RO81076B1 - Procedeu pentru prepararea unor corticoide - Google Patents
Procedeu pentru prepararea unor corticoideInfo
- Publication number
- RO81076B1 RO81076B1 RO93718A RO9371878A RO81076B1 RO 81076 B1 RO81076 B1 RO 81076B1 RO 93718 A RO93718 A RO 93718A RO 9371878 A RO9371878 A RO 9371878A RO 81076 B1 RO81076 B1 RO 81076B1
- Authority
- RO
- Romania
- Prior art keywords
- formula
- corticoids
- preparation
- alkali metal
- acid anhydride
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedeu pentru prepararea unor corticoide cu formula generala I: (vezi formula) în care n reprezinta 2 sau 3, x reprezinta hidrogen, clor sau fluor, Y reprezinta metal alcalin sau N-metil glucamina, caracterizat prin aceea ca, se trateaza un compuscu formula generala II: (vezi formula) în care X are semnificatia aratata mai sus, cu anhidrida a acidului succinic sau anhidrida acidului glutamic în raport în greutate de 1...2,5:0,5...1, la temperatura de fierbere a amestecului de reactie folosind ca solvent piridina, apoi procedeul este transformat în sare de metal alcalin, sau în sare de N-metilglucamina, în mod cunoscut.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772715853 DE2715853A1 (de) | 1977-04-06 | 1977-04-06 | Wasserloesliche kortikoide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO81076B1 true RO81076B1 (ro) | 1983-01-30 |
| RO81076A2 RO81076A2 (ro) | 1983-02-01 |
Family
ID=6005979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7893718A RO81076A2 (ro) | 1977-04-06 | 1978-04-04 | Procedeu pentru prepararea unor corticoide |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS53149963A (ro) |
| AT (1) | ATA239978A (ro) |
| AU (1) | AU3481178A (ro) |
| BE (1) | BE865760A (ro) |
| BG (1) | BG28578A3 (ro) |
| CA (1) | CA1113452A (ro) |
| CH (1) | CH638537A5 (ro) |
| CS (1) | CS198295B2 (ro) |
| DD (1) | DD135082A5 (ro) |
| DE (1) | DE2715853A1 (ro) |
| DK (1) | DK153378A (ro) |
| EG (1) | EG13249A (ro) |
| ES (1) | ES468572A1 (ro) |
| FI (1) | FI781053A7 (ro) |
| FR (1) | FR2386557A1 (ro) |
| GB (1) | GB1602266A (ro) |
| IE (1) | IE46602B1 (ro) |
| IL (1) | IL54443A0 (ro) |
| IT (1) | IT1094296B (ro) |
| LU (1) | LU79375A1 (ro) |
| NL (1) | NL7803188A (ro) |
| NO (1) | NO781200L (ro) |
| NZ (1) | NZ186745A (ro) |
| PL (1) | PL114096B1 (ro) |
| PT (1) | PT67872B (ro) |
| RO (1) | RO81076A2 (ro) |
| SE (1) | SE7803837L (ro) |
| SU (1) | SU668611A3 (ro) |
| ZA (1) | ZA781977B (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4948533A (en) * | 1984-03-28 | 1990-08-14 | The Upjohn Company | 11a-hydroxy steroid diester |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1169444B (de) * | 1961-02-22 | 1964-05-06 | Schering Ag | Verfahren zur Herstellung von ?-16ª-Methylsteroiden |
| YU34304B (en) * | 1968-08-17 | 1979-04-30 | Schering Ag | Process for preparing corticoid-21-mono-phosphates |
| DK290774A (ro) * | 1973-06-08 | 1975-02-03 | Schering Ag |
-
1977
- 1977-04-06 DE DE19772715853 patent/DE2715853A1/de not_active Withdrawn
