RU2004134322A - Микрочастицы, включающие углеводные сферы, ковалентно связанные с аллергеном - Google Patents
Микрочастицы, включающие углеводные сферы, ковалентно связанные с аллергеном Download PDFInfo
- Publication number
- RU2004134322A RU2004134322A RU2004134322/15A RU2004134322A RU2004134322A RU 2004134322 A RU2004134322 A RU 2004134322A RU 2004134322/15 A RU2004134322/15 A RU 2004134322/15A RU 2004134322 A RU2004134322 A RU 2004134322A RU 2004134322 A RU2004134322 A RU 2004134322A
- Authority
- RU
- Russia
- Prior art keywords
- microparticle
- allergen
- sphere
- microparticle according
- pollen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Claims (12)
1. Микрочастица, включающая (а) сферу, по существу состоящую из трехмерного поперечно связанного углевода и (б) аллергена, который ковалентно привязан к сфере, где (и) аллерген получают из растительной пыльцы.
2. Микрочастица по п.1, где углеводная сфера состоит главным образом из агарозы.
3. Микрочастица по п.1, где аллерген получают из травяной пыльцы.
4. Микрочастица по п.3, где аллерген получают из пыльцы тимофеевки луговой.
5. Микрочастица по п.1, где размер частицы находится в диапазоне 0,1-10 мкм.
6. Микрочастица по п.5, где размер частицы находится в диапазоне 0,5-5 мкм.
7. Микрочастица по любому из пп.1-6, отличающаяся тем, что микрочастица применяется для вакцинации.
8. Микрочастица по любому из пп.1-6, отличающаяся тем, что микрочастица применяется для лечения аллергии.
9. Лекарственное средство для лечения иммунной системы, отличающееся тем, что оно включает микрочастицы по любому из пп.1-8.
10. Лекарственное средство по п.9, отличающееся тем, что оно приготавливается для парентерального применения.
11. Диагностическая тест-система для измерения высвобождающихся клеточных медиаторов, отличающаяся тем, что она включает микрочастицы по любому из пп.1-6.
12. Диагностическая тест-система по п.11, где высвобождающийся клеточный медиатор, который должен быть измерен, является интерлейкином.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02008283.0 | 2002-04-22 | ||
| EP02008283A EP1356826A1 (en) | 2002-04-22 | 2002-04-22 | Microparticles comprising carbohydrate beads covalently linked with allergen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004134322A true RU2004134322A (ru) | 2005-08-27 |
| RU2329830C2 RU2329830C2 (ru) | 2008-07-27 |
Family
ID=28685856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004134322/15A RU2329830C2 (ru) | 2002-04-22 | 2003-04-17 | Микрочастицы, включающие углеводные сферы, ковалентно связанные с аллергеном |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8454964B2 (ru) |
| EP (2) | EP1356826A1 (ru) |
| JP (1) | JP4814490B2 (ru) |
| CN (1) | CN100460019C (ru) |
| AT (1) | ATE419874T1 (ru) |
| AU (1) | AU2003224104B2 (ru) |
| CA (1) | CA2482973C (ru) |
| DE (1) | DE60325713D1 (ru) |
| ES (1) | ES2318124T3 (ru) |
| RU (1) | RU2329830C2 (ru) |
| WO (1) | WO2003089009A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10329087B4 (de) * | 2003-06-27 | 2014-02-13 | Biomedical International R + D Gmbh | Antigenhaltige Mikrosphären zur Allergietherapie |
| WO2008157687A1 (en) * | 2007-06-19 | 2008-12-24 | Timothy O'shaughnessy | User health status |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| EP2316481A1 (en) | 2009-10-30 | 2011-05-04 | Biomay Ag | Pharmaceutical composition for the treatment and prevention of a rhinovirus infection |
