RS50758B - Postupak za dobijanje proizvoda tipa tiazolo (3,4,5-de) (4,1) benzotiazepina - Google Patents

Postupak za dobijanje proizvoda tipa tiazolo (3,4,5-de) (4,1) benzotiazepina

Info

Publication number
RS50758B
RS50758B RSP-2009/0238A RSP20090238A RS50758B RS 50758 B RS50758 B RS 50758B RS P20090238 A RSP20090238 A RS P20090238A RS 50758 B RS50758 B RS 50758B
Authority
RS
Serbia
Prior art keywords
trifluoromethyl
benzothiazepine
dihydro
thiazolo
imino
Prior art date
Application number
RSP-2009/0238A
Other languages
English (en)
Inventor
Stéphane Mutti
Michel Lavigne
Michel Cheve
Joel Malpart
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of RS50758B publication Critical patent/RS50758B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Postupak za dobijanje metansulfonata 6,6-dioksida 2-imino-9-trifluorometil-4,5-dihidro-2H,7H-tiazolo[3,4,5-de][4,l]benzotiazepina karakterističan po tome što:a) 4-trifluorometilanilin I se zaštiti u prisustvu di-terc-butil dikarbonata u monohlorobenzenu na refluksu zatim,b) 4-trifluorometil fenilkarbamat terc-butila izolovan u prethodnoj etapi se transformiše u 2-hidroksimetil-4-trifluorometil fenilkarbamat bez izolovanja intermedijera 2-formil-4-trifluorometil fenilkarbamata zatim,c) 2-hidroksimetil-4-trifluorometil fenilkarbamat izolovan u prethodnoj etapi se transformiše direktno u 7 -trifluorometil-1,5-dihidro-3H-[4,l]benzotiazepin-2-on u prisustvu kiseline tioglikolne ijedne katalitičke količine kiseline p-toluen sulfonske zatim,d) 7-trifluorometil-l,5-dihidro-3H-[4,l]benzotiazepin-2-on izolovan u prethodnoj etapi se redukuje kako bi se dobio 7 -trifluorometil-1,2,3,5-tetrahidro-[4,l]benzotiazepin zatim,e) 7 -trifluorometil-l,2,3,5-tetrahidro-[4,l]benzotiazepin izolovan u prethodnoj etapi se transformiše u bromhidrat 2-imino-9-trifluorometil-4,5-dihidro-2H,7H-tiazolo[3,4,5-de][4,l]benzotiazepina u prisustvu broma, kalijum tiocijanata u sirćetnoj kiselini zatim,f) bromhidrat 2-imino-9-trifluorometil-4,5-dihidro-2H,7H-tiazolo[3,4,5-de][4, ljbenzotiazepina se oksidiše u 6,6-dioksid 2-imino-9-trifluorometil-4,5-dihidro-2H,7H-tiazolo[3,4,5-de][4,l]benzotiazepina zatim se transformiše u prisustvu kiseline metan sulfonske u metansulfonat 6,6-dioksida 2-imino-9-trifluorometil-4,5-dihidro-2H.7H-tiazolo[3,4,5-de] [4,1 jbenzo-tiazepina.Prijava sadrži još 14 zavisnih patentnih zahteva.
RSP-2009/0238A 2003-12-12 2004-12-07 Postupak za dobijanje proizvoda tipa tiazolo (3,4,5-de) (4,1) benzotiazepina RS50758B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0314574A FR2863612B1 (fr) 2003-12-12 2003-12-12 PROCEDE DE FABRICATION DE PRODUIT DE TYPE THIAZOLO[3,4,5-de] [4,1]BENZOTHIAZEPINE
PCT/FR2004/003138 WO2005066146A1 (fr) 2003-12-12 2004-12-07 Procede de fabrication de produit de type thiazolo[3,4,5-de][4,1]benzothiazepine

Publications (1)

Publication Number Publication Date
RS50758B true RS50758B (sr) 2010-08-31

Family

ID=34610602

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0238A RS50758B (sr) 2003-12-12 2004-12-07 Postupak za dobijanje proizvoda tipa tiazolo (3,4,5-de) (4,1) benzotiazepina

Country Status (17)

Country Link
EP (1) EP1694658B1 (sr)
JP (1) JP2007519621A (sr)
AR (1) AR046872A1 (sr)
AT (1) ATE423773T1 (sr)
CY (1) CY1109046T1 (sr)
DE (1) DE602004019678D1 (sr)
DK (1) DK1694658T3 (sr)
ES (1) ES2322857T3 (sr)
FR (1) FR2863612B1 (sr)
HR (1) HRP20090237T1 (sr)
PL (1) PL1694658T3 (sr)
PT (1) PT1694658E (sr)
RS (1) RS50758B (sr)
SI (1) SI1694658T1 (sr)
TW (1) TW200530256A (sr)
UY (1) UY28665A1 (sr)
WO (1) WO2005066146A1 (sr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3810450B2 (ja) * 1993-09-24 2006-08-16 武田薬品工業株式会社 縮合環化合物とその用途
JPH08259447A (ja) * 1995-03-24 1996-10-08 Takeda Chem Ind Ltd コレシストキニン拮抗剤
FR2766487B1 (fr) * 1997-07-28 1999-08-27 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant

Also Published As

Publication number Publication date
TW200530256A (en) 2005-09-16
AR046872A1 (es) 2005-12-28
SI1694658T1 (sl) 2009-08-31
HRP20090237T1 (en) 2009-06-30
WO2005066146A1 (fr) 2005-07-21
CY1109046T1 (el) 2014-07-02
EP1694658A1 (fr) 2006-08-30
DE602004019678D1 (de) 2009-04-09
UY28665A1 (es) 2005-07-29
ATE423773T1 (de) 2009-03-15
JP2007519621A (ja) 2007-07-19
DK1694658T3 (da) 2009-06-15
EP1694658B1 (fr) 2009-02-25
PT1694658E (pt) 2009-04-23
PL1694658T3 (pl) 2009-07-31
ES2322857T3 (es) 2009-06-30
FR2863612A1 (fr) 2005-06-17
FR2863612B1 (fr) 2006-03-03

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