RU2004131859A - Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции - Google Patents
Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции Download PDFInfo
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- RU2004131859A RU2004131859A RU2004131859/15A RU2004131859A RU2004131859A RU 2004131859 A RU2004131859 A RU 2004131859A RU 2004131859/15 A RU2004131859/15 A RU 2004131859/15A RU 2004131859 A RU2004131859 A RU 2004131859A RU 2004131859 A RU2004131859 A RU 2004131859A
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- 239000000203 mixture Substances 0.000 title claims abstract 26
- 230000000843 anti-fungal effect Effects 0.000 title claims 4
- 238000010438 heat treatment Methods 0.000 title 1
- 239000002085 irritant Substances 0.000 title 1
- 239000000314 lubricant Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 6
- 150000005846 sugar alcohols Polymers 0.000 claims abstract 4
- 208000035143 Bacterial infection Diseases 0.000 claims abstract 3
- 206010017533 Fungal infection Diseases 0.000 claims abstract 3
- 208000031888 Mycoses Diseases 0.000 claims abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract 3
- 230000002538 fungal effect Effects 0.000 claims abstract 3
- 239000003349 gelling agent Substances 0.000 claims abstract 3
- 239000003002 pH adjusting agent Substances 0.000 claims abstract 3
- -1 azole compound Chemical class 0.000 claims 7
- 229940121375 antifungal agent Drugs 0.000 claims 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 2
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 claims 2
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 150000007524 organic acids Chemical group 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims 1
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims 1
- ZCJYUTQZBAIHBS-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 ZCJYUTQZBAIHBS-UHFFFAOYSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- JLGKQTAYUIMGRK-UHFFFAOYSA-N 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 JLGKQTAYUIMGRK-UHFFFAOYSA-N 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229960005074 butoconazole Drugs 0.000 claims 1
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- VEVFSWCSRVJBSM-HOFKKMOUSA-N ethyl 4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 VEVFSWCSRVJBSM-HOFKKMOUSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 229960001274 fenticonazole Drugs 0.000 claims 1
- 229960004884 fluconazole Drugs 0.000 claims 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
- 229960000690 flutrimazole Drugs 0.000 claims 1
- QHMWCHQXCUNUAK-UHFFFAOYSA-N flutrimazole Chemical compound C1=CC(F)=CC=C1C(N1C=NC=C1)(C=1C(=CC=CC=1)F)C1=CC=CC=C1 QHMWCHQXCUNUAK-UHFFFAOYSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229960004849 isoconazole Drugs 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 claims 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950005137 saperconazole Drugs 0.000 claims 1
- 229960005429 sertaconazole Drugs 0.000 claims 1
- 229960000580 terconazole Drugs 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 238000010792 warming Methods 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001050 lubricating effect Effects 0.000 abstract 1
- 238000005461 lubrication Methods 0.000 abstract 1
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (18)
1. Безводная противогрибковая гелеобразная композиция, включающая, по меньшей мере, один многоатомный спирт, желатинирующий агент и противогрибковое азольное соединение.
2. Композиция по п.1, в которой указанное противогрибковое соединение включает имидазольное соединение.
3. Композиция по п.2, в которой указанное имидазольное соединение выбрано из группы, состоящей из эконазола, терконазола, саперконазола, итраконазола, бутаконазола, клотримазола, тиоконазола, флуконазола и кетоконазола, вериконазола, фентиконазола, сертаконазола, позаконазола, бифоназола, оксиконазола, сулконазола, элубиола, ворконазола, изоконазола, флутримазола, тиоконазола и их фармацевтически приемлемых солей.
4. Композиция по п.1, которая дополнительно включает агент, регулирующий рН.
5. Композиция по п.1, в которой указанный многоатомный спирт выбран из группы, состоящей из глицерина, алкиленгликоля, полиэтиленгликоля и их смесей.
6. Композиция по п.1, в которой желатинирующий агент представляет собой гидроксипропилцеллюлозу.
7. Композиция по п.4, в которой агент, регулирующий рН, представляет собой органическую кислоту.
8. Композиция по п.7, в которой указанная органическая кислота представляет собой альфа-гидроксикислоту.
9. Композиция по п.8, в которой указанная альфа-гидроксикислота представляет собой молочную кислоту.
10. Композиция по п.5, в которой указанный полиэтиленгликоль выбран из группы, состоящей из полиэтиленгликоля 300, полиэтиленгликоля 400 и их смесей.
11. Композиция по п.1, причем указанная композиция включает от около 75 до около 99 мас.% многоатомного спирта, от около 0,1 до около 4 мас.% гидроксипропилцеллюлозы, от около 0,1 до около 1 мас.% молочной кислоты и от около 0,25 до около 20 мас.% противогрибкового средства.
12. Композиция по п.1, причем композиция представляет собой светлый прозрачный гель.
13. Способ лечения вульвовагинального кандидоза, включающий введение нуждающейся в этом пациентке композиции по п.1.
