RU1795966C - Способ получени производных дитрет-бутиловых эфиров 3,4-оксибензоилоксипропаноламинов - Google Patents

Способ получени производных дитрет-бутиловых эфиров 3,4-оксибензоилоксипропаноламинов

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Publication number
RU1795966C
RU1795966C SU894742910A SU4742910A RU1795966C RU 1795966 C RU1795966 C RU 1795966C SU 894742910 A SU894742910 A SU 894742910A SU 4742910 A SU4742910 A SU 4742910A RU 1795966 C RU1795966 C RU 1795966C
Authority
RU
Russia
Prior art keywords
beats
heart
compounds
general formula
contractions
Prior art date
Application number
SU894742910A
Other languages
English (en)
Inventor
Патил Ганшиям
Л.Матиер Уильям
Х.Кс.Май Кионг
Original Assignee
Е.И.Дюпон Де Немур Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Е.И.Дюпон Де Немур Энд Компани filed Critical Е.И.Дюпон Де Немур Энд Компани
Application granted granted Critical
Publication of RU1795966C publication Critical patent/RU1795966C/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)

Claims (1)

  1. Формула изобретени 
    Способ получени  производных дитрет- бутиловых эфиров 3,4-оксибензоилоксипро- паноламинов общей формулы
    OA/NNX N- -R , и, он и но
    где RI - С1-С4-алкил;
    R2 - С1-С4-алкил, аминогруппа, тетра- гидрофуранил,
    отличающийс  тем, что дитрет-бути- ловый эфир 3,4-диоксибензоилгалоида общей формулы
    о о.
    - )г „-СС1- , к... - 1 R.
    .У
    О
    где Ri имеет указанной значение, подвергают взаимодействию с соответствующим аминодиолом общей формулы
    ,
    но и н о где R2 имеет указанное значение.
    Таблиц«2
    Эффекты при местном применении соединений За и Зс или Тнмблолэ н« изменени , вызванные изопротеренололом. в соиращеникх сердца
    у анестезироинных собак
    Примечан-ие. HR - сокращений сердца.
    bpm ударов в минуту.. ; , При 0.135% концентрации а течение 60 мин Тимолол обеспечивал снижение на 39 ударов минуту сокращений сердца в то врем , как в той же концентрации соединени  За и Зс обеспечивали снижение толмю на 2 удара/мин и 7 ударов/мин, соответственно. Заметим, что разбавитель также обеспечивал снижение на 2 удара/мин сокращений сердца в течение 60 мин. .
    Т а б л и ц а 1
    о Л
    1® НХхыцХр
    UA
    mt °n
    О
    Соединение формулы I:
    Таблица Э
    Таблице 4
SU894742910A 1988-12-15 1989-12-14 Способ получени производных дитрет-бутиловых эфиров 3,4-оксибензоилоксипропаноламинов RU1795966C (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,006 US4897417A (en) 1988-12-15 1988-12-15 Prodrugs of 3,4-hydroxy benzoyloxypropanolamines

Publications (1)

Publication Number Publication Date
RU1795966C true RU1795966C (ru) 1993-02-15

Family

ID=23092341

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894742910A RU1795966C (ru) 1988-12-15 1989-12-14 Способ получени производных дитрет-бутиловых эфиров 3,4-оксибензоилоксипропаноламинов

Country Status (16)

Country Link
US (1) US4897417A (ru)
EP (1) EP0373590B1 (ru)
JP (1) JPH0653714B2 (ru)
AT (1) ATE102182T1 (ru)
AU (1) AU619367B2 (ru)
CA (1) CA2005373A1 (ru)
DE (1) DE68913462T2 (ru)
DK (1) DK633989A (ru)
FI (1) FI895977A0 (ru)
HU (1) HU203222B (ru)
IL (1) IL92649A0 (ru)
NO (1) NO895041L (ru)
NZ (1) NZ231752A (ru)
PT (1) PT92589B (ru)
RU (1) RU1795966C (ru)
ZA (1) ZA899619B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966914A (en) * 1988-12-15 1990-10-30 E. I. Du Pont De Nemours And Company Oculoselective beta-blockers as antiglaucoma agents
US4935422A (en) * 1988-12-15 1990-06-19 E. I. Du Pont De Nemours And Company Acyloxypropanolamines
US5536749A (en) * 1994-10-13 1996-07-16 Sl Pharmaceuticals, Inc. Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US20070254950A1 (en) * 2004-05-25 2007-11-01 Othera Pharmaceuticals, Inc. Oculoselective Drugs and Prodrugs
JP5240586B2 (ja) 2007-01-29 2013-07-17 ブイライフ サイエンス テクノロジーズ ピーブイティー リミテッド 糖尿病性合併症治療用薬学的組成物
WO2010016044A1 (en) * 2008-08-05 2010-02-11 University College Cork, National University Of Ireland, Cork Treatment of retinal degeneration
CN104387265B (zh) * 2014-10-30 2016-10-26 盐城师范学院 一种4,5-二羟基-2-甲基苯甲酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195085A (en) * 1975-09-26 1980-03-25 Merck & Co., Inc. Compositions and methods for treating glaucoma by the topical administration of t-butylamino-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy-2-phopanol hydrogen maleate
US4405642A (en) * 1980-11-28 1983-09-20 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4402974A (en) * 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4455317A (en) * 1981-06-23 1984-06-19 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4582855A (en) * 1981-11-12 1986-04-15 American Hospital Supply Corporation Aromatic and esters of hydroxypropylamines
EP0105838B1 (en) * 1982-09-30 1989-06-21 William John Louis 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
US4579867A (en) * 1984-04-09 1986-04-01 American Hospital Supply Corporation Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents

Also Published As

Publication number Publication date
IL92649A0 (en) 1990-08-31
PT92589A (pt) 1990-06-29
HU203222B (en) 1991-06-28
HUT53065A (en) 1990-09-28
DK633989D0 (da) 1989-12-14
EP0373590A2 (en) 1990-06-20
EP0373590A3 (en) 1991-03-27
DE68913462D1 (de) 1994-04-07
PT92589B (pt) 1995-09-12
HU896641D0 (en) 1990-02-28
US4897417A (en) 1990-01-30
ATE102182T1 (de) 1994-03-15
NO895041D0 (no) 1989-12-14
NZ231752A (en) 1991-03-26
DE68913462T2 (de) 1994-07-14
JPH0653714B2 (ja) 1994-07-20
EP0373590B1 (en) 1994-03-02
NO895041L (no) 1990-06-18
FI895977A0 (fi) 1989-12-14
AU619367B2 (en) 1992-01-23
CA2005373A1 (en) 1990-06-15
JPH02258751A (ja) 1990-10-19
DK633989A (da) 1990-06-16
AU4679989A (en) 1990-06-21
ZA899619B (en) 1991-08-28

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