CA2902387A1 - Chronic wound dressing with variable pore sizes - Google Patents
Chronic wound dressing with variable pore sizes Download PDFInfo
- Publication number
- CA2902387A1 CA2902387A1 CA2902387A CA2902387A CA2902387A1 CA 2902387 A1 CA2902387 A1 CA 2902387A1 CA 2902387 A CA2902387 A CA 2902387A CA 2902387 A CA2902387 A CA 2902387A CA 2902387 A1 CA2902387 A1 CA 2902387A1
- Authority
- CA
- Canada
- Prior art keywords
- skin substitute
- slits
- layer
- wound
- porosity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000001684 chronic effect Effects 0.000 title abstract description 15
- 239000011148 porous material Substances 0.000 title description 6
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 18
- 241001116389 Aloe Species 0.000 claims abstract description 9
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract 3
- 230000001225 therapeutic effect Effects 0.000 claims abstract 3
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- 230000000774 hypoallergenic effect Effects 0.000 claims description 4
- HKIKAXXIWJHWLY-ZIIYPAMZSA-N Aloesin Chemical compound C=12OC(CC(=O)C)=CC(=O)C2=C(C)C=C(O)C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HKIKAXXIWJHWLY-ZIIYPAMZSA-N 0.000 claims description 3
- HKIKAXXIWJHWLY-QEVGBQTESA-N Aloesin Natural products O=C(CC=1Oc2c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)c(O)cc(C)c2C(=O)C=1)C HKIKAXXIWJHWLY-QEVGBQTESA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000002759 woven fabric Substances 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 39
- 208000027418 Wounds and injury Diseases 0.000 abstract description 39
- 239000004677 Nylon Substances 0.000 abstract description 10
- 229920001778 nylon Polymers 0.000 abstract description 10
- 230000035876 healing Effects 0.000 abstract description 8
- 206010019909 Hernia Diseases 0.000 abstract description 7
- 239000004744 fabric Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960000074 biopharmaceutical Drugs 0.000 description 7
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 4
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 4
- 210000000416 exudates and transudate Anatomy 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000003397 biobrane Substances 0.000 description 3
- 238000009581 negative-pressure wound therapy Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010056340 Diabetic ulcer Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 229920002529 medical grade silicone Polymers 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A61F13/01021—
-
- A61F13/01038—
Abstract
An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. The skin substitute is directed at chronic wound treatment and hernia repair.
Description
CHRONIC WOUND DRESSING WITH VARIABLE PORE SIZES
RELATED APPLICATIONS
This application is a Continuation-in-Part of US Patent Application 13/897,430, filed May 19, 2013.
FIELD OF THE INVENTION
This invention relates to dressings and bandages for chronic wounds, including hernias.
BACKGROUND OF THE INVENTION
Wound management involves removal of all non-viable tissue at the wound site, preserving the remaining viable tissue, and provng a most but not wet environment An example of successful burn wound dressing is Biobrane, granted US at. No, 4,725,279, In 1979 Biobrane was initially studied by American Burn Surgeons; it is still popular world-wide.
In 2007 new art was introduced by this inventor with AV/BAT and then with AWBAT Plus, granted US Pat. 7,815,931 and covered by several copending patent applications. The key to the success of these products was better porosity in the dressing.
Recently, this inventor has revisited the art of dressing design. The present invention allows passage of fluid adjacent to the wound through the primary dressing into a secondary absorbent dressing as well as improving the kinetics of uninterrupted wound healing. Technology of this dressing has evolved into a new product which possesses all the characteristics and attributes known to be important for optimal wound healing, as well as containing certain advances that result in minimization of wound desiccation and infection complication.
SUMMARY OF THE INVENTION
Wound sites have variable amounts of exudate/transudate/plasma present, from dry to weepy. The clinician must cleanly debride the wound, close it and manage wound healing in a moist but not wet environment to achieve optimal results in both acute and chronic wounds.
The present invention provides a dressing that possesses all the properties and attributes of an ideal skin substitute and, in addition, has 'variable porosity' controlled by the clinician from zero porosity to what the wound requires. The present invention enables the clinician to move the fluid exuding from the wound through the primary dressing into an absorbent secondary dressing without disturbing the kinetics of healing or causing pain to the patient.
RELATED APPLICATIONS
This application is a Continuation-in-Part of US Patent Application 13/897,430, filed May 19, 2013.
