RU2004132205A - Комбинации эпинастина, белладонны и псевдоэфедрина в качестве новых фармацевтических составов - Google Patents
Комбинации эпинастина, белладонны и псевдоэфедрина в качестве новых фармацевтических составов Download PDFInfo
- Publication number
- RU2004132205A RU2004132205A RU2004132205/15A RU2004132205A RU2004132205A RU 2004132205 A RU2004132205 A RU 2004132205A RU 2004132205/15 A RU2004132205/15 A RU 2004132205/15A RU 2004132205 A RU2004132205 A RU 2004132205A RU 2004132205 A RU2004132205 A RU 2004132205A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- pseudoephedrine
- oral administration
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 11
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 title claims 9
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 title claims 8
- 229960003908 pseudoephedrine Drugs 0.000 title claims 8
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 title claims 7
- 229960003449 epinastine Drugs 0.000 title claims 6
- 150000003839 salts Chemical class 0.000 claims 18
- 239000002775 capsule Substances 0.000 claims 9
- GERIGMSHTUAXSI-UHFFFAOYSA-N bis(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 4-phenyl-2,3-dihydro-1h-naphthalene-1,4-dicarboxylate Chemical compound CN1C(C2)CCC1CC2OC(=O)C(C1=CC=CC=C11)CCC1(C(=O)OC1CC2CCC(N2C)C1)C1=CC=CC=C1 GERIGMSHTUAXSI-UHFFFAOYSA-N 0.000 claims 8
- FMCGSUUBYTWNDP-ONGXEEELSA-N (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol Chemical compound CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 FMCGSUUBYTWNDP-ONGXEEELSA-N 0.000 claims 7
- FMCGSUUBYTWNDP-UHFFFAOYSA-N N-Methylephedrine Natural products CN(C)C(C)C(O)C1=CC=CC=C1 FMCGSUUBYTWNDP-UHFFFAOYSA-N 0.000 claims 7
- 229940092732 belladonna alkaloid Drugs 0.000 claims 7
- 229960002221 methylephedrine Drugs 0.000 claims 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 201000010105 allergic rhinitis Diseases 0.000 claims 3
- 239000000739 antihistaminic agent Substances 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- AHVYPIQETPWLSZ-UHFFFAOYSA-N 1-methyl-2,5-dihydropyrrole Chemical compound CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 claims 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 229930013930 alkaloid Natural products 0.000 claims 2
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims 2
- 230000003501 anti-edematous effect Effects 0.000 claims 2
- 230000001387 anti-histamine Effects 0.000 claims 2
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- -1 fatty acid esters Chemical class 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 2
- 239000012188 paraffin wax Substances 0.000 claims 2
- 235000019809 paraffin wax Nutrition 0.000 claims 2
- 235000019271 petrolatum Nutrition 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 208000017022 seasonal allergic rhinitis Diseases 0.000 claims 2
- 230000001932 seasonal effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- RKUNBYITZUJHSG-QXULXFAOSA-N (-)-Hyoscyamine Natural products C1([C@H](CO)C(=O)OC2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 RKUNBYITZUJHSG-QXULXFAOSA-N 0.000 claims 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 241001106067 Atropa Species 0.000 claims 1
- 229930003347 Atropine Natural products 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 229920001218 Pullulan Polymers 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- NTCYWJCEOILKNG-ROLPUNSJSA-N [(1r,2s)-1-hydroxy-1-phenylpropan-2-yl]-dimethylazanium;chloride Chemical compound Cl.CN(C)[C@@H](C)[C@H](O)C1=CC=CC=C1 NTCYWJCEOILKNG-ROLPUNSJSA-N 0.000 claims 1
- WPUIZWXOSDVQJU-XYPWUTKMSA-N [(1s,5r)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylprop-2-enoate Chemical compound C([C@H]1CC[C@@H](C2)N1C)C2OC(=O)C(=C)C1=CC=CC=C1 WPUIZWXOSDVQJU-XYPWUTKMSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 1
- 229960000396 atropine Drugs 0.000 claims 1
- 235000013339 cereals Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229960002548 epinastine hydrochloride Drugs 0.000 claims 1
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims 1
- 210000002388 eustachian tube Anatomy 0.000 claims 1
- 235000013312 flour Nutrition 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims 1
- 229960003210 hyoscyamine Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229940051020 methylephedrine hydrochloride Drugs 0.000 claims 1
- 201000009240 nasopharyngitis Diseases 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 claims 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims 1
