CY1111645T1 - Συνθετικα ολιγονουκλεοτιδια διπλης ελικας για την στοχευμενη αναστολη της γονιδιακης εκφρασης - Google Patents

Συνθετικα ολιγονουκλεοτιδια διπλης ελικας για την στοχευμενη αναστολη της γονιδιακης εκφρασης

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Publication number
CY1111645T1
CY1111645T1 CY20111100021T CY111100021T CY1111645T1 CY 1111645 T1 CY1111645 T1 CY 1111645T1 CY 20111100021 T CY20111100021 T CY 20111100021T CY 111100021 T CY111100021 T CY 111100021T CY 1111645 T1 CY1111645 T1 CY 1111645T1
Authority
CY
Cyprus
Prior art keywords
gene expression
double
synthetic composition
targeted inhibition
elisa
Prior art date
Application number
CY20111100021T
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English (en)
Inventor
Eugen Uhlmann
Jochen Huber
Niki Gunkel
Sandra Neumann
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of CY1111645T1 publication Critical patent/CY1111645T1/el

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/319—Chemical structure of the backbone linked by 2'-5' linkages, i.e. having a free 3'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η εφεύρεση αφορά παράγωγα ολιγονουκλεοτιδίων, τα οποία τουλάχιστον εν μέρει είναι διπλής έλικας και τα οποία σε τουλάχιστον ένα 3'-άκρο περιλαμβάνει μία 2'5'-συζευγμένη ρίζα ολιγονουκλεοτιδίου, καθώς και τη χρήση τους με σκοπό τη στοχευμένη αναστολή της γονιδιακής έκφρασης.
CY20111100021T 2001-07-12 2011-01-04 Συνθετικα ολιγονουκλεοτιδια διπλης ελικας για την στοχευμενη αναστολη της γονιδιακης εκφρασης CY1111645T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10133858A DE10133858A1 (de) 2001-07-12 2001-07-12 Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
EP02743264A EP1409670B1 (de) 2001-07-12 2002-07-05 Synthetische doppelsträngige oligonucleotide zur gezielten hemmung der genexpression

Publications (1)

Publication Number Publication Date
CY1111645T1 true CY1111645T1 (el) 2015-10-07

Family

ID=7691504

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100021T CY1111645T1 (el) 2001-07-12 2011-01-04 Συνθετικα ολιγονουκλεοτιδια διπλης ελικας για την στοχευμενη αναστολη της γονιδιακης εκφρασης

Country Status (14)

Country Link
US (1) US8772469B2 (el)
EP (1) EP1409670B1 (el)
JP (1) JP4643906B2 (el)
AT (1) ATE484586T1 (el)
AU (1) AU2002345089B2 (el)
CA (1) CA2453301C (el)
CY (1) CY1111645T1 (el)
DE (2) DE10133858A1 (el)
DK (1) DK1409670T3 (el)
ES (1) ES2354062T3 (el)
IL (2) IL159758A0 (el)
MX (1) MXPA04000179A (el)
PT (1) PT1409670E (el)
WO (1) WO2003008576A2 (el)

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Also Published As

Publication number Publication date
EP1409670B1 (de) 2010-10-13
CA2453301A1 (en) 2003-01-30
EP1409670A2 (de) 2004-04-21
ATE484586T1 (de) 2010-10-15
PT1409670E (pt) 2011-01-12
US8772469B2 (en) 2014-07-08
US20030139585A1 (en) 2003-07-24
DK1409670T3 (da) 2011-02-07
IL159758A (en) 2010-12-30
JP4643906B2 (ja) 2011-03-02
AU2002345089B2 (en) 2007-04-05
CA2453301C (en) 2013-05-28
JP2004535204A (ja) 2004-11-25
WO2003008576A2 (de) 2003-01-30
WO2003008576A3 (de) 2003-10-23
DE50214715D1 (de) 2010-11-25
ES2354062T3 (es) 2011-03-09
IL159758A0 (en) 2004-06-20
MXPA04000179A (es) 2004-03-18
DE10133858A1 (de) 2003-02-06

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