RS67133B1 - Liofilizovane kompozicije velike površine koje sadrže arsen za oralnu administraciju kod pacijenta - Google Patents

Liofilizovane kompozicije velike površine koje sadrže arsen za oralnu administraciju kod pacijenta

Info

Publication number
RS67133B1
RS67133B1 RS20250815A RSP20250815A RS67133B1 RS 67133 B1 RS67133 B1 RS 67133B1 RS 20250815 A RS20250815 A RS 20250815A RS P20250815 A RSP20250815 A RS P20250815A RS 67133 B1 RS67133 B1 RS 67133B1
Authority
RS
Serbia
Prior art keywords
arsenic
patients
area
oral administration
high surface
Prior art date
Application number
RS20250815A
Other languages
English (en)
Inventor
Krishna Vaddi
Kumar Kurumaddali
Original Assignee
Quetzal Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quetzal Therapeutics Llc filed Critical Quetzal Therapeutics Llc
Publication of RS67133B1 publication Critical patent/RS67133B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RS20250815A 2015-02-01 2016-02-01 Liofilizovane kompozicije velike površine koje sadrže arsen za oralnu administraciju kod pacijenta RS67133B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562110574P 2015-02-01 2015-02-01
US201562142709P 2015-04-03 2015-04-03
EP21192594.6A EP3981414B1 (en) 2015-02-01 2016-02-01 High surface-area lyophilized compositions comprising arsenic for oral administration in patients

Publications (1)

Publication Number Publication Date
RS67133B1 true RS67133B1 (sr) 2025-09-30

Family

ID=56544541

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20250815A RS67133B1 (sr) 2015-02-01 2016-02-01 Liofilizovane kompozicije velike površine koje sadrže arsen za oralnu administraciju kod pacijenta

Country Status (20)

Country Link
US (6) US10111836B2 (sr)
EP (3) EP4599823A1 (sr)
JP (3) JP6928768B2 (sr)
CN (2) CN117899029A (sr)
AU (4) AU2016211186A1 (sr)
CA (2) CA2975406C (sr)
DK (1) DK3981414T3 (sr)
ES (2) ES2899226T3 (sr)
FI (1) FI3981414T3 (sr)
HR (1) HRP20251032T1 (sr)
HU (1) HUE072537T2 (sr)
LT (1) LT3981414T (sr)
MX (2) MX390835B (sr)
PL (1) PL3981414T3 (sr)
PT (1) PT3981414T (sr)
RS (1) RS67133B1 (sr)
SI (1) SI3981414T1 (sr)
SM (1) SMT202500321T1 (sr)
TW (3) TW202337477A (sr)
WO (1) WO2016123603A2 (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20251032T1 (hr) 2015-02-01 2025-10-24 Quetzal Therapeutics, Llc Liofilizirani pripravci s visokim površinskim područjem koji sadrže arsen za oralnu primjenu kod pacijenata
MX384297B (es) 2016-12-01 2025-03-14 Eupharma Pty Ltd Composiciones de arsénico.
KR101844049B1 (ko) * 2016-12-05 2018-03-30 주식회사 케마스 육산화사비소의 결정다형을 포함하는 간암 예방 또는 치료용 약학 조성물
KR101844050B1 (ko) 2016-12-09 2018-05-14 주식회사 케마스 육산화사비소의 결정다형을 포함하는 암 예방 또는 치료용 약학 조성물
US20190374611A1 (en) * 2017-01-18 2019-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment patients suffering from myeloproliferative disorders
US11583552B2 (en) * 2021-02-17 2023-02-21 Manoj Maniar Pharmaceutical formulation of arsenic trioxide
JP7428842B1 (ja) 2023-03-29 2024-02-06 artience株式会社 活性エネルギー線硬化型インキ、その製造方法、および印刷物
WO2025172482A1 (en) * 2024-02-14 2025-08-21 Institut Gustave Roussy Oral composition of arsenic trioxide for cancer treatment

