RO132299A3 - Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () - Google Patents
Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active ()Info
- Publication number
- RO132299A3 RO132299A3 ROA201700340A RO201700340A RO132299A3 RO 132299 A3 RO132299 A3 RO 132299A3 RO A201700340 A ROA201700340 A RO A201700340A RO 201700340 A RO201700340 A RO 201700340A RO 132299 A3 RO132299 A3 RO 132299A3
- Authority
- RO
- Romania
- Prior art keywords
- immunologically active
- active proteins
- immunogen
- preparing
- egg
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Invenţia se referă la un procedeu de obţinere a unui biopreparat imunologic, utilizat în tratamentul deficienţelor imune şi infecţiilor cu germeni sensibili sau rezistenţi la antibiotice. Procedeul conform invenţiei constă în imunizarea unor găini ouătoare din rasa Leghorn sau Rhode Island Red, de 18...20 săptămâni, cu un imunogen complex, format din 18...24 antigene preparate din bacterii, levuri, ciuperci, virusuri, paraziţi, inactivate cu formol şi binar etilenimină în amestec cu glutamat de sodiu, ca imunomodulator, un marker biologic şi un adjuvant imunologic uzual, imunogenul fiind structurat în trei variante: un imunogen standard, format din 1...24 antigene, un imunogen specific, format într-un suport imun, realizat după imunizarea cu 20 de microbi, şi reimunizat cu un antigen monospecific, format din şapte tulpini bacteriene ale aceleiaşi specii, şi un imunogen personalizat, format din antigene preparate dintr-un produs patogen prelevat de la un pacient, sau din 20...26 tulpini microbiene frecvent izolate de la pacienţi, inocularea fiind realizată parenteral, cu câte 2 ml din fiecare variantă, la un interval de 30 şi, respectiv, 44 de zile de la prima inoculare, după care se recoltează ouăle care conţin minimum 300 mg/ou proteine imunologic active (PIA), şi din care se foloseşte gălbenuşul pentru IgY, albuşul pentru PIA, membrana cochilieră pentru PIA şi imunomodulatori, rezultând preparate care se condiţionează uzual, în vederea utilizării preventive şi curative.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201700340A RO132299A3 (ro) | 2017-06-06 | 2017-06-06 | Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () |
| EP18814708.6A EP3651793A1 (en) | 2017-06-06 | 2018-06-05 | Composition, preparation method and evaluation of a complex immunogen named i-spga for production of immunological active proteins (iap) |
| CN201880050871.0A CN111263639A (zh) | 2017-06-06 | 2018-06-05 | 用于免疫活性蛋白(iap)生产的名为i-spga的复合免疫原的组分、制备方法和评估 |
| US16/620,100 US11458196B2 (en) | 2017-06-06 | 2018-06-05 | Composition, preparation method and evaluation of a complex immunogen named I-SPGA for production of immunological active proteins (IAP) |
| PCT/RO2018/000008 WO2019039948A1 (en) | 2017-06-06 | 2018-06-05 | COMPOSITION, PROCESS FOR THE PREPARATION AND EVALUATION OF A COMPLEX IMMUNOGEN CALLED I-SPGA FOR THE PRODUCTION OF IMMUNOLOGICALLY ACTIVE PROTEINS (IAP) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ROA201700340A RO132299A3 (ro) | 2017-06-06 | 2017-06-06 | Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO132299A0 RO132299A0 (ro) | 2017-12-29 |
| RO132299A3 true RO132299A3 (ro) | 2018-12-28 |
Family
ID=60688726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA201700340A RO132299A3 (ro) | 2017-06-06 | 2017-06-06 | Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11458196B2 (ro) |
| EP (1) | EP3651793A1 (ro) |
| CN (1) | CN111263639A (ro) |
| RO (1) | RO132299A3 (ro) |
| WO (1) | WO2019039948A1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO132299A3 (ro) * | 2017-06-06 | 2018-12-28 | Fântână Raul Sorin | Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO56778A2 (ro) | 1971-12-31 | 1974-08-01 | ||
