RU11061U1 - CARBON FACILITIES (OPTIONS) - Google Patents

Abstract

1. A dressing containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10-10) 1 / cm 2. The dressing according to claim 1, characterized in that said film is made of polyethylene terephthalate. The dressing according to claim 1, characterized in that said film is made of a thickness of 3-100 microns. A dressing containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10-10) 1 / cm, and one of the surfaces of the aforementioned the film is equipped with a monolayer of animal cells grown on it. 5. The dressing according to claim 4, characterized in that the monolayer of animal cells consists of keratinocytes. The dressing according to claim 4, characterized in that the monolayer of animal cells consists of fibroblasts. The dressing according to claim 4, characterized in that said film is made of polyethylene terephthalate. The dressing according to claim 4, characterized in that said film is made of a thickness of 3-100 microns. A dressing containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10-10) 1 / cm, and the film is impregnated with at least at least one drug and / or biologically active substance. 10. The dressing according to claim 9, characterized in that the film is impregnated with an antiseptic. The dressing according to claim 9, characterized in that the film is impregnated

Description

Bandage

This group of useful models relates to medicine, and more specifically to dressings used in various fields of surgery, and, in particular, can be used to restore the skin of patients with burns and other types of wounds.

The development of surgical treatment methods requires the development of dressings with chemical inertness and non-toxicity, good bioaffinity properties, as well as providing favorable conditions for cell proliferation and differentiation and tissue formation.

Known medical dressing for the treatment of wounds containing a layer of activated carbon tissue made on the basis of viscose. The fabric has a twill weave with a fabric density of 165-175 threads / 10 cm along the main threads and 105-115 threads / 10 cm along the weft threads, each thread having a twist of 76-84 cr / m and consists of 1050-1150 filaments with a bean-shaped cross-section, the maximum size of which is not more than 14 microns, and the minimum is not less than 7 microns (see RF patent No. 2000762 Pokl.Ab F 13/54, OPZ glare 15.10.93).

Known medical dressing provides the outflow of wound exudate and microorganisms from the surface of the wound, however, this dressing does not allow you to visually monitor the condition of the wound and is difficult to manufacture.

Known aseptic dressing containing a liquid absorbent material and a retaining pad with fixation elements located on top of it. The retaining pad is made of elastic tape (see USSR author's certificate No. 1803083 according to class A 61 F 13/00, published 03/23/93).

Known dressing suppresses pathogenic microflora, provides the outflow of wound exudate, but has a complex design and does not provide visual monitoring of the state of the wound.

MPJ: L 61 F 13/00, C 12 N5 / 00,

(options)

Known medical dressing, made in the form of a moistened substrate of polyurethane foam (see USSR author's certificate No. 1822796 according to class A61L 15/00, published 06/23/93).

The known dressing has a limited scope, as it is used only in the treatment of burns and wounds in an oxygen baromagnetotherapeutic chamber.

Known antimicrobial dressing containing a base of natural cellulose fibers and an antimicrobial preparation, which is used as sangrivitrin, in the following ratio of components, wt.%; the basis of natural fibers - 98, 9; sanguirythrin-0.14-2.0.

(see USSR author's certificate No. 1825627 according to class A6IL 15/16, published 07.07.93).

The well-known antimicrobial dressing has reduced adhesive properties, high adsorption ability against wound exudate and helps to suppress pathogenic microflora, however, its disadvantage is the inability to simulate the surface of a wound with a complex relief and to monitor the state of the wound.

A specific form of dressings are wound dressings. Recently, various wound types of wound dressings have been developed, differing in the chemical composition of the base, and in the medicinal substances added to them.

Known medical dressing for the treatment of wounds and burns, containing a polymer film based on polyolefins with a thickness of 20 to 150 microns with sorption-bound iodine grafted in the thickness of the film with N-vinylpyrrolidone (see USSR author's certificate No. 1708352, class A61L 15/16, published 01/30/92)

A medical dressing has an antiseptic effect, however, in the process of processing the film to give it bactericidal properties, it becomes brown and thereby loses its transparency.

