RS61209B1 - Dobijanje plga mikrosfera napunjenih peptidima sa karakteristikama kontrolisanog oslobađanja - Google Patents

Dobijanje plga mikrosfera napunjenih peptidima sa karakteristikama kontrolisanog oslobađanja

Info

Publication number
RS61209B1
RS61209B1 RS20201537A RSP20201537A RS61209B1 RS 61209 B1 RS61209 B1 RS 61209B1 RS 20201537 A RS20201537 A RS 20201537A RS P20201537 A RSP20201537 A RS P20201537A RS 61209 B1 RS61209 B1 RS 61209B1
Authority
RS
Serbia
Prior art keywords
preparation
controlled release
release characteristics
plga microspheres
peptide loaded
Prior art date
Application number
RS20201537A
Other languages
English (en)
Inventor
Evangelos Karavas
Efthymios Koutris
Katerina Minioti
Sotiria Chaitidou
Georgia Papanikolaou
Theofanis Mantourlias
Original Assignee
Pharmathen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmathen Sa filed Critical Pharmathen Sa
Publication of RS61209B1 publication Critical patent/RS61209B1/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RS20201537A 2014-03-31 2014-03-31 Dobijanje plga mikrosfera napunjenih peptidima sa karakteristikama kontrolisanog oslobađanja RS61209B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2014/000858 WO2015149820A1 (en) 2014-03-31 2014-03-31 Preparation of peptide loaded plga microspheres with controlled release characteristics
EP14717411.4A EP3125871B1 (en) 2014-03-31 2014-03-31 Preparation of peptide loaded plga microspheres with controlled release characteristics

Publications (1)

Publication Number Publication Date
RS61209B1 true RS61209B1 (sr) 2021-01-29

Family

ID=50486884

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20201537A RS61209B1 (sr) 2014-03-31 2014-03-31 Dobijanje plga mikrosfera napunjenih peptidima sa karakteristikama kontrolisanog oslobađanja

Country Status (22)

Country Link
US (1) US9943483B2 (sr)
EP (1) EP3125871B1 (sr)
JP (1) JP6494657B2 (sr)
KR (1) KR102218655B1 (sr)
CN (2) CN106170284A (sr)
AU (1) AU2014389015B2 (sr)
BR (1) BR112016022550B1 (sr)
CA (1) CA2944561C (sr)
CY (1) CY1124037T1 (sr)
DK (1) DK3125871T3 (sr)
EA (1) EA032580B1 (sr)
ES (1) ES2837044T3 (sr)
HR (1) HRP20210058T1 (sr)
HU (1) HUE052289T2 (sr)
LT (1) LT3125871T (sr)
MX (1) MX371139B (sr)
PL (1) PL3125871T3 (sr)
PT (1) PT3125871T (sr)
RS (1) RS61209B1 (sr)
SI (1) SI3125871T1 (sr)
WO (1) WO2015149820A1 (sr)
ZA (1) ZA201607413B (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2932532C (en) 2012-12-04 2021-06-22 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
CN107106499B (zh) * 2014-11-02 2021-09-17 纳诺精密医疗有限公司 用于延长释放治疗剂的可植入医药装置
KR102068578B1 (ko) * 2016-08-16 2020-01-21 중앙대학교 산학협력단 세포전달을 위한 다공성 마이크로스피어 및 이의 제조방법
CN110139826A (zh) * 2016-12-12 2019-08-16 法斯瑞斯公司 具有负的表面电荷的微粒和纳米颗粒
CN108113975B (zh) * 2018-02-02 2020-10-09 中国人民解放军军事科学院军事医学研究院 一种基于涡漩振荡器的plga微球制备方法及其应用
KR101936040B1 (ko) * 2018-04-23 2019-01-08 주식회사 씨트리 안정화된 단상 혼합액을 이용하는 생분해성 미립구의 제조방법
CN109106688B (zh) * 2018-08-22 2021-08-17 丽珠医药集团股份有限公司 一种醋酸奥曲肽微球的制备方法
KR102181231B1 (ko) * 2018-11-22 2020-11-20 주식회사 메디포럼제약 로티고틴 함유 고분자 미립자의 제조방법
JP2021147329A (ja) * 2020-03-16 2021-09-27 株式会社リコー 粒子の製造方法
US20210346296A1 (en) * 2020-05-08 2021-11-11 M. Technique Co., Ltd. A biologically active substance uniformly dispersed microsphere and a sustained release formulation comprising the same
US11617720B2 (en) 2020-05-08 2023-04-04 M. Technique Co., Ltd. Main agent uniformly dispersed microsphere and a sustained release formulation comprising the same
JP6810502B1 (ja) * 2020-05-08 2021-01-06 エム・テクニック株式会社 生理活性物質が均一に分散されたマイクロスフェアー及びそれを含有する徐放性製剤
US11865213B2 (en) * 2021-07-05 2024-01-09 Mapi Pharma Ltd. Semaglutide depot systems and use thereof
CN116139256A (zh) * 2023-03-14 2023-05-23 复旦大学附属肿瘤医院 生长抑素/生长抑素类似物缓释膜及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US5538739A (en) 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
US6913767B1 (en) * 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US6902743B1 (en) * 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
WO2001010414A1 (en) 1999-08-04 2001-02-15 Oakwood Laboratories L.L.C. Slow release microspheres
WO2005110369A2 (en) * 2004-04-30 2005-11-24 American Pharmaceutical Partners, Inc. Sustained-release microspheres and methods of making and using same
US20100086597A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for the sustained release of octreotide with a low initial burst
US20100086596A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for releasing an octreotide compound without an initial time lag
US20100151033A1 (en) * 2008-12-15 2010-06-17 Novartis Ag Octreotide depot formulation with constantly high exposure levels

Also Published As

Publication number Publication date
ES2837044T3 (es) 2021-06-29
CN114191538A (zh) 2022-03-18
HRP20210058T1 (hr) 2021-03-05
CN106170284A (zh) 2016-11-30
MX2016012846A (es) 2017-05-09
ZA201607413B (en) 2018-11-28
SI3125871T1 (sl) 2021-03-31
LT3125871T (lt) 2020-12-28
CY1124037T1 (el) 2022-03-24
BR112016022550A2 (sr) 2017-08-15
EA201691884A1 (ru) 2017-02-28
JP6494657B2 (ja) 2019-04-03
EP3125871B1 (en) 2020-10-21
US20170281547A1 (en) 2017-10-05
AU2014389015B2 (en) 2019-05-09
CA2944561C (en) 2019-06-18
KR20160137608A (ko) 2016-11-30
WO2015149820A1 (en) 2015-10-08
MX371139B (es) 2020-01-20
EP3125871A1 (en) 2017-02-08
US9943483B2 (en) 2018-04-17
BR112016022550B1 (pt) 2023-03-28
EA032580B1 (ru) 2019-06-28
CA2944561A1 (en) 2015-10-08
KR102218655B1 (ko) 2021-02-22
PT3125871T (pt) 2021-01-06
JP2017509661A (ja) 2017-04-06
HUE052289T2 (hu) 2021-04-28
AU2014389015A1 (en) 2016-09-29
PL3125871T3 (pl) 2021-04-19
DK3125871T3 (da) 2020-12-21

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