RO97963B1 - Procedeu de obtinere a etilsuccinatului de eritromicina - Google Patents
Procedeu de obtinere a etilsuccinatului de eritromicinaInfo
- Publication number
- RO97963B1 RO97963B1 RO128740A RO12874087A RO97963B1 RO 97963 B1 RO97963 B1 RO 97963B1 RO 128740 A RO128740 A RO 128740A RO 12874087 A RO12874087 A RO 12874087A RO 97963 B1 RO97963 B1 RO 97963B1
- Authority
- RO
- Romania
- Prior art keywords
- erythromycin ethylsuccinate
- erythromycin
- solution
- chloride
- ethylsuccinate
- Prior art date
Links
- 229960000741 erythromycin ethylsuccinate Drugs 0.000 title abstract 3
- NSYZCCDSJNWWJL-YXOIYICCSA-N erythromycin ethylsuccinate Chemical compound O1[C@H](C)C[C@H](N(C)C)[C@@H](OC(=O)CCC(=O)OCC)[C@@H]1O[C@H]1[C@@](O)(C)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)[C@@H]1C NSYZCCDSJNWWJL-YXOIYICCSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- XFKCVVFQGHCLIP-UHFFFAOYSA-N 2-ethylbutanedioyl dichloride Chemical compound CCC(C(Cl)=O)CC(Cl)=O XFKCVVFQGHCLIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002002 slurry Substances 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia de fata se refera la un procedeu de obtinere a etilsuccinatului de eritromicina prin acilarea solutiei de eritromicina în clorura de metilen sau cloroform, cu clorura de monoetil succinil sub forma de solutie în solventii mentionati mai sus,în prezenta de bicarbonat de sodiu la un raport de 2,5....3,5 moli/moli de clorura acida, la temperatura de 0...27 degree C, se izoleaza produsul de reactie prin filtrarea precipitatului rezultat, care apoi se suspenda în apa rece în cantitate de 1 g la 15 ...30 ml, se filtreaza suspensia si se usuca la presiune redusa, la temperatura de 20...30 degree C. Procedeul este simplu si permite utilizarea etilsuccinatului de eritromicina pentru uz farmaceutic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128740A RO97963B1 (ro) | 1987-06-24 | 1987-06-24 | Procedeu de obtinere a etilsuccinatului de eritromicina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO128740A RO97963B1 (ro) | 1987-06-24 | 1987-06-24 | Procedeu de obtinere a etilsuccinatului de eritromicina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO97963B1 true RO97963B1 (ro) | 1989-10-30 |
Family
ID=40906087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO128740A RO97963B1 (ro) | 1987-06-24 | 1987-06-24 | Procedeu de obtinere a etilsuccinatului de eritromicina |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO97963B1 (ro) |
-
1987
- 1987-06-24 RO RO128740A patent/RO97963B1/ro unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69021455D1 (de) | Verfahren zur Herstellung von Ascorbinsäure. | |
| JPS51136646A (en) | Production of phenylalkane carboxylic acid and blood sugar and lipid lowering agent containing same | |
| OA05897A (fr) | Procédé d'obtention d'alumine pure par attaque acide de minerais alumineux contenant d'autres éléments. | |
| RO97963B1 (ro) | Procedeu de obtinere a etilsuccinatului de eritromicina | |
| FR2401144A1 (fr) | Derives de benzimidazole contenant du soufre, procede pour leur preparation et intermediaires utiles pour leur production | |
| FR2429770A1 (fr) | Aglycones derivant de glycosides d'anthracycline et procede pour les preparer | |
| CH540295A (fr) | Procédé de séparation de la bétaïne d'une solution aqueuse contenant des impuretés | |
| FR2398049A1 (fr) | Nouveaux analogues de l'angiotensine ii et procede permettant de les preparer | |
| GB1216975A (en) | Process for the production of watersoluble dyes and optical brighteners | |
| TW305845B (ro) | ||
| ES373916A1 (es) | Procedimiento para la obtencion de monohidrato de carbonatosodico. | |
| ES8303418A1 (es) | Un procedimiento para la preparacion de derivados de benzo (4,5 pinano 2,3c) pirrol. | |
| Guthrie et al. | 490. Periodate oxidation. Part I. Structure and some reactions of periodate-oxidised methyl 4: 6-O-benzylidene-α-D-glucoside | |
| KR910009816B1 (ko) | 피리딘 유도체의 제조방법 | |
| SU508212A3 (ru) | Способ получени производных хитозана | |
| SU430547A1 (ru) | Способ получепия бензол сульфонил семи карбазидов | |
| RO67533B (ro) | Procedeu pentru prepararea unor derivati de 3-triaziniltiometilcefalosporina | |
| SU447405A1 (ru) | Способ получени 3-алкиламино или 3-диалкиламино-4-хлорпиридин- -оксидов | |
| BE822369A (fr) | Procede de preparation du chlorure de l'acide alpha-chloro-acrylique | |
| RO94048B1 (ro) | Procedeu pentru obtinerea 3'-clor-4'(p-clor) fenoxi-3,5-diiodsalicilanilidei microparticule | |
| GB1341921A (en) | Process for the preparation of semisynthetic penicillins | |
| GB1476919A (en) | Process for the preparation of n-acetoacetyl-2,5-dimethoxy- 4-chloroanilide | |
| SU69007A1 (ru) | Способ выделени сульфидина | |
| Li et al. | The synthesis of bis (benzo-15-crown-5) derivatives and their use in potassium-PVC membrane electrodes | |
| SU803861A3 (ru) | Способ получени соли памоиновойКиСлОТы и пилОКАРпиНА |