RU2000123108A - Способ получения фузидиевой кислоты - Google Patents
Способ получения фузидиевой кислотыInfo
- Publication number
- RU2000123108A RU2000123108A RU2000123108/13A RU2000123108A RU2000123108A RU 2000123108 A RU2000123108 A RU 2000123108A RU 2000123108/13 A RU2000123108/13 A RU 2000123108/13A RU 2000123108 A RU2000123108 A RU 2000123108A RU 2000123108 A RU2000123108 A RU 2000123108A
- Authority
- RU
- Russia
- Prior art keywords
- producing
- acid
- fuzidic
- crystallization
- followed
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 4
- 229960004675 Fusidic Acid Drugs 0.000 claims 2
- IECPWNUMDGFDKC-MZJAQBGESA-N Fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000005712 crystallization Effects 0.000 claims 2
- 241000682907 Fusidium Species 0.000 claims 1
- 239000012531 culture fluid Substances 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
Claims (1)
- Способ получения фузидиевой кислоты путем экстракции фильтрата культуральной жидкости продуцента Fusidium coccineum органическим растворителем с последующей реэкстракцией водным щелочным раствором, выделением и кристаллизацией, отличающийся тем, что кристаллизацию и очистку фузидиевой кислоты ведут безводным метанолом с последующей перекристаллизацией водным метанолом с содержанием его в растворе не более 25%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2000123108A RU2192470C2 (ru) | 2000-09-05 | 2000-09-05 | Способ получения фузидиевой кислоты |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2000123108A RU2192470C2 (ru) | 2000-09-05 | 2000-09-05 | Способ получения фузидиевой кислоты |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000123108A true RU2000123108A (ru) | 2002-08-27 |
| RU2192470C2 RU2192470C2 (ru) | 2002-11-10 |
Family
ID=20239798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000123108A RU2192470C2 (ru) | 2000-09-05 | 2000-09-05 | Способ получения фузидиевой кислоты |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2192470C2 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2208110B1 (es) * | 2002-11-19 | 2005-03-16 | Ercros Industrial, S.A. | Formas cristalinas de acido fusidico y procedimientos para su obtencion. |
| EP1945654B1 (en) * | 2005-10-31 | 2015-08-19 | Leo Pharma A/S | Preparation of an antibiotic crystalline fusidic acid |
-
2000
- 2000-09-05 RU RU2000123108A patent/RU2192470C2/ru not_active IP Right Cessation
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