FIELD OF THE INVENTION
This invention relates to dressings and bandages for chronic wounds, including hernias.
BACKGROUND OF THE INVENTION
Wound management involves removal of all non-viable tissue at the wound site, preserving the remaining viable tissue, and provng a most but not wet environment An example of successful burn wound dressing is Biobrane, granted US at. No, 4,725,279, In 1979 Biobrane was initially studied by American Burn Surgeons; it is still popular world-wide.
In 2007 new art was introduced by this inventor with AV/BAT and then with AWBAT Plus, granted US Pat. 7,815,931 and covered by several copending patent applications. The key to the success of these products was better porosity in the dressing.
Recently, this inventor has revisited the art of dressing design. The present invention allows passage of fluid adjacent to the wound through the primary dressing into a secondary absorbent dressing as well as improving the kinetics of uninterrupted wound healing. Technology of this dressing has evolved into a new product which possesses all the characteristics and attributes known to be important for optimal wound healing, as well as containing certain advances that result in minimization of wound desiccation and infection complication.
SUMMARY OF THE INVENTION
Wound sites have variable amounts of exudate/transudate/plasma present, from dry to weepy. The clinician must cleanly debride the wound, close it and manage wound healing in a moist but not wet environment to achieve optimal results in both acute and chronic wounds.
The present invention provides a dressing that possesses all the properties and attributes of an ideal skin substitute and, in addition, has 'variable porosity' controlled by the clinician from zero porosity to what the wound requires. The present invention enables the clinician to move the fluid exuding from the wound through the primary dressing into an absorbent secondary dressing without disturbing the kinetics of healing or causing pain to the patient.
2 The present invention is cost effective at every level. Patients get their wounds managed with minimal pain and optimal healing times. The dressing is cost effective as the hospital needs to inventory only one primary dressing for acute wounds (burns) and one for chronic wounds;
each has a two year shelf-life at room temperature.
The present invention is composed of two biological layers sprayed on in separate operations. The first layer sprayed onto the nylon side of the "variable porosity" silicone membrane will be: (1) a solution of pure Aloe (Aloesin, Immuno10, Qmatrix and Loesyn - each hydrophilic and hygroscopic.); (2) a solution of pure Aloe and hypoallergenic USP
Pharmaceutical Grade porcine gelatin; or (3) a fine suspension of pure Aloe, gelatin and Extra Cellular Matrix (ECM ¨ as fine insoluble particles or hollow spheres in water ¨ the latter possesses improved healing properties). In vitro, the Aloe component has been demonstrated to cause a variety of cells to attach and proliferate; as well as increase synthesis of collagen and alpha smooth muscle actin. ECM may be added to the biologicals described above and is a mixture from human fibroblasts that is known to cause rapid cell proliferation and tissue growth. Previous wound dressings and skin substitutes, as taught in US Pat. 7,815,931 contain
each has a two year shelf-life at room temperature.
The present invention is composed of two biological layers sprayed on in separate operations. The first layer sprayed onto the nylon side of the "variable porosity" silicone membrane will be: (1) a solution of pure Aloe (Aloesin, Immuno10, Qmatrix and Loesyn - each hydrophilic and hygroscopic.); (2) a solution of pure Aloe and hypoallergenic USP
Pharmaceutical Grade porcine gelatin; or (3) a fine suspension of pure Aloe, gelatin and Extra Cellular Matrix (ECM ¨ as fine insoluble particles or hollow spheres in water ¨ the latter possesses improved healing properties). In vitro, the Aloe component has been demonstrated to cause a variety of cells to attach and proliferate; as well as increase synthesis of collagen and alpha smooth muscle actin. ECM may be added to the biologicals described above and is a mixture from human fibroblasts that is known to cause rapid cell proliferation and tissue growth. Previous wound dressings and skin substitutes, as taught in US Pat. 7,815,931 contain
3 gelatin, a pure Aloe component, chondroitin 4 & 6 sulfate, and vitamin C &
E. In contrast the current dressing will have two layers of biologicals applied in separate spraying operations as described above. The first coat will contact the wound after the second coat of hypoallergenic bovine spongiform encephalopathy (BSE)-free United Staes Pharmaceutical (USP) -grade gelatin interacts with fibrin in the wound to achieve early adherence, The second coat of biologicals stimulates the healing process during the interval where the dressing invention is in contact with the wound and is stable requiring 100 degree water for 30 minutes to remove from the "variable porosity" silicone/nylon surface.
