RO82679B - PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA - Google Patents
PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATAInfo
- Publication number
- RO82679B RO82679B RO104817A RO10481781A RO82679B RO 82679 B RO82679 B RO 82679B RO 104817 A RO104817 A RO 104817A RO 10481781 A RO10481781 A RO 10481781A RO 82679 B RO82679 B RO 82679B
- Authority
- RO
- Romania
- Prior art keywords
- suspension
- micropacked
- becampicillin
- preparing
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Inventia se refera la un procedeu de preparare a unei suspensii de bacampicilina microîncapsulata prin care hidroclorura de b campicilina se acopera cu un învelis format dintr-un amestec de etilceluloza si hidroxipropilceluloza asociate într-un raport de 1,5:1......2:1, si dintr-un material de umplutura dintr-un polimer organic, greutatea învelisului reprezentînd circa 54% din greutatea miezului microcapsulele obtinute fiind apoi amestecate cu un vehicul de suspensie care determina în mediul apos de suspensie un pH cuprins între 7,2 si 8,2 suspensia obtinuta prezentînd un nivel maxim de ampicilina în serul sanguin de cel putin 6 mg/ml dupa administrare orala.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/180,537 US4321253A (en) | 1980-08-22 | 1980-08-22 | Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration |
Publications (2)
Publication Number | Publication Date |
---|---|
RO82679A RO82679A (ro) | 1984-05-23 |
RO82679B true RO82679B (ro) | 1984-07-30 |
Family
ID=22660812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO104817A RO82679B (ro) | 1980-08-22 | 1981-07-08 | PROCEDEU DE PREPARARE A UNEI SUSPENSII DE BACAMPICILINA MICROîNCAPSULATA |
Country Status (41)
Country | Link |
---|---|
US (1) | US4321253A (ro) |
JP (1) | JPS5775986A (ro) |
KR (1) | KR860000513B1 (ro) |
AR (1) | AR227201A1 (ro) |
AT (1) | AT370994B (ro) |
AU (1) | AU529965B2 (ro) |
BE (1) | BE890028A (ro) |
BG (1) | BG42000A3 (ro) |
CA (1) | CA1137414A (ro) |
CH (1) | CH650674A5 (ro) |
CS (1) | CS225845B2 (ro) |
DD (1) | DD201644A5 (ro) |
DE (1) | DE3132614C2 (ro) |
DK (1) | DK158971C (ro) |
DZ (1) | DZ315A1 (ro) |
ES (1) | ES504905A0 (ro) |
FI (1) | FI72647C (ro) |
FR (1) | FR2488798A1 (ro) |
GB (1) | GB2082539B (ro) |
GR (1) | GR74983B (ro) |
HK (1) | HK43786A (ro) |
HU (1) | HU188679B (ro) |
IE (1) | IE51506B1 (ro) |
IL (1) | IL63617A (ro) |
IN (1) | IN156538B (ro) |
IT (1) | IT1138161B (ro) |
KE (1) | KE3626A (ro) |
LU (1) | LU83572A1 (ro) |
MX (1) | MX5731A (ro) |
MY (1) | MY8600597A (ro) |
NL (1) | NL191978C (ro) |
NO (1) | NO154821C (ro) |
NZ (1) | NZ198106A (ro) |
PH (1) | PH17125A (ro) |
PL (1) | PL232141A1 (ro) |
PT (1) | PT73555B (ro) |
RO (1) | RO82679B (ro) |
SE (1) | SE448819B (ro) |
SU (1) | SU1364226A3 (ro) |
YU (1) | YU43985B (ro) |
ZA (1) | ZA815793B (ro) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2950977A1 (de) * | 1978-12-22 | 1980-07-10 | Donald E Panoz | Neue galenische zubereitungsform fuer die orale verabreichung von medikamenten mit programmierter besetzung, sowie verfahren zu ihrer herstellung |
SE8103843L (sv) * | 1981-06-18 | 1982-12-19 | Astra Laekemedel Ab | Farmaceutisk mixtur |
SE8203953D0 (sv) * | 1982-06-24 | 1982-06-24 | Astra Laekemedel Ab | Pharmaceutical mixture |
US4994260A (en) * | 1982-05-28 | 1991-02-19 | Astra Lakemedel Aktiebolag | Pharmaceutical mixture |
EP0111560A4 (en) * | 1982-06-14 | 1987-02-03 | Key Pharma | ASPIRINE WITH CONTINUOUS LEVEL. |
US4508702A (en) * | 1982-06-14 | 1985-04-02 | Key Pharmaceuticals, Inc. | Sustained release aspirin |
US4634587A (en) * | 1982-07-09 | 1987-01-06 | Key Pharmaceuticals, Inc. | Sustained release quinidine dosage form |