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US5773419A (en) 1995-03-03 1998-06-30 Falcon; Juan Method of treating cancer with tannic acid
CN1044559C (zh) 1995-08-23 1999-08-11 哈尔滨医科大学附属第一医院 抗白血病、肝癌、淋巴瘤注射液
IL136051A0 (en) 1997-11-10 2001-05-20 Sloan Kettering Inst Cancer Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
US7276359B1 (en) * 1998-03-13 2007-10-02 Wyeth Polynucleotide composition, method of preparation, and use thereof
CN1131922C (zh) 1998-10-19 2003-12-24 张在喆 一种通过弹性键搭架与收拢的帐篷
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
CN101385732A (zh) * 2000-02-29 2009-03-18 布里斯托尔-迈尔斯斯奎布公司 低剂量艾替开韦制剂及其应用
AUPR874601A0 (en) * 2001-11-08 2001-11-29 Unisearch Limited Selective targeting of apoptotic cells
US7521071B2 (en) 2002-10-09 2009-04-21 Versitech Limited Formulation of oral compositions comprising arsenic trioxide and methods of use thereof
US8906422B2 (en) 2002-10-09 2014-12-09 The University Of Hong Kong Method for inhibiting cancer using arsenic trioxide
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
CN1251688C (zh) 2003-12-09 2006-04-19 重庆维特瑞医药开发有限公司 三氧化二砷冻干粉针及其生产方法
JP4292985B2 (ja) 2003-12-25 2009-07-08 Jsr株式会社 感放射線性組成物、マイクロレンズとその形成方法および液晶表示素子
CN1698650A (zh) 2004-05-21 2005-11-23 哈尔滨伊达药业有限公司 一种治疗原发性肝癌的亚砷酸注射液及其制备方法
CN1326528C (zh) 2004-07-13 2007-07-18 东南大学 砒霜磁性纳米明胶微球的制备工艺
WO2007069272A2 (en) 2005-10-21 2007-06-21 Panacea Biotec Limited Pharmaceutical composition comprising at least one anticancer drug and at least one polymer
US20080089951A1 (en) * 2006-10-11 2008-04-17 The University Of Hong Kong Method for Inhibiting Cancer Using Arsenic Trioxide
CN101322719B (zh) 2007-06-15 2012-03-07 杭州民生药业有限公司 一种三氧化二砷固体脂质纳米粒及其制剂
US8168224B2 (en) * 2007-12-19 2012-05-01 Beijing Shengyiyao Science & Technology Development Co., Ltd. Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof
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EP2525783A1 (en) 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
CN103142648B (zh) * 2011-12-07 2015-04-15 浙江中医药大学 一种砷化合物溶液及其制备的包载砷化合物的白蛋白纳米粒和冻干制剂
CN103408477B (zh) 2013-08-22 2015-06-10 陈鹏飞 一种含砷配位化合物及其制备方法
CN107206022B (zh) 2015-01-29 2020-10-16 益友制药私人有限公司 含砷的组合物及其在治疗方法中的用途
HRP20251032T1 (hr) 2015-02-01 2025-10-24 Quetzal Therapeutics, Llc Liofilizirani pripravci s visokim površinskim područjem koji sadrže arsen za oralnu primjenu kod pacijenata

Also Published As

Publication number Publication date
HK1248113A1 (zh) 2018-10-12
CA3225480A1 (en) 2016-08-04
EP3250214B1 (en) 2021-09-01
ES2899226T3 (es) 2022-03-10
EP3981414A1 (en) 2022-04-13
US20200060974A1 (en) 2020-02-27
AU2016211186A1 (en) 2017-08-17
WO2016123603A2 (en) 2016-08-04
US10653628B2 (en) 2020-05-19
AU2021203752A1 (en) 2021-07-08
WO2016123603A3 (en) 2016-11-03
PL3981414T3 (pl) 2025-10-06
AU2025259861A1 (en) 2025-11-20
MX2020012611A (es) 2021-02-09
EP3981414B1 (en) 2025-06-25
TWI790191B (zh) 2023-01-21
LT3981414T (lt) 2025-09-25
AU2021203752B2 (en) 2023-08-31
JP2021152059A (ja) 2021-09-30
MX2017009913A (es) 2018-08-15
NZ734201A (en) 2024-03-22
TW202337477A (zh) 2023-10-01
SMT202500321T1 (it) 2025-11-10
EP3250214A2 (en) 2017-12-06
TW202228734A (zh) 2022-08-01
EP3250214A4 (en) 2018-09-19
JP2024161468A (ja) 2024-11-19
NZ772450A (en) 2024-07-05
EP4599823A1 (en) 2025-08-13
FI3981414T3 (fi) 2025-07-29
CA2975406A1 (en) 2016-08-04
US12364664B2 (en) 2025-07-22
TW201642879A (zh) 2016-12-16
US10272045B2 (en) 2019-04-30
DK3981414T3 (da) 2025-07-14
SI3981414T1 (sl) 2025-10-30
US20160235679A1 (en) 2016-08-18
ES3034734T3 (en) 2025-08-22
HUE072537T2 (hu) 2025-11-28
US20240269076A1 (en) 2024-08-15
US10111836B2 (en) 2018-10-30
CN107530373B (zh) 2023-12-29
CA2975406C (en) 2025-07-22
CN107530373A (zh) 2018-01-02
AU2023214307B2 (en) 2025-08-21
MX390835B (es) 2025-03-21
US20210069115A1 (en) 2021-03-11
US20190029963A1 (en) 2019-01-31
PT3981414T (pt) 2025-07-22
AU2023214307A1 (en) 2023-08-31
JP7539855B2 (ja) 2024-08-26
JP2018503696A (ja) 2018-02-08
US20230310325A1 (en) 2023-10-05
HRP20251032T1 (hr) 2025-10-24
CN117899029A (zh) 2024-04-19
JP6928768B2 (ja) 2021-09-01

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