RU2004113373A - Антитела против человеческого тканевого фактора - Google Patents
Антитела против человеческого тканевого фактора Download PDFInfo
- Publication number
- RU2004113373A RU2004113373A RU2004113373/13A RU2004113373A RU2004113373A RU 2004113373 A RU2004113373 A RU 2004113373A RU 2004113373/13 A RU2004113373/13 A RU 2004113373/13A RU 2004113373 A RU2004113373 A RU 2004113373A RU 2004113373 A RU2004113373 A RU 2004113373A
- Authority
- RU
- Russia
- Prior art keywords
- rfviia
- ffr
- value
- human
- preferably less
- Prior art date
Links
- 101000635804 Homo sapiens Tissue factor Proteins 0.000 title claims 29
- 238000012360 testing method Methods 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 26
- 238000003556 assay Methods 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 238000004458 analytical method Methods 0.000 claims 18
- 230000003024 amidolytic effect Effects 0.000 claims 10
- 230000035602 clotting Effects 0.000 claims 8
- 238000002965 ELISA Methods 0.000 claims 6
- 108010054265 Factor VIIa Proteins 0.000 claims 6
- 239000001963 growth medium Substances 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 206010053567 Coagulopathies Diseases 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000043136 MAP kinase family Human genes 0.000 claims 2
- 108091054455 MAP kinase family Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 210000000628 antibody-producing cell Anatomy 0.000 claims 2
- 238000007820 coagulation assay Methods 0.000 claims 2
- 238000012875 competitive assay Methods 0.000 claims 2
- 230000002860 competitive effect Effects 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000008054 signal transmission Effects 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 238000013507 mapping Methods 0.000 claims 1
- 108010013773 recombinant FVIIa Proteins 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101437 | 2001-10-02 | ||
| DKPA200101437 | 2001-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004113373A true RU2004113373A (ru) | 2005-03-27 |
Family
ID=8160743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004113373/13A RU2004113373A (ru) | 2001-10-02 | 2002-09-30 | Антитела против человеческого тканевого фактора |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1434802A1 (cs) |
| JP (1) | JP2005512970A (cs) |
| KR (1) | KR20040045478A (cs) |
| CN (1) | CN1575302A (cs) |
| BR (1) | BR0213046A (cs) |
| CA (1) | CA2460917A1 (cs) |
| CZ (1) | CZ2004454A3 (cs) |
| HU (1) | HUP0401658A2 (cs) |
| IL (1) | IL160998A0 (cs) |
| MX (1) | MXPA04003051A (cs) |
| NO (1) | NO20041802L (cs) |
| PL (1) | PL368989A1 (cs) |
| RU (1) | RU2004113373A (cs) |
| WO (1) | WO2003029295A1 (cs) |
| ZA (1) | ZA200402303B (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| WO2002078738A1 (fr) * | 2001-03-26 | 2002-10-10 | Koji Suzuki | Agents ameliorant la rheologie sanguine |
| AU2003277832A1 (en) * | 2002-10-31 | 2004-05-25 | Novo Nordisk A/S | Humanized tissue factor antibodies |
| EP1587549A2 (en) * | 2003-01-22 | 2005-10-26 | Novo Nordisk A/S | Radiolabelled tissue factor binding agent and the use thereof |
| US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| EP1633309A4 (en) * | 2003-05-30 | 2007-06-13 | Centocor Inc | METHOD FOR INHIBITING TUMOR GROWTH WITH ANTI-TISSUE FACTOR ANTIBODIES |
| WO2005004793A2 (en) * | 2003-06-19 | 2005-01-20 | Tanox Inc. | Compositions and methods for treating coagulation related disorders |
| WO2005020927A2 (en) * | 2003-08-29 | 2005-03-10 | Centocor, Inc. | Method of promoting graft survival with anti-tissue factor antibodies |
| JP2007523099A (ja) * | 2004-02-20 | 2007-08-16 | ノボ ノルディスク アクティーゼルスカブ | 組み合わせ療法 |
| EP3524685B1 (en) | 2006-09-08 | 2021-11-03 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
