PT968722E - Vacina viva melhorada contra brsv. - Google Patents
Vacina viva melhorada contra brsv. Download PDFInfo
- Publication number
- PT968722E PT968722E PT99115633T PT99115633T PT968722E PT 968722 E PT968722 E PT 968722E PT 99115633 T PT99115633 T PT 99115633T PT 99115633 T PT99115633 T PT 99115633T PT 968722 E PT968722 E PT 968722E
- Authority
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- Portugal
- Prior art keywords
- virus
- adjuvants
- vet
- adjuvant
- immunity
- Prior art date
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- 229960005486 vaccine Drugs 0.000 title claims abstract 5
- 239000002671 adjuvant Substances 0.000 claims abstract 13
- 241000711895 Bovine orthopneumovirus Species 0.000 claims abstract 11
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000036039 immunity Effects 0.000 claims abstract 5
- 208000015181 infectious disease Diseases 0.000 claims abstract 4
- 239000004094 surface-active agent Substances 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract 3
- -1 polyoxypropylene Polymers 0.000 claims abstract 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000024932 T cell mediated immunity Effects 0.000 claims abstract 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims abstract 2
- 229920001400 block copolymer Polymers 0.000 claims abstract 2
- 230000028993 immune response Effects 0.000 claims abstract 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract 2
- 229940032094 squalane Drugs 0.000 claims abstract 2
- 229940031439 squalene Drugs 0.000 claims abstract 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims abstract 2
- 241000700605 Viruses Species 0.000 claims 5
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000186216 Corynebacterium Species 0.000 claims 2
- 229920002307 Dextran Polymers 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 229960002086 dextran Drugs 0.000 claims 2
- 229940047124 interferons Drugs 0.000 claims 2
- 230000008774 maternal effect Effects 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 claims 1
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 claims 1
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 102000000589 Interleukin-1 Human genes 0.000 claims 1
- 108010002352 Interleukin-1 Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 102000013967 Monokines Human genes 0.000 claims 1
- 108010050619 Monokines Proteins 0.000 claims 1
- 241000186366 Mycobacterium bovis Species 0.000 claims 1
- 241000702259 Orbivirus Species 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 241000186429 Propionibacterium Species 0.000 claims 1
- 208000035415 Reinfection Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 229920006243 acrylic copolymer Polymers 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- WXNRAKRZUCLRBP-UHFFFAOYSA-N avridine Chemical compound CCCCCCCCCCCCCCCCCCN(CCCN(CCO)CCO)CCCCCCCCCCCCCCCCCC WXNRAKRZUCLRBP-UHFFFAOYSA-N 0.000 claims 1
- 229950010555 avridine Drugs 0.000 claims 1
- 229960000074 biopharmaceutical Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 230000002134 immunopathologic effect Effects 0.000 claims 1
- 229940117681 interleukin-12 Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229940055019 propionibacterium acne Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 102000003390 tumor necrosis factor Human genes 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 3
- 229920001451 polypropylene glycol Polymers 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (5)
- ΡΕ968722 1 REIVINDICAÇÕES 1. Utilização de um Vírus Sincitial Respiratório de Bovinos modificado vivo e de um ou mais adjuvantes em combinação com um ou mais estabilizadores, veículos e adjuvantes aceitáveis do ponto de vista farmacêutico, seleccionados de entre os adjuvantes que proporcionem uma resposta imunológica multifacetada contra o BRSV modificado, sendo os adjuvantes referidos seleccionados de entre aqueles que proporcionem imunidade mediada por células e imunidade local (IgA segregado) e que para além disso sejam elementos do conjunto constituído por: esqualano e o esqualeno (ou outros óleos de origem animal); copolímeros em blocos, de preferência Pluronic® (L121); Saponina; detergentes ou tensioactivos não iónicos, de preferência mono-oleato de polioxietileno(20)-sorbitano Tween®- -80; Quil® A, óleos minerais, de preferência Drakeol® ou Marcol®, óleos vegetais; adjuvantes provenientes de Corynebacterium como por exemplo de Corynebacterium parvum; adjuvantes provenientes de Propionibacterium, de preferência de Propionibacterium acne; Mycobacterium bovis (Bacíllus Calmette e Guerinn, ou BCG); interleuquinas seleccionadas de entre a interleuqina 2 e a interleuquina-12; monoquinas, de preferência a interleuquina 1; factor de necrose tumoral; interferões de preferência interferões gama; combinações de saponina com hidróxido de alumínio ou 2 ΡΕ968722 de Quil® com hidróxido de alumínio; lipossomas; adjuvante iscom; extracto de paredes celulares de micobactérias; glicopéptidos sintéticos, de preferência dipéptidos muramílicos ou outros derivados; Avridina; Lípido A; sulfato de dextrano; DEAE-Dextrano ou DEAE-Dextrano com fosfato de alumínio; carboxipolimetilenos, de preferência o Carbopol®; EMA; emulsões de copolímeros acrílicos, de preferência Neocryl® A640; proteínas de vaccinia ou de vírus de varíola; adjuvantes que sejam partículas subvirais. de preferência o orbivirus; toxina da cólera; brometo de dimetildiocledecilmónio; ou misturas destes, na preparação de uma vacina de Vírus Sincitial Respiratório de Bovinos de dose única, de tal forma que a vacina origine uma imunidade positiva contra a infecção por BRSV após uma única administração.
