RU2005110674A - Конъюгаты гидроксиалкилкрахмала и аллергена - Google Patents
Конъюгаты гидроксиалкилкрахмала и аллергена Download PDFInfo
- Publication number
- RU2005110674A RU2005110674A RU2005110674/15A RU2005110674A RU2005110674A RU 2005110674 A RU2005110674 A RU 2005110674A RU 2005110674/15 A RU2005110674/15 A RU 2005110674/15A RU 2005110674 A RU2005110674 A RU 2005110674A RU 2005110674 A RU2005110674 A RU 2005110674A
- Authority
- RU
- Russia
- Prior art keywords
- use according
- starch
- allergen
- hydroxyalkyl starch
- case
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (14)
1. Применение конъюгата из гидроксиалкилкрахмала и аллергена, в котором по меньшей мере один гидроксиалкилкрахмал ковалентно связан с аллергеном, для гипосенсибилизации.
2. Применение по п.1, причем гидроксиалкилкрахмал связан с аллергеном непосредственно или через линкер.
3. Применение по п.1, причем гидроксиалкилкрахмалом является гидроксиэтилкрахмал, гидроксипропилкрахмал или гидроксибутилкрахмал.
4. Применение по п.1, причем гидроксиэтилкрахмал имеет среднюю молекулярную массу от 1 до 300 кДа, предпочтительно среднюю молекулярную массу от 5 до 200 кДа.
5. Применение по п.1, причем гидроксиэтилкрахмал имеет молекулярную степень замещения от 0,1 до 0,8 и соотношение замещения С2:С6 в пределах от 2 до 20, в каждом случае в расчете на гидроксиэтильные группы.
6. Применение по п.1, причем аллерген выбран из группы, состоящей из полипептидов или протеинов.
7. Применение по п.6, причем аллергеном является гликопротеин.
8. Применение по п.7, причем гидроксиалкилкрахмал связан с полипептидной цепью или с одной или несколькими сахаридными цепями гликопротеина.
9. Применение по п.1 для гипосенсибилизации аллергиков, в случае которых обнаружена опосредованная IgE сенсибилизация или у которых наблюдались клинические симптомы.
10. Применение по п.1, причем специфическая иммунотерапия используется для лечения аллергий на пыльцу, клещей, волосы (слюну) млекопитающих, грибы, укусы насекомых, пищевые продукты и натуральный каучук/латекс.
11. Применение по п.1, причем терапия используется для лечения астматиков, страдающих сенной лихорадкой пациентов и пациентов, которые обладают другими клинически релевантными реакциями на аллергены мгновенного типа.
12. Применение по п.1, причем введение осуществляется подкожно, через слизистую оболочку, орально, перорально или подъязычно.
13. Применение по п.1, причем иммунотерапия в случае аэроаллергенов осуществляется предсезонно или постоянно.
