RS20050955A - Dna-based aptamers for human cathepsin g - Google Patents

Dna-based aptamers for human cathepsin g

Info

Publication number
RS20050955A
RS20050955A YUP-2005/0955A YUP20050955A RS20050955A RS 20050955 A RS20050955 A RS 20050955A YU P20050955 A YUP20050955 A YU P20050955A RS 20050955 A RS20050955 A RS 20050955A
Authority
RS
Serbia
Prior art keywords
cathepsin
dna
human cathepsin
based aptamers
chaing
Prior art date
Application number
YUP-2005/0955A
Other languages
English (en)
Inventor
Roberto Porta
Manlio Palumbo
Barbara Gatto
Rodolfo Pescador
Laura Iris Ferro
Original Assignee
Gentium Spa,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentium Spa, filed Critical Gentium Spa,
Publication of RS20050955A publication Critical patent/RS20050955A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Predmetni pronalazak se odnosi na identifikaciju nepeptidnih inhibitora katepsina okarakterisanih visokim nivoom selektivnosti i koji se efikasno mogu koristiti u lečenje i profilaksi inflamatornih pojavljivanja i prokoagulnantnih stanja. Katepsin G-inhibirajući aptameri prema pronalasku , sastoje se od linearne DNK ili polinukepotidnih sekvenci sa dužinom lanca od njamanje 60 nukepotida i u suštini nisu podvrgnuti efikasnom sparivanju baza.
YUP-2005/0955A 2003-06-30 2004-06-18 Dna-based aptamers for human cathepsin g RS20050955A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03425428A EP1493810A1 (en) 2003-06-30 2003-06-30 DNA-based aptamers for human cathepsin G
PCT/EP2004/006599 WO2005003347A2 (en) 2003-06-30 2004-06-18 Dna-based aptamers for human cathepsin g

Publications (1)

Publication Number Publication Date
RS20050955A true RS20050955A (en) 2008-06-05

Family

ID=33427291

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0955A RS20050955A (en) 2003-06-30 2004-06-18 Dna-based aptamers for human cathepsin g

Country Status (16)

Country Link
US (2) US20060148745A1 (sr)
EP (3) EP1493810A1 (sr)
JP (2) JP2007506413A (sr)
KR (1) KR20060035624A (sr)
CN (1) CN1816625A (sr)
AU (1) AU2004254014B2 (sr)
BR (1) BRPI0412081A (sr)
CA (1) CA2528686A1 (sr)
IL (1) IL172407A0 (sr)
IS (1) IS8176A (sr)
MX (1) MXPA05013800A (sr)
NO (1) NO20060429L (sr)
RS (1) RS20050955A (sr)
RU (1) RU2360000C2 (sr)
WO (1) WO2005003347A2 (sr)
ZA (1) ZA200510093B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI482857B (zh) * 2013-10-21 2015-05-01 Nat Univ Tsing Hua 針對糖化血紅素及血紅素具有高專一性的適合體及其應用
EP3193906B1 (en) * 2014-09-18 2020-11-11 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin Use of peptide inhibitors of il-36 proteolytic processing for the treatment and/or reduction of inflammation
RU2683868C1 (ru) * 2018-11-30 2019-04-02 Акционерное общество "Молочный комбинат "Ставропольский" Способ производства молочного сахара

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE318832T1 (de) 1990-06-11 2006-03-15 Gilead Sciences Inc Verfahren zur vervendung von nukleinsäureliganden
EP0572529A4 (en) * 1991-02-21 1994-11-02 Gilead Sciences Inc SPECIFIC APTAMER OF BIOMOLECULES AND PROCESS FOR PRODUCING THE SAME.
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
DE69738454D1 (de) * 1996-05-20 2008-02-21 Us Gov Health & Human Serv Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
AU5492499A (en) * 1998-08-21 2000-03-14 University Of Virginia Patent Foundation Signal generating oligonucleotide-based biosensor
AUPQ051099A0 (en) * 1999-05-24 1999-06-17 Tachas, George Dr Novel products and processes in treatment and/or prophylaxis

Also Published As

Publication number Publication date
JP2007506413A (ja) 2007-03-22
US20060148745A1 (en) 2006-07-06
ZA200510093B (en) 2008-04-30
AU2004254014B2 (en) 2010-06-10
JP2011078414A (ja) 2011-04-21
NO20060429L (no) 2006-01-26
WO2005003347A2 (en) 2005-01-13
EP2236609A3 (en) 2011-07-20
US7838506B2 (en) 2010-11-23
IL172407A0 (en) 2006-04-10
RU2006102521A (ru) 2006-06-27
EP1493810A1 (en) 2005-01-05
AU2004254014A1 (en) 2005-01-13
EP2236609A2 (en) 2010-10-06
MXPA05013800A (es) 2006-06-27
CN1816625A (zh) 2006-08-09
EP1618196A2 (en) 2006-01-25
US20080176814A1 (en) 2008-07-24
IS8176A (is) 2005-12-12
WO2005003347A3 (en) 2005-09-15
KR20060035624A (ko) 2006-04-26
BRPI0412081A (pt) 2006-09-05
RU2360000C2 (ru) 2009-06-27
CA2528686A1 (en) 2005-01-13

Similar Documents

Publication Publication Date Title
PL1974039T3 (pl) Żywność o niskiej zawartości akryloamidu
MX2009011256A (es) Nuevas asparaginasas y sus usos.
NZ594755A (en) Cyclosporin analogues for preventing or treating hepatitis c infection
MY140031A (en) Carbonyl compounds
EP1596854A4 (en) TREATMENT OF DISEASES RELATED TO REDUCED STICK OXIDE BIOVERABILITY, INCLUDING INCREASED ARGINASE
MXPA05011707A (es) Dihidroquinazolinas sustituidas con propiedades antivirales.
YU84603A (sh) Novi inhibitori tirozin kinaze
SI1983000T1 (sl) Postopek za zdravljenje multiple skleroze z zaviranjem aktivnosti il-17
CY1111645T1 (el) Συνθετικα ολιγονουκλεοτιδια διπλης ελικας για την στοχευμενη αναστολη της γονιδιακης εκφρασης
ATE460481T1 (de) Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung
TW200510334A (en) Preraration and use of aryl alkyl acid derivatives for the treatment of obesity
GB0209891D0 (en) Novel compounds
BR0315689A (pt) Alvo para terapia de dano cognitivo
MY142988A (en) Novel aminobenzophenone compounds
RS20050744A (en) Benzopyran compounds useful for treating inflammatory conditions
TW200700057A (en) Alpha ketoamide compounds as cysteine protease inhibitors
ATE268745T1 (de) Verfahren und vorrichtung zur nutzung der bei der herstellung von 1,2-dichlorethan anfallenden reaktionswärme
RS20050955A (en) Dna-based aptamers for human cathepsin g
DE602005005675D1 (de) Verfahren zum trennen und reinigen von cäsium-131 von bariumnitrat
GB0300718D0 (en) Proteins
ITMI20051991A1 (it) Purificazione di prodotti beta-lattamici
RS33304A (en) Phosphonic and compounds as inhibitors of serine proteases
EA200301299A1 (ru) Применение ингибиторов il-18 для лечения и предотвращения повреждений цнс
IL169256A0 (en) Metalloprotease proteins
MXPA04000805A (es) Peptidos que tienen actividad antiangiogenica.