RU96123916A - APPLICATION OF CYCLODEXTRIN AS A MUKOADHESIV, COMPOSITION BASED ON INTRACONAZOLE AND CYCLODEXTRIN AND METHOD FOR PRODUCING IT - Google Patents

APPLICATION OF CYCLODEXTRIN AS A MUKOADHESIV, COMPOSITION BASED ON INTRACONAZOLE AND CYCLODEXTRIN AND METHOD FOR PRODUCING IT

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Publication number
RU96123916A
RU96123916A RU96123916/14A RU96123916A RU96123916A RU 96123916 A RU96123916 A RU 96123916A RU 96123916/14 A RU96123916/14 A RU 96123916/14A RU 96123916 A RU96123916 A RU 96123916A RU 96123916 A RU96123916 A RU 96123916A
Authority
RU
Russia
Prior art keywords
cyclodextrin
composition
intraconazole
derivative
amount
Prior art date
Application number
RU96123916/14A
Other languages
Russian (ru)
Other versions
RU2164418C2 (en
Inventor
Путтеман Петер
Карел Йозеф Франсуа Марк
Каролус Леонарда Снукс Эрик
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of RU96123916A publication Critical patent/RU96123916A/en
Application granted granted Critical
Publication of RU2164418C2 publication Critical patent/RU2164418C2/en

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Claims (9)

1. Применение циклодекстрина или его производного в качестве мукоадгезива в эмульсии или водном растворе, причем упомянутый циклодекстрин или его производное используется в количестве от 10% мас. до 70 мас.% по отношению к общей массе композиции.1. The use of cyclodextrin or its derivative as a mucoadhesive in an emulsion or aqueous solution, wherein said cyclodextrin or its derivative is used in an amount of from 10% wt. up to 70 wt.% in relation to the total weight of the composition. 2. Применение по п. 1, отличающееся тем, что количество циклодекстрина изменяется в пределах от 30 мас.% до 60 мас.% по отношению к общей массе композиции. 2. The use according to claim 1, characterized in that the amount of cyclodextrin varies from 30 wt.% To 60 wt.% With respect to the total weight of the composition. 3. Применение по п. 1, отличающееся тем, что композиция содержит также лекарственное средство. 3. The use according to claim 1, characterized in that the composition also contains a drug. 4. Применение по п. 1, отличающееся тем, что композиция является вагинальным препаратом. 4. The use according to claim 1, characterized in that the composition is a vaginal preparation. 5. Композиция, представляющая собой мукоадгезивную эмульсию, содержащую интраконазол и циклодекстрин или его производное в количестве от 10 мас.% до 70 мас.% по отношению к общей массе композиции. 5. The composition, which is a mucoadhesive emulsion containing intraconazole and cyclodextrin or its derivative in an amount of from 10 wt.% To 70 wt.% In relation to the total weight of the composition. 6. Композиция по п. 5, отличающаяся тем, что является эмульсией вода-в-масле. 6. The composition according to p. 5, characterized in that it is a water-in-oil emulsion. 7. Композиция по п. 5, отличающаяся тем, что pH составляет от 1 до 4. 7. The composition according to p. 5, characterized in that the pH is from 1 to 4. 8. Композиция по п. 5, отличающаяся тем, что массовое отношение интраконазола к циклодекстрину находится в пределах от 1:700 до 1:2. 8. The composition according to p. 5, characterized in that the mass ratio of intraconazole to cyclodextrin is in the range from 1: 700 to 1: 2. 9. Композиция по п. 5, отличающаяся тем, что имеет следующий состав, мас.%:
Интраконазол - 0,1 - 5
Циклодекстрин - 10 - 70
Загуститель - 0,05 - 5
Эмульгатор - 0,5 - 10
Стабилизирующий агент - 0,5 - 10
10. Способ получения композиции по любому из пп. 5-9, отличающийся тем, что терапевтически эффективное количество интраконазола и циклодекстрина или его производное смешивают с водой и масляной фазой до однородного состояния.9. The composition according to p. 5, characterized in that it has the following composition, wt.%:
Intraconazole - 0.1 - 5
Cyclodextrin - 10 - 70
Thickener - 0.05 - 5
Emulsifier - 0.5 - 10
Stabilizing agent - 0.5 - 10
10. A method of obtaining a composition according to any one of paragraphs. 5-9, characterized in that the therapeutically effective amount of intraconazole and cyclodextrin or its derivative are mixed with water and the oil phase until a homogeneous state.
RU96123916/14A 1994-05-18 1995-05-10 Use of cyclodextrin as mucoadhesive agent, composition based on intraconazol and cyclodextrin and method of its preparing RU2164418C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94201402.8 1994-05-18
EP94201402 1994-05-18

Publications (2)

Publication Number Publication Date
RU96123916A true RU96123916A (en) 1999-02-27
RU2164418C2 RU2164418C2 (en) 2001-03-27

Family

ID=8216883

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96123916/14A RU2164418C2 (en) 1994-05-18 1995-05-10 Use of cyclodextrin as mucoadhesive agent, composition based on intraconazol and cyclodextrin and method of its preparing

Country Status (30)

Country Link
US (1) US5814330A (en)
EP (1) EP0759741B1 (en)
JP (1) JP3862748B2 (en)
KR (1) KR100369703B1 (en)
CN (1) CN1091590C (en)
AP (1) AP731A (en)
AT (1) ATE174790T1 (en)
AU (1) AU680767B2 (en)
BG (1) BG62754B1 (en)
BR (1) BR9507873A (en)
CZ (1) CZ285606B6 (en)
DE (1) DE69506857T2 (en)
DK (1) DK0759741T3 (en)
EE (1) EE03304B1 (en)
ES (1) ES2127529T3 (en)
FI (1) FI964589A (en)
HK (1) HK1010688A1 (en)
HU (1) HU218082B (en)
IL (1) IL113742A (en)
MY (1) MY113846A (en)
NO (1) NO309507B1 (en)
NZ (1) NZ285761A (en)
OA (1) OA10321A (en)
PL (1) PL179619B1 (en)
RO (1) RO117145B1 (en)
RU (1) RU2164418C2 (en)
SK (1) SK282623B6 (en)
TW (1) TW438601B (en)
WO (1) WO1995031178A1 (en)
ZA (1) ZA954023B (en)

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