E. In contrast the current dressing will have two layers of biologicals applied in separate spraying operations as described above. The first coat will contact the wound after the second coat of hypoallergenic bovine spongiform encephalopathy (BSE)-free United Staes Pharmaceutical (USP) -grade gelatin interacts with fibrin in the wound to achieve early adherence, The second coat of biologicals stimulates the healing process during the interval where the dressing invention is in contact with the wound and is stable requiring 100 degree water for 30 minutes to remove from the "variable porosity" silicone/nylon surface.
4 BRIEF DESCRIPTION OF THE FIGURES
Figure 1. A diagram of he preferred embodiment of the invention, showing the slit openings in the silicone layer DETAILED DESCRIPTION
The present invention is similar in composition to earlier skin substitutes in that they each have a thin silicone component and an underlying thin knitted nylon component. The present invention differs from its ancestors in that it has "variable porosity" controlled by the clinician;
the pore size in the thin silicone will be essentially zero (with no stretch, in relaxed mode) to a higher porosity (proportional to the stretch applied). See Figure 1 for the optional stretch modes. In addition, the present invention differs from prior art in the composition of biological coatings applied to both components and how these coatings interact with the wound over time.
The pores of prior art skin substitutes/dressings are of a fixed size (Biobrane 1.2%; AWBAT and AWBAT Plus 5.5% and 7.5%) in the unstretched open position; the silicone is cured while the skin substitute pores are open. Once cured the pores cannot close or be reduced in size;
this causes wound desiccation and punctate scarring. As in Fig .1, in contrast, the openings are made after the silicone component has been cured, and are in the shape of slits, not holes. The figure shows the skin substitute silicone layer up with the slits exposed.
The preferred embodiment of the invention 101 is shown in Fig. 1. In this embodiment, designed for chronic wounds and hernia repair, a regular pattern with slits 102,103 both parallel and perpendicular in the same row is presented. The slits made in the silicone are approximately .125" long with a space of 0.50", between the slits; off-set parallel rows of slits are 0.25"
apart. Rows of slits perpendicular to the above are also .125" long with a space of 0.50", between the next slit; off-set parallel rows of slits are 0.25"
apart. In this configuration the silicone/nylon membrane can be stretched in any direction and the slits will open. Porosity therefore increases proportionally to the amount of stretch applied. Obviously, there is a maximum amount of stretching of the preferred embodiment before the dressing fails.
Chronic, slow healing wounds require similar treatment as burns in that all necrotic tissue must be removed before closing the wound with a primary dressing. In the chronic wound treatment, exudate and other fluids are often removed with negative pressure wound therapy (NPWT). A
negative pressure above the wound or a positive pressure from the wound causes exudate and other wound fluids to pass through the primary dressing into a secondary dressing. The primary dressings currently used during NPWT are: urethane foam, polyvinyl alcohol foam or cotton gauze;
all require frequent dressing changes and infection complications have been reported when these dressings are not changed frequently.
The use of the present invention 101 has a large benefit because it is stable on the wound, compatible with or without NPWT, and possesses biologicals that aid in the healing process. The preferred embodiment of the invention is preferred for closing the chronic wound because it provides improved porosity as well as an increased rate of porosity caused by stretching the invention. Since chronic wounds are generally in the lower extremities, punctate scarring such as caused by the predecessor AWBAT
invention is not a clinical concern. An example of chronic wounds that benefit from this novel art are: pressure sores, diabetic ulcers, chronic vascular ulcers, and hernias.
The present invention 101 will have two layers of biologicals; first a clotting outer layer containing hypoallergenic BSE free USP
Pharmaceutical grade gelatin. This layer contacts the wound first and stimulates initial adherence of the dressing to the cleanly debrided wound.
The second layer of pure Aloe or Aloesin, pure Aloe and BSE free gelatin, or a mixture of pure Aloe, BSE free gelatin and ECM interact with the wound to stimulate the rate of healing while adherent to the wound. The first layer is deposited directly on the nylon side of the "variable porosity"
silicone/nylon surface and is stable, i.e. requires 100 degree water for 30 minutes to remove from the "variable porosity" silicone/nylon surface.
An alternate embodiment of the present invention, to provide support and therapy for hernias, a restricted set of requirements are needed. In particular, the mesh/silicone structure has to be thin enough to be inserted with laparoscopic surgical techniques.
