RO112427B1 - Procedeu pentru obtinerea derivatilor de 7-beta-substitut-4-aza-5alfa-androstan-3-ona - Google Patents

Procedeu pentru obtinerea derivatilor de 7-beta-substitut-4-aza-5alfa-androstan-3-ona Download PDF

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Publication number
RO112427B1
RO112427B1 RO94-01868A RO9401868A RO112427B1 RO 112427 B1 RO112427 B1 RO 112427B1 RO 9401868 A RO9401868 A RO 9401868A RO 112427 B1 RO112427 B1 RO 112427B1
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RO
Romania
Prior art keywords
compound
inert
general formula
alk
formula
Prior art date
Application number
RO94-01868A
Other languages
English (en)
Romanian (ro)
Inventor
Raman K Bakshi
Gary H Rasmusson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of RO112427B1 publication Critical patent/RO112427B1/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/80—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings
    • C07C59/82—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings the keto group being part of a ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
RO94-01868A 1992-05-20 1993-05-11 Procedeu pentru obtinerea derivatilor de 7-beta-substitut-4-aza-5alfa-androstan-3-ona RO112427B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/886,049 US5237064A (en) 1992-05-20 1992-05-20 Process for producing 7β-substituted-aza-5αandrostan-3-ones
PCT/US1993/004443 WO1993023376A1 (en) 1992-05-20 1993-05-11 NEW PROCESS FOR PRODUCING 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES

Publications (1)

Publication Number Publication Date
RO112427B1 true RO112427B1 (ro) 1997-09-30

Family

ID=25388268

Family Applications (1)

Application Number Title Priority Date Filing Date
RO94-01868A RO112427B1 (ro) 1992-05-20 1993-05-11 Procedeu pentru obtinerea derivatilor de 7-beta-substitut-4-aza-5alfa-androstan-3-ona

Country Status (11)

Country Link
US (2) US5237064A (OSRAM)
CN (1) CN1084519A (OSRAM)
AU (1) AU4243993A (OSRAM)
CZ (1) CZ283794A3 (OSRAM)
FI (1) FI945441A0 (OSRAM)
HU (1) HUT68232A (OSRAM)
RO (1) RO112427B1 (OSRAM)
RU (1) RU2114117C1 (OSRAM)
SK (1) SK137894A3 (OSRAM)
TW (1) TW234129B (OSRAM)
WO (1) WO1993023376A1 (OSRAM)

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AU4251993A (en) * 1992-05-20 1993-12-13 Merck & Co., Inc. Substituted 4-aza-5A-androstan-ones as 5A-reductase inhibitors
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DE69405760T2 (de) * 1993-06-28 1998-04-09 Merck & Co Inc 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
EP0748221B1 (en) * 1993-11-04 1999-04-14 Merck & Co. Inc. 7-substituted-4-aza-steroid derivatives as 5-alpha- reductase inhibitors
IL111467A0 (en) * 1993-11-12 1994-12-29 Merck & Co Inc Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors
WO1995013815A1 (en) * 1993-11-18 1995-05-26 Merck & Co., Inc. Combination method for the treatment of patterned alopecia
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
US5585383A (en) * 1995-05-03 1996-12-17 Merck & Co., Inc. Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
JPH11513684A (ja) * 1995-10-19 1999-11-24 メルク エンド カンパニー インコーポレーテッド １６−置換−６−アザ−ステロイド５α−レダクターゼ阻害剤
US5763361A (en) * 1995-10-23 1998-06-09 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors
WO1997015558A1 (en) * 1995-10-23 1997-05-01 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives
AU5791698A (en) * 1996-12-09 1998-07-03 Merck & Co., Inc. Methods and compositions for preventing and treating bone loss
US5994334A (en) * 1997-02-05 1999-11-30 University Of Maryland Androgen synthesis inhibitors
AU6462598A (en) * 1997-03-17 1998-10-12 Merck & Co., Inc. Methods and compositions for treating polycystic ovary syndrome
US5994335A (en) * 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
US6187925B1 (en) 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
CA2386095A1 (en) * 1999-09-30 2001-04-05 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
KR100503193B1 (ko) * 2002-08-19 2005-07-25 한미약품 주식회사 3-옥소-4-아자-5α-안드로스탄 화합물의 선택적인 제조방법
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
TWI280133B (en) * 2002-11-07 2007-05-01 Upjohn Co Process for preparing C-7 substituted steroids
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CN1989680B (zh) * 2005-07-06 2012-01-11 松下电器产业株式会社 无刷直流电动机和使用它的电气装置
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法
US7847457B2 (en) * 2007-05-09 2010-12-07 Federal-Mogul World Wide, Inc BLDC motor assembly
ES2552087T3 (es) 2009-02-05 2015-11-25 Tokai Pharmaceuticals, Inc. Nuevos profármacos de inhibidores de CYP17 esteroidales/antiandrógenos
US9884067B2 (en) 2013-03-14 2018-02-06 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
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Also Published As

Publication number Publication date
US5237064A (en) 1993-08-17
HUT68232A (en) 1995-06-28
RU2114117C1 (ru) 1998-06-27
US5578726A (en) 1996-11-26
TW234129B (OSRAM) 1994-11-11
SK137894A3 (en) 1995-05-10
WO1993023376A1 (en) 1993-11-25
FI945441A7 (fi) 1994-11-18
CN1084519A (zh) 1994-03-30
RU94046041A (ru) 1996-10-10
FI945441L (fi) 1994-11-18
CZ283794A3 (en) 1995-10-18
AU4243993A (en) 1993-12-13
FI945441A0 (fi) 1994-11-18

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