RO82504B - PROCEDEU PENTRU PREPARAREA UNOR DERIVATI DE &-FLUORMETILHISTIDINA - Google Patents

PROCEDEU PENTRU PREPARAREA UNOR DERIVATI DE &-FLUORMETILHISTIDINA

Info

Publication number
RO82504B
RO82504B RO104835A RO10483581A RO82504B RO 82504 B RO82504 B RO 82504B RO 104835 A RO104835 A RO 104835A RO 10483581 A RO10483581 A RO 10483581A RO 82504 B RO82504 B RO 82504B
Authority
RO
Romania
Prior art keywords
derivatives
fluormethylhistidine
preparing
carbon atoms
general formula
Prior art date
Application number
RO104835A
Other languages
English (en)
Other versions
RO82504A (ro
Inventor
Clifford H. Shunk
Original Assignee
Merck & Co. Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc filed Critical Merck & Co. Inc
Publication of RO82504B publication Critical patent/RO82504B/ro
Publication of RO82504A publication Critical patent/RO82504A/ro

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de alfa-fluormetilhistidina cu formula generala I: (vezi formula) în care R reprezinta o grupa alchil cu 1...3 atomi de carbon, de preferinta -CH3. Procedeul consta în aceea ca o baza Schiff cu formula generala II: (vezi formula) an care R reprezinta semnificatia sus-mentionata, iar R1 reprezinta un radical alchil-fenil cu 1...3atomi de carbon, în gruparea alchil se supune hidrolizei selective prin eluarea prin silicagel, folosind drept eluent alcanoli inferiori, diclormetan sau triclormetan.
RO81104835A 1980-07-21 1981-07-10 Procedeu pentru prepararea unor derivati de &-fluormetilhistidina RO82504A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17039780A 1980-07-21 1980-07-21

Publications (2)

Publication Number Publication Date
RO82504B true RO82504B (ro) 1983-08-30
RO82504A RO82504A (ro) 1983-09-26

Family

ID=22619706

Family Applications (1)

Application Number Title Priority Date Filing Date
RO81104835A RO82504A (ro) 1980-07-21 1981-07-10 Procedeu pentru prepararea unor derivati de &-fluormetilhistidina

Country Status (2)

Country Link
RO (1) RO82504A (ro)
SU (1) SU1026653A3 (ro)

Also Published As

Publication number Publication date
SU1026653A3 (ru) 1983-06-30
RO82504A (ro) 1983-09-26

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