RO95481B1 - Procedeu pentru prepararea 2-clor-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo[d,g] [1,3,6] dioxazocinei optic active - Google Patents
Procedeu pentru prepararea 2-clor-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo[d,g] [1,3,6] dioxazocinei optic activeInfo
- Publication number
- RO95481B1 RO95481B1 RO125920A RO12592086A RO95481B1 RO 95481 B1 RO95481 B1 RO 95481B1 RO 125920 A RO125920 A RO 125920A RO 12592086 A RO12592086 A RO 12592086A RO 95481 B1 RO95481 B1 RO 95481B1
- Authority
- RO
- Romania
- Prior art keywords
- optically active
- dioxazocine
- dibenzo
- methylpropyl
- chloro
- Prior art date
Links
- SQODSURYUNVIBL-UHFFFAOYSA-N 3-(3-chlorobenzo[d][1,3,6]benzodioxazocin-5-yl)-n,n,2-trimethylpropan-1-amine Chemical compound O1COC2=CC=C(Cl)C=C2N(CC(CN(C)C)C)C2=CC=CC=C21 SQODSURYUNVIBL-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 6
- -1 2-chloro-12- (3-diethylamino-2-methylpropyl) -12H-dibenzo [d, g] [1,3,6] dioxazocine Chemical compound 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- MNPXCHCSWCJIDS-UHFFFAOYSA-N dioxazocine Chemical class C1=CC=NOOC=C1 MNPXCHCSWCJIDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea 2-clor-12-(3-dietilamino-2- metilpropil)-12H-dibenzo[d,g][1,3,6]dioxazocinei optic active prin tratarea produsului racemic cu un acid organic optic activ. Inventia consta în aceea ca 2-clor-12-(3-dimetilamino-2-metil- propil)-12H-dibenzo[d,g][1,3,6]dioxazocina racemica, sub forma de suspensie apoasa sau solutie în diclormetan, se agita la temperatura camerei cu acid tartric optic activ, în raport molar de 1:...1,1, obtinîndu-se tartratul opticactiv al derivatului de dioxazocina, care se filtreaza si se usuca, dupa care se dizolva în amestec de apa:diclormetan 1:1, se adauga sub agitare solutie apoasa de amoniac 25% pîna la atingerea pH-ului 10, se separa faza organica si se îndeparteaza solventul sub presiune redusa, iar reziduul vîscos se dizolva în izopropanol, se raceste la 0 degree C cu formarea de cristale care se filtreaza si usuca, dupa care, daca se doreste, enantiometrul obtinut se poate transforma într-o sare de aditie acida, farmaceutic acceptabila, prin metode cunoscute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO125920A RO95481B1 (ro) | 1986-12-17 | 1986-12-17 | Procedeu pentru prepararea 2-clor-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo[d,g] [1,3,6] dioxazocinei optic active |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO125920A RO95481B1 (ro) | 1986-12-17 | 1986-12-17 | Procedeu pentru prepararea 2-clor-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo[d,g] [1,3,6] dioxazocinei optic active |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO95481B1 true RO95481B1 (ro) | 1988-09-16 |
Family
ID=40904766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO125920A RO95481B1 (ro) | 1986-12-17 | 1986-12-17 | Procedeu pentru prepararea 2-clor-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo[d,g] [1,3,6] dioxazocinei optic active |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO95481B1 (ro) |
-
1986
- 1986-12-17 RO RO125920A patent/RO95481B1/ro unknown
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