- 229960002646 scopolamine Drugs 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229920001169 thermoplastic Polymers 0.000 claims 1
- 239000004416 thermosoftening plastic Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02007568A EP1350512A1 (en) | 2002-04-03 | 2002-04-03 | Combinations of epinastine, belladonna and pseudoephedrine as new pharmaceutical formulations |
| EP02007568.5 | 2002-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004132205A true RU2004132205A (ru) | 2005-09-10 |
Family
ID=27838061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004132205/15A RU2004132205A (ru) | 2002-04-03 | 2003-03-28 | Комбинации эпинастина, белладонны и псевдоэфедрина в качестве новых фармацевтических составов |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030228359A1 (https=) |
| EP (2) | EP1350512A1 (https=) |
| JP (1) | JP2005522467A (https=) |
| AR (1) | AR039221A1 (https=) |
| AU (1) | AU2003221532A1 (https=) |
| BR (1) | BR0308982A (https=) |
| CA (1) | CA2477751A1 (https=) |
| MX (1) | MXPA04009582A (https=) |
| PE (1) | PE20040080A1 (https=) |
| PL (1) | PL371382A1 (https=) |
| RU (1) | RU2004132205A (https=) |
| WO (1) | WO2003082285A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| US20030104017A1 (en) * | 2001-10-26 | 2003-06-05 | Boehringer Ingelheim International Gmbh | Epinastine formulation for oral administration |
| KR20050092429A (ko) * | 2003-01-22 | 2005-09-21 | 니찌방 가부시기가이샤 | 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환치료약의 눈의 국소 조직으로의 이행 방법 |
| EP1675550A4 (en) * | 2003-09-24 | 2007-10-10 | Combinatorx Inc | THERAPEUTIC DOSAGE DIAGRAMS FOR ADMINISTRATION OF MEDICINAL COMBINATIONS |
| RU2006132043A (ru) * | 2004-02-06 | 2008-03-20 | МЕДА Фарма ГмбХ унд Ко.КГ (DE) | Комбинация и фармацевтический препарат для лечения ринита |
| JP4936420B2 (ja) * | 2005-08-02 | 2012-05-23 | 塩野義製薬株式会社 | 徐放性顆粒剤 |
| JP5162141B2 (ja) * | 2007-02-20 | 2013-03-13 | エスエス製薬株式会社 | フィルムコーティング用組成物 |
| RU2366446C1 (ru) * | 2008-06-27 | 2009-09-10 | Сергей Анатольевич Небера | Гомеопатическое средство для лечения конъюнктивитов |
| US8298591B2 (en) * | 2008-09-10 | 2012-10-30 | Micro-Dose Life Sciences Llc | Anti-fever botanical composition and uses thereof |
| RU2554740C2 (ru) * | 2009-05-01 | 2015-06-27 | Апталис Фарматек, Инк. | Композиции перорально распадающихся таблеток, содержащие комбинации высоко- и низкодозовых лекарственных средств |
| JP5852816B2 (ja) * | 2010-09-10 | 2016-02-03 | ロート製薬株式会社 | 液状医薬組成物、及びこれを含有する軟カプセル剤 |
| RU2478377C1 (ru) * | 2011-08-08 | 2013-04-10 | Алексей Владимирович Брынцалов | Комбинированный препарат орвиум для устранения симптомов простудных заболеваний и гриппа |
| CN110237079B (zh) * | 2019-07-01 | 2021-05-14 | 山西大学 | 一种百部生物碱类似物的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10298107A (ja) * | 1997-04-25 | 1998-11-10 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| US6613357B2 (en) * | 2000-01-13 | 2003-09-02 | Osmotica Corp. | Osmotic device containing pseudoephedrine and an H1 antagonist |
-
2002
- 2002-04-03 EP EP02007568A patent/EP1350512A1/en not_active Withdrawn
-
2003
- 2003-03-25 US US10/396,234 patent/US20030228359A1/en not_active Abandoned
- 2003-03-28 EP EP03717248A patent/EP1492532A1/en not_active Withdrawn
- 2003-03-28 WO PCT/EP2003/003263 patent/WO2003082285A1/en not_active Ceased
- 2003-03-28 PL PL03371382A patent/PL371382A1/xx unknown
- 2003-03-28 AU AU2003221532A patent/AU2003221532A1/en not_active Abandoned
- 2003-03-28 CA CA002477751A patent/CA2477751A1/en not_active Abandoned
- 2003-03-28 JP JP2003579822A patent/JP2005522467A/ja active Pending
- 2003-03-28 BR BR0308982-7A patent/BR0308982A/pt not_active Application Discontinuation
- 2003-03-28 RU RU2004132205/15A patent/RU2004132205A/ru not_active Application Discontinuation
- 2003-03-28 MX MXPA04009582A patent/MXPA04009582A/es unknown
- 2003-04-01 PE PE2003000332A patent/PE20040080A1/es not_active Application Discontinuation
- 2003-04-02 AR ARP030101144A patent/AR039221A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1492532A1 (en) | 2005-01-05 |
| US20030228359A1 (en) | 2003-12-11 |
| BR0308982A (pt) | 2005-01-04 |
| PL371382A1 (en) | 2005-06-13 |
| CA2477751A1 (en) | 2003-10-09 |
| AR039221A1 (es) | 2005-02-09 |
| WO2003082285A1 (en) | 2003-10-09 |
| EP1350512A1 (en) | 2003-10-08 |
| JP2005522467A (ja) | 2005-07-28 |
| MXPA04009582A (es) | 2005-01-11 |
| AU2003221532A1 (en) | 2003-10-13 |
| PE20040080A1 (es) | 2004-04-22 |
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