The knitted nylon component would be the thinnest commercially-available mesh, the preferred material nylon. Either 12/1 or 15/1 denier filament would be used to knit the mesh. Alternatively, polypropylene or other filaments used in mesh hernia repair devices could be used. The mesh would be combined with the medical grade silicone as above to produce the structure of the invention.
The slits in the silicone layer would be shorter in length than in the chronic wound embodiment above. The pattern of slits, alternating in orientation in the same row with multiple rows, would remain the same.
The biologicals applied to the chronic wound implementation of the invention will be applied to the mesh side of the hernia repair embodiment.
Optionally, the biologicals can be applied to the silicone layer as we These are the preferred embodiments of the invention. The technology to create the two forms of the invention is listed in the preferred embodiments of this invention, but other methods are possible and are within the contemplation of this patent.
Figure 1. A diagram of he preferred embodiment of the invention, showing the slit openings in the silicone layer DETAILED DESCRIPTION
The present invention is similar in composition to earlier skin substitutes in that they each have a thin silicone component and an underlying thin knitted nylon component. The present invention differs from its ancestors in that it has "variable porosity" controlled by the clinician;
the pore size in the thin silicone will be essentially zero (with no stretch, in relaxed mode) to a higher porosity (proportional to the stretch applied). See Figure 1 for the optional stretch modes. In addition, the present invention differs from prior art in the composition of biological coatings applied to both components and how these coatings interact with the wound over time.
The pores of prior art skin substitutes/dressings are of a fixed size (Biobrane 1.2%; AWBAT and AWBAT Plus 5.5% and 7.5%) in the unstretched open position; the silicone is cured while the skin substitute pores are open. Once cured the pores cannot close or be reduced in size;
this causes wound desiccation and punctate scarring. As in Fig .1, in contrast, the openings are made after the silicone component has been cured, and are in the shape of slits, not holes. The figure shows the skin substitute silicone layer up with the slits exposed.
The preferred embodiment of the invention 101 is shown in Fig. 1. In this embodiment, designed for chronic wounds and hernia repair, a regular pattern with slits 102,103 both parallel and perpendicular in the same row is presented. The slits made in the silicone are approximately .125" long with a space of 0.50", between the slits; off-set parallel rows of slits are 0.25"
apart. Rows of slits perpendicular to the above are also .125" long with a space of 0.50", between the next slit; off-set parallel rows of slits are 0.25"
apart. In this configuration the silicone/nylon membrane can be stretched in any direction and the slits will open. Porosity therefore increases proportionally to the amount of stretch applied. Obviously, there is a maximum amount of stretching of the preferred embodiment before the dressing fails.
Chronic, slow healing wounds require similar treatment as burns in that all necrotic tissue must be removed before closing the wound with a primary dressing. In the chronic wound treatment, exudate and other fluids are often removed with negative pressure wound therapy (NPWT). A
negative pressure above the wound or a positive pressure from the wound causes exudate and other wound fluids to pass through the primary dressing into a secondary dressing. The primary dressings currently used during NPWT are: urethane foam, polyvinyl alcohol foam or cotton gauze;
all require frequent dressing changes and infection complications have been reported when these dressings are not changed frequently.
The use of the present invention 101 has a large benefit because it is stable on the wound, compatible with or without NPWT, and possesses biologicals that aid in the healing process. The preferred embodiment of the invention is preferred for closing the chronic wound because it provides improved porosity as well as an increased rate of porosity caused by stretching the invention. Since chronic wounds are generally in the lower extremities, punctate scarring such as caused by the predecessor AWBAT
invention is not a clinical concern. An example of chronic wounds that benefit from this novel art are: pressure sores, diabetic ulcers, chronic vascular ulcers, and hernias.
The present invention 101 will have two layers of biologicals; first a clotting outer layer containing hypoallergenic BSE free USP
Pharmaceutical grade gelatin. This layer contacts the wound first and stimulates initial adherence of the dressing to the cleanly debrided wound.
The second layer of pure Aloe or Aloesin, pure Aloe and BSE free gelatin, or a mixture of pure Aloe, BSE free gelatin and ECM interact with the wound to stimulate the rate of healing while adherent to the wound. The first layer is deposited directly on the nylon side of the "variable porosity"
silicone/nylon surface and is stable, i.e. requires 100 degree water for 30 minutes to remove from the "variable porosity" silicone/nylon surface.
