RU2005114491A - Соединения, составы и способы их использования - Google Patents

Соединения, составы и способы их использования Download PDF

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Publication number
RU2005114491A
RU2005114491A RU2005114491/04A RU2005114491A RU2005114491A RU 2005114491 A RU2005114491 A RU 2005114491A RU 2005114491/04 A RU2005114491/04 A RU 2005114491/04A RU 2005114491 A RU2005114491 A RU 2005114491A RU 2005114491 A RU2005114491 A RU 2005114491A
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RU
Russia
Prior art keywords
optionally substituted
alkyl
phenyl
hydrogen
substituted
Prior art date
Application number
RU2005114491/04A
Other languages
English (en)
Russian (ru)
Inventor
Ксиангпинг КВИАН (US)
Ксиангпинг Квиан
Густав БЕРДЖИНС (US)
Густав Берджинс
Дэвид Джей Младший МОРГАНС (US)
Дэвид Джей Младший МОРГАНС
Стивен Дэвид НАЙТ (US)
Стивен Дэвид Найт
Дашь нт ДХЭНЭК (US)
Дашьянт ДХЭНЭК
Original Assignee
Цитокинетикс, Инк. (Us)
Цитокинетикс, Инк.
Смитклайн Бихем Корпорейшн (Us)
Смитклайн Бихем Корпорейшн
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Publication date
Application filed by Цитокинетикс, Инк. (Us), Цитокинетикс, Инк., Смитклайн Бихем Корпорейшн (Us), Смитклайн Бихем Корпорейшн filed Critical Цитокинетикс, Инк. (Us)
Publication of RU2005114491A publication Critical patent/RU2005114491A/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005114491/04A 2002-10-11 2003-10-02 Соединения, составы и способы их использования RU2005114491A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41788902P 2002-10-11 2002-10-11
US60/417,889 2002-10-11

Publications (1)

Publication Number Publication Date
RU2005114491A true RU2005114491A (ru) 2006-02-10

Family

ID=32094113

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005114491/04A RU2005114491A (ru) 2002-10-11 2003-10-02 Соединения, составы и способы их использования

Country Status (19)

Country Link
US (1) US7476743B2 (https=)
EP (1) EP1558588A4 (https=)
JP (1) JP2006502219A (https=)
KR (1) KR20050075356A (https=)
CN (1) CN1726198A (https=)
AR (1) AR044193A1 (https=)
AU (1) AU2003282665A1 (https=)
BR (1) BR0315247A (https=)
CA (1) CA2501938A1 (https=)
IL (1) IL167936A0 (https=)
IS (1) IS7798A (https=)
MX (1) MXPA05003830A (https=)
NO (1) NO20052267L (https=)
NZ (1) NZ539643A (https=)
PL (1) PL375889A1 (https=)
RU (1) RU2005114491A (https=)
TW (1) TW200418818A (https=)
WO (1) WO2004032840A2 (https=)
ZA (1) ZA200503733B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2522450C2 (ru) * 2008-08-07 2014-07-10 Чжэцзян Хисунь Фармасьютикал Ко., Лтд. Соединения, оказывающие возбуждающее действие на рецептор активатора пролиферации пероксисом подтипа б, способ получения и применение указанных соединений

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101170925B1 (ko) * 2004-06-18 2012-08-07 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 암 치료용 키네신 방추 단백질 (ksp) 억제제로서의n-(1-(1-벤질-4-페닐-1h-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물
CN101027309B (zh) 2004-08-18 2010-10-27 阿斯利康(瑞典)有限公司 所选择的稠合嘧啶酮的对映体和在治疗和预防癌症中的用途
DE102006023337A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh Triazolderivate II
JP5343363B2 (ja) * 2008-01-31 2013-11-13 アイシン精機株式会社 シートクッション調整装置
JP2013523867A (ja) 2010-04-15 2013-06-17 ノバルティス アーゲー Ksp阻害剤としてのトリアゾール化合物
WO2012095691A1 (en) * 2011-01-15 2012-07-19 Jubilant Life Sciences Ltd. An improved process for producing aminopyridines
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
AU2013363398B2 (en) 2012-12-20 2017-06-01 Tempest Therapeutics, Inc. Triazolone compounds and uses thereof
US9776976B2 (en) 2013-09-06 2017-10-03 Inception 2, Inc. Triazolone compounds and uses thereof
RU2751512C2 (ru) 2015-06-22 2021-07-14 Байер Фарма Акциенгезельшафт Конъюгаты антитела и лекарственного средства (adc) и конъюгаты антитела и пролекарства (apdc), содержащие ферментативно расщепляемые группы
TW201722958A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート(adc)
US20250215039A1 (en) * 2022-03-30 2025-07-03 Primefour Therapeutics, Inc. Nucleosides for treating cancer

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BE793532A (fr) * 1971-12-29 1973-06-29 Upjohn Co Nouvelles 1,2,4-triazol-3-ones et leur preparation
US3748339A (en) * 1972-05-05 1973-07-24 Upjohn Co 2-(3-(1-(dimethylamino)alkyl)-1,5-dihydro-5-oxo - 1 - substituted-4h-1,2,4-triazol-4-yl)benzophenone and process
IT1068010B (it) * 1976-11-17 1985-03-21 Montedison Spa Nuovi esteri fosforici derivati dall' 1-2-4 triazolo ad azione insetticida,nematocida e acaricida e loro preparazione
NL7712430A (nl) * 1976-11-17 1978-05-19 Montedison Spa Nieuwe fosforzuuresters, afgeleid van 1.2.4- -triazool, met een insecticide, nematocide en acaricide werking en werkwijze ter bereiding daarvan.
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US5250558A (en) * 1992-01-28 1993-10-05 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
GB9211193D0 (en) * 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
IL106142A (en) * 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
AU722883B2 (en) * 1995-10-18 2000-08-10 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
JP2002234874A (ja) * 2000-09-26 2002-08-23 Tanabe Seiyaku Co Ltd 5−フェニルベンジルアミン誘導体、その製法及びその合成中間体
WO2002034699A2 (en) * 2000-10-26 2002-05-02 Merck & Co., Inc. Mammalian metabolites of a tachykinin receptor antagonist
MXPA04012642A (es) * 2002-06-14 2005-03-23 Merck & Co Inc Inhibidores de la cinesina mitotica.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2522450C2 (ru) * 2008-08-07 2014-07-10 Чжэцзян Хисунь Фармасьютикал Ко., Лтд. Соединения, оказывающие возбуждающее действие на рецептор активатора пролиферации пероксисом подтипа б, способ получения и применение указанных соединений

Also Published As

Publication number Publication date
MXPA05003830A (es) 2005-06-23
PL375889A1 (en) 2005-12-12
NO20052267L (no) 2005-05-31
AR044193A1 (es) 2005-09-07
AU2003282665A1 (en) 2004-05-04
EP1558588A4 (en) 2006-11-02
EP1558588A2 (en) 2005-08-03
TW200418818A (en) 2004-10-01
CN1726198A (zh) 2006-01-25
ZA200503733B (en) 2006-02-22
NZ539643A (en) 2006-11-30
US20060189671A1 (en) 2006-08-24
IL167936A0 (en) 2009-02-11
CA2501938A1 (en) 2004-04-22
WO2004032840A2 (en) 2004-04-22
US7476743B2 (en) 2009-01-13
BR0315247A (pt) 2005-08-30
JP2006502219A (ja) 2006-01-19
WO2004032840A3 (en) 2004-10-14
IS7798A (is) 2005-04-11
KR20050075356A (ko) 2005-07-20

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Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20080117