respiratório, para melhoria da estabilidade de uma composição farmacêutica e do desempenho de aerossolização de uma composição farmacêutica e para reduzir o potencial de aquecimento global de uma composição farmacêutica
EP3515432B1 (fr) 2016-09-19 2021-08-25 Mexichem Fluor S.A. de C.V. Composition pharmaceutique comprenant glycopyrrolate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100312357B1 (ko) * 1992-12-09 2002-04-24 데이비드 이. 프랭크하우저 안정화된약제의에어로졸용액제제
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols

Also Published As

Publication number Publication date
CN1726038A (zh) 2006-01-25
WO2004054580A1 (fr) 2004-07-01
AU2003303029A1 (en) 2004-07-09
PL375868A1 (en) 2005-12-12
KR20050085650A (ko) 2005-08-29
CA2510043A1 (fr) 2004-07-01
ZA200503546B (en) 2006-10-25
BR0317340A (pt) 2005-11-08
JP2006510680A (ja) 2006-03-30
EP1575588A1 (fr) 2005-09-21
MXPA05006383A (es) 2005-08-29
IL169178A0 (en) 2007-07-04

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Legal Events

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20080220