EP0113373B1 (en) * | 1982-07-09 | 1991-08-28 | Key Pharmaceuticals, Inc. | Sustained release quinidine dosage form |
AU569277B2 (en) * | 1983-03-03 | 1988-01-28 | Dow Chemical Company, The | Aqueuos dispersion of water-insoluble organophilic cellulose ether for sustained release of active agents |
US4555399A (en) * | 1983-11-18 | 1985-11-26 | Key Pharmaceuticals, Inc. | Aspirin tablet |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
SE8405611D0 (sv) * | 1984-11-09 | 1984-11-09 | Astra Laekemedel Ab | Process for stabilization of bacampicillin hydrochloride |
US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
GB8628359D0 (en) * | 1986-11-27 | 1986-12-31 | Zyma Sa | Galenical formulation |
US4853229A (en) * | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
RU2123863C1 (ru) * | 1992-04-30 | 1998-12-27 | Шеринг Корпорейшн | Содержащая гидратированный цефтибутен порошковая антибактериальная композиция, предназначенная для орального использования в виде суспензии |
US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
US6270804B1 (en) * | 1998-04-03 | 2001-08-07 | Biovail Technologies Ltd. | Sachet formulations |
IN191482B (ro) * | 1999-03-19 | 2003-12-06 | Ranbaxy Lab Ltd | |
JP4711478B2 (ja) * | 1999-08-13 | 2011-06-29 | 旭化成ケミカルズ株式会社 | 味がマスクされた薬物 |
US20050037086A1 (en) * | 1999-11-19 | 2005-02-17 | Zycos Inc., A Delaware Corporation | Continuous-flow method for preparing microparticles |
EP1712222A3 (en) | 1999-12-23 | 2012-06-20 | Pfizer Products Inc. | Pharmaceutical compositions providing enhanced drug concentrations |
EP1118333A1 (en) * | 2000-01-18 | 2001-07-25 | Eurand International S.P.A. | Compositions with enhanced oral bioavailability |
US6551617B1 (en) | 2000-04-20 | 2003-04-22 | Bristol-Myers Squibb Company | Taste masking coating composition |
AU2001257107A1 (en) | 2000-04-20 | 2001-11-07 | Bristol-Myers Squibb Company | Taste masking coating composition |
CA2410052A1 (en) * | 2000-06-02 | 2001-12-13 | Zycos Inc. | Delivery systems for bioactive agents |
FR2822834B1 (fr) * | 2001-04-02 | 2005-02-25 | Flamel Tech Sa | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
JP2004532257A (ja) * | 2001-05-31 | 2004-10-21 | シーマ・ラブス、インコーポレイテッド | 高水溶性薬剤のテイスト・マスキング |
KR20030015655A (ko) * | 2001-08-17 | 2003-02-25 | 한미약품공업 주식회사 | 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물 |
FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
ATE407674T1 (de) * | 2002-04-09 | 2008-09-15 | Flamel Tech Sa | Orale pharmazeutische formulierung in form einer wässrigen suspension von mikrokapseln zur modifizierten freisetzung von amoxicillin |
ATE419840T1 (de) | 2002-04-09 | 2009-01-15 | Flamel Tech Sa | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
FR2842736B1 (fr) | 2002-07-26 | 2005-07-22 | Flamel Tech Sa | Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s) |
FR2842735B1 (fr) * | 2002-07-26 | 2006-01-06 | Flamel Tech Sa | Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os |
FR2843117B1 (fr) * | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
US7632521B2 (en) * | 2003-07-15 | 2009-12-15 | Eurand, Inc. | Controlled release potassium chloride tablets |
FR2860516B1 (fr) * | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
FR2862536B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
FR2885526B1 (fr) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | Medicament oral a base d'inhibiteur de pompe a protons |
WO2017065189A1 (ja) * | 2015-10-13 | 2017-04-20 | テクノガード株式会社 | 胃腸管粘膜保護組成物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3549746A (en) * | 1967-11-02 | 1970-12-22 | Bristol Myers Co | Antibiotic composition |
