RO71879B - Procedeu pentru prepararea prin sinteza a vincaminei si a stereoizomerilor sai - Google Patents
Procedeu pentru prepararea prin sinteza a vincaminei si a stereoizomerilor saiInfo
- Publication number
- RO71879B RO71879B RO77000A RO7700073A RO71879B RO 71879 B RO71879 B RO 71879B RO 77000 A RO77000 A RO 77000A RO 7700073 A RO7700073 A RO 7700073A RO 71879 B RO71879 B RO 71879B
- Authority
- RO
- Romania
- Prior art keywords
- stereoisomers
- formula
- vincamine
- temperature
- apovincaldehyde
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedeu pentru prepararea vincaminei si stereoizomerilor sai cu formula I: (vezi form. in desc.) caracterizat prin aceea ca se transforma vincaminolul si/sau stereoizomerii sai cu formula II:(vezi form. in desc.) prin deshisratare oxidativa sub act iunea anhidridei fosforice si a dimetilsulfoxidului la o temperatura cuprinsa între 0 si 150 degree C, de preferinta, în prezenta de piridina, în apovincaldehida si sau stereoizomerii sai cu formula III: (vezi form. in desc.) prin deshidratare oxidativa subactiunea anhidridei fosforice si a dimetilsulfoxidului la o temperatura cuprinsa între 0 si 150 degree C, de preferinta, în prezenta de piridina, în apovincaldehida si sau stereoizomerii sai cu formula III: (vezi form. in desc.) care apoi se transforma pri n tratare cu o cianura alcalina, de exemplu, cu cianura de sodiu si acid acetic în metanol în prezenta bioxidului de mangan, la temperatura ambianta, în aprovincamina si sau stereoizomerii sai formula IV:(vezi form. in desc.)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7244673A FR2211004A5 (ro) | 1972-12-15 | 1972-12-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO71879A RO71879A (ro) | 1983-04-29 |
| RO71879B true RO71879B (ro) | 1983-04-30 |
Family
ID=9108745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO77000A RO71879B (ro) | 1972-12-15 | 1973-12-14 | Procedeu pentru prepararea prin sinteza a vincaminei si a stereoizomerilor sai |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3925392A (ro) |
| JP (1) | JPS518960B2 (ro) |
| AT (1) | AT347605B (ro) |
| AU (1) | AU475209B2 (ro) |
| BE (1) | BE808324A (ro) |
| CA (1) | CA1018528A (ro) |
| CH (1) | CH587849A5 (ro) |
| CS (1) | CS189620B2 (ro) |
| DE (2) | DE2362363A1 (ro) |
| ES (1) | ES421540A1 (ro) |
| FR (1) | FR2211004A5 (ro) |
| GB (2) | GB1450199A (ro) |
| IE (1) | IE38624B1 (ro) |
| NL (1) | NL152559B (ro) |
| RO (1) | RO71879B (ro) |
| ZA (1) | ZA739505B (ro) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK88960C (da) * | 1957-10-12 | 1960-05-09 | Jens Rasmussen | Cykelstativ. |
| US4044012A (en) * | 1974-05-07 | 1977-08-23 | Richter Gedeon Vegyeszeti Gyar Rt. | Indolo-quinolizidine derivatives |
| CH625239A5 (ro) * | 1974-08-09 | 1981-09-15 | Buskine Sa | |
| HU171163B (hu) * | 1974-09-27 | 1977-11-28 | Richter Gedeon Vegyeszet | Sposob poluchenija proizvodnykh trans eburnamenina |
| HU198207B (en) * | 1985-04-19 | 1989-08-28 | Richter Gedeon Vegyeszet | Process for production of derivatives of eburnamenin and medical compositions containing them |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2168853B1 (ro) * | 1972-01-24 | 1975-04-25 | Centre Etd Ind Pharma |
-
1972
- 1972-12-15 FR FR7244673A patent/FR2211004A5/fr not_active Expired
-
1973
- 1973-12-06 BE BE138607A patent/BE808324A/xx unknown
- 1973-12-10 IE IE2229/73A patent/IE38624B1/xx unknown
- 1973-12-12 AU AU63510/73A patent/AU475209B2/en not_active Expired
- 1973-12-12 US US423901A patent/US3925392A/en not_active Expired - Lifetime
- 1973-12-12 CA CA188,036A patent/CA1018528A/en not_active Expired
- 1973-12-13 NL NL737317100A patent/NL152559B/xx unknown
- 1973-12-13 CS CS738650A patent/CS189620B2/cs unknown
- 1973-12-14 GB GB3228275A patent/GB1450199A/en not_active Expired
- 1973-12-14 ZA ZA739505A patent/ZA739505B/xx unknown
- 1973-12-14 DE DE2362363A patent/DE2362363A1/de active Pending
- 1973-12-14 GB GB5814673A patent/GB1450198A/en not_active Expired
- 1973-12-14 RO RO77000A patent/RO71879B/ro unknown
- 1973-12-14 DE DE2365683A patent/DE2365683A1/de active Pending
- 1973-12-15 JP JP48140241A patent/JPS518960B2/ja not_active Expired
- 1973-12-15 ES ES421540A patent/ES421540A1/es not_active Expired
- 1973-12-15 CH CH1760373A patent/CH587849A5/xx not_active IP Right Cessation
- 1973-12-17 AT AT1053473A patent/AT347605B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2365683A1 (de) | 1975-11-27 |
| JPS518960B2 (ro) | 1976-03-22 |
| AT347605B (de) | 1979-01-10 |
| NL152559B (nl) | 1977-03-15 |
| GB1450198A (en) | 1976-09-22 |
| GB1450199A (en) | 1976-09-22 |
| US3925392A (en) | 1975-12-09 |
| JPS4987700A (ro) | 1974-08-22 |
| DE2362363A1 (de) | 1974-07-04 |
| CA1018528A (en) | 1977-10-04 |
| IE38624B1 (en) | 1978-04-26 |
| ES421540A1 (es) | 1976-04-01 |
| AU6351073A (en) | 1975-06-12 |
| RO71879A (ro) | 1983-04-29 |
| CS189620B2 (en) | 1979-04-30 |
| CH587849A5 (ro) | 1977-05-13 |
| FR2211004A5 (ro) | 1974-07-12 |
| ZA739505B (en) | 1974-11-27 |
| NL7317100A (ro) | 1974-06-18 |
| BE808324A (fr) | 1974-06-06 |
| IE38624L (en) | 1974-06-15 |
| AU475209B2 (en) | 1976-08-12 |
| ATA1053473A (de) | 1978-05-15 |
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