-
1978
- 1978-03-21 NZ NZ186745A patent/NZ186745A/xx unknown
- 1978-03-23 NL NL7803188A patent/NL7803188A/xx not_active Application Discontinuation
- 1978-03-29 DD DD78204456A patent/DD135082A5/xx unknown
- 1978-03-30 SU SU782595445A patent/SU668611A3/ru active
- 1978-03-31 BG BG039252A patent/BG28578A3/xx unknown
- 1978-04-03 CH CH357378A patent/CH638537A5/de not_active IP Right Cessation
- 1978-04-04 PL PL1978205800A patent/PL114096B1/pl unknown
- 1978-04-04 LU LU79375A patent/LU79375A1/de unknown
- 1978-04-04 IL IL54443A patent/IL54443A0/xx unknown
- 1978-04-04 RO RO7893718A patent/RO81076A2/ro unknown
- 1978-04-05 SE SE7803837A patent/SE7803837L/xx unknown
- 1978-04-05 IE IE672/78A patent/IE46602B1/en unknown
- 1978-04-05 PT PT67872A patent/PT67872B/pt unknown
- 1978-04-05 EG EG239/78A patent/EG13249A/xx active
- 1978-04-05 AU AU34811/78A patent/AU3481178A/en active Pending
- 1978-04-05 IT IT21995/78A patent/IT1094296B/it active
- 1978-04-05 NO NO781200A patent/NO781200L/no unknown
- 1978-04-05 ES ES468572A patent/ES468572A1/es not_active Expired
- 1978-04-05 CA CA300,512A patent/CA1113452A/en not_active Expired
- 1978-04-05 AT AT0239978A patent/ATA239978A/de not_active Application Discontinuation
- 1978-04-06 ZA ZA00781977A patent/ZA781977B/xx unknown
- 1978-04-06 FI FI781053A patent/FI781053A7/fi not_active Application Discontinuation
- 1978-04-06 BE BE186622A patent/BE865760A/xx not_active IP Right Cessation
- 1978-04-06 JP JP4077278A patent/JPS53149963A/ja active Pending
- 1978-04-06 FR FR7810202A patent/FR2386557A1/fr active Granted
- 1978-04-06 DK DK153378A patent/DK153378A/da not_active IP Right Cessation
- 1978-04-06 CS CS782252A patent/CS198295B2/cs unknown
- 1978-04-06 GB GB13527/78A patent/GB1602266A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE7803837L (sv) | 1978-10-07 |
| DK153378A (da) | 1978-10-07 |
| LU79375A1 (de) | 1978-07-13 |
| RO81076A2 (ro) | 1983-02-01 |
| IT1094296B (it) | 1985-07-26 |
| PT67872A (fr) | 1978-05-01 |
| IE46602B1 (en) | 1983-07-27 |
| SU668611A3 (ru) | 1979-06-15 |
| BG28578A3 (bg) | 1980-05-15 |
| ZA781977B (en) | 1979-03-28 |
| NL7803188A (nl) | 1978-10-10 |
| CH638537A5 (en) | 1983-09-30 |
| IE780672L (en) | 1978-10-06 |
| CA1113452A (en) | 1981-12-01 |
| JPS53149963A (en) | 1978-12-27 |
| IT7821995A0 (it) | 1978-04-05 |
| FI781053A7 (fi) | 1978-10-07 |
| DE2715853A1 (de) | 1978-10-19 |
| NO781200L (no) | 1978-10-09 |
| PT67872B (fr) | 1979-11-14 |
| ATA239978A (de) | 1981-06-15 |
| CS198295B2 (en) | 1980-05-30 |
| IL54443A0 (en) | 1978-07-31 |
| PL205800A1 (pl) | 1979-01-29 |
| DD135082A5 (de) | 1979-04-11 |
| FR2386557A1 (fr) | 1978-11-03 |
| GB1602266A (en) | 1981-11-11 |
| NZ186745A (en) | 1980-10-24 |
| FR2386557B1 (ro) | 1980-02-01 |
| EG13249A (en) | 1980-12-31 |
| ES468572A1 (es) | 1978-12-01 |
| PL114096B1 (en) | 1981-01-31 |
| AU3481178A (en) | 1979-10-11 |
| BE865760A (fr) | 1978-10-06 |
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