US3873521A (en) * | 1970-09-17 | 1975-03-25 | Astra Laekemedel Ab | Esters of {60 -amino penicillins |
ZA718014B (en) | 1970-12-23 | 1972-08-30 | Beecham Group Ltd | Pharmaceutical formulations |
US4016254A (en) * | 1972-05-19 | 1977-04-05 | Beecham Group Limited | Pharmaceutical formulations |
GB1455296A (en) * | 1973-05-24 | 1976-11-10 | Beecham Group Ltd | Veterinary treatment |
GB1479655A (en) | 1974-03-08 | 1977-07-13 | Beecham Group Ltd | Antibiotic preparations |
US4127647A (en) * | 1975-04-08 | 1978-11-28 | Meiji Seika Kaisha, Ltd. | Process for preparation of stable amorphous macrolide antibiotic solids |
JPS5840529B2 (ja) * | 1975-09-29 | 1983-09-06 | 明治製菓株式会社 | ケイコウヨウセイザイノセイホウ |
GB1561301A (en) * | 1976-01-02 | 1980-02-20 | Beecham Group Ltd | Orally administrable pharmaceutical composition |
ZA793935B (en) * | 1978-08-04 | 1980-07-30 | Beecham Group Ltd | Powders |
JPS57105316A (en) * | 1980-12-23 | 1982-06-30 | Hitachi Cable Ltd | Method of fitting heat-shrinkable tube |
-
1980
- 1980-08-22 US US06/180,537 patent/US4321253A/en not_active Expired - Lifetime
-
1981
- 1981-06-23 IN IN405/DEL/81A patent/IN156538B/en unknown
- 1981-07-08 DZ DZ816254A patent/DZ315A1/fr active
- 1981-07-08 RO RO104817A patent/RO82679B/ro unknown
- 1981-07-09 HU HU812005A patent/HU188679B/hu unknown
- 1981-07-09 SU SU813310057A patent/SU1364226A3/ru active
- 1981-07-10 CS CS815334A patent/CS225845B2/cs unknown
- 1981-07-10 BG BG052867A patent/BG42000A3/xx unknown
- 1981-07-10 PL PL23214181A patent/PL232141A1/xx unknown
- 1981-08-05 GB GB8123977A patent/GB2082539B/en not_active Expired
- 1981-08-14 CH CH5277/81A patent/CH650674A5/fr not_active IP Right Cessation
- 1981-08-18 DE DE3132614A patent/DE3132614C2/de not_active Expired
- 1981-08-19 AR AR286473A patent/AR227201A1/es active
- 1981-08-19 AT AT0362781A patent/AT370994B/de not_active IP Right Cessation
- 1981-08-19 CA CA000384168A patent/CA1137414A/en not_active Expired
- 1981-08-19 GR GR65819A patent/GR74983B/el unknown
- 1981-08-20 IE IE1911/81A patent/IE51506B1/en not_active IP Right Cessation
- 1981-08-20 NZ NZ198106A patent/NZ198106A/xx unknown
- 1981-08-20 FI FI812574A patent/FI72647C/fi not_active IP Right Cessation
- 1981-08-20 IL IL63617A patent/IL63617A/xx not_active IP Right Cessation
- 1981-08-20 DD DD81232705A patent/DD201644A5/de not_active IP Right Cessation
- 1981-08-20 IT IT23587/81A patent/IT1138161B/it active
- 1981-08-20 BE BE0/205725A patent/BE890028A/fr not_active IP Right Cessation
- 1981-08-20 PH PH26070A patent/PH17125A/en unknown
- 1981-08-20 LU LU83572A patent/LU83572A1/fr unknown
- 1981-08-20 YU YU2017/81A patent/YU43985B/xx unknown
- 1981-08-21 KR KR1019810003057A patent/KR860000513B1/ko active
- 1981-08-21 AU AU74416/81A patent/AU529965B2/en not_active Expired
- 1981-08-21 ES ES504905A patent/ES504905A0/es active Granted
- 1981-08-21 SE SE8104974A patent/SE448819B/sv not_active IP Right Cessation
- 1981-08-21 NO NO812827A patent/NO154821C/no unknown
- 1981-08-21 FR FR8116074A patent/FR2488798A1/fr active Granted
- 1981-08-21 JP JP56131418A patent/JPS5775986A/ja active Granted
- 1981-08-21 NL NL8103902A patent/NL191978C/xx not_active IP Right Cessation
- 1981-08-21 ZA ZA815793A patent/ZA815793B/xx unknown
- 1981-08-21 PT PT73555A patent/PT73555B/pt unknown
- 1981-08-21 DK DK372181A patent/DK158971C/da not_active IP Right Cessation
- 1981-08-24 MX MX573181A patent/MX5731A/es unknown
-
1986
- 1986-04-04 KE KE3626A patent/KE3626A/xx unknown
- 1986-06-09 HK HK437/86A patent/HK43786A/xx not_active IP Right Cessation
- 1986-12-30 MY MY597/86A patent/MY8600597A/xx unknown
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