- 2. A utilização de acordo com a reivindicação 1, em que o adjuvante inclua também um tensioactivo.
- 3. A utilização de acordo com a reivindicação 2, em que o adjuvante também inclua um tensioactivo presente numa concentração final de cerca de 0,0015 a 0,20 % (em volume).
- 4. A utilização de acordo com a reivindicação 2 ou a 3, em que o tensioactivo seja mono-oleato de poli-oxietileno-sorbitano. 3 ΡΕ968722
- 5. A utilização de acordo com qualquer uma das reivindicações 1 a 4, em que a vacina também inclua Virus de Rino-traqueite de Bovinos (BHV-IV), Virus de Diarreia de Bovinos (BVDV), e Virus de Parainfluenza 3 (PI-3V). Lisboa, 27 de Agosto de 2007 ι ΡΕ968722 BIBLIOGRAFIA CITADA NA DESCRIÇÃO A lista da bibliografia citada pela requerente destina-se unicamente ao leitor. Ela não integra o documento de patente Europeia. Ainda que se tenha tido grande cuidado na compilação da bibliografia, não se podem excluir erros nem omissões, e o EPO rejeita qualquer responsabilidade a este respeito. Documentos de patentes citados na descrição • EP 129923 A • US 4772466 A • US 5047238 A Outra literatura citada na descrição • KIMMAN e tal. J. Clin. • Vet. Immunol. Immunopathol., 1989, Microbiol., 1987, 25, 1097- 22(2), 145-160. 1106 . • Bovine Respiratory Syncytial Vírus • STOTT et al. J. Hyg. Camb. and the effect of the amount of 1984, 93, 251-261. vírus, vírus replication, route of • THOMAS et al. Agri-Practice, administration and maternal 1986, 5. antibodies, J. Clin. Microbiol., • SYVRUD et al. Vet. Med., 1987, 25(6), 1.097-1.106 1988, 83, 429-430. • Bovine Respiratory Syncytial Virus • Veterinary Pharmaceuticals & infection, and re-infection in cal- Biologicals. 1993, 78, 484, ves with and without maternal anti 740-741, 956-960, 982-983. bodies. Vet Q., 1991, 13(1), 47-59 • Agri-Practice. Vet. Med. • BAKER, Human and Bovine Respiratory Outubro 1983, 78, 1599-1604. Syncytial Virus immunopathologic • Bovine Vet. Fórum 1, 16 de mechanisms. Semin. Immunol. 1990, Fevereiro de 1986, 2. 2(5), 369-374, • SVYRUD et al. Vet. Med., • THOMAS et al., Agri-Practice 7(5), 1988, 429-430 26-30
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24037394A | 1994-05-10 | 1994-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT968722E true PT968722E (pt) | 2007-09-06 |
Family
ID=22906268
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99115633T PT968722E (pt) | 1994-05-10 | 1995-05-08 | Vacina viva melhorada contra brsv. |
| PT70083787T PT1820512E (pt) | 1994-05-10 | 1995-05-08 | Vacina viva modificada melhorada contra brsv |
| PT95918442T PT759780E (pt) | 1994-05-10 | 1995-05-08 | Vacina melhorada de vsrb vivo modificado |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT70083787T PT1820512E (pt) | 1994-05-10 | 1995-05-08 | Vacina viva modificada melhorada contra brsv |
| PT95918442T PT759780E (pt) | 1994-05-10 | 1995-05-08 | Vacina melhorada de vsrb vivo modificado |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5733555A (pt) |
| EP (4) | EP0968722B1 (pt) |
| JP (3) | JP3993230B2 (pt) |
| KR (1) | KR100374434B1 (pt) |
| CN (1) | CN1268393C (pt) |
| AT (2) | ATE365049T1 (pt) |
| AU (1) | AU711350B2 (pt) |
| BR (1) | BR9507717A (pt) |
| CA (1) | CA2189979C (pt) |
| DE (2) | DE69535520T2 (pt) |
| DK (2) | DK0968722T3 (pt) |
| ES (3) | ES2287997T3 (pt) |
| GR (1) | GR3034402T3 (pt) |
| HK (1) | HK1024412A1 (pt) |
| MY (1) | MY111829A (pt) |
| NZ (1) | NZ285324A (pt) |
| PT (3) | PT968722E (pt) |
| SI (2) | SI0968722T1 (pt) |
| WO (1) | WO1995030437A1 (pt) |
| ZA (1) | ZA953703B (pt) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| DE69332105T2 (de) * | 1992-09-29 | 2003-03-06 | Inhale Therapeutic Systems San | Pulmonale abgabe von aktiven fragmenten des parathormons |
