RU2004131859A - Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции - Google Patents

Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции Download PDF

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RU2004131859A
RU2004131859A RU2004131859/15A RU2004131859A RU2004131859A RU 2004131859 A RU2004131859 A RU 2004131859A RU 2004131859/15 A RU2004131859/15 A RU 2004131859/15A RU 2004131859 A RU2004131859 A RU 2004131859A RU 2004131859 A RU2004131859 A RU 2004131859A
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RU2004131859/15A
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RU2306133C2 (ru
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Наваз АХМАД (US)
Наваз АХМАД
Кристофер Скотт ЛЭМБ (US)
Кристофер Скотт ЛЭМБ
Эмили Касилио ЛОНАРДО (US)
Эмилия Касилио ЛОНАРДО
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МакНЕЙЛ-ППС, ИНК. (US)
МакНЕЙЛ-ППС, ИНК.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (18)

1. Безводная противогрибковая гелеобразная композиция, включающая, по меньшей мере, один многоатомный спирт, желатинирующий агент и противогрибковое азольное соединение.
2. Композиция по п.1, в которой указанное противогрибковое соединение включает имидазольное соединение.
3. Композиция по п.2, в которой указанное имидазольное соединение выбрано из группы, состоящей из эконазола, терконазола, саперконазола, итраконазола, бутаконазола, клотримазола, тиоконазола, флуконазола и кетоконазола, вериконазола, фентиконазола, сертаконазола, позаконазола, бифоназола, оксиконазола, сулконазола, элубиола, ворконазола, изоконазола, флутримазола, тиоконазола и их фармацевтически приемлемых солей.
4. Композиция по п.1, которая дополнительно включает агент, регулирующий рН.
5. Композиция по п.1, в которой указанный многоатомный спирт выбран из группы, состоящей из глицерина, алкиленгликоля, полиэтиленгликоля и их смесей.
6. Композиция по п.1, в которой желатинирующий агент представляет собой гидроксипропилцеллюлозу.
7. Композиция по п.4, в которой агент, регулирующий рН, представляет собой органическую кислоту.
8. Композиция по п.7, в которой указанная органическая кислота представляет собой альфа-гидроксикислоту.
9. Композиция по п.8, в которой указанная альфа-гидроксикислота представляет собой молочную кислоту.
10. Композиция по п.5, в которой указанный полиэтиленгликоль выбран из группы, состоящей из полиэтиленгликоля 300, полиэтиленгликоля 400 и их смесей.
11. Композиция по п.1, причем указанная композиция включает от около 75 до около 99 мас.% многоатомного спирта, от около 0,1 до около 4 мас.% гидроксипропилцеллюлозы, от около 0,1 до около 1 мас.% молочной кислоты и от около 0,25 до около 20 мас.% противогрибкового средства.
12. Композиция по п.1, причем композиция представляет собой светлый прозрачный гель.
13. Способ лечения вульвовагинального кандидоза, включающий введение нуждающейся в этом пациентке композиции по п.1.
14. Способ лечения бактериального вагиноза, включающий введение нуждающейся в этом пациентке композиции по п.1.
15. Способ лечения пациентки как с вульвовагинальным кандидозом, так и с бактериальным вагинозом, включающий введение указанной пациентке композиции по п.1.
16. Композиция по п.7, причем композиция доводит рН влагалища до кислотного рН от около 2 до около 5.
17. Способ лечения пациента как с грибковыми, так и с бактериальными инфекциями ротовой полости, включающий введение указанному пациенту композиции по п.1.
18. Способ лечения пациента как с грибковыми, так и с бактериальными инфекциями ногтей, включающий введение указанному пациенту композиции по п.1.
RU2004131859/15A 2002-05-01 2003-05-01 Согревающие и нераздражающие смазывающие противогрибковые гелеобразные композиции RU2306133C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/137,509 US7005408B2 (en) 2002-05-01 2002-05-01 Warming and nonirritating lubricant compositions and method of comparing irritation
US10/137509 2002-05-01
US10/389,871 2003-03-17
US10/389,871 US7285517B2 (en) 2002-05-01 2003-03-17 Warming and nonirritating lubricant compositions and method of comparing irritation
US10/389871 2003-03-17

Publications (2)

Publication Number Publication Date
RU2004131859A true RU2004131859A (ru) 2005-06-10
RU2306133C2 RU2306133C2 (ru) 2007-09-20

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US (1) US20070287714A1 (ru)
EP (1) EP1620069B1 (ru)
JP (1) JP2005529901A (ru)
KR (1) KR20050025166A (ru)
AT (1) ATE396705T1 (ru)
AU (1) AU2003234311A1 (ru)
BR (1) BRPI0309765B8 (ru)
CA (1) CA2484318C (ru)
DE (1) DE60321400D1 (ru)
MX (1) MXPA04010889A (ru)
RU (1) RU2306133C2 (ru)
WO (1) WO2003092650A1 (ru)

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KR20050025166A (ko) 2005-03-11
CA2484318C (en) 2014-01-28
JP2005529901A (ja) 2005-10-06
EP1620069B1 (en) 2008-05-28
CA2484318A1 (en) 2003-11-13
US20070287714A1 (en) 2007-12-13
WO2003092650A1 (en) 2003-11-13
DE60321400D1 (de) 2008-07-10
BRPI0309765B1 (pt) 2015-09-15
MXPA04010889A (es) 2005-07-14
RU2306133C2 (ru) 2007-09-20
EP1620069A2 (en) 2006-02-01
AU2003234311A1 (en) 2003-11-17
BR0309765A (pt) 2007-04-10
BRPI0309765B8 (pt) 2021-05-25
ATE396705T1 (de) 2008-06-15

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