RU2002135042A - METHOD FOR PREPARING THE READY-FORMED FORM OF THE INSULIN PROLONGED ACTION - Google Patents
METHOD FOR PREPARING THE READY-FORMED FORM OF THE INSULIN PROLONGED ACTIONInfo
- Publication number
- RU2002135042A RU2002135042A RU2002135042/15A RU2002135042A RU2002135042A RU 2002135042 A RU2002135042 A RU 2002135042A RU 2002135042/15 A RU2002135042/15 A RU 2002135042/15A RU 2002135042 A RU2002135042 A RU 2002135042A RU 2002135042 A RU2002135042 A RU 2002135042A
- Authority
- RU
- Russia
- Prior art keywords
- insulin
- ester
- dilute acid
- preparing
- crystals
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims 18
- 108090001061 Insulin Proteins 0.000 title claims 9
- 102000004877 Insulin Human genes 0.000 title claims 9
- 230000002035 prolonged Effects 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 3
- AQEFLFZSWDEAIP-UHFFFAOYSA-N Di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N M-Cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 2
- 108010005991 Pork Regular Insulin Proteins 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 239000008366 buffered solution Substances 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000005712 crystallization Effects 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- -1 insulin ester Chemical class 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 229960001322 trypsin Drugs 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229950008679 Protamine sulfate Drugs 0.000 claims 1
- 239000003929 acidic solution Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000011097 chromatography purification Methods 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000002459 sustained Effects 0.000 claims 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2001129232A UA46669C2 (en) | 2001-12-29 | 2001-12-29 | Production of controlled-release dosage forms of insulin |
UA2001129232 | 2001-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2002135042A true RU2002135042A (en) | 2004-07-20 |
RU2252782C2 RU2252782C2 (en) | 2005-05-27 |
Family
ID=35824764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002135042/15A RU2252782C2 (en) | 2001-12-29 | 2002-12-26 | Method for production of insulin drug of durable action |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2252782C2 (en) |
UA (1) | UA46669C2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100017667A (en) * | 2007-06-01 | 2010-02-16 | 노보 노르디스크 에이/에스 | Stable non-aqueous pharmaceutical compositions |
PL2254906T3 (en) | 2008-03-18 | 2017-04-28 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
MX2014012096A (en) | 2012-04-11 | 2014-11-21 | Novo Nordisk As | Insulin formulations. |
EP3554534B1 (en) | 2016-12-16 | 2021-06-23 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
-
2001
- 2001-12-29 UA UA2001129232A patent/UA46669C2/en unknown
-
2002
- 2002-12-26 RU RU2002135042/15A patent/RU2252782C2/en not_active IP Right Cessation
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