RO73530B - Procedeu de preparare a derivatilor fenoxipropilaminici - Google Patents
Procedeu de preparare a derivatilor fenoxipropilaminiciInfo
- Publication number
- RO73530B RO73530B RO83897A RO8389775A RO73530B RO 73530 B RO73530 B RO 73530B RO 83897 A RO83897 A RO 83897A RO 8389775 A RO8389775 A RO 8389775A RO 73530 B RO73530 B RO 73530B
- Authority
- RO
- Romania
- Prior art keywords
- radical
- alkyl radical
- carbon atoms
- general formula
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de fenoxipropilamina, avînd formula generala I: (vezi formula) în care R1 reprezinta hidrogen sau un radical alchil cu 1...4 atomi de carbon, R2 reprezinta hidrogen, un radical alchilcu 1...4 atomi de carbon, un radical ciclohexil sau fenil, sau R2 si R1 reprezinta împreuna un radical tetrametilen sau pentametilen, R3 reprezinta un radical alchil ramificat cu 3 sau 4 atomi de carbon, sau un radical 2''-hidroximetil-propil, R4 estehidrogen sau un radical alchil cu 1...3 atomi de carbon si a sarurilor lor acceptabile din punctul de vedere farmaceutic, procedeu prin care derivati de p-aminofenol, avînd formula generala II: (vezi formula) în care X reprezinta radicalul (vezi for mula) iar R1, R2, R3, R4 si R5 au semnificatia din formula I, reactioneaza cu amine avînd formula generala III: (vezi formula) în care R3 este definit ca mai sus, într-un raport în greutate 1 la 1,09...17,3 la o temperatura cuprinsa între temperaturacamerei de fierbere a amestecului de reactie, într-un mediu de reactie format din amina materie prima, eventual amestecata cu apa sau un amestec de apa si etanol, iar produsul de reactie poate fi trecut, eventual sub forma de saruri acceptabile dinpunctul de vedere farmaceutic.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT939174A AT335466B (de) | 1974-11-22 | 1974-11-22 | Verfahren zur herstellung von neuen 3-(p-ureidophenoxy)-2-hydroxy-aminopropanen und deren saureadditionssalzen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO73530A RO73530A (ro) | 1984-06-21 |
| RO73530B true RO73530B (ro) | 1984-08-30 |
Family
ID=3613746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO83897A RO73530B (ro) | 1974-11-22 | 1975-11-12 | Procedeu de preparare a derivatilor fenoxipropilaminici |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS51125249A (ro) |
| AT (1) | AT335466B (ro) |
| CA (1) | CA1060450A (ro) |
| CH (1) | CH616657A5 (ro) |
| CS (1) | CS181690B2 (ro) |
| DD (1) | DD123522A1 (ro) |
| ES (1) | ES442867A1 (ro) |
| LU (1) | LU73840A1 (ro) |
| PL (1) | PL96542B1 (ro) |
| RO (1) | RO73530B (ro) |
| SU (1) | SU612621A3 (ro) |
-
1974
- 1974-11-22 AT AT939174A patent/AT335466B/de not_active IP Right Cessation
-
1975
- 1975-10-09 CS CS7500006845A patent/CS181690B2/cs unknown
- 1975-10-14 CH CH1331375A patent/CH616657A5/de not_active IP Right Cessation
- 1975-11-12 RO RO83897A patent/RO73530B/ro unknown
- 1975-11-12 CA CA239,424A patent/CA1060450A/en not_active Expired
- 1975-11-18 SU SU752189804A patent/SU612621A3/ru active
- 1975-11-20 PL PL1975184866A patent/PL96542B1/pl unknown
- 1975-11-20 LU LU73840A patent/LU73840A1/xx unknown
- 1975-11-20 DD DD189592A patent/DD123522A1/xx unknown
- 1975-11-21 JP JP50139370A patent/JPS51125249A/ja active Granted
- 1975-11-21 ES ES442867A patent/ES442867A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA939174A (de) | 1976-07-15 |
| CA1060450A (en) | 1979-08-14 |
| CS181690B2 (en) | 1978-03-31 |
| SU612621A3 (ru) | 1978-06-25 |
| RO73530A (ro) | 1984-06-21 |
| LU73840A1 (ro) | 1976-09-06 |
| ES442867A1 (es) | 1977-04-01 |
| JPS549196B2 (ro) | 1979-04-21 |
| DD123522A1 (ro) | 1977-01-05 |
| PL96542B1 (pl) | 1977-12-31 |
| JPS51125249A (en) | 1976-11-01 |
| AT335466B (de) | 1977-03-10 |
| CH616657A5 (en) | 1980-04-15 |
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