Forging is a dressing material DDB-M, consisting of a polyethylene film, on one of the surface of which a mixture of talc and drugs is applied. The film contains rows of rectangular holes with side sizes of 1 and 3 mm at a distance of I mm, forming rectangles of a continuous surface with side sizes of 100 and 200 mm (see RF patent No. 209 3126, A6I F 13/00, published July 20, 1997).

Due to the presence of sections of a continuous surface, the known dressing does not provide gas exchange over the entire surface of the wound, which is necessary for the effective course of reparative processes. The film has low adhesion to wound surfaces and requires additional fixation with a plaster or bandage.

The task to which this group of utility models is directed was the development of a dressing that would be easy to manufacture, securely attached to the wound surface, would ensure the uniform penetration of gases through it, necessary for the effective course of reparative processes, but at the same time time would prevent microorganisms from entering the wound

The problem is solved by a group of utility models united by a single inventive concept, namely, in a dressing containing a biocompatible film of an optically transparent polymer with through holes, said holes are made with a diameter D (0.01 - 3.0) μm and a hole density N (10 - 10) I / CM.

The problem is also solved by the fact that in a dressing containing a biocompatible polymer film of an optically transparent polymer with through holes, said holes are made with a diameter D (0.01 - 3.0) μm and a hole density of N (10 - 10) I / CM while one of the surfaces of the film is equipped with a monolayer of animal cells grown on it. On the surface of the film, keratinocytes (when applying a dressing to damaged skin) or fibroblasts can be grown.

through holes, said holes are made with a diameter of D (0,01

-3.0) microns and a hole density of N (10 - 10) I / CM, and the film is impregnated with drugs. The film may be impregnated with an antiseptic (for example, chlorhexadine, nodopyrone or its analogs, catapol and other known antiseptics). The film may be impregnated with anesthetics (e.g. novocaine, anilocaine and other known anesthetics). The film can also be impregnated with drugs that stimulate reparative processes in the wound (for example, sea buckthorn oil, fir resin extract, pine and other known drugs).

The problem is also solved by the fact that in a dressing containing a biocompatible film of an optically transparent polymer with through holes, said holes are made with a diameter of D (0.01

-3.0) microns and a hole density of N (10 - 10) I / CM, and at least one layer of the drug and / or biologically active substance is applied to the film. At least one layer of an antiseptic (for example, chlorhexadine, iodopyron or its analogues, catapol and other known antiseptics) can be applied to the PA film. At least one layer of anesthetic can be applied to the film (for example, novocaine, anilocaine and other known anesthetics). At least one layer of a preparation that stimulates reparative processes in the wound (for example, sea buckthorn oil, fir resin extract, pine and other known preparations) can also be applied to the PA film.

As the polymeric material for the ejavanny film can be taken polyethylene terephthalate, carboxymethyl cellulose, polyimide, polyurethane and others. The film thickness may be 3-100 microns. The through holes in the film could be made cylindrical, conical or narrowed in the central part. The last two types of holes are preferably used when the film is impregnated with a drug and / or biologically active substance. The axes of the through holes can be parallel to each other and perpendicular to the surface of the film. The film can also be equipped with additional perforation (through holes with a diameter of 1-3 mm, located at a distance of 5-10 mm from each other).