| CA2846858C (en) | 2011-08-31 | 2022-03-08 | Perosphere, Inc. | Methods for effectively and rapidly desensitizing allergic patients |
| EP2761293B1 (en) | 2011-09-30 | 2022-04-06 | Wake Forest University Health Sciences | Bioscaffolds for formation of motor endplates and other specialized tissue structures |
| US10441768B2 (en) | 2015-03-18 | 2019-10-15 | University of Pittsburgh—of the Commonwealth System of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
| WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
| ES2824554T3 (es) | 2015-12-16 | 2021-05-12 | Tcer Ab | Plataforma de reactividad de células T |
| EP3182125A1 (en) * | 2015-12-16 | 2017-06-21 | Ab Tcer | T-cell reactivity platform |
| US11744889B2 (en) * | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
| CN114631506B (zh) * | 2022-03-10 | 2023-08-18 | 中国水产科学研究院黑龙江水产研究所 | 一种水产养殖饲料投放装置及操作方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8204244L (sv) * | 1982-07-09 | 1984-01-10 | Ulf Schroder | Kristalliserad kolhydratsmatris for biologiskt aktiva substanser |
| JP2594123B2 (ja) * | 1987-09-12 | 1997-03-26 | 株式会社林原生物化学研究所 | 減感作剤 |
| US5091318A (en) * | 1990-04-13 | 1992-02-25 | Abbott Laboratories | Binding of allergens to a solid phase |
| WO1995019437A1 (en) * | 1994-01-14 | 1995-07-20 | University Of Manitoba | Cross-reactive allergen |
| CA2200550A1 (en) * | 1994-09-23 | 1996-04-04 | Kuang Hsu | Chitosan induced immunopotentiation |
| DE19713001A1 (de) * | 1997-03-27 | 1998-10-01 | Merck Patent Gmbh | Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung |
| ES2243229T3 (es) * | 1999-02-03 | 2005-12-01 | Powderject Res Ltd | Formulaciones de particulas de hidrogel. |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| JP3610551B2 (ja) * | 2000-07-03 | 2005-01-12 | 顧▲徳▼生物科技股▲分▼有限公司 | ＩｇＹ（ΔＦｃ）抗体の作製およびその使用 |
-
2002
- 2002-04-22 EP EP02008283A patent/EP1356826A1/en not_active Withdrawn
-
2003
- 2003-04-17 RU RU2004134322/15A patent/RU2329830C2/ru not_active IP Right Cessation
- 2003-04-17 AU AU2003224104A patent/AU2003224104B2/en not_active Ceased
- 2003-04-17 WO PCT/EP2003/004103 patent/WO2003089009A1/en active Application Filing
- 2003-04-17 US US10/510,655 patent/US8454964B2/en not_active Expired - Fee Related
- 2003-04-17 ES ES03720503T patent/ES2318124T3/es not_active Expired - Lifetime
- 2003-04-17 CA CA2482973A patent/CA2482973C/en not_active Expired - Fee Related
- 2003-04-17 CN CNB038089343A patent/CN100460019C/zh not_active Expired - Fee Related
- 2003-04-17 JP JP2003585760A patent/JP4814490B2/ja not_active Expired - Fee Related
- 2003-04-17 AT AT03720503T patent/ATE419874T1/de active
- 2003-04-17 DE DE60325713T patent/DE60325713D1/de not_active Expired - Lifetime
- 2003-04-17 EP EP03720503A patent/EP1496942B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1496942A1 (en) | 2005-01-19 |
| JP4814490B2 (ja) | 2011-11-16 |
| ATE419874T1 (de) | 2009-01-15 |
| CA2482973C (en) | 2011-11-22 |
| ES2318124T3 (es) | 2009-05-01 |
| AU2003224104A1 (en) | 2003-11-03 |
| CN100460019C (zh) | 2009-02-11 |
| CN1646173A (zh) | 2005-07-27 |
| CA2482973A1 (en) | 2003-10-30 |
| EP1356826A1 (en) | 2003-10-29 |
| JP2005529880A (ja) | 2005-10-06 |
| AU2003224104B2 (en) | 2008-05-29 |
| RU2329830C2 (ru) | 2008-07-27 |
| US20050095298A1 (en) | 2005-05-05 |
| EP1496942B1 (en) | 2009-01-07 |
| WO2003089009A1 (en) | 2003-10-30 |
| US8454964B2 (en) | 2013-06-04 |
| DE60325713D1 (de) | 2009-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20150418 |