RO85817B - Procedeu pentru prepararea de halogenuri de acizi 2-(3-arilizoxazol-5-il)-benzoici - Google Patents
Procedeu pentru prepararea de halogenuri de acizi 2-(3-arilizoxazol-5-il)-benzoiciInfo
- Publication number
- RO85817B RO85817B RO109857A RO10985780A RO85817B RO 85817 B RO85817 B RO 85817B RO 109857 A RO109857 A RO 109857A RO 10985780 A RO10985780 A RO 10985780A RO 85817 B RO85817 B RO 85817B
- Authority
- RO
- Romania
- Prior art keywords
- isoxazol
- aryl
- phosphorus
- preparing
- thionyl
- Prior art date
Links
- 150000004820 halides Chemical class 0.000 title abstract 2
- 239000005711 Benzoic acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- -1 phenoxyphenyl Chemical group 0.000 abstract 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- VSWLXYAZJZQIKA-UHFFFAOYSA-N tetrachloromethane;triphenylphosphane Chemical compound ClC(Cl)(Cl)Cl.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 VSWLXYAZJZQIKA-UHFFFAOYSA-N 0.000 abstract 1
- HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 abstract 1
- LSJNBGSOIVSBBR-UHFFFAOYSA-N thionyl fluoride Chemical compound FS(F)=O LSJNBGSOIVSBBR-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea halogenurilor de 2 (3-aril-5-izoxazol-5-il)-benzoil cu formula generala I:(vezi formula) în care X si Y sînt, independent, alesi dintr-un grup constînd din halogen, hidrogen, alchil inferior, alcoxi inferior, halogen-alchil inferior, fenoxi-fenil si cian si unde X1 este clor, brom, fluor, sau iod, conform caruia 3'-(aril)-spiro [izobenzofuran-1(3H),5'(4-izoxazol]-3-ona cu formula generala II: (vezi formula) în care X si y sînt diferiti ca mai sus, reactioneaza în prezeneta de apa, cu halogenura acida, aleasa dintr-un grup constînd din clorura de tionil, bromura de tionil, fluorura de tionil, triclorura de fosfor, tribromura de fosfor si oxi-clorura de fosfor, clorura de oxalil, tetraclorura de carbon-trifenilfosfina si oxibromura de fosfor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/013,853 US4197405A (en) | 1979-02-22 | 1979-02-22 | Thermolysis of 3'-(Aryl)-spiro[isobenzofuran-1(3H),5'(4'H)-isoxazol]-3-one |
| US06/019,049 US4223154A (en) | 1979-03-09 | 1979-03-09 | Preparation of 2-(3-aryl-5-isoxazol) benzoyl halide |
| US06/039,935 US4230866A (en) | 1979-05-17 | 1979-05-17 | Preparation of 3-aryl-isoxazol-5-yl-benzoic acid and salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85817A RO85817A (ro) | 1984-11-25 |
| RO85817B true RO85817B (ro) | 1984-11-30 |
Family
ID=27359971
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO100262A RO80464B (ro) | 1979-02-22 | 1980-02-21 | Procedeu de preparare a unor derivati ai acidului 2-(3-aril-5-il) benzoic |
| RO109857A RO85817B (ro) | 1979-02-22 | 1980-02-21 | Procedeu pentru prepararea de halogenuri de acizi 2-(3-arilizoxazol-5-il)-benzoici |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO100262A RO80464B (ro) | 1979-02-22 | 1980-02-21 | Procedeu de preparare a unor derivati ai acidului 2-(3-aril-5-il) benzoic |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0015140B1 (ro) |
| AR (1) | AR222067A1 (ro) |
| AU (1) | AU527290B2 (ro) |
| BG (3) | BG30928A3 (ro) |
| BR (1) | BR8001036A (ro) |
| CA (1) | CA1137493A (ro) |
| DD (1) | DD151062A5 (ro) |
| DE (1) | DE3065860D1 (ro) |
| DK (1) | DK75180A (ro) |
| ES (3) | ES488768A0 (ro) |
| HU (1) | HU184724B (ro) |
| IL (1) | IL59451A0 (ro) |
| MX (1) | MX5929E (ro) |
| NO (3) | NO150278C (ro) |
| PH (2) | PH14889A (ro) |
| RO (2) | RO80464B (ro) |
| TR (1) | TR20875A (ro) |