14. Применение по п.1, причем иммунотерапия в случае аллергиков с аллергией к укусам насекомых осуществляется по Rush-способу или ультра-Rush-способу.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10242076A DE10242076A1 (de) | 2002-09-11 | 2002-09-11 | HAS-Allergen-Konjugate |
DE10242076.9 | 2002-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2005110674A true RU2005110674A (ru) | 2005-10-27 |
RU2325925C2 RU2325925C2 (ru) | 2008-06-10 |
Family
ID=31895808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005110674/15A RU2325925C2 (ru) | 2002-09-11 | 2003-09-02 | Конъюгаты гидроксиалкилкрахмала и аллергена |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060121062A1 (ru) |
EP (1) | EP1536838B1 (ru) |
JP (1) | JP2006503074A (ru) |
KR (1) | KR20050073451A (ru) |
CN (1) | CN1681535A (ru) |
AT (1) | ATE353018T1 (ru) |
AU (1) | AU2003258697B2 (ru) |
CA (1) | CA2497008C (ru) |
DE (2) | DE10242076A1 (ru) |
PL (1) | PL376481A1 (ru) |
RU (1) | RU2325925C2 (ru) |
WO (1) | WO2004030701A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
KR101045422B1 (ko) * | 2002-09-11 | 2011-06-30 | 프레제니우스 카비 도이치란트 게엠베하 | 하이드록시알킬 전분 유도체의 제조 방법 |
BRPI0413450A (pt) * | 2003-08-08 | 2006-10-17 | Fresenius Kabi De Gmbh | conjugados de hidroxialquil amido e g-csf |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
ES2390885T3 (es) * | 2004-03-11 | 2012-11-19 | Fresenius Kabi Deutschland Gmbh | Conjugados de hidroxialquilalmidón y una proteína |
WO2005092928A1 (en) * | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
EP2070950A1 (en) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkyl starch derivatives and process for their preparation |
EP2070951A1 (en) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Method for producing a hydroxyalkyl starch derivatives with two linkers |
MX2011003117A (es) * | 2008-09-19 | 2011-04-21 | Nektar Therapeutics | Conjugados polimericos de peptidos terapeuticos. |
CA2859444A1 (en) * | 2011-12-13 | 2013-06-20 | Immunogen, Inc. | Use of n-hydroxysuccinimide to improve conjugate stability |
RU2497828C1 (ru) * | 2012-06-22 | 2013-11-10 | Федеральное Государственное Бюджетное Учреждение Науки Институт Химии Коми Научного Центра Уральского Отделения Российской Академии Наук | Гидрофильный конъюгат гидроксиэтилкрахмала и 2,6-диизоборнил-4-метилфенола |
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DE10209821A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
KR101045422B1 (ko) * | 2002-09-11 | 2011-06-30 | 프레제니우스 카비 도이치란트 게엠베하 | 하이드록시알킬 전분 유도체의 제조 방법 |
-
2002
- 2002-09-11 DE DE10242076A patent/DE10242076A1/de not_active Withdrawn
-
2003
- 2003-09-02 AT AT03798884T patent/ATE353018T1/de not_active IP Right Cessation
- 2003-09-02 JP JP2004540576A patent/JP2006503074A/ja active Pending
- 2003-09-02 PL PL03376481A patent/PL376481A1/xx not_active Application Discontinuation
- 2003-09-02 KR KR1020057004012A patent/KR20050073451A/ko not_active Application Discontinuation
- 2003-09-02 CA CA2497008A patent/CA2497008C/en not_active Expired - Fee Related
- 2003-09-02 AU AU2003258697A patent/AU2003258697B2/en not_active Ceased
- 2003-09-02 US US10/527,554 patent/US20060121062A1/en not_active Abandoned
- 2003-09-02 CN CNA038214636A patent/CN1681535A/zh active Pending
- 2003-09-02 WO PCT/EP2003/009750 patent/WO2004030701A1/de active IP Right Grant
- 2003-09-02 DE DE50306438T patent/DE50306438D1/de not_active Expired - Lifetime
- 2003-09-02 EP EP03798884A patent/EP1536838B1/de not_active Expired - Lifetime
- 2003-09-02 RU RU2005110674/15A patent/RU2325925C2/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL376481A1 (en) | 2005-12-27 |
US20060121062A1 (en) | 2006-06-08 |
CN1681535A (zh) | 2005-10-12 |
DE10242076A1 (de) | 2004-03-25 |
EP1536838A1 (de) | 2005-06-08 |
DE50306438D1 (de) | 2007-03-22 |
RU2325925C2 (ru) | 2008-06-10 |
CA2497008C (en) | 2011-11-01 |
KR20050073451A (ko) | 2005-07-13 |
AU2003258697B2 (en) | 2009-07-23 |
JP2006503074A (ja) | 2006-01-26 |
WO2004030701A1 (de) | 2004-04-15 |
ATE353018T1 (de) | 2007-02-15 |
CA2497008A1 (en) | 2004-04-15 |
AU2003258697A1 (en) | 2004-04-23 |
EP1536838B1 (de) | 2007-01-31 |
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Legal Events
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MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110903 |