| RO75101A2 (ro) | 1979-03-22 | 1980-09-30 | Laboratorul De Virusuri Aviare,Ro | Vaccin inactivat contra leucozei enzootice bovine si ovine si procedeu de preparare a lui |
| RO80570B1 (ro) | 1982-04-22 | 1984-09-30 | Victor Ionel Patrascu | Procedeu de preparare a vaccinului contra bolii lui marek |
| US5853765A (en) | 1982-06-03 | 1998-12-29 | Dcv, Inc. | Anti-cholesterolemic egg, vaccine and method for production, and use |
| SE9100556D0 (sv) | 1991-02-26 | 1991-02-26 | Holmgren Jan | Preparation and use of formalin-killed colonization-factor-antigen (cfa)-expressing e coli organisms for vaccination against enteric infection/diarrhea caused by enterotoxigenic e coli bacteria in humans |
| DE69632235T2 (de) | 1995-10-18 | 2004-08-26 | Akzo Nobel N.V. | Newcastle-Krankheitsvirus-Kombinationsimpfstoff |
| US20060029617A1 (en) | 1997-10-03 | 2006-02-09 | Charreyre Catherine E | Porcine circovirus and Helicobacter combination vaccines and methods of use |
| US20040005327A1 (en) | 2002-05-16 | 2004-01-08 | Subramanian Iyer | Immune T-cell stimulation |
| JP4873632B2 (ja) * | 2004-01-21 | 2012-02-08 | メリアル リミテッド | 改良された不活化ｆｃｖワクチン |
| WO2007124755A1 (en) * | 2006-05-02 | 2007-11-08 | The Antibody Project Aps | Method for immunizing an avian species |
| EP2183281A1 (en) * | 2007-08-30 | 2010-05-12 | Ågerup, Bengt | LOCAL ADMINISTRATION OF CHICKEN YOLK IMMUNE GLOBULINS (IgY) TO TREAT AND PREVENT FUNGAL INFECTIONS |
| US8679504B2 (en) * | 2008-05-22 | 2014-03-25 | University Of Georgia Research Foundation Inc. | Poultry viral materials and methods related thereto |
| WO2011044158A1 (en) | 2009-10-09 | 2011-04-14 | New York Blood Center, Inc. | Immunopotentiator-linked oligomeric influenza immunogenic compositions |
| WO2014134439A1 (en) | 2013-03-01 | 2014-09-04 | New York Blood Center, Inc. | Immunogenic composition for mers coronavirus infection |
| RO130063A8 (ro) * | 2014-08-28 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea ovotransferinei moderne () |
| RO130213A8 (ro) | 2014-10-29 | 2017-06-30 | Romvac Company S.A. | Producerea şi folosirea oului hiperimun - pc2 |
| CN105518377B (zh) | 2014-10-31 | 2018-10-26 | 深圳市大疆创新科技有限公司 | 一种气体泄漏的处理方法、装置及飞行器 |
| RO130418A8 (ro) * | 2015-01-13 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea ovotransferinei pc2 () |
| CN104892756A (zh) * | 2015-06-18 | 2015-09-09 | 成都安蒂康生物科技有限公司 | 一种抗菌鸡卵黄复合抗体及其制备方法与应用 |
| RO130852A8 (ro) * | 2015-09-03 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea oului hiperimun personalizat () în tratamentul de urgenţă al pacienţilor infectaţi cu germeni patogeni |
| RO130965A8 (ro) | 2015-10-16 | 2017-06-30 | Romvac Company S.A. | Producerea şi utilizarea oului hiperimun personalizat () în tratamentul psoriazisului |
| RO132299A3 (ro) | 2017-06-06 | 2018-12-28 | Fântână Raul Sorin | Compoziţie şi metodă de preparare şi evaluare a unui imunogen complex numit i-spga, destinat producerii de proteine imunologic active () |
-
2017
- 2017-06-06 RO ROA201700340A patent/RO132299A3/ro unknown
-
2018
- 2018-06-05 CN CN201880050871.0A patent/CN111263639A/zh active Pending
- 2018-06-05 WO PCT/RO2018/000008 patent/WO2019039948A1/en unknown
- 2018-06-05 US US16/620,100 patent/US11458196B2/en active Active
- 2018-06-05 EP EP18814708.6A patent/EP3651793A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN111263639A (zh) | 2020-06-09 |
| RO132299A0 (ro) | 2017-12-29 |
| US20210121552A1 (en) | 2021-04-29 |
| WO2019039948A1 (en) | 2019-02-28 |
| EP3651793A1 (en) | 2020-05-20 |
| US11458196B2 (en) | 2022-10-04 |
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