SU1744946A1 - Method of preparing mixture of isomers of 9-(2- chloroethyl)-7-nitroso-l-homocitrulline and 9-(2- chloroethyl)-9-nitroso-l-homocitrulline - Google Patents
Method of preparing mixture of isomers of 9-(2- chloroethyl)-7-nitroso-l-homocitrulline and 9-(2- chloroethyl)-9-nitroso-l-homocitrullineInfo
- Publication number
- SU1744946A1 SU1744946A1 SU4744599/04A SU4744599A SU1744946A1 SU 1744946 A1 SU1744946 A1 SU 1744946A1 SU 4744599/04 A SU4744599/04 A SU 4744599/04A SU 4744599 A SU4744599 A SU 4744599A SU 1744946 A1 SU1744946 A1 SU 1744946A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- chloroethyl
- isomers
- homocitrulline
- nitroso
- mixture
- Prior art date
Links
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
FIELD: production of urea, particularly, preparation of mixture of isomers of 9-(2-chloroethyl)-7- (or 9)-nitroso-L- homocitrulline (I and II) used in medicinal agents. SUBSTANCE: synthesis is carried out by treatment of lysine with KOH and copper sulfate in aqueous medium and carbomoylating agent such as 1,3-bis-(2-chloroethyl)-1- nitrosourea at 32-36 C is subsequently added and the complex is decomposed with oxalic acid in the presence of HCL, nitrosated with NaNOin HCl at pH of 1-2. The resulting mixture of isomers is divided in two stages: from aqueous alcoholic solution of hydrochloric acid followed by neutralization with aqueous NHto pH of 5.2- 5.4 from -2 to +2C; crystallization from -10 to 12 C and copper complex to water to alcohol weight ratio of 1: (4.5-5) : (2:2.4) in first stage, and mixture of isomers compound I to compound II weight ratio of (23-27) : (47- 73) with main product content of 98-99.7% is 38.9%. EFFECT: more efficient preparation method.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4744599/04A SU1744946A1 (en) | 1989-10-03 | 1989-10-03 | Method of preparing mixture of isomers of 9-(2- chloroethyl)-7-nitroso-l-homocitrulline and 9-(2- chloroethyl)-9-nitroso-l-homocitrulline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4744599/04A SU1744946A1 (en) | 1989-10-03 | 1989-10-03 | Method of preparing mixture of isomers of 9-(2- chloroethyl)-7-nitroso-l-homocitrulline and 9-(2- chloroethyl)-9-nitroso-l-homocitrulline |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1744946A1 true SU1744946A1 (en) | 1998-11-10 |
Family
ID=60532796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4744599/04A SU1744946A1 (en) | 1989-10-03 | 1989-10-03 | Method of preparing mixture of isomers of 9-(2- chloroethyl)-7-nitroso-l-homocitrulline and 9-(2- chloroethyl)-9-nitroso-l-homocitrulline |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1744946A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2503657C1 (en) * | 2012-08-24 | 2014-01-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Nδ-NITROSO-Nδ-[(2-CHLOROETHYL)CARBAMOYL]-L- ORNITHINE |
-
1989
- 1989-10-03 SU SU4744599/04A patent/SU1744946A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2503657C1 (en) * | 2012-08-24 | 2014-01-10 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Nδ-NITROSO-Nδ-[(2-CHLOROETHYL)CARBAMOYL]-L- ORNITHINE |
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