RS51818B - Supstituisani karboksamidi kao antagonisti grupe i metabotrofičnih receptora - Google Patents

Supstituisani karboksamidi kao antagonisti grupe i metabotrofičnih receptora

Info

Publication number
RS51818B
RS51818B RS20110336A RSP20110336A RS51818B RS 51818 B RS51818 B RS 51818B RS 20110336 A RS20110336 A RS 20110336A RS P20110336 A RSP20110336 A RS P20110336A RS 51818 B RS51818 B RS 51818B
Authority
RS
Serbia
Prior art keywords
formula
compound
mmol
phenyl
pain
Prior art date
Application number
RS20110336A
Other languages
English (en)
Serbian (sr)
Inventor
Matthew Joseph Fisher
Sean Patrick Hollinshead
Ryan Thomas Backer
Steven Lee Kuklish
Edward C.R. Smith
Kumiko Takeuchi
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RS51818B publication Critical patent/RS51818B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20110336A 2006-06-08 2007-06-07 Supstituisani karboksamidi kao antagonisti grupe i metabotrofičnih receptora RS51818B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81183906P 2006-06-08 2006-06-08

Publications (1)

Publication Number Publication Date
RS51818B true RS51818B (sr) 2011-12-31

Family

ID=39673278

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20110336A RS51818B (sr) 2006-06-08 2007-06-07 Supstituisani karboksamidi kao antagonisti grupe i metabotrofičnih receptora

Country Status (30)

Country Link
US (1) US7960419B2 (https=)
EP (1) EP2076502B1 (https=)
JP (1) JP5108878B2 (https=)
KR (1) KR101051559B1 (https=)
CN (1) CN101466691B (https=)
AT (1) ATE509921T1 (https=)
AU (1) AU2007347428B2 (https=)
BR (1) BRPI0712862A2 (https=)
CA (1) CA2652074C (https=)
CR (1) CR10410A (https=)
CY (1) CY1111588T1 (https=)
DK (1) DK2076502T3 (https=)
EA (1) EA014233B1 (https=)
EC (1) ECSP088939A (https=)
ES (1) ES2362949T3 (https=)
HR (1) HRP20110436T1 (https=)
IL (1) IL195632A (https=)
MA (1) MA30620B1 (https=)
MX (1) MX2008015485A (https=)
MY (1) MY148084A (https=)
NO (1) NO341474B1 (https=)
NZ (1) NZ573352A (https=)
PL (1) PL2076502T3 (https=)
PT (1) PT2076502E (https=)
RS (1) RS51818B (https=)
SI (1) SI2076502T1 (https=)
TN (1) TNSN08506A1 (https=)
UA (1) UA95480C2 (https=)
WO (1) WO2008103185A2 (https=)
ZA (1) ZA200809111B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
CA2720631C (en) 2008-04-04 2012-08-28 Eli Lilly And Company 3-indazolyl-4-pyridylisothiazoles
EP2443113A1 (en) * 2009-06-15 2012-04-25 The University Of Edinburgh Amido-isothiazole compounds and their use as inhibitors of 11beta-hsd1 for the treatment of metabolic syndrome and related disorders
EP2477983B1 (en) 2009-09-16 2015-04-15 The University Of Edinburgh (4-phenyl-piperidin-1-yl)-[5-1h-pyrazol-4yl)-thiophen-3-yl]-methanone compounds and their use
WO2011135276A1 (en) 2010-04-29 2011-11-03 The University Of Edinburgh 3, 3 -disubstituted- ( 8 - aza - bicyclo [3.2.1] oct- 8 - yl) -[5- (1h - pyrazol - 4 -yl) -thiophen-3 -yl] methanones as inhibitors of 11 (beta) -hsd1
ES2641469T3 (es) 2012-11-13 2017-11-10 Nissan Chemical Industries, Ltd. Compuesto de 2-piridona
WO2018054846A1 (de) 2016-09-23 2018-03-29 Bayer Aktiengesellschaft N3-cyclisch substituierte thienouracile und ihre verwendung
CN117567266B (zh) * 2023-11-07 2024-06-14 康龙化成手性医药技术(宁波)有限公司 一种制备2-甲基环丙羧酸的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72091A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-aryl 5-isothiazolyl)urea derivatives
DE4328425A1 (de) * 1993-08-24 1995-03-02 Basf Ag Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung
DK124393D0 (da) * 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
DE19542372A1 (de) * 1995-11-14 1997-05-15 Bayer Ag Acylierte 5-Aminoisothiazole
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP3411262B2 (ja) * 1999-08-20 2003-05-26 萬有製薬株式会社 新規スピロ化合物
EP1435948A1 (en) * 2001-08-06 2004-07-14 Pharmacia Italia S.p.A. Aminoisoxazole derivatives active as kinase inhibitors
WO2005030128A2 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Pyrazole modulators of metabotropic glutamate receptors
WO2005113534A2 (en) * 2004-05-12 2005-12-01 Schering Corporation Cxcr1 and cxcr2 chemokine antagonists
JP2008513434A (ja) * 2004-09-23 2008-05-01 ファイザー・プロダクツ・インク トロンボポイエチン受容体アゴニスト

Also Published As

Publication number Publication date
UA95480C2 (uk) 2011-08-10
SI2076502T1 (sl) 2011-09-30
CA2652074C (en) 2013-08-06
EP2076502B1 (en) 2011-05-18
IL195632A (en) 2013-11-28
IL195632A0 (en) 2009-09-01
NO341474B1 (no) 2017-11-27
JP2009539874A (ja) 2009-11-19
KR20090008460A (ko) 2009-01-21
MX2008015485A (es) 2009-03-06
CA2652074A1 (en) 2008-08-28
CN101466691B (zh) 2011-07-27
WO2008103185A2 (en) 2008-08-28
PT2076502E (pt) 2011-06-07
MY148084A (en) 2013-02-28
HK1131984A1 (en) 2010-02-12
BRPI0712862A2 (pt) 2012-12-18
PL2076502T3 (pl) 2011-09-30
ZA200809111B (en) 2009-12-30
TNSN08506A1 (en) 2010-04-14
HRP20110436T1 (hr) 2011-08-31
NO20085028L (no) 2008-12-02
MA30620B1 (fr) 2009-08-03
US7960419B2 (en) 2011-06-14
CN101466691A (zh) 2009-06-24
EP2076502A2 (en) 2009-07-08
EA200870516A1 (ru) 2009-06-30
NZ573352A (en) 2011-10-28
DK2076502T3 (da) 2011-07-25
JP5108878B2 (ja) 2012-12-26
AU2007347428A1 (en) 2008-08-28
CR10410A (es) 2008-11-28
ES2362949T3 (es) 2011-07-15
KR101051559B1 (ko) 2011-07-22
CY1111588T1 (el) 2015-10-07
AU2007347428B2 (en) 2012-02-09
US20090182025A1 (en) 2009-07-16
ATE509921T1 (de) 2011-06-15
WO2008103185A3 (en) 2008-10-30
ECSP088939A (es) 2009-01-30
EA014233B1 (ru) 2010-10-29

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