An alternate embodiment of the present invention, to provide support and therapy for hernias, a restricted set of requirements are needed. In particular, the mesh/silicone structure has to be thin enough to be inserted with laparoscopic surgical techniques.
The knitted nylon component would be the thinnest commercially-available mesh, the preferred material nylon. Either 12/1 or 15/1 denier filament would be used to knit the mesh. Alternatively, polypropylene or other filaments used in mesh hernia repair devices could be used. The mesh would be combined with the medical grade silicone as above to produce the structure of the invention.
The slits in the silicone layer would be shorter in length than in the chronic wound embodiment above. The pattern of slits, alternating in orientation in the same row with multiple rows, would remain the same.
The biologicals applied to the chronic wound implementation of the invention will be applied to the mesh side of the hernia repair embodiment.
Optionally, the biologicals can be applied to the silicone layer as we These are the preferred embodiments of the invention. The technology to create the two forms of the invention is listed in the preferred embodiments of this invention, but other methods are possible and are within the contemplation of this patent.
Claims (3)
1. A skin substitute, the skin substitute comprised of two layers of material, the first layer of material comprised of a silicone membrane, the second layer comprised of a woven fabric, the two layers combined together with a combination means such that the two layers form a single structure, the preferred combination method is heating, the first layer possessing a plurality of slits in its surface, said slits made after the two layers are combined, said slits in a regular pattern, the regular pattern comprising alternating perpendicular orientation, both horizontal and vertical, said first layer and said second layer treated with a one or more medicinal or therapeutic substances, the porosity of said skin substitute minimized in the mode where no stretching tension is exerted on the skin substitute, the porosity of said skin substitute variable proportional to the amount of stretching tension and the direction in which said stretching tension is placed on the skin substitute.
2. The skin substitute of Claim 1 where the plurality of slits are each approximately .125 inch long and arranged in a plurality of rows.
3. The skin substitute of Claim 1 where the medicinal and therapeutic substances are selected from the list of hypoallergenic BSE free USP
Pharmaceutical grade gelatin, pure aloe, aloesin and ECM.
Pharmaceutical grade gelatin, pure aloe, aloesin and ECM.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361773707P | 2013-03-06 | 2013-03-06 | |
US61/773,707 | 2013-03-06 | ||
US13/897,430 | 2013-05-19 | ||
US13/897,430 US9017405B2 (en) | 2013-03-06 | 2013-05-19 | Skin substitute and wound dressing with variable pore sizes |
US14/159,332 | 2014-01-20 | ||
US14/159,332 US20150202343A1 (en) | 2014-01-20 | 2014-01-20 | Chronic Wound Dressing with Variable Pore Sizes |
PCT/US2014/020924 WO2014138309A1 (en) | 2013-03-06 | 2014-03-05 | Chronic wound dressing with variable pore sizes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2902387A1 true CA2902387A1 (en) | 2014-09-12 |
Family
ID=51491926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2902387A Abandoned CA2902387A1 (en) | 2013-03-06 | 2014-03-05 | Chronic wound dressing with variable pore sizes |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2902387A1 (en) |
WO (1) | WO2014138309A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106039404A (en) * | 2015-04-08 | 2016-10-26 | 上海宏创医疗科技有限公司 | Preparation method for extracellular matrix (ECM) composite biological patch |
US20220008611A1 (en) | 2019-05-13 | 2022-01-13 | E. Aubrey Woodroof | Improved skin substitute adherence, stretchability, and compliance for skin substitutes |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006837A1 (en) * | 1995-08-16 | 1997-02-27 | Integra Lifesciences Corporation | Perforated artificial skin grafts |
US20090234305A1 (en) * | 2008-03-15 | 2009-09-17 | Ernest Aubrey Woodroof | Temporary skin substitute comprised of biological compounds of plant and animal origins |
US20090230592A1 (en) * | 2008-03-15 | 2009-09-17 | Aubrey Woodroof | Laser-Perforated Skin Substitute |
EP2394617B1 (en) * | 2010-06-10 | 2013-12-11 | MedSkin Solutions Dr. Suwelack AG | Layer-like perforated biomatrices |
-
2014
- 2014-03-05 CA CA2902387A patent/CA2902387A1/en not_active Abandoned
- 2014-03-05 WO PCT/US2014/020924 patent/WO2014138309A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014138309A1 (en) | 2014-09-12 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request |
Effective date: 20190116 |
|
FZDE | Discontinued |
Effective date: 20210831 |