RU2002135038A - METHOD FOR PREPARING THE READY-FORMED DOSAGE FORM OF INSULIN OF SHORT-TIME ACTION - Google Patents
METHOD FOR PREPARING THE READY-FORMED DOSAGE FORM OF INSULIN OF SHORT-TIME ACTIONInfo
- Publication number
- RU2002135038A RU2002135038A RU2002135038/15A RU2002135038A RU2002135038A RU 2002135038 A RU2002135038 A RU 2002135038A RU 2002135038/15 A RU2002135038/15 A RU 2002135038/15A RU 2002135038 A RU2002135038 A RU 2002135038A RU 2002135038 A RU2002135038 A RU 2002135038A
- Authority
- RU
- Russia
- Prior art keywords
- insulin
- preparing
- human insulin
- dosage form
- short
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 15
- 108090001061 Insulin Proteins 0.000 title claims 7
- 102000004877 Insulin Human genes 0.000 title claims 7
- 239000002552 dosage form Substances 0.000 title claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- AQEFLFZSWDEAIP-UHFFFAOYSA-N Di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- 108010005991 Pork Regular Insulin Proteins 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000005712 crystallization Effects 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 229960001322 trypsin Drugs 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 108010026951 Short-Acting Insulin Proteins 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000011097 chromatography purification Methods 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- -1 insulin ester Chemical class 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2001129229 | 2001-12-29 | ||
UA2001129229A UA46666C2 (en) | 2001-12-29 | 2001-12-29 | Method for preparing dosage form of short-term acting insulin |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2002135038A true RU2002135038A (en) | 2004-07-20 |
RU2261107C2 RU2261107C2 (en) | 2005-09-27 |
Family
ID=35850191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002135038/15A RU2261107C2 (en) | 2001-12-29 | 2002-12-26 | Method for preparing ready medicinal formulation of insulin with short effect |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2261107C2 (en) |
UA (1) | UA46666C2 (en) |
-
2001
- 2001-12-29 UA UA2001129229A patent/UA46666C2/en unknown
-
2002
- 2002-12-26 RU RU2002135038/15A patent/RU2261107C2/en not_active IP Right Cessation
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