| YU (1) | YU47080A (ro) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0003906A2 (hu) * | 1997-06-19 | 2001-05-28 | Du Pont Pharmaceuticals Co. | Xa faktort gátló hatású heterociklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények |
| US5998424A (en) | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| DE19904389A1 (de) * | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
| FR2869218B1 (fr) | 2004-04-21 | 2006-06-09 | Europlak Sa | Dispositif de cerclage gastrique ou "anneau gastrique" motorise comportant au moins une antenne de reception desorientee pour l'alimentation, la commande a distance et l'envoi de donnees, par induction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032644A (en) * | 1975-12-29 | 1977-06-28 | Sandoz, Inc. | Isoxazolyl benzoic acids |
| US4140515A (en) * | 1977-05-12 | 1979-02-20 | Monsanto Company | Aryl-3-isoxazole benzoates as plant growth regulants and herbicides |
-
1980
- 1980-02-20 DE DE8080300481T patent/DE3065860D1/de not_active Expired
- 1980-02-20 EP EP80300481A patent/EP0015140B1/en not_active Expired
- 1980-02-20 ES ES488768A patent/ES488768A0/es active Granted
- 1980-02-21 AR AR280040A patent/AR222067A1/es active
- 1980-02-21 MX MX808653U patent/MX5929E/es unknown
- 1980-02-21 PH PH23670A patent/PH14889A/en unknown
- 1980-02-21 TR TR20875A patent/TR20875A/xx unknown
- 1980-02-21 BG BG046704A patent/BG30928A3/xx unknown
- 1980-02-21 HU HU80403A patent/HU184724B/hu unknown
- 1980-02-21 CA CA000346196A patent/CA1137493A/en not_active Expired
- 1980-02-21 YU YU00470/80A patent/YU47080A/xx unknown
- 1980-02-21 BR BR8001036A patent/BR8001036A/pt unknown
- 1980-02-21 NO NO800486A patent/NO150278C/no unknown
- 1980-02-21 DK DK75180A patent/DK75180A/da not_active Application Discontinuation
- 1980-02-21 RO RO100262A patent/RO80464B/ro unknown
- 1980-02-21 DD DD80219203A patent/DD151062A5/de unknown
- 1980-02-21 RO RO109857A patent/RO85817B/ro unknown
- 1980-02-21 BG BG048155A patent/BG31500A3/xx unknown
- 1980-02-21 AU AU55790/80A patent/AU527290B2/en not_active Ceased
- 1980-02-21 BG BG048156A patent/BG31501A3/xx unknown
- 1980-02-22 IL IL59451A patent/IL59451A0/xx unknown
- 1980-05-08 ES ES491274A patent/ES8104260A1/es not_active Expired
- 1980-05-08 ES ES491273A patent/ES8104259A1/es not_active Expired
-
1981
- 1981-07-14 PH PH25909A patent/PH17486A/en unknown
-
1983
- 1983-04-08 NO NO831258A patent/NO151006C/no unknown
- 1983-04-08 NO NO831257A patent/NO831257L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES491273A0 (es) | 1981-04-01 |
| YU47080A (en) | 1983-02-28 |
| BG30928A3 (en) | 1981-09-15 |
| EP0015140B1 (en) | 1983-12-14 |
| ES8103064A1 (es) | 1981-02-16 |
| NO831258L (no) | 1980-08-25 |
| NO150278B (no) | 1984-06-12 |
| PH14889A (en) | 1982-01-08 |
| NO151006B (no) | 1984-10-15 |
| RO80464A (ro) | 1983-04-29 |
| AU527290B2 (en) | 1983-02-24 |
| NO800486L (no) | 1980-08-25 |
| TR20875A (tr) | 1982-11-18 |
| BR8001036A (pt) | 1980-10-29 |
| NO150278C (no) | 1984-09-19 |
| ES8104259A1 (es) | 1981-04-01 |
| BG31500A3 (en) | 1982-01-15 |
| AR222067A1 (es) | 1981-04-15 |
| AU5579080A (en) | 1981-10-29 |
| DK75180A (da) | 1980-08-23 |
| ES491274A0 (es) | 1981-04-16 |
| IL59451A0 (en) | 1980-05-30 |
| EP0015140A1 (en) | 1980-09-03 |
| DE3065860D1 (en) | 1984-01-19 |
| CA1137493A (en) | 1982-12-14 |
| PH17486A (en) | 1984-09-04 |
| DD151062A5 (de) | 1981-09-30 |
| ES488768A0 (es) | 1981-02-16 |
| NO831257L (no) | 1980-08-25 |
| HU184724B (en) | 1984-10-29 |
| BG31501A3 (en) | 1982-01-15 |
| NO151006C (no) | 1985-01-30 |
| MX5929E (es) | 1984-08-29 |
| ES8104260A1 (es) | 1981-04-16 |
| RO85817A (ro) | 1984-11-25 |
| RO80464B (ro) | 1983-04-30 |
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