14. Способ лечения бактериального вагиноза, включающий введение нуждающейся в этом пациентке композиции по п.1.
15. Способ лечения пациентки как с вульвовагинальным кандидозом, так и с бактериальным вагинозом, включающий введение указанной пациентке композиции по п.1.
16. Композиция по п.7, причем композиция доводит рН влагалища до кислотного рН от около 2 до около 5.
17. Способ лечения пациента как с грибковыми, так и с бактериальными инфекциями ротовой полости, включающий введение указанному пациенту композиции по п.1.
18. Способ лечения пациента как с грибковыми, так и с бактериальными инфекциями ногтей, включающий введение указанному пациенту композиции по п.1.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/137509 | 2002-05-01 | ||
US10/137,509 US7005408B2 (en) | 2002-05-01 | 2002-05-01 | Warming and nonirritating lubricant compositions and method of comparing irritation |
US10/389871 | 2003-03-17 | ||
US10/389,871 US7285517B2 (en) | 2002-05-01 | 2003-03-17 | Warming and nonirritating lubricant compositions and method of comparing irritation |
US10/389,871 | 2003-03-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2004131859A true RU2004131859A (ru) | 2005-06-10 |
RU2306133C2 RU2306133C2 (ru) | 2007-09-20 |
Family
ID=29406251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004131859/15A RU2306133C2 (ru) | 2002-05-01 | 2003-05-01 | Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции |
Country Status (12)
Country | Link |
---|---|
US (1) | US20070287714A1 (ru) |
EP (1) | EP1620069B1 (ru) |
JP (1) | JP2005529901A (ru) |
KR (1) | KR20050025166A (ru) |
AT (1) | ATE396705T1 (ru) |
AU (1) | AU2003234311A1 (ru) |
BR (1) | BRPI0309765B8 (ru) |
CA (1) | CA2484318C (ru) |
DE (1) | DE60321400D1 (ru) |
MX (1) | MXPA04010889A (ru) |
RU (1) | RU2306133C2 (ru) |
WO (1) | WO2003092650A1 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004037305A1 (en) | 2002-10-21 | 2004-05-06 | Allegiance Corporation | Coating composition for skin-contacting surface of elastomeric articles and articles containing the same |
US20060188528A1 (en) | 2005-02-23 | 2006-08-24 | Ansell Healthcare Products Llc | Spreadable warming lubricant |
US7709428B2 (en) | 2005-02-23 | 2010-05-04 | Ansell Healthcare Products Llc | Thickened spreadable warming lubricant |
US9579297B2 (en) | 2005-12-28 | 2017-02-28 | Teikoku Seiyaku Co., Ltd. | Pharmaceutical composition for application to nail |
US20080020023A1 (en) * | 2006-07-20 | 2008-01-24 | Shiping Wang | Nonaqueous coating composition for elastomeric articles and articles containing the same |
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-
2003
- 2003-05-01 AT AT03816835T patent/ATE396705T1/de not_active IP Right Cessation
- 2003-05-01 DE DE60321400T patent/DE60321400D1/de not_active Expired - Lifetime
- 2003-05-01 KR KR1020047017601A patent/KR20050025166A/ko not_active Application Discontinuation
- 2003-05-01 JP JP2004500835A patent/JP2005529901A/ja active Pending
- 2003-05-01 CA CA2484318A patent/CA2484318C/en not_active Expired - Fee Related
- 2003-05-01 RU RU2004131859/15A patent/RU2306133C2/ru active
- 2003-05-01 AU AU2003234311A patent/AU2003234311A1/en not_active Abandoned
- 2003-05-01 MX MXPA04010889A patent/MXPA04010889A/es active IP Right Grant
- 2003-05-01 BR BRPI0309765A patent/BRPI0309765B8/pt not_active IP Right Cessation
- 2003-05-01 EP EP03816835A patent/EP1620069B1/en not_active Expired - Lifetime
- 2003-05-01 WO PCT/US2003/013475 patent/WO2003092650A1/en active Application Filing
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2007
- 2007-07-27 US US11/829,512 patent/US20070287714A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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JP2005529901A (ja) | 2005-10-06 |
ATE396705T1 (de) | 2008-06-15 |
DE60321400D1 (de) | 2008-07-10 |
BRPI0309765B8 (pt) | 2021-05-25 |
WO2003092650A1 (en) | 2003-11-13 |
AU2003234311A1 (en) | 2003-11-17 |
RU2306133C2 (ru) | 2007-09-20 |
EP1620069A2 (en) | 2006-02-01 |
BRPI0309765B1 (pt) | 2015-09-15 |
US20070287714A1 (en) | 2007-12-13 |
CA2484318A1 (en) | 2003-11-13 |
BR0309765A (pt) | 2007-04-10 |
CA2484318C (en) | 2014-01-28 |
MXPA04010889A (es) | 2005-07-14 |
EP1620069B1 (en) | 2008-05-28 |
KR20050025166A (ko) | 2005-03-11 |
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