As the studies conducted by the authors showed, a dressing containing a polymer biocompatible film made of an optically transparent polymer with through pores with a diameter of D (0.01 - 3.0) μm and a pore density of N (10 - 10) I / CM prevents the penetration of microorganisms to the wound, but does not prevent the penetration of gases (oxygen and carbon dioxide) to ensure reparative processes in the wound. The tool eliminates desiccation of the bottom of the wound and at the same time provides the ability to visually control the healing process of the wound. Good results were obtained using films of polyethylene terephthalate, carboxylmethyl cellulose and polyimides. If the film has a thickness of less than 3 μm, a hole diameter of more than 3.0 μm and a hole density of more than 10 I / CM, then its mechanical strength is insufficient. When the film thickness is more than 100 μm, the hole diameter is less than 0.01 μm and the hole density is less than 10 I / CM, the conditions of gas exchange and penetration of water-soluble substances through the film are worsened, as well as the conditions for visual observation of cell growth and the state of the wound surface when The film is covered with a monolayer of animal cells grown on it. Due to the presence of an electrostatic charge on the surface of the film, the claimed dressing is reliably held on the wound surface. The monolayer of animal cells deposited on the film surface allows the use of the inventive dressing to repair damaged tissues (for example, the skin when applying a keratinocyte monolayer). Impregnation of the dressing with antiseptics or applying them in the form of a layer helps to suppress pathogenic microflora, and impregnation with anesthetics or applying them in the form of a layer allows you to expand the scope of the dressing.

Filling the holes in the film with sea buckthorn oil, fir resin, pine resin extracts and other similar preparations, as well as applying them to the film as a layer, can stimulate reparative processes in the wound.

The inventive dressing means is shown in the drawing, where: in FIG. 1 shows a dressing with a cylindrical pore in cross section; in FIG. 2 shows a cross section of a conical pore means;

in FIG. 3 shows a cross section of a dressing with pores narrowed in the central part;

in FIG. 4 shows a dressing provided on one of the surfaces with a monolayer of animal cells.

The dressing consists of a film 1 made of a biocompatible optically transparent polymer (polyethylene terephthalate, carboxymethyl cellulose, polyimide, etc.). In the film 1, through holes 2 are made with a diameter of D (0.01 - 3.0) μm. The density of holes 2 N is (10 - 10) 1 / cm2. The holes 2 can be made cylindrical (Fig. 1), conical (Fig. 2) or narrowed in the central part (Fig. 3), the Axes of the through holes 2 can be parallel to each other (Fig. 3) and can be located to the surfaces 3 film 1 at various angles (Fig. 1).

In the second variant of the dressing, a monolayer of 4 animal cells (for example, keratinocytes, fibroblasts) is grown on one of the surfaces 3 of film 1. This variant of the dressing is used to restore the damage to the corresponding tissues of the patient.

In a third embodiment of the dressing, the openings of the film are filled with drugs and / or biologically active substance.

In a fourth embodiment of the dressing, at least one layer of the drug and / or biologically active substance is applied to the film.

The third and fourth versions of the dressing are used as an antiseptic and therapeutic coating.

The inventive dressing is made as follows. A polymer film with a thickness of 3-100 μm, for example polyethylene terephthalate, is irradiated with accelerated heavy ions, for example carbon, chlorine, nitrogen, oxygen, argon, xenon. The type of ions and their energy are chosen by calculation, depending on the energy loss of the particles as they pass through the irradiated film. When irradiating the film, it should be borne in mind that there should be a minimum number of holes having a spatial overlap along their entire length, since this reduces its mechanical strength.

This condition limits the value of the density of holes N to a maximum value of 10 1 / cm with a minimum diameter of D of 0.01 μm. A predetermined shape of the holes (cylindrical, conical, or with% wall in the central part) is obtained by choosing the appropriate type and energy of the ions used to bombard the slug. Then, the film treated with the corresponding ions is irradiated with ultraviolet radiation and then subjected to chemical etching, which leads to the formation of through holes in the film. It should be noted that the shape of the holes can also be controlled by the modes of post-radiation processing of the film, i.e. sensitizing ultraviolet radiation and chemical etching. So, for etching holes with a shape close to cylindrical, etching is carried out at high temperature and diluted alkaline solutions. Low-temperature etching in concentrated solutions leads to the formation of holes narrowed in the central part. If ultraviolet irradiation and chemical etching are carried out on one side of the film, then conical holes are formed (in the form of a truncated cone),

In the second variant of the dressing (Fig. 4), live cells (for example, keratinocytes, fibroblasts) are cultured by known methods on one of the surfaces of the film with the holes formed by the above method, until their myolayer forms.

