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Application filed by Merck & Co. IncfiledCriticalMerck & Co. Inc
Publication of RO82504BpublicationCriticalpatent/RO82504B/ro
Publication of RO82504ApublicationCriticalpatent/RO82504A/ro
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de alfa-fluormetilhistidina cu formula generala I: (vezi formula) în care R reprezinta o grupa alchil cu 1...3 atomi de carbon, de preferinta -CH3. Procedeul consta în aceea ca o baza Schiff cu formula generala II: (vezi formula) an care R reprezinta semnificatia sus-mentionata, iar R1 reprezinta un radical alchil-fenil cu 1...3atomi de carbon, în gruparea alchil se supune hidrolizei selective prin eluarea prin silicagel, folosind drept eluent alcanoli inferiori, diclormetan sau triclormetan.
RO81104835A1980-07-211981-07-10Procedeu pentru prepararea unor derivati de &-fluormetilhistidina
RO82504A
(ro)
Derives heteromonocycliques etheterobicycliques de l'acide 7 actylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci, et utilisation en therapeutique