| CA2136677A1 (en) * | 1993-12-29 | 1995-06-30 | Intervet, Inc. | Method of intranasally administering to bovines a trivalent vaccine containing modified live ibrv, pl3v and brsv |
| MX9603936A (es) * | 1994-03-07 | 1997-05-31 | Inhale Therapeutic Syst | Metodos y composiciones para el suministro pulmonar de insulina. |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| AU711350B2 (en) * | 1994-05-10 | 1999-10-14 | Zoetis Services Llc | Improved modified live BRSV vaccine |
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| NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
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| AU711350B2 (en) * | 1994-05-10 | 1999-10-14 | Zoetis Services Llc | Improved modified live BRSV vaccine |
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1995
- 1995-05-08 AU AU24387/95A patent/AU711350B2/en not_active Expired
- 1995-05-08 MY MYPI95001214A patent/MY111829A/en unknown
- 1995-05-08 AT AT99115633T patent/ATE365049T1/de active
- 1995-05-08 NZ NZ285324A patent/NZ285324A/en not_active IP Right Cessation
- 1995-05-08 DK DK99115633T patent/DK0968722T3/da active
- 1995-05-08 EP EP99115633A patent/EP0968722B1/en not_active Expired - Lifetime
- 1995-05-08 SI SI9530731T patent/SI0968722T1/sl unknown
- 1995-05-08 DK DK95918442T patent/DK0759780T3/da active
- 1995-05-08 JP JP52920895A patent/JP3993230B2/ja not_active Expired - Lifetime
- 1995-05-08 EP EP07007405A patent/EP1844791A1/en not_active Withdrawn
- 1995-05-08 EP EP07008378.7A patent/EP1820512B1/en not_active Expired - Lifetime
- 1995-05-08 KR KR1019960706404A patent/KR100374434B1/ko not_active IP Right Cessation
- 1995-05-08 PT PT99115633T patent/PT968722E/pt unknown
- 1995-05-08 WO PCT/US1995/006053 patent/WO1995030437A1/en active IP Right Grant
- 1995-05-08 ES ES99115633T patent/ES2287997T3/es not_active Expired - Lifetime
- 1995-05-08 DE DE69535520T patent/DE69535520T2/de not_active Expired - Lifetime
- 1995-05-08 ES ES07008378T patent/ES2429401T3/es not_active Expired - Lifetime
- 1995-05-08 SI SI9530374T patent/SI0759780T1/xx unknown
- 1995-05-08 BR BR9507717A patent/BR9507717A/pt not_active IP Right Cessation
- 1995-05-08 ES ES95918442T patent/ES2149361T3/es not_active Expired - Lifetime
- 1995-05-08 EP EP95918442A patent/EP0759780B1/en not_active Expired - Lifetime
- 1995-05-08 AT AT95918442T patent/ATE195255T1/de active
- 1995-05-08 DE DE69518316T patent/DE69518316T2/de not_active Expired - Lifetime
- 1995-05-08 CN CNB951939424A patent/CN1268393C/zh not_active Expired - Lifetime
- 1995-05-08 PT PT70083787T patent/PT1820512E/pt unknown
- 1995-05-08 ZA ZA953703A patent/ZA953703B/xx unknown
- 1995-05-08 PT PT95918442T patent/PT759780E/pt unknown
- 1995-05-08 CA CA2189979A patent/CA2189979C/en not_active Expired - Lifetime
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1996
- 1996-04-25 US US08/638,879 patent/US5733555A/en not_active Expired - Lifetime
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1997
- 1997-12-18 US US08/993,400 patent/US5958423A/en not_active Expired - Lifetime
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2000
- 2000-06-21 HK HK00103769A patent/HK1024412A1/xx not_active IP Right Cessation
- 2000-09-13 GR GR20000402092T patent/GR3034402T3/el unknown
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2007
- 2007-03-07 JP JP2007057402A patent/JP2007137905A/ja not_active Withdrawn
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2011
- 2011-08-26 JP JP2011184908A patent/JP2011246489A/ja active Pending
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