In the third and fourth versions of the dressing, the pleika with the holes obtained in the aforementioned manner is treated with the appropriate medication (antiseptic, anesthetic, or drugs that stimulate reparative processes). In this case, a film with conical holes is preferably used. In order to fill the holes in the third variant of the dressing agent faster with the medicine, one can create a vacuum on one side of the film. In the case of applying antiseptic formulations, additional sterilization is not carried out. In the manufacture of films with other types of drugs or biologically active substances, the procedure for manufacturing a dressing is carried out under sterile conditions (in particular, in laminar boxes, etc.) from originally sterile materials.

We declare a dressing agent HcnoHbaj-roT as follows. Dressing is applied to the wound surface. Due to its electret properties, the film adheres tightly to the wound surface and does not require the use of additional fixing elements. In case of II and P1-degree burns, it is advisable to apply a film with an anesthetic to the early s-rock after an injury. If there are signs of wound contamination after a thorough toilet of wound surfaces, it is advisable to prevent the application of microbial inflammation by applying a film with antiseptic impregnation or with a layer of antibacterial substance. In the case of using a dressing in the II and III phases of the wound healing process, it is advisable to use films with preparations that are able to adapt the healing processes of wounds. When using the second variant of the dressing (with a monolayer of animal cells), the agent is applied to a suitably prepared wound surface with the side on which the animal cells are grown. The procedure for preparing wounds for the application of wound dressing involves the preliminary removal of dead tissue, suppression of microflora, relief of inflammatory phenomena. If necessary, cjotne gauze dressings are applied over the dressing.

Claims (22)

1. A dressing agent containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10 ³ - 10 ⁹ ) 1 / cm ² .  2. The dressing according to claim 1, characterized in that the said film is made of polyethylene terephthalate.  3. The dressing according to claim 1, characterized in that the said film is made with a thickness of 3 - 100 microns. 4. A dressing agent containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10 ³ - 10 ⁹ ) 1 / cm ² , and one of the surfaces of said film is provided with a monolayer of animal cells grown on it.  5. The dressing according to claim 4, characterized in that the monolayer of animal cells consists of keratinocytes.  6. The dressing according to claim 4, characterized in that the monolayer of animal cells consists of fibroblasts.  7. The dressing according to claim 4, characterized in that the said film is made of polyethylene terephthalate.  8. The dressing according to claim 4, characterized in that the said film is made of a thickness of 3 - 100 microns. 9. A dressing containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10 ³ - 10 ⁹ ) 1 / cm ² , and the film is impregnated with at least one drug and / or biologically active substance.  10. The dressing according to claim 9, characterized in that the film is impregnated with an antiseptic.  11. The dressing according to claim 9, characterized in that the film is impregnated with an anesthetic.  12. The dressing according to claim 9, characterized in that the film is impregnated with a drug that stimulates reparative processes.  13. A dressing according to claim 9, characterized in that the film is impregnated with an anti-inflammatory substance.  14. The dressing according to claim 9, characterized in that the said film is made of polyethylene terephthalate.  15. The dressing according to claim 9, characterized in that the said film is made of a thickness of 3 to 100 microns. 16. A dressing agent containing a biocompatible film of an optically transparent polymer with through holes, characterized in that the said holes are made with a diameter of D = 0.01 - 3.0 μm and a density of N = (10 ³ - 10 ⁹ ) 1 / cm ² , and at least one layer of the drug and / or biologically active substance is applied to the film.  17. A dressing according to claim 16, characterized in that said film is made of polyethylene terephthalate.  18. The dressing according to clause 16, characterized in that the said film is made of a thickness of 3 to 100 microns.  19. The dressing according to clause 16, characterized in that at least one layer of an antiseptic is applied to the film.  20. The dressing according to clause 16, characterized in that at least one layer of anesthetic is applied to the film.  21. The dressing according to clause 16, characterized in that at least one layer of anti-inflammatory substance is applied to the film. 22. A dressing according to claim 16, characterized in that at least one layer of a preparation stimulating reparative processes is applied to the film.