RO86313B1 - Procedeu de obtinere a acidului fenilacetic - Google Patents
Procedeu de obtinere a acidului fenilaceticInfo
- Publication number
- RO86313B1 RO86313B1 RO110895A RO11089583A RO86313B1 RO 86313 B1 RO86313 B1 RO 86313B1 RO 110895 A RO110895 A RO 110895A RO 11089583 A RO11089583 A RO 11089583A RO 86313 B1 RO86313 B1 RO 86313B1
- Authority
- RO
- Romania
- Prior art keywords
- cyanide
- benzyl
- water
- mol
- sulfuric acid
- Prior art date
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 6
- 229960003424 phenylacetic acid Drugs 0.000 title abstract 3
- 239000003279 phenylacetic acid Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 abstract 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 abstract 3
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 abstract 2
- 229940073608 benzyl chloride Drugs 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 229910003556 H2 SO4 Inorganic materials 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a acidului fenilacetic, prin reactia clorurii de benzil cu cianura de sodiu si hidroliza cianurii de benzil astfel formata cu apa si acid sulfuric, caracterizata prin aceea ca se agita un amestec de cianura de sodiu, clorura de benzil, apa si alcool metilic la temperatura de reflux, timp de 4 ore, se îndepparteaza alcoolul metilic prin distilare la peresiune normala, se extrage clorura de sodiu si cianura de sodiu luata în lucru, se separa cianura de benzil bruta si se purifica preliminar prin spalare cu 2 vol solutie de NaCl 26%, cianura de benzil se distileaza la presiune redusa si apoi se supune hidrolizei cu 3-4 mol apa/mol, cianura de benzil, în prezenta acidului sulfuric concentrat în doua trepte de temperatura, în prima trapta la 90-110 degree C, cu utilizarea unui mol de acid sulfuric concentrat mol H2SO4/mol cianura de benzil în trapta a doua, hidrolizatul se suspenda îmn 2-4 vol apa, se izoleaza acidul fenilacetic brut si se purifica prin solvire la pH 6,5-7 într-o solutie de NaOH 30-40%, se decoloreaza cu 1,5% carbune activ, se cristalizeaza la pH 1-1,5 si se usuca sub vid la 45-50 degree C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110895A RO86313B1 (ro) | 1983-05-07 | 1983-05-07 | Procedeu de obtinere a acidului fenilacetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO110895A RO86313B1 (ro) | 1983-05-07 | 1983-05-07 | Procedeu de obtinere a acidului fenilacetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO86313A2 RO86313A2 (ro) | 1985-03-15 |
| RO86313B1 true RO86313B1 (ro) | 1985-03-31 |
Family
ID=20113053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO110895A RO86313B1 (ro) | 1983-05-07 | 1983-05-07 | Procedeu de obtinere a acidului fenilacetic |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO86313B1 (ro) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455557C (zh) * | 2006-09-18 | 2009-01-28 | 武汉有机实业股份有限公司 | 甲基苯乙酸的制造方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408419B (zh) * | 2013-08-19 | 2014-10-15 | 江苏九九久科技股份有限公司 | 一种处理7-adca萃取液的方法 |
-
1983
- 1983-05-07 RO RO110895A patent/RO86313B1/ro unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100455557C (zh) * | 2006-09-18 | 2009-01-28 | 武汉有机实业股份有限公司 | 甲基苯乙酸的制造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| RO86313A2 (ro) | 1985-03-15 |
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