| CN101423552B (zh) * | 2008-02-29 | 2012-05-16 | 复旦大学 | 一种人源抗人组织因子Fab及其制备方法 |
| AU2013203150B2 (en) * | 2008-12-09 | 2016-09-22 | Genmab A/S | Human antibodies against tissue factor |
| UA109633C2 (uk) * | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| AU2016277670B2 (en) * | 2008-12-09 | 2019-02-07 | Genmab A/S | Human antibodies against tissue factor |
| WO2010131235A1 (en) * | 2009-05-15 | 2010-11-18 | University Of The Free State | Inhibitory antibody fragments to human tissue factor |
| HUE035599T2 (en) | 2010-06-15 | 2018-05-28 | Genmab As | Human antibody drug conjugates against tissue factor |
| US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
| WO2017028823A1 (zh) * | 2015-08-20 | 2017-02-23 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
| WO2018036117A1 (zh) * | 2016-08-22 | 2018-03-01 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
| CN106938051B (zh) | 2016-08-22 | 2019-10-11 | 复旦大学 | 靶向于组织因子的抗体-药物偶联物 |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| MX2020011823A (es) | 2018-05-07 | 2021-03-29 | Genmab As | Metodos para tratar cancer con combinacion de anticuerpo anti-muerte programada-1 (pd-1) y conjugado de anticuerpo anti-factor de tejido y farmaco. |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001978A (en) * | 1987-03-31 | 1999-12-14 | The Scripps Research Institute | Human tissue factor related DNA segments polypeptides and antibodies |
| US5223427A (en) * | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| JP2779193B2 (ja) * | 1989-02-02 | 1998-07-23 | 帝人株式会社 | 抗ヒト組織因子モノクローナル抗体 |
| ES2231817T3 (es) * | 1995-06-07 | 2005-05-16 | Ortho-Mcneil Pharmaceutical, Inc. | Anticuerpos del factor anti-tejido injertados a cdr y procedimientos de uso de los mismos. |
| AU752730B2 (en) * | 1998-04-03 | 2002-09-26 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (TF) and process for constructing humanized antibody |
| KR20030008205A (ko) * | 1999-10-01 | 2003-01-24 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 관련 질환의 예방 및 치료 |
| HK1049184A1 (zh) * | 2000-03-16 | 2003-05-02 | Genentech, Inc. | 具有增强抗凝血效能的抗组织因子抗体 |
-
2002
- 2002-09-30 PL PL02368989A patent/PL368989A1/xx not_active Application Discontinuation
- 2002-09-30 IL IL16099802A patent/IL160998A0/xx unknown
- 2002-09-30 CA CA002460917A patent/CA2460917A1/en not_active Abandoned
- 2002-09-30 CZ CZ2004454A patent/CZ2004454A3/cs unknown
- 2002-09-30 KR KR10-2004-7004942A patent/KR20040045478A/ko not_active Withdrawn
- 2002-09-30 RU RU2004113373/13A patent/RU2004113373A/ru not_active Application Discontinuation
- 2002-09-30 EP EP02800043A patent/EP1434802A1/en not_active Withdrawn
- 2002-09-30 WO PCT/DK2002/000644 patent/WO2003029295A1/en not_active Ceased
- 2002-09-30 CN CNA028208463A patent/CN1575302A/zh active Pending
- 2002-09-30 BR BR0213046-7A patent/BR0213046A/pt not_active IP Right Cessation
- 2002-09-30 MX MXPA04003051A patent/MXPA04003051A/es unknown
- 2002-09-30 HU HU0401658A patent/HUP0401658A2/hu unknown
- 2002-09-30 JP JP2003532540A patent/JP2005512970A/ja not_active Withdrawn
-
2004
- 2004-03-24 ZA ZA200402303A patent/ZA200402303B/en unknown
- 2004-04-30 NO NO20041802A patent/NO20041802L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200402303B (en) | 2004-11-25 |
| WO2003029295A1 (en) | 2003-04-10 |
| EP1434802A1 (en) | 2004-07-07 |
| PL368989A1 (en) | 2005-04-04 |
| CA2460917A1 (en) | 2003-04-10 |
| BR0213046A (pt) | 2005-06-28 |
| JP2005512970A (ja) | 2005-05-12 |
| CN1575302A (zh) | 2005-02-02 |
| IL160998A0 (en) | 2004-08-31 |
| MXPA04003051A (es) | 2004-07-05 |
| CZ2004454A3 (cs) | 2004-09-15 |
| HUP0401658A2 (hu) | 2004-11-29 |
| NO20041802L (no) | 2004-04-30 |
| KR20040